CN-122011407-A - Supermolecule hyaluronic acid emulsifier and preparation method and application thereof

Abstract

The invention discloses a supermolecule hyaluronic acid emulsifier and a preparation method and application thereof, and belongs to the technical field of supermolecules. The invention firstly disperses hyaluronic acid and fatty acid sodium in water or ethanol water solution, then adds alcohol, forms a uniform system through stirring, and then obtains supermolecule hyaluronic acid emulsifier powder through reduced pressure distillation and vacuum drying. The supermolecule hyaluronic acid emulsifier powder is simple in preparation, low in cost, suitable for industrial production, good in stability of the prepared emulsion and capable of being used in the fields of cosmetics and medicines.

Inventors

• ZHANG JIAXIANG
• ZHANG YUE
• ZHANG XIN

Assignees

• 优姿康生物科技(无锡)有限公司

Dates

Publication Date

20260512

Application Date

20260129

Claims (10)

1. 1. A method for preparing a supramolecular hyaluronic acid emulsifier, comprising the steps of: (1) Dispersing hyaluronic acid and fatty acid sodium in a solvent to obtain a dispersion liquid; (2) Adding alcohol into the dispersion liquid, and stirring for 3-15h at 25-60 ℃ to obtain a uniform system; (3) And (3) carrying out reduced pressure distillation and drying on the uniform system to obtain the supermolecule hyaluronic acid emulsifier powder.
2. 2. The method according to claim 1, wherein the solvent in the step (1) is water or an aqueous ethanol solution having a mass fraction of 40-60%.
3. 3. The method according to claim 1, wherein the mass ratio of hyaluronic acid, solvent, sodium fatty acid, alcohol is 10-55:300-650:10-30:15-80.
4. 4. The method according to claim 1, wherein the sodium fatty acid in step (2) is one or more of sodium stearate, sodium linoleate, sodium palmitoleate, sodium myristate, sodium oleate, sodium cocoate, sodium laurate, sodium palmitate, and sodium isostearate.
5. 5. The method of claim 1, wherein the alcohol in step (2) is one or more of butyl octanol, decyl alcohol, decyl tetradecyl alcohol, arachidyl alcohol, hexyl decyl alcohol, cetyl alcohol, cetostearyl alcohol, polydimethylsiloxane alcohol, behenyl alcohol, lanosterol, lanolin alcohol, coco oil alcohol, stearyl alcohol, and palm oil alcohol.
6. 6. The supramolecular hyaluronic acid emulsifier powder prepared by the method of any of claims 1-5.
7. 7. Use of the supramolecular hyaluronic acid emulsifier powder according to claim 6 for the preparation of cosmetic or pharmaceutical fields.
8. 8. A cosmetic, characterized in that it uses the supramolecular hyaluronic acid emulsifier powder according to claim 6.
9. 9. A method for emulsion stability and sun protection, characterized in that the supramolecular hyaluronic acid emulsifier powder according to claim 6 is used.
10. 10. A method for enhancing the SPF of a sunscreen using the supramolecular hyaluronate emulsifier powder of claim 6.

Description

Supermolecule hyaluronic acid emulsifier and preparation method and application thereof Technical Field The invention relates to a supermolecule hyaluronic acid emulsifier, a preparation method and application thereof, and belongs to the technical field of supermolecules. Background In the fields of cosmetics, medicines, foods and the like, an emulsion system is a critical product form, and the realization of the core function of the emulsion system is highly dependent on the performance of an emulsifier. The emulsifier promotes the oil phase and the water phase which are mutually insoluble to form a uniform and stable dispersion system by reducing the interfacial tension of oil and water, simultaneously inhibits unstable phenomena such as droplet flocculation, coalescence and the like, and ensures the uniformity and the effectiveness of the product in the storage and use processes. Along with the continuous improvement of the requirements of consumers on the safety, mildness and functionality of products, the traditional synthetic emulsifier (such as sodium dodecyl benzene sulfonate, polyoxyethylene ether and the like) has the defects of potential skin irritation, poor biocompatibility, difficult biodegradation and the like, the application scene of the traditional synthetic emulsifier is gradually limited, and the development of natural, safe and multifunctional green emulsifier has become the core trend of industry development. Hyaluronic Acid (HA) is a natural polysaccharide, which is a uniformly repeated linear glycosaminoglycan formed by polymerizing 2000-25000N-acetylglucosamine and disaccharide units of glucuronic Acid which are alternately combined together through beta-1, 3 glycosidic bonds and beta-1, 4 glycosidic bonds, is widely used in connective tissues, joint fluids, skin and other parts of human bodies, and HAs excellent biocompatibility, biodegradability and unique moisturizing performance. The molecular chain of the skin-care gel is rich in a large number of active groups such as carboxyl, hydroxyl and the like, so that a breathable moisture-preserving film can be formed on the surface of the skin, the moisture state of the skin is maintained, the endogenous hyaluronic acid synthesis can be promoted by regulating the cell activity, and the skin-care gel has the effects of repairing skin barriers, resisting wrinkles and resisting aging and the like, and is widely applied to the fields of cosmetics, biological medicines and the like. Based on these advantages, hyaluronic acid is an ideal substrate for developing natural emulsifiers. However, the existing emulsification related technology based on hyaluronic acid still has a plurality of defects to be solved urgently, and the large-scale application of the technology is limited. For example, (1) pure hyaluronic acid is extremely strong in hydrophilicity and lacks hydrophobic groups, is difficult to directly adsorb on an oil-water interface and reduce interfacial tension, has weak emulsifying capacity when being singly used, and is usually used in combination with other surfactants, so that the complexity of a formula is increased, the emulsion stability is possibly reduced due to competitive adsorption among different components, and (2) in the prior art, the hyaluronic acid is subjected to hydrophobic modification by chemical modification means, such as grafting of hydrophobic groups such as aryl, alkenyl succinic anhydride or coumarin derivatives through esterification, although the emulsifying capacity of the hyaluronic acid can be improved, organic solvents and chemical reagents are needed in the chemical modification process, reaction residue risks exist, the biological safety of products is influenced, and the modification process is complex, high in cost and is unfavorable for industrial production. In addition, the stability of the existing hyaluronic acid emulsion systems remains to be improved. The emulsion is easily affected by environmental factors such as temperature change, pH fluctuation, ionic strength and the like in the storage, transportation and use processes, and has the problems of layering, oil separation, droplet aggregation and the like. Moreover, the existing hyaluronic acid emulsifier has a single emulsifying function, so that the requirement of the current product on multifunctional integration is difficult to meet. The supermolecular system realizes ordered assembly of molecules through intermolecular non-covalent bonds (such as hydrogen bonds, electrostatic effect, hydrophobic effect, pi-pi accumulation and the like), and provides a brand new idea for developing novel functional materials. At present, although researches on the formation of hybrid synergistic complexes of hyaluronic acid through hydrogen bonds are mentioned to improve the durability of hyaluronic acid in the medical and aesthetic fields, related reports of building hyaluronic acid-based emulsifiers by utilizing supermolecule self-assembly are no