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CN-122011117-A - Cyclic peptide for resisting ultraviolet injury and application thereof in cosmetics

CN122011117ACN 122011117 ACN122011117 ACN 122011117ACN-122011117-A

Abstract

The invention belongs to the technical field of cosmetics, and particularly relates to a cyclic peptide for resisting ultraviolet injury and application thereof in cosmetics. The structure of the cyclic peptide is shown as a formula (I) or (II). The cyclic peptide can effectively reduce ultraviolet-induced ROS (reactive oxygen species) generation, remove free radicals, inhibit MMP-1 expression and promote COL1A1 synthesis, thereby realizing the effects of resisting photoaging and repairing skin injury. (I) (II)

Inventors

  • TIAN LONGFEI
  • XU DETIAN

Assignees

  • 深圳肽盛渼生物科技有限公司

Dates

Publication Date
20260512
Application Date
20251112

Claims (9)

  1. 1. A cyclic peptide or a pharmaceutically acceptable salt thereof for resisting ultraviolet injury, wherein the structural formula of the cyclic peptide is shown as formula (I) or (II): (I) (II)。
  2. 2. use of a cyclic peptide or a pharmaceutically acceptable salt thereof according to claim 1 in the manufacture of an agent or composition for combating uv damage.
  3. 3. The use of claim 2, wherein said combating uv damage comprises reducing uv-induced ROS production, scavenging free radicals, inhibiting MMP-1 expression, promoting COL1A1 synthesis.
  4. 4. The use according to claim 2, wherein the composition comprises a cosmetic.
  5. 5. The use according to claim 4, wherein the cosmetic formulation comprises a cream, an emulsion, an aqueous solution, an oil, a gel, a powder, a tablet, a mud, a patch, a film, an aerosol, a spray, a lyophilized preparation or a nano-preparation.
  6. 6. The use according to claim 4, wherein the cosmetic is for the anti-photoaging, sun protection and repair of skin lesions.
  7. 7. A cosmetic comprising the cyclic peptide according to claim 1 or a pharmaceutically acceptable salt thereof.
  8. 8. The cosmetic product according to claim 7, wherein the formulation of the cosmetic product comprises a cream, an emulsion, an aqueous solution, an oil, a gel, a powder, a tablet, a mud, a patch, a film, an aerosol, a spray, a lyophilized preparation or a nano-preparation.
  9. 9. The cosmetic according to claim 7, wherein the cosmetic is used for skin anti-photoaging, sun protection and repair of skin damage.

Description

Cyclic peptide for resisting ultraviolet injury and application thereof in cosmetics Technical Field The invention belongs to the technical field of cosmetics, and particularly relates to a cyclic peptide for resisting ultraviolet injury and application of the cyclic peptide in cosmetics. Background Ultraviolet (UV) radiation is a major environmental factor responsible for skin photoaging and skin cancer. UV radiation can induce the production of Reactive Oxygen Species (ROS), leading to DNA damage, protein denaturation and lipid peroxidation, thereby inducing skin inflammation, photoaging and skin cancer. Therefore, the development of safe and effective ultraviolet injury resistant components has important significance. Currently, the most commonly used anti-ultraviolet cosmetics mainly depend on physical sunscreens (such as titanium dioxide and zinc oxide) or chemical sunscreens (such as avobenzone and octocrylene). However, these sunscreens are susceptible to photodegradation, inadequate stability, or may cause skin irritation, and therefore there is a need to develop a novel uv active ingredient that is safe, efficient, naturally derived and has bioremediation functions. In recent years, cyclic peptides are an important direction for developing skin care actives because of their strong structural rigidity, high enzymolysis resistance stability and abundant biological activity. Through screening a polypeptide library and verifying a cell model, the inventor discovers two novel cyclic peptides which can obviously relieve cell oxidative stress and collagen degradation caused by ultraviolet rays and improve the antioxidant defensive capacity of skin cells, thereby realizing the effect of resisting ultraviolet injury. Disclosure of Invention The invention aims to provide a cyclic peptide with ultraviolet injury resisting activity, which can effectively reduce ultraviolet-induced ROS (reactive oxygen species) generation, remove free radicals, inhibit MMP-1 expression and promote COL1A1 synthesis, thereby realizing the effects of resisting photoaging and repairing skin injury. Specifically, the invention provides a cyclic peptide for resisting ultraviolet injury or pharmaceutically acceptable salt thereof, wherein the structural formula of the cyclic peptide is shown as a formula (I) or a formula (II): (I) (II)。 The invention also provides the use of a cyclic peptide or a pharmaceutically acceptable salt thereof as described herein in the manufacture of an agent or composition for combating uv damage. Further, the protection against uv damage includes reducing uv-induced ROS production, scavenging free radicals, inhibiting MMP-1 expression, promoting COL1A1 synthesis. Further, the composition includes a cosmetic. Further, the formulation of the cosmetic comprises ointment, cream, emulsion, water, oil, gel, powder, tablet, mud, patch, film, aerosol, spray, freeze-dried preparation or nano-preparation. Further, the cosmetic is used for skin photoaging resistance, sun protection and skin damage repair. The present invention also provides a cosmetic comprising a cyclic peptide as described herein or a pharmaceutically acceptable salt thereof. Further, the formulation of the cosmetic comprises ointment, cream, emulsion, water, oil, gel, powder, tablet, mud, patch, film, aerosol, spray, freeze-dried preparation or nano-preparation. Further, the cosmetic is used for skin photoaging resistance, sun protection and skin damage repair. As used herein, "amino acids" are referred to herein by their commonly known three-letter abbreviations or by the single-letter abbreviations recommended by the IUPAC-IUB biochemical nomenclature committee. The three-letter or one-letter abbreviations for amino acids Are conventional and Are alanine (Ala or A), arginine (Are or R), asparagine (Asn or N), aspartic acid (Asp or D), cysteine (Cys or C), glutamic acid (Glu or E), glutamine (Gln or Q), histidine (His or H), isoleucine (Ile or I), leucine (Leu or L), lysine (Lys or K), methionine (Met or M), phenylalanine (Phe or F), proline (Pro or P), serine (Ser or S), threonine (Thr or T), tryptophan (Trp or W), tyrosine (Tyr or Y) and valine (Val or V). When a three letter abbreviation is used, amino acids may be in either the L-configuration or the D-configuration with respect to the α -carbon (ca) unless it is explicitly preceded by "L" or "D", or as is clear from the context of the abbreviation used. For example, "Ala" means alanine without specifying a configuration for the alpha-carbon, and "D-Ala" and "L-Ala" mean D-alanine and L-alanine, respectively. When single letter abbreviations are used, the single letter abbreviations do not designate configuration with respect to the α -carbon unless explicitly stated. When polypeptide sequences are presented in strings of single letter abbreviations or three letter abbreviations (or mixtures thereof), the sequences are presented in the amino (N) to carboxyl (C) direction according to convent