CN-122010963-A - Polycyclic SMARCA2 inhibitor and application thereof

Abstract

The invention relates to a polycyclic SMARCA2 inhibitor and application thereof. In particular, the present invention relates to SMARCA2 inhibitors having the structure of formula (I) and pharmaceutical compositions thereof, their use as SMARCA2 inhibitors and their use in the manufacture of a medicament for the treatment of cancer or tumour associated at least in part with SMARCA 2. Wherein each substituent of formula (I) is as defined in the specification.

Inventors

• DU XINMING
• LI ZHENG
• DENG HAIBING
• ZHANG YONGXIAN
• YU HONGPING
• CHEN ZHUI

Assignees

• 上海和誉生物医药科技有限公司

Dates

Publication Date

20260512

Application Date

20251110

Priority Date

20241112

Claims (20)

1. 1. A compound of formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Wherein X is CR 5 , N, or a bond; Y 1 is selected from -O(CR 6a R 6b ) m1 O-、-(CR 6a R 6 b)m 2 O(CR 6a R 6b )m 3 -、-O(CR 6a R 6b ) m4 N(R 7 )-、-N(R 8 )(CR 9a R 9b ) m5 -、-CR 6a R 6b -、-O-、-S-、-S(O)-、-S(O) 2 -、-S(O) 2 N(R 10 )-、-S(O)(＝NR 11 )- and a bond, m1 is 1,2 or 3, m2 is 0,1 or 2, m3 is 0,1 or 2, m4 is 0,1 or 2, m5 is 0,1 or 2, wherein m2 and m3 are not both 0; Y 2 is selected from -O(CR 12a R 12b ) n1 -、-N(R 13 )(CR 14a R 14b ) n2 -、-(CR 15a R 15b ) n3 -、-N(R 16 )-、-O-、-S-、-S(O)-、-S(O) 2 -、-S(O) 2 N(R 17 )-、-S(O)(＝NR 18 )- and a bond, n1 is 1 or 2, n2 is 1 or 2, n3 is 1 or 2, provided that when Y 2 is selected from -O(CR 12a R 12b ) n1 -、-N(R 13 )(CR 14a R 14b ) n2 -、-N(R 16 )-、-O- or-S-, Y 1 is not C (O); R 1 is selected from hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), independently optionally further substituted with one OR more deuterium groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); r 2 is selected from hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, 11-25 membered heterocycloalkylene tricyclic, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), independently optionally further substituted with one OR more deuterium groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =o, =s, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 ) and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one OR more substituents selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 3a , each R 3b , each R 4a , and each R 4b is independently selected from hydrogen, deuterium, and mixtures thereof, Halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), OR R 3a and R 4a ,R 3a and R 3b ,R 4a and R 4b together with the portion directly linked thereto form a C 3-10 cycloalkyl group, 3-10 membered heterocyclyl, C 6-10 aryl or 5-10 membered heteroaryl, each of which is independently optionally further substituted with one or more groups selected from deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, halo-substituted C 1-10 alkyl, deuterium-substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-to 10-membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =o, =s, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ) substituents OR R 3a and R 3b ,R 4a and R 4b together with the carbon atom to which they are directly attached form a C (O); R 5 is selected from hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), independently optionally further substituted with one OR more deuterium groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 6a and each R 6b is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-to 10-membered heterocyclyl, C 6-10 aryl, 5-to 10-membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), OR R 6a and R 6b together with the directly attached carbon atoms form a C (O), which is optionally further independently selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 7 and R 8 are each independently selected from hydrogen, deuterium, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-C (=nr 25 )R 24 and-C 0-8 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 9a and each R 9b is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-to 10-membered heterocyclyl, C 6-10 aryl, 5-to 10-membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), OR R 9a and R 9b together with the directly attached carbon atoms form a C (O), which is optionally further independently selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); each R 9c is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), independently optionally further substituted with one OR more deuterium groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 10 and R 11 are each independently selected from hydrogen, deuterium, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-C (=nr 25 )R 24 and-C 0-8 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 12a and each R 12b is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-to 10-membered heterocyclyl, C 6-10 aryl, 5-to 10-membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), OR R 12a and R 12b together with the directly attached carbon atoms form a C (O), which is optionally further independently selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 13 is selected from hydrogen, deuterium, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-C (=nr 25 )R 24 and-C 0-8 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 14a and each R 14b is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-to 10-membered heterocyclyl, C 6-10 aryl, 5-to 10-membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), OR R 14a and R 14b together with the directly attached carbon atoms form a C (O), which is optionally further independently selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 15a and each R 15b is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-to 10-membered heterocyclyl, C 6-10 aryl, 5-to 10-membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 ), OR R 15a and R 15b together with the directly attached carbon atoms form a C (O), C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl or 5-10 membered heteroaryl, each of which is independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, halogen, C 1-10 alkyl, Deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-to 10-membered heterocyclyl, c 6-10 aryl, 5-10 membered heteroaryl, =o, =s, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 16 is selected from hydrogen, deuterium, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-C (=nr 25 )R 24 and-C 0-8 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 17 and R 18 are each independently selected from hydrogen, deuterium, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-C (=nr 25 )R 24 