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CN-122011409-A - Chitin supermolecule emulsifier and its preparation method and application

CN122011409ACN 122011409 ACN122011409 ACN 122011409ACN-122011409-A

Abstract

The invention discloses a chitosan supermolecule emulsifier and a preparation method and application thereof, and belongs to the technical field of supermolecule emulsifier preparation. The chitosan supermolecular emulsifier is prepared by taking chitosan, fatty acid, sodium fatty acid, alcohol and a solvent as raw materials, dispersing for 2-6 hours at 25-50 ℃, then heating to 60-80 ℃ and stirring for reaction for 8-15 hours to obtain a suspension, and finally, carrying out spray drying on the suspension to obtain the chitosan supermolecular emulsifier. The chitosan supermolecule emulsifier prepared by the invention has the advantages of good emulsion stability, good environment adaptability, good biocompatibility, simple preparation, low cost, suitability for industrial production, and can be used in the fields of medicines, cosmetics and the like.

Inventors

  • ZHANG JIAXIANG
  • ZHANG YUE
  • ZHANG XIN

Assignees

  • 优姿康生物科技(无锡)有限公司

Dates

Publication Date
20260512
Application Date
20260204

Claims (10)

  1. 1. A method for preparing a chitosan supermolecular emulsifier, comprising the steps of: Dispersing chitosan, fatty acid, sodium fatty acid, alcohol and solvent according to the mass ratio of 1.5-25:5-20:0-10:45-93.5:150 at 25-50 ℃ for 2-6 hours, heating to 60-80 ℃ and stirring for reacting for 8-15 hours to obtain a suspension, and finally drying the suspension to obtain the chitosan supermolecular emulsifier powder.
  2. 2. The method according to claim 1, wherein the chitosan is one or more of chitosan, chitosan oligosaccharide, carboxymethyl chitosan, hydroxyethyl chitosan, acetylated chitosan, hydroxypropyl chitosan, succinylated chitosan, and sulfonated chitosan, and the fatty acid is one or more of undecylenic acid, linolenic acid, stearic acid, linoleic acid, palmitoleic acid, myristic acid, tall oil acid, oleic acid, hydrogenated coco acid, capric acid, lauric acid, palmitic acid, stearic acid, isostearic acid, butyl octanoic acid, docosahexaenoic acid, eicosapentaenoic acid, and caproic acid.
  3. 3. The method according to claim 1, wherein the fatty acid sodium is one or more of sodium stearate, sodium linoleate, sodium palmitoleate, sodium myristate, sodium oleate, sodium cocoate, sodium laurate, sodium palmitate, sodium isostearate, and the alcohol is one or more of butyl octanol, decyl alcohol, decyl tetradecanol, peanut alcohol, hexyl decyl alcohol, cetyl alcohol, cetostearyl alcohol, polydimethylsiloxane alcohol, myristyl alcohol, behenyl alcohol, octyl dodecanol, lanolin alcohol, cocoyl alcohol, isocetyl alcohol, isostearyl alcohol, stearyl alcohol, oleyl alcohol, lauryl alcohol, and palm oleyl alcohol.
  4. 4. The method of claim 1, wherein the rotational speed of the stirring is 300-800rpm.
  5. 5. The method of claim 1, wherein the dispersion is an ultrasonic dispersion, the power of the ultrasonic being 50-500W.
  6. 6. The method according to claim 1, wherein the solvent is water and the drying is spray drying, in particular at a temperature of 180-220 ℃ and a pressure of 0.3-0.5MPa for 6-12h.
  7. 7. A chitosan supermolecular emulsifier powder prepared by the method of any one of claims 1-6.
  8. 8. Use of the chitosan supermolecular emulsifier powder of claim 7 in the preparation of a medicament or cosmetic.
  9. 9. A cosmetic comprising the chitosan supermolecular emulsifier powder according to claim 7.
  10. 10. A method for improving the storage stability and the multifunction of an emulsion, which is characterized in that the chitosan supermolecular emulsifier powder of claim 7 is adopted.

