CN-122011118-A - Microorganism-derived cyclic octapeptide compound and application thereof

Abstract

The invention relates to the technical field of microbial medicaments, in particular to a microbial source cyclic octapeptide compound and application thereof. The application of the microorganism source cyclic octapeptide compound shown in the formula I in the aspect of promoting plant growth regulator. Specific compounds are described in the claims. The cyclic octapeptide surugamides provided by the invention has remarkable plant growth promoting activity, and can be used as an ideal compound of a growth regulator for promoting plant growth. The invention has good application prospect.

Inventors

• BAI YAN
• PAN HUAQI
• ZHANG WENKUN
• HU JIANGCHUN

Assignees

• 中国科学院沈阳应用生态研究所

Dates

Publication Date

20260512

Application Date

20260112

Priority Date

20260109

Claims (5)

1. 1. The application of the microbial source cyclopeptide compound is characterized in that the microbial source cyclopeptide compound shown in the formula I is applied to the application of the microbial source cyclopeptide compound as a regulator for promoting plant growth.
2. 2. The application of the microbial-source cyclopeptide compound as claimed in claim 1, wherein the microbial-source cyclopeptide compound shown in the formula I is used as a plant root growth promoting regulator.
3. 3. The application of the microbial-source cyclopeptide compound as claimed in claim 1, which is characterized in that the microbial-source cyclopeptide compound shown in the formula I is applied as a plant stem growth promoting regulator.
4. 4. The use of a microbial-derived cyclic octapeptide compound as claimed in claim 1 or 2, wherein the microbial-derived cyclic octapeptide compound represented by formula I I is a kind of In the formula, R 1 、R 2 、R 3 may be the same or different and are selected from H or methyl.
5. 5. A plant growth promoting regulator is characterized in that the plant growth promoting regulator contains a microorganism source cyclopeptide compound shown in a formula I.

Description

Microorganism-derived cyclic octapeptide compound and application thereof Technical Field The invention relates to the technical field of microbial medicaments, in particular to a microbial source cyclic octapeptide compound and application thereof. Background According to the report published in 2019 in united nations, the global population is estimated to reach 97 billion in 2050, which is about 20 billion greater than the current population. In order to meet the increasing grain demands, crop yields must be greatly increased. Plant growth regulators have an important role in improving crop quality and yield and improving agricultural practices. The use of plant growth regulators began in the 30 s of the 20 th century, such as ethylene and acetylene. From this, many natural plant growth regulators that promote plant growth have been found, including Gibberellins (GA), auxins, abscisic acid, brassinosteroids, cytokinins, and the like. The global market for plant growth regulators has experienced a substantial increase in sales from about $15 to about $20-30 per million in 2015 to about $2022. Therefore, the need for plant growth regulators has attracted extensive attention from the scholars. In recent years, marine natural products have received attention due to their remarkable structural diversity and strong biological activity. Although marine natural products have been widely studied as pesticides and fungicides, surprisingly few reports have been made on their use as plant growth regulators. The present invention provides the use of 4 cyclooctapeptide compounds surugamides isolated from Streptomyces sp.NA 13 as plant growth regulators. Disclosure of Invention The invention aims to provide a microbial source cyclic octapeptide compound and application thereof. In order to achieve the above purpose, the invention adopts the technical scheme that: the application of the microorganism-source cyclopeptide compound is shown in the formula I and the application of the microorganism-source cyclopeptide compound as a plant growth promoting regulator. The microbial source cyclic octapeptide compound shown in the formula I is applied to the application of the microbial source cyclic octapeptide compound serving as a regulator for promoting plant root growth. The microbial source cyclic octapeptide compound shown in the formula I is applied to the application of the microbial source cyclic octapeptide compound serving as a regulator for promoting plant stem growth. The microorganism-derived cyclic octapeptide compound shown in the formula I I is a kind of In the formula, R 1、R2、R3 may be the same or different and are selected from H or methyl. Further preferably, the compound is The compound is obtained by fermenting, separating and purifying Streptomyces sp.NA 13 isolated from Streptomyces deep sea. A plant growth promoting agent contains microorganism-derived cyclic octapeptide compound shown in formula I. The invention has the advantages that: The cyclic octapeptide is obtained by separating the strain for the first time, and the cyclic octapeptide compound can promote plant growth, and is an ideal compound of a growth regulator for promoting crop root and stem growth. Drawings FIG. 1 shows the effect of the present invention on root growth of rice obtained in the examples of the present invention on the growth of rice root system by cyclopeptide surugamides and positive control gibberellin and trans-zeatin, and the a-d groups are surugamide A, surugamide B, trans-zeatin and gibberellin, respectively, compared with the blank control. FIG. 2 shows the effect of the example of the invention on corn root growth of cyclopeptide surugamides and positive control gibberellin and trans-zeatin, for groups e-j surugamide A, surugamide B, surugamide C, surugamide D, respectively, and trans-zeatin and gibberellin compared to the control blank. Detailed Description For a better understanding of the present invention, reference will be made to the following description of specific examples, but the protection of this patent is not limited thereto. The microbial source cyclopeptide compound shown in the following example is obtained by referring to application number 202211283332.6, the invention name is disclosed in the examples of preparation and application of deep sea streptomycete and antifeedant and antifungal active substances, the compounds 1-4 are described, and the structural analysis of the obtained cyclopeptide compound 1-4 is as follows: The hydrogen profile of compound 1 (DMSO-d 6) showed 8 amide protons δH8.45（1H,d,J= 8.2 Hz）,8.27（1H,d,J= 7.4 Hz）,8.01（1H,d,J= 7.4 Hz）,7.83（1H,s）,7.77（1H,d,J= 6.2 Hz）,7.70（1H,m）, 7.67（1H,s）,7.52（1H,s） and 8 alpha hydrogen protons δH4.37（1H,m）,4.30（1H,m）,4.27（1H,t,J= 6.7 Hz）,4.23（1H,m）,4.18（1H,m）,4.16（1H,m）,4.07（1H,t,J= 7.1 Hz）,3.86（1H,t,J= 6.4 Hz）, suggesting that compound 1 has 8 amino acid residues (table 1). The carbon spectrum of compound 1 (DMSO-d 6) shows 8 carbonyl signals