and-C 0-8 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, =O, =S, -C 0-8 alkyl-SF 5 、-C 0-8 alkyl-S (O) (=n-R 19 )R 20 、-C 0-8 alkyl-n=s (O) R 20 R 21 、-C 0-8 alkyl-n=sr 20 R 21 、-C 0-8 alkyl-O-S (O) 2 R 22 、-C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) SR 23 、-C 0-8 alkyl-S-C (O) R 24 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-P (O) (R 24 ) 2 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 19 is independently selected from hydrogen, deuterium, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) R 24 and-C 0-8 alkyl-C (O) NR 25 R 26 , optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, halogen-substituted C 1-10 alkyl, Deuterium substituted C 1-10 alkyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (substituted for R 25 )-C(O)R 24 ; Each R 20 and each R 21 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-10 alkyl, C 2-10 alkenyl, c 2-10 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl and 5-10 membered heteroaryl, or R 20 and R 21 together with the sulfur atom to which they are directly attached form a 3-10 membered heterocyclyl, optionally further substituted with one or more groups selected from deuterium, or a salt thereof, Halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, halogen-substituted C 1-10 alkyl, Deuterium substituted C 1-10 alkyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-S (O) r R 22 、-C 0-8 alkyl-O-R 23 、-C 0-8 alkyl-C (O) OR 23 、-C 0-8 alkyl-C (O) R 24 、-C 0-8 alkyl-O-C (O) R 24 、-C 0-8 alkyl-NR 25 R 26 、-C 0-8 alkyl-C (=nr 25 )R 24 、-C 0-8 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-8 alkyl-C (O) NR 25 R 26 and-C 0-8 alkyl-N (substituted for R 25 )-C(O)R 24 ; Each R 22 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-10 alkyl, C 2-10 alkenyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, and-NR 25 R 26 , each of which is independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, cyano, hydroxy, = O, C 1-10 alkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkoxy, 3-12 membered heterocyclyl, 3-12 membered heteroaryloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, and-NR 25 R 26 ; Each R 23 is independently selected from the group consisting of hydrogen, deuterium, C 1-10 alkyl, C 2-10 alkenyl, C 3-12 cycloalkyl, 3-12 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, and 11-25 membered heterocarbon tricyclic, each of which is independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, hydroxy, =o, cyano, C 1-10 alkyl, halo-substituted C 1-10 alkyl, deuterium-substituted C 1-10 alkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkoxy, 3-12 membered heterocyclyl, 3-12 membered heteroepoxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, and-NR 25 R 26 ; Each R 24 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-10 alkyl, C 1-10 alkoxy, C 2-10 alkenyl, C 2-10 Alkynyl, C 3-12 cycloalkyl, C 3-12 cycloalkoxy, 3-12 membered heterocyclyl, 3-12 membered heteroepoxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy and-NR 25 R 26 , which are independently optionally further substituted with one or more groups selected from deuterium, halogen, hydroxy, =O, cyano, C 1-10 alkyl, halogen-substituted C 1-10 alkyl, Deuterium substituted C 1-10 alkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkoxy, 3-12 membered heterocyclyl, 3-12 membered heteroaryloxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy and-NR 25 R 26 ; Each R 25 and each R 26 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, C 3-12 cycloalkyl, 3-to 12-membered heterocyclyl, C 6-10 aryl, 5-to 10-membered heteroaryl, sulfinyl, sulfonyl, methanesulfonyl, isopropylsulfonyl, cyclopropylsulfonyl, p-toluenesulfonyl, aminosulfonyl, dimethylaminosulfonyl and C 1-10 alkanoyl, said groups being independently optionally further substituted with one or more groups selected from deuterium, halogen, hydroxy, = O, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, Halogen substituted C 1-10 alkyl, deuterium substituted C 1-10 alkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkoxy, 3-12 membered heterocyclyl, 3-12 membered heteroepoxy, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, amino, mono C 1-10 alkylamino, di C 1-10 alkylamino and C 1-10 alkanoyl; Or R 25 and R 26 together with the nitrogen atom to which they are directly attached form a 4-10 membered heterocyclyl or 5-10 membered heteroaryl, said 4-10 membered heterocyclyl or 5-10 membered heteroaryl optionally further substituted with one or more substituents selected from deuterium, halogen, hydroxy, = O, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, halo-substituted C 1-10 alkyl, deuterium-substituted C 1-10 alkyl, C 1-10 alkoxy, C 3-12 cycloalkyl, C 3-12 cycloalkoxy, 3-12 membered heterocyclyl, 3-12 membered heteroaryl, C 6-10 aryl, C 6-10 aryloxy, 5-10 membered heteroaryl, 5-10 membered heteroaryloxy, amino, mono C 1-10 alkylamino, di C 1-10 alkylamino and C 1-10 alkanoyl; each r is independently 0,1 or 2.
2. 2. A compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 1, wherein Y 1 is selected from -O(CR 6a R 6b )O-、-O(CR 6a R 6b )-、-O(CR 6a R 6b )(CR 6a R 6b )-、-(CR 6a R 6b )O(CR 6a R 6b )-、-O(CR 6a R 6b )N(R 7 )-、-CR 6a R 6b -、-O-、-N(R 8 )(CR 9a R 9b )-、-S-、-S(O)-、-S(O) 2 -、-S(O) 2 N(R 10 )-、-S(O)(＝NR 11 )- and a bond; Y 2 is selected from -O(CR 12a R 12b )-、-N(R 13 )(CR 14a R 14b )-、-(CR 15a R 15b )-、-N(R 16 )-、-O-、-S-、-S(O)-、-S(O) 2 -、-S(O) 2 N(R 17 )-、-S(O)(＝NR 18 )- or a bond; provided that the conditions are that, when Y 2 is selected from the group consisting of-O (CR 12a R 12b )-、-N(R 13 )(CR 14a R 14b )-、-N(R 16 ) -, -O-or-S-, Y 1 is not C (O); R 1 is selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), independently optionally further substituted with one OR more deuterium groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 2 is selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, 11-25 membered heterocycloalkylene tricyclic, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), independently optionally further substituted with one OR more deuterium groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, =s, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 ) and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one OR more substituents selected from deuterium, Halogen, cyano, nitro, azido, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 3a and each R 3b , each R 4a and each R 4b are each independently selected from hydrogen, deuterium, and mixtures thereof, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), OR