Description

Chitin supermolecule emulsifier and its preparation method and application Technical Field The invention relates to a chitosan supermolecule emulsifier and a preparation method and application thereof, belonging to the technical field of supermolecule emulsifier preparation. Background The emulsifier is used as a core base material in the fields of medicine, cosmetics and the like, plays a key role in stabilizing an immiscible system and regulating and controlling interface performance, and the performance directly determines the stability, safety and functional characteristics of the emulsion. Most of traditional emulsifying agents are chemically synthesized small molecular surfactants, and although the emulsifying efficiency is high, the traditional emulsifying agents have the defects of insufficient biocompatibility, poor degradability, easy irritation initiation and the like, are subject to strict limitation in high-end application scenes, and the development of green, safe and high-performance natural-based emulsifying agents becomes industry consensus. The chitosan material has wide sources, excellent biocompatibility, degradability and modifiable molecular structure, and becomes a research hot spot in the field of natural emulsifying agents. Chitosan is a deacetylated product of chitin, and as a natural cationic polysaccharide, the molecular chain of chitosan contains a large number of amino groups and hydroxyl groups, and has unique interfacial activity and reaction activity. The chitosan oligosaccharide is a low molecular weight degradation product of chitosan, the water solubility and the bioactivity are better, and the modified chitosan such as carboxymethyl, hydroxyethyl, acetylation and the like optimizes the key performances such as hydrophilicity, water solubility and the like through chemical modification, so that the chitosan material system is formed together. However, when a single chitosan-based material is used as an emulsifier, there are problems of insufficient emulsion stability, weak interfacial adsorption capacity, sensitivity to environmental conditions, and the like. Furthermore, the emulsification performance of most modified chitosan depends on a specific modification degree, and the preparation process is complex and the batch stability is poor. Supermolecule emulsifier forms stable supermolecule structure based on non-covalent bond self-assembly such as intermolecular hydrogen bond, electrostatic action, hydrophobic interaction, etc., has interface stability and functional adjustability which are incomparable with traditional emulsifier, and becomes the leading direction of the field of emulsifying materials in recent years. However, in the prior art, the development of the chitosan supermolecular emulsifier still has a plurality of bottlenecks, namely, the supermolecular structure has poor controllability, the self-assembly process is easily influenced by pH, ionic strength and the like, a uniform and stable emulsion interface structure is difficult to form, the preparation method is complex, severe reaction conditions or a large amount of organic solvents are needed, and the existing product has single function, is difficult to simultaneously meet multiple functions, and is limited to be applied to a complex system. At present, some documents disclose composite emulsifying agents, for example, CN113426366A discloses a soluble chitosan-PVP composite emulsifying agent, a preparation method and application thereof, wherein the soluble chitosan and polyvinylpyrrolidone are mixed and then dissolved in distilled water, and the mixture is heated and stirred for 1 to 2 hours at a temperature of between 30 and 50 ℃ to obtain the soluble chitosanPVP compound emulsifier, but the supermolecule structure is not regulated enough, and the emulsion stability is limited. The literature (Qian Xiaoqing, wang Limin, zhang Wen, lei Dandan, zhang Xinping, zhang Guijun, what expands, wu Zijian. Chitosan-based Pickering emulsions and their use in food [ J ]. Food science, 2023, 44 (21): 386-395.) mentions chitosan nanocomposite particles of chitosan-protein, chitosan-polysaccharide, chitosan-polyphenol, chitosan-fatty acid, chitosan-whey protein-resveratrol and the like for Pickering emulsions, improving the ability of chitosan to stabilize emulsions, but having great difficulty in structure regulation, poor environmental adaptation and the like. Therefore, the chitosan supermolecule emulsifier is developed, solves the problems of poor emulsion stability, complex preparation, single function and the like of the existing product, realizes the high-efficiency application in multiple fields, and has important theoretical and practical significance. Disclosure of Invention In order to solve the problems, the invention provides a chitosan supermolecule emulsifier, and a preparation method and application thereof. Specifically, chitosan, fatty acid, sodium fatty acid, alcohol and solvent are used as raw