R 3a and R 4a ,R 3a and R 3b ,R 4a and R 4b together with the portion directly linked thereto form a C 3-8 cycloalkyl group, 3-8 membered heterocyclyl, C 6-8 aryl or 5-8 membered heteroaryl, each of which is independently optionally further substituted with one or more groups selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, =s, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Or R 3a and R 3b ,R 4a and R 4b together with the carbon atom to which they are directly attached form a C (O); R 5 is selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), independently optionally further substituted with one OR more deuterium groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 6a and each R 6b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), OR R 6a and R 6b together with the directly attached carbon atoms form a C (O), which is optionally further independently selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 7 and R 8 are each independently selected from hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-C (=nr 25 )R 24 and-C 0-4 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 9a and each R 9b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), OR R 9a and R 9b together with the directly attached carbon atoms form a C (O), which is optionally further independently selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 9c is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), independently optionally further substituted with one OR more deuterium groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 10 and R 11 are each independently selected from hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-C (=nr 25 )R 24 and-C 0-4 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 12a and each R 12b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), OR R 12a and R 12b together with the directly attached carbon atoms form a C (O), which is optionally further independently selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 13 is selected from hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-C (=nr 25 )R 24 and-C 0-4 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 14a and each R 14b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), OR R 14a and R 14b together with the directly attached carbon atoms form a C (O), which is optionally further independently selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Each R 15a and each R 15b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 ), OR R 15a and R 15b together with the directly attached carbon atoms form a C (O), C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl or 5-8 membered heteroaryl, each of which is independently optionally further substituted with one or more groups selected from deuterium, halogen, cyano, C 1-4 alkyl, halogen-substituted C 1-4 alkyl, Deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, =s, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 16 is selected from hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-C (=nr 25 )R 24 and-C 0-4 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); R 17 and R 18 are each independently selected from hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-C (=nr 25 )R 24 and-C 0-4 alkyl-C (O) NR 25 R 26 , independently optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -C 0-4 alkyl-SF 5 、-C 0-4 alkyl-S (O) (=n-R 19 )R 20 、-C 0-4 alkyl-n=s (O) R 20 R 21 、-C 0-4 alkyl-n=sr 20 R 21 、-C 0-4 alkyl-O-S (O) 2 R 22 、-C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) SR 23 、-C 0-4 alkyl-S-C (O) R 24 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-P (O) (R 24 ) 2 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (R 25 )-C(O)R 24 substituents substituted); Wherein R 19 、R 20 、R 21 、R 22 、R 23 、R 24 、R 25 、R 26 and R are as defined in claim 1.
3. 3. The compound of formula (I), stereoisomer, or pharmaceutically acceptable salt thereof according to claim 1, wherein each R 19 is independently selected from hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) R 24 and-C 0-4 alkyl-C (O) NR 25 R 26 , optionally further substituted with one OR more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, halo-substituted C 1-4 alkyl, Deuterium substituted C 1-4 alkyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (substituted for R 25 )-C(O)R 24 ; Each R 20 and each R 21 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl and 5-8 membered heteroaryl, or R 20 and R 21 together with the sulfur atom to which they are directly attached form a 3-6 membered heterocyclyl, optionally further substituted with one or more groups selected from deuterium, or a salt thereof, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, halo-substituted C 1-4 alkyl, Deuterium substituted C 1-4 alkyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -C 0-4 alkyl-S (O) r R 22 、-C 0-4 alkyl-O-R 23 、-C 0-4 alkyl-C (O) OR 23 、-C 0-4 alkyl-C (O) R 24 、-C 0-4 alkyl-O-C (O) R 24 、-C 0-4 alkyl-NR 25 R 26 、-C 0-4 alkyl-C (=nr 25 )R 24 、-C 0-4 alkyl-N (R 25 )-C(＝NR 26 )R 24 、-C 0-4 alkyl-C (O) NR 25 R 26 and-C 0-4 alkyl-N (substituted for R 25 )-C(O)R 24 ; Each R 22 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, and-NR 25 R 26 , each of which is independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, cyano, hydroxy, = O, C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroaryloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and-NR 25 R 26 ; Each R 23 is independently selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, and 11-25 membered heterocarbon tricyclic, each of which is independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, hydroxy, =o, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroepoxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and-NR 25 R 26 ; Each R 24 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 2-4 alkenyl, C 2-4 Alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroepoxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy and-NR 25 R 26 , which are independently optionally further substituted with one or more groups selected from deuterium, halogen, hydroxy, =O, cyano, C 1-4 alkyl, halogen-substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroaryloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy and-NR 25 R 26 ; Each R 25 and each R 26 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, sulfinyl, sulfonyl, methanesulfonyl, isopropylsulfonyl, cyclopropylsulfonyl, p-toluenesulfonyl, aminosulfonyl, Dimethylaminosulfonyl and C 1-4 alkanoyl, said groups being independently optionally further substituted with one or more groups selected from deuterium, halogen, hydroxy, = O, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroepoxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, amino, mono C 1-4 alkylamino, di C 1-4 alkylamino and C 1-4 alkanoyl; Or R 25 and R 26 together with the nitrogen atom to which they are directly attached form a 4-8 membered heterocyclyl or 5-8 membered heteroaryl, said 4-8 membered heterocyclyl or 5-8 membered heteroaryl optionally being further substituted with one or more substituents selected from deuterium, halogen, hydroxy, = O, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroaryl, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, amino, mono C 1-4 alkylamino, di C 1-4 alkylamino and C 1-4 alkanoyl.
4. 4. The compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 1, wherein the compound of formula (I) is a compound of formula (IIa): Wherein X is CR 5 , N, or a bond; Y 1 is selected from -O(CR 6a R 6b )O-、-O(CR 6a R 6b )-、-O(CR 6a R 6b )(CR 6a R 6b )-、-(CR 6a R 6b )O(CR 6a R 6b )-、-O(CR 6a R 6b )N(R 7 )-、-CR 6a R 6b -、-O-、-N(R 8 )(CR 9a R 9b )-、-S-、-S(O)-、-S(O) 2 -、-S(O) 2 N(R 10 )-、-S(O)(＝NR 11 )- and a bond; Y 2 is selected from -O(CR 12a R 12b )-、-N(R 13 )(CR 14a R 14b )-、-(CR 15a R 15b )-、-N(R 16 )-、-O-、-S-、-S(O)-、-S(O) 2 -、-S(O) 2 N(R 17 )-、-S(O)(＝NR 18 )- and a bond; provided that the conditions are that, when Y 2 is selected from the group consisting of-O (CR 12a R 12b )-、-N(R 13 )(CR 14a R 14b )-、-N(R 16 ) -, -O-or-S-, Y 1 is not C (O); R 1 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 , and-N (R 25 )-C(O)R 24 , which are independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 , and-N (R 25 )-C(O)R 24 ; R 2 is selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, 11-25 membered heterocycloalkylene tricyclic 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 -P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , which are independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 8-membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted with a substituent of R 25 )-C(O)R 24 ; R 3a 、R 3b 、R 4a and R 4b are each independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 Alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , or R 3a and R 4a ,R 3a and R 3b ,R 4a and R 4b together with the moiety to which they are directly attached form a C 3-8 cycloalkyl group, 3-8 membered heterocyclyl, C 6-8 aryl or 5-8 membered heteroaryl, each of which is independently optionally further substituted with one or more groups selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted with a substituent of R 25 )-C(O)R 24 ; Or R 3a and R 3b ,R 4a and R 4b together with the carbon atom to which they are directly attached form a C (O); R 5 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 , and-N (R 25 )-C(O)R 24 , which are independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 , and-N (R 25 )-C(O)R 24 ; Each R 6a and each R 6b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 Alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , or R 6a and R 6b together with the carbon atom to which they are directly attached form a C (O), said groups being independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; R 7 and R 8 are each independently selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-C(O)OR 23 、-C(O)SR 23 、-C(O)R 24 、-C(＝NR 25 )R 24 , and-C (O) NR 25 R 26 , each of which is independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 , and-N (R 25 )-C(O)R 24 ; Each R 9a and each R 9b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 Alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , or R 9a and R 9b together with the carbon atom to which they are directly attached form a C (O), said groups being independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; R 10 and R 11 are each independently selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-C(O)OR 23 、-C(O)SR 23 、-C(O)R 24 、-C(＝NR 25 )R 24 , and-C (O) NR 25 R 26 , each of which is independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 , and-N (R 25 )-C(O)R 24 ; r 12a and R 12b are each independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 Alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , or R 12a and R 12b together with the carbon atom to which they are directly attached form a C (O), said groups being independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; R 13 is selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-C(O)OR 23 、-C(O)SR 23 、-C(O)R 24 、-C(＝NR 25 )R 24 , and-C (O) NR 25 R 26 , which are independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 , and-N (R 25 )-C(O)R 24 ; R 14a and R 14b are each independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 Alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , or R 14a and R 14b together with the carbon atom to which they are directly attached form a C (O), said groups being independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; R 15a and R 15b are each independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 Alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , or R 15a and R 15b together with the carbon atom to which they are directly attached form a C 3-6 cycloalkyl group), 3-6 membered heterocyclyl, C 6-8 aryl or 5-8 membered heteroaryl, each of which is independently optionally further substituted with one or more groups selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted with a substituent of R 25 )-C(O)R 24 ; R 16 is selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-C(O)OR 23 、-C(O)SR 23 、-C(O)R 24 、-C(＝NR 25 )R 24 , and-C (O) NR 25 R 26 , which are independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 , and-N (R 25 )-C(O)R 24 ; R 17 and R 18 are each independently selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-C(O)OR 23 、-C(O)SR 23 、-C(O)R 24 、-C(＝NR 25 )R 24 , and-C (O) NR 25 R 26 , each of which is independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 , and-N (R 25 )-C(O)R 24 ; Wherein R 19 、R 20 、R 21 、R 22 、R 23 、R 24 、R 25 、R 26 and R are as defined in claim 1.
5. 5. The compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 1, wherein the compound of formula (I) is a compound of formula (IIIa 1-1) or formula (IIIa 1-2) as follows: Wherein each Y 1 is independently selected from -O(CR 6a R 6b )O-、-O(CR 6a R 6b )-、-O(CR 6a R 6b )(CR 6a R 6b )-、-(CR 6a R 6b )O(CR 6a R 6b )-、-O(CR 6a R 6b )N(R 7 )-、-CR 6a R 6b -、-O-、-S-、-S(O)-、-S(O) 2 - and a bond; Each R 1 is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 , and-NR 25 R 26 ; Each R 2 is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, 11-25 membered heterocycloalkylene tricyclic 、-SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 、-C(O)R 24 、-C(O)NR 25 R 26 and-NR 25 R 26 , which are independently optionally further substituted with one or more substituents selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; Each R 3a and each R 4a together with the moiety to which they are directly attached form a C 3-8 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl or 5-8 membered heteroaryl, each of which is independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, =s, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 and-NR 25 R 26 ; Each R 3b and each R 4b are independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 , each of which is independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, =s, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 , and-NR 25 R 26 ; Each R 6a and each R 6b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, -SF 5 、-O-R 23 and-NR 25 R 26 , or R 6a and R 6b together with the carbon atom to which they are directly attached form a C (O), said groups being independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, substituents substituted with C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, =s, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 and-NR 25 R 26 ; Each R 7 is independently selected from hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, and-SF 5 , each of which is independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, =s, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 , and-NR 25 R 26 ; Wherein R 22 、R 23 、R 24 、R 25 、R 26 and R are as defined in claim 1.
6. 6. The compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 1, wherein the compound of formula (I) is a compound of formula (IVa 1-1) or (IVa 1-2) as follows: Wherein each Y 1 is independently selected from -O(CR 6a R 6b )O-、-O(CR 6a R 6b )-、-O(CR 6a R 6b )(CR 6a R 6b )-、-(CR 6a R 6b )O(CR 6a R 6b )-、-O(CR 6a R 6b )N(R 7 )-、-CR 6a R 6b -、-O-、-S-、-S(O)-、-S(O) 2 - and a bond; Each ring a is independently C 3-6 cycloalkyl, 3-6 membered heterocyclyl, phenyl or 5-6 membered heteroaryl, said 3-6 membered heterocyclyl and 5-6 membered heteroaryl containing one or more heteroatoms selected from nitrogen, oxygen or sulfur; Each R a is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 , p is 0, 1,2,3, or 4; Each R 1 is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 ; Each R 2 is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, 11-25 membered heterocycloalkylene tricyclic, -SF 5 、-O-R 23 、-C(O)R 24 、-C(O)NR 25 R 26 and-NR 25 R 26 , which are independently optionally further substituted with one or more substituents selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; each R 6a and each R 6b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 and-NR 25 R 26 , or R 6a and R 6b together with the carbon atom to which they are directly attached form a C (O); Each R 7 is independently selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, and-SF 5 ; Wherein R 22 、R 23 、R 24 、R 25 、R 26 and R are as defined in claim 1.
7. 7. The compound of formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 6, wherein the compound of formula (I) is a compound of formula (Va-1-1) or formula (Va-1-2) as follows: Wherein R a and R 2 are as defined in claim 6.
8. 8. The compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 1, wherein the compound of formula (I) is a compound of formula (IIIa 2) as follows: Wherein Y 1 is selected from -O(CR 6a R 6b )O-、-O(CR 6a R 6b )-、-O(CR 6a R 6b )(CR 6a R 6b )-、-(CR 6a R 6b )O(CR 6a R 6b )-、-O(CR 6a R 6b )N(R 7 )-、-CR 6a R 6b -、-O-、-S-、-S(O)-、-S(O) 2 - and a bond; R 1 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 , and-NR 25 R 26 ; R 2 is selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 、-C(O)R 24 、-C(O)NR 25 R 26 and-NR 25 R 26 , which are independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; R 3a 、R 3b 、R 4a and R 4b are each independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 ; Or R 3a and R 3b ,R 4a and R 4b together with the carbon atom to which they are directly attached form a C (O); R 15a and R 15b are each independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 , and-NR 25 R 26 , or R 15a and R 15b together with the carbon atom to which they are directly attached form a C (O); Wherein any one of the three groups R 3a and R 4a ,R 4a and R 4b ,R 15a and R 15b together with the moiety to which they are directly attached form a C 3-8 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl or 5-8 membered heteroaryl, the remaining two groups being independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, =s, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 and-NR 25 R 26 ; Each R 6a and each R 6b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, -SF 5 、-O-R 23 and-NR 25 R 26 , or R 6a and R 6b together with the carbon atom to which they are directly attached form a C (O), said groups being independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, substituents substituted with C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, =s, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 and-NR 25 R 26 ; R 7 is selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, and-SF 5 , which are independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =O, =S, -SF 5 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-O-C(O)R 24 , and-NR 25 R 26 ; Wherein R 22 、R 23 、R 24 、R 25 、R 26 and R are as defined in claim 1.
9. 9. The compound of formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 8, wherein the compound of formula (I) is a compound of formula (IVa 21), (IVa 22), or (IVa 23) as follows: Wherein each Y 1 is independently-O-, -C (O) -or a bond; in the compounds of formula (IVa 21), ring A is selected from C 3-6 cycloalkyl, 3-6 membered heterocyclyl, phenyl or 5-6 membered heteroaryl, said 3-6 membered heterocyclyl and 5-6 membered heteroaryl containing one or more heteroatoms selected from nitrogen, oxygen or sulphur; Each ring a' in a compound of formula (IVa 22) or (IVa 23) is independently selected from C 3-6 cycloalkyl or a 3-6 membered heterocyclyl containing one or more heteroatoms selected from nitrogen, oxygen or sulfur; Each R a is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 , p is 0, 1,2,3, or 4; R 1 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 ; R 2 is selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 、-C(O)R 24 、-C(O)NR 25 R 26 and-NR 25 R 26 , which are independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; R 3a 、R 3b 、R 4a 、R 4b 、R 15a and R 15b are each independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 and-NR 25 R 26 , or R 3a and R 3b ,R 4a and R 4b ,R 15a and R 15b together with the carbon atom to which they are directly attached form a C (O); Wherein R 22 、R 23 、R 24 、R 25 、R 26 and R are as defined in claim 8.
10. 10. The compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 1, wherein the compound of formula (I) is a compound of formula (IIIa 3) as follows: Wherein Y 1 is selected from -O(CR 6a R 6b )O-、-O(CR 6a R 6b )-、-O(CR 6a R 6b )(CR 6a R 6b )-、-(CR 6a R 6b )O(CR 6a R 6b )-、-O(CR 6a R 6b )N(R 7 )-、-O-、-S-、-S(O)-、-S(O) 2 - and a bond; R 1 is selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 ; R 2 is selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 、-C(O)R 24 、-C(O)NR 25 R 26 and-NR 25 R 26 , which are independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; each R 6a and each R 6b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 and-NR 25 R 26 , or R 6a and R 6b together with the carbon atom to which they are directly attached form a C (O); R 7 is selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, and-SF 5 ; Each R a is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 , p is selected from 0, 1, 2, 3, or 4; Wherein R 22 、R 23 、R 24 、R 25 、R 26 and R are as defined in claim 1.
11. 11. A compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 1, wherein Y 1 is selected from -O-CH 2 -O-、-O-CH 2 -CH 2 -、-CH 2 -O-CH 2 -、-O-C(O)-NH-、-O-C(O)-CH 2 -、-C(O)-O-CH 2 - and-O-CH 2 -NH-; or Y 1 is-O-CH 2 -or-O-C (O) -; 2 -or-O-C (O) -.
12. 12. The compound of formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, according to claim 1, wherein the compound of formula (I) is a compound of formula (IIb 1) or formula (IIb 2) as follows: Wherein each X is independently CR 5 or N; each R 1 is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , which are independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ; Each R 2 is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 -P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , which are independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; Each R 3a and each R 4a is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 Alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , or each of R 3a and R 4a together with the moiety to which they are directly attached independently form a C 3-8 cycloalkyl group, 3-8 membered heterocyclyl, C 6-8 aryl or 5-8 membered heteroaryl, each of which is independently optionally further substituted with one or more groups selected from deuterium, halogen, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (substituted with a substituent of R 25 )-C(O)R 24 ; Each R 5 is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , which are independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ; Each R 9c is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 , which are independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-SF 5 、-S(O)(＝N-R 19 )R 20 、-N＝S(O)R 20 R 21 、-N＝SR 20 R 21 、-O-S(O) 2 R 22 、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)SR 23 、-S-C(O)R 24 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(＝NR 25 )R 24 、-N(R 25 )-C(＝NR 26 )R 24 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ; Wherein R 19 、R 20 、R 21 、R 22 、R 23 、R 24 、R 25 、R 26 and R are as defined in claim 1.
13. 13. The compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 1, wherein the compound of formula (I) is a compound of formula (IIIb 1) or formula (IIIb 2) as follows: Wherein each R 1 is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 ; Each R 2 is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 and-NR 25 R 26 , which are independently optionally further substituted with one or more groups selected from deuterium, Halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(O)NR 25 R 26 and-N (R 25 )-C(O)R 24 ) independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl 、＝O、＝S、-S(O) r R 22 、-O-R 23 、-C(O)OR 23 、-C(O)R 24 、-O-C(O)R 24 、-P(O)(R 24 ) 2 、-NR 25 R 26 、-C(O)NR 25 R 26 and-N (substituted by the substituents R 25 )-C(O)R 24 ; Each R 9c is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 ; Each R a is independently selected from the group consisting of hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 , and-NR 25 R 26 , each p is independently selected from the group consisting of 0,1, 2,3, or 4; Wherein R 22 、R 23 、R 24 、R 25 、R 26 and R are as defined in claim 1.
14. 14. A compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 7, wherein R a is selected from hydrogen, deuterium, fluoro, chloro, bromo, cyano, methyl, ethyl, isopropyl, trifluoromethyl, tridecylmethyl, vinyl, ethynyl, cyclopropyl, hydroxy, methoxy, isopropoxy, cyclopropoxy, amino, mono-C 1-10 alkylamino and di-C 1-10 alkylamino; Each R 2 is independently hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -O-R 23 、-NR 25 R 26 , and-C (O) NR 25 R 26 , each of which is independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, 3-8 membered heterocyclyl-substituted C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, -O-R 23 、-NR 25 R 26 , and-C (O) NR 25 R 26 ; Each R 23 is independently selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, and 11-25 membered heterocarbon tricyclic, each of which is independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, hydroxy, =o, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroepoxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and-NR 25 R 26 ; Each R 25 and each R 26 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, sulfinyl, sulfonyl, methanesulfonyl, isopropylsulfonyl, cyclopropylsulfonyl, p-toluenesulfonyl, aminosulfonyl, Dimethylaminosulfonyl and C 1-4 alkanoyl, said groups being independently optionally further substituted with one or more groups selected from deuterium, halogen, hydroxy, = O, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroepoxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, amino, mono C 1-4 alkylamino, di C 1-4 alkylamino and C 1-4 alkanoyl; Or R 25 and R 26 together with the nitrogen atom to which they are directly attached form a 4-8 membered heterocyclyl or 5-8 membered heteroaryl, said 4-8 membered heterocyclyl or 5-8 membered heteroaryl optionally being further substituted with one or more substituents selected from deuterium, halogen, hydroxy, = O, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroaryl, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, amino, mono C 1-4 alkylamino, di C 1-4 alkylamino and C 1-4 alkanoyl.
15. 15. The compound of formula (I), stereoisomer, or pharmaceutically acceptable salt thereof, according to claim 1, wherein R 1 is selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 , hydroxy, C 1-4 alkoxy, halo-substituted C 1-4 alkoxy, deuterium-substituted C 1-4 alkoxy, C 3-6 Cycloalkoxy, 3-6 membered heteroaryloxy, C 6-8 aryloxy, 5-8 membered heteroaryloxy, amino, mono C 1-10 alkylamino, di C 1-10 alkylamino, mono-C 3-6 cycloalkyl substituted amino, mono-3-6 membered heterocyclyl substituted amino, mono-C 6-8 aryl substituted amino, and mono-5-8 membered heteroaryl substituted amino; R 2 is selected from the group consisting of C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -O-R 23 、-C(O)R 24 、-C(O)NR 25 R 26 and-NR 25 R 26 , each independently optionally further substituted with one or more groups selected from deuterium, halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 8-membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, =o, -O-R 23 、-C(O)R 24 、-C(O)NR 25 R 26 and-NR 25 R 26 , each of which is independently optionally further substituted with one or more substituents selected from deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, Deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-8 membered heterocyclyl, Substituents for C 6-8 aryl, 5-8 membered heteroaryl, =o, -O-R 23 、-C(O)R 24 and-NR 25 R 26 ; each R 6a and each R 6b is independently selected from hydrogen, deuterium, halogen, cyano, C 1-4 alkyl, halo substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, -SF 5 、-O-R 23 and-NR 25 R 26 , or R 6a and R 6b together with the carbon atom to which they are directly attached form a C (O); Each R 7 is independently selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, and 5-8 membered heteroaryl; Each R 23 is independently selected from the group consisting of hydrogen, deuterium, C 1-4 alkyl, C 2-4 alkenyl, C 3-6 cycloalkyl, 3-6 membered heterocyclyl, C 6-8 aryl, 5-8 membered heteroaryl, and 11-25 membered heterocarbon tricyclic, each of which is independently optionally further substituted with one or more substituents selected from the group consisting of deuterium, halogen, hydroxy, =o, cyano, C 1-4 alkyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroepoxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, and-NR 25 R 26 ; Each R 24 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 2-4 alkenyl, C 2-4 Alkynyl, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroepoxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy and-NR 25 R 26 , which are independently optionally further substituted with one or more groups selected from deuterium, halogen, hydroxy, =O, cyano, C 1-4 alkyl, halogen-substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroaryloxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy and-NR 25 R 26 ; Each R 25 and each R 26 is independently selected from the group consisting of hydrogen, deuterium, hydroxy, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, 3-to 6-membered heterocyclyl, C 6-8 aryl, 5-to 8-membered heteroaryl, sulfinyl, sulfonyl, methanesulfonyl, isopropylsulfonyl, cyclopropylsulfonyl, p-toluenesulfonyl, aminosulfonyl, Dimethylaminosulfonyl and C 1-4 alkanoyl, said groups being independently optionally further substituted with one or more groups selected from deuterium, halogen, hydroxy, = O, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, Halogen substituted C 1-4 alkyl, deuterium substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroepoxy, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, amino, mono C 1-4 alkylamino, di C 1-4 alkylamino and C 1-4 alkanoyl; Or R 25 and R 26 together with the nitrogen atom to which they are directly attached form a 4-8 membered heterocyclyl or 5-8 membered heteroaryl, said 4-8 membered heterocyclyl or 5-8 membered heteroaryl optionally being further substituted with one or more substituents selected from deuterium, halogen, hydroxy, = O, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, halo-substituted C 1-4 alkyl, deuterium-substituted C 1-4 alkyl, C 1-4 alkoxy, C 3-6 cycloalkyl, C 3-6 cycloalkoxy, 3-6 membered heterocyclyl, 3-6 membered heteroaryl, C 6-8 aryl, C 6-8 aryloxy, 5-8 membered heteroaryl, 5-8 membered heteroaryloxy, amino, mono C 1-4 alkylamino, di C 1-4 alkylamino and C 1-4 alkanoyl.
16. 16. A compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 6 or 9, wherein ring a is selected from phenyl, pyridyl, pyrimidinyl, pyridazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl, furanyl, oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, thiadiazolyl, cyclobutyl, oxetanyl, azetidinyl, cyclopentyl, oxolanyl, azetidinyl, cyclohexyl, tetrahydropyranyl, dioxanyl, piperidinyl, piperazinyl and morpholinyl; R a is selected from the group consisting of hydrogen, deuterium, fluorine, chlorine, bromine, cyano, methyl, ethyl, isopropyl, trifluoromethyl, tridecyl, vinyl, ethynyl, cyclopropyl, hydroxy, methoxy, isopropoxy, cyclopropoxy, amino, mono-C 1-10 alkylamino and di-C 1-10 alkylamino.
17. 17. A compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 9, wherein ring a' is selected from cyclopropyl, cyclobutyl, oxetanyl, azetidinyl, cyclopentyl, oxolanyl, azetidinyl, cyclohexyl, tetrahydropyranyl, dioxane, piperidinyl, piperazinyl and morpholinyl; R a is selected from the group consisting of hydrogen, deuterium, fluorine, chlorine, bromine, cyano, methyl, ethyl, isopropyl, trifluoromethyl, tridecyl, vinyl, ethynyl, cyclopropyl, hydroxy, methoxy, isopropoxy, cyclopropoxy, amino, mono-C 1-10 alkylamino and di-C 1-10 alkylamino.
18. 18. A compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 12, wherein R 9c is selected from hydrogen, deuterium, fluoro, chloro, bromo, cyano, methyl, ethyl, isopropyl, trifluoromethyl, tridecylmethyl, vinyl, ethynyl, cyclopropyl, hydroxy, methoxy, isopropoxy, cyclopropoxy, amino, mono-C 1-10 alkylamino and di-C 1-10 alkylamino.
19. 19. A compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof according to claim 1, selected from the group consisting of:
20. 20. a pharmaceutical composition comprising a compound of formula (I), a stereoisomer thereof or a pharmaceutically acceptable salt thereof as claimed in any one of claims 1-19 and a pharmaceutically acceptable carrier.

Description

Polycyclic SMARCA2 inhibitor and application thereof Technical Field The invention belongs to the field of drug synthesis, and particularly relates to a polycyclic SMARCA2 inhibitor and application thereof. Background The SWI/SNF complex is an ATP dependent chromatin remodeling complex and plays an important role in physiological activities such as DNA repair, replication and transcriptional activation of genes. The complex is composed of multiple subunits, including ATP-dependent catalytic subunits (e.g., smarca2\4), core regulatory subunits (e.g., SMARCB 1), and other variable subunits (e.g., ARID 1A). Studies have reported that the SWI/SNF complex subunit plays an important role in tumor suppression, with about 20% of human malignancies having mutations in the complex subunit. SMARCA4, also known as BRG1, can accomplish activation or inhibition of transcription in the complex by the action of atpase. SMARCA4 is also the most commonly mutated atpase subunit in cancer, and has mutations in common malignant tumors such as lung cancer, colon cancer, bladder urothelial cancer, invasive breast ductal cancer, and the like. Wherein about 10% of non-small cell lung cancer patients carry SMARCA4 mutations. It is reported that patients with non-small cell lung cancer with SMARCA4 homozygous deletion are more likely to develop drug resistance and have poor curative effects. SMARCA2 and SMARCA4 are identical to ATPase subunits of SWI/SNF complex, and they have high homology (> 75%). It has been reported that in SMARCA4 mutated tumor cells, lowering SMARCA2 gene expression by RNAi technology can inhibit proliferation of tumor cells, demonstrating the synthetic lethal relationship of SMARCA2 and SMARCA 4. SMARCA2 knockout mice can grow normally, suggesting safety for targeting SMARCA 2. Patients with SMARCA4 deficiency may therefore have better clinical efficacy with SMARCA2 targeted treatment regimens. There is no approved drug for SMARCA2 on the market, and the need for drug development for this target is urgent. Protein targeting chimera (PROTAC) technology has been attracting attention since the advent of 2001, and a number of drugs based on this technology are now entering the clinical research stage, with some compounds already entering clinical stage 3. PROTAC is used as a heterobifunctional molecule, one end of which is a small molecule ligand compound capable of recognizing target protein, and the other end is a ligand capable of recognizing E3 ubiquitin ligase, and the two are connected through a connecting bond (Linker). PROTAC molecules initiate ubiquitination of target proteins in vivo by forming a ternary complex with the target proteins and E3 ubiquitin ligase, thereby mediating degradation of the target proteins by proteasomes. Therefore, the development of novel SMARCA2 small molecule ligand compounds is of great importance, and PROTAC molecules targeting SMARCA2 can be obtained based on the novel SMARCA2 small molecule ligand compounds. Disclosure of Invention The invention aims to provide a polycyclic SMARCA2 inhibitor and application thereof. The compound SMARCA2 of the invention has strong inhibition effect, especially selective inhibition effect on SMARCA2, and can be widely applied to the preparation of medicaments for treating cancers or tumors at least partially related to SMARCA 2. The first aspect of the present invention provides a compound of formula (I), a stereoisomer thereof, or a pharmaceutically acceptable salt thereof: Wherein X is CR 5, N, or a bond; Is that Y 1 is selected from -O(CR6aR6b)m1O-、-(CR6aR6b)m2O(CR6aR6b)m3-、-O(CR6aR6b)m4N(R7)-、-N(R8)(CR9aR9b)m5-、-CR6aR6b-、-O-、-S-、-S(O)-、-S(O)2-、-S(O)2N(R10)-、-S(O)(＝NR11)- and a bond, m1 is 1, 2 or 3, m2 is 0, 1 or 2, m3 is 0, 1 or 2, m4 is 0, 1 or 2, m5 is 0, 1 or 2, wherein m2 and m3 are not both 0; Y 2 is selected from -O(CR12aR12b)n1-、-N(R13)(CR14aR14b)n2-、-(CR15aR15b)n3-、-N(R16)-、-O-、-S-、-S(O)-、-S(O)2-、-S(O)2N(R17)-、-S(O)(＝NR18)- and a bond, n1 is 1 or 2, n2 is 1 or 2, n3 is 1 or 2, provided that when Y 2 is selected from -O(CR12aR12b)n1-、-N(R13)(CR14aR14b)n2-、-N(R16)-、-O- or-S-, Y 1 is not C (O); Wherein the directions in which the groups defined for "Y 1" and "Y 2" are attached include both directions, for example "-O (CR 6aR6b)m4N(R7) -" the nitrogen atom "of" N "may be attached to either the right 6-membered nitrogen-containing heteroaromatic ring or to the left" carbon atom "of C (R 3aR3b) or C (R 4aR4b); R 1 is selected from hydrogen, deuterium, halogen, cyano, nitro, azido, C 1-10 alkyl, C 2-10 alkenyl, C 2-10 alkynyl, c 3-10 cycloalkyl, 3-10 membered heterocyclyl, C 6-10 aryl, 5-10 membered heteroaryl, -C 0-8 alkyl-SF 5、-C0-8 alkyl-S (O) (=n-R 19)R20、-C0-8 alkyl-n=s (O) R 20R21、-C0-8 alkyl-n=sr 20R21、-C0-8 alkyl-O-S (O) 2R22、-C0-8 alkyl-S (O) rR22、-C0-8 alkyl-O-R 23、-C0-8 alkyl-C (O) OR 23、-C0-8 alkyl-C (O) SR 23、-C0-8 alkyl-S-C (O) R 24、-C0-8 alkyl-C (O) R 24、-C0-8 alkyl-O-C (O) R 24、-C0-8 alkyl-P (O) (R 24)2、-C0-8 alkyl