CN-122011786-A - Full bio-based physical cross-linked hydrogel and preparation method thereof

CN122011786ACN 122011786 ACN122011786 ACN 122011786ACN-122011786-A

Abstract

The application discloses a full bio-based physical cross-linked hydrogel and a preparation method thereof, and relates to the field of preparation of hydrogel functional materials. The preparation method of the all-bio-based physical crosslinked hydrogel comprises the following specific steps of S1, mixing gelatin and starch, heating and standing at a low temperature to obtain all-bio-based raw gel, S2, carrying out primary salting-out on the all-bio-based raw gel, S3, carrying out directional stretching on the hydrogel subjected to primary salting-out treatment, and S4, carrying out secondary salting-out on the stretched hydrogel. The tensile strength of the full bio-based physical crosslinked hydrogel prepared by the method can reach 7.81-10.37 MPa, and the Young modulus range can reach 12.32-47.32 MPa.

Inventors

LU LU
CUI BO
GUO LI
KANG XUEMIN
LIU TONGTONG
ZHANG ZHIJUN
MENG FANFU
LI CHENGHAI

Assignees

齐鲁工业大学(山东省科学院)

Dates

Publication Date: 20260512
Application Date: 20260331

Claims (10)

1. The full bio-based physical crosslinked hydrogel is characterized in that the tensile strength of the full bio-based physical crosslinked hydrogel ranges from 7.81 MPa to 10.37 MPa, and the Young modulus of the full bio-based physical crosslinked hydrogel ranges from 12.32 MPa to 47.32 MPa.
2. A preparation method of the all-bio-based physical crosslinked hydrogel is characterized in that the all-bio-based physical crosslinked hydrogel is the all-bio-based physical crosslinked hydrogel according to claim 1, and comprises the following steps: s1, mixing gelatin and starch, heating and standing at a low temperature to obtain full bio-based raw gel; S2, carrying out primary salting-out on the whole bio-based raw gel; s3, directionally stretching the hydrogel subjected to the first salting-out treatment; s4, salting out the stretched hydrogel again.
3. The preparation method of the all-bio-based physical cross-linked hydrogel according to claim 2, wherein the step S1 specifically comprises the steps of placing gelatin and starch in ultrapure water, heating and stirring to obtain a uniform mixed solution, performing ultrasonic treatment on the mixed solution to effectively remove bubbles and obtain an ultrasonic treatment feed liquid, and then pouring the ultrasonic treatment feed liquid into a glass mold, and standing at a low temperature to obtain the all-bio-based raw gel.
4. The method for producing a fully bio-based physically crosslinked hydrogel according to claim 3, wherein in step S1, the mass of gelatin is 5% -7% of the sum of gelatin, starch and ultrapure water, the mass of starch is 3% -5% of the sum of gelatin, starch and ultrapure water, and the mass of ultrapure water is 88% -92% of the sum of gelatin, starch and ultrapure water.
5. The method for preparing the all-bio-based physical crosslinked hydrogel according to claim 3, wherein in the step S1, the condition of heating and stirring is that the stirring temperature is 75-90 ℃ and the stirring time is 1.5-3.5 h.
6. The method for preparing a fully bio-based physical cross-linked hydrogel according to claim 3, wherein in the step S1, the ultrasonic power is 90-120W and the ultrasonic time is 8-15 min during ultrasonic treatment.
7. The method for preparing the all-bio-based physical crosslinked hydrogel according to claim 3, wherein in the step S1, the condition of low-temperature standing is that the low-temperature range is 2-6 ℃ and the standing time is 1-3 h.
8. The method for preparing the full bio-based physical cross-linked hydrogel according to claim 2, wherein the step S2 specifically comprises the steps of cutting the full bio-based raw gel into rectangular hydrogel, soaking the rectangular hydrogel in organic salt solution to obtain a hydrogel primary product, and sucking the organic salt solution on the surface of the hydrogel primary product by using water absorption paper to obtain the first salting-out hydrogel.
9. The method for preparing the all-bio-based physical cross-linked hydrogel according to claim 2, wherein the step S3 specifically comprises the steps of stretching the first salting-out hydrogel to 150% -250% of the original length of the first salting-out hydrogel along the length direction, and then fixing the stretched state of the first salting-out hydrogel to obtain the stretched hydrogel.
10. The method for preparing the all-bio-based physical crosslinked hydrogel according to claim 2, wherein the step S4 comprises the steps of immersing the stretched hydrogel in an organic salt solution to obtain a re-salted-out hydrogel, and sucking the organic salt solution on the surface of the re-salted-out hydrogel with a water absorbing paper to obtain the all-bio-based physical crosslinked hydrogel.

Description

Full bio-based physical cross-linked hydrogel and preparation method thereof Technical Field The application relates to the field of preparation of hydrogel functional materials, in particular to a full-bio-based physical cross-linked hydrogel and a preparation method thereof. Background The hydrogel has wide application prospect in the fields of food engineering, tissue engineering, wearable sensors and the like. At present, the full bio-based hydrogel is valued by research and development personnel because of the degradability, however, the full bio-based hydrogel prepared in the prior art has the problem of poor tensile strength and Young's modulus, which greatly limits the development and practical application of the full bio-based hydrogel. Therefore, the application particularly provides an all-bio-based physical crosslinked hydrogel with better tensile strength and Young's modulus and a preparation method thereof. Disclosure of Invention In order to solve the problems, the invention provides an all-bio-based physical cross-linked hydrogel and a preparation method thereof. In order to achieve the above purpose, the technical scheme adopted in the experiment is as follows: The full bio-based physical crosslinked hydrogel has a tensile strength ranging from 7.81 MPa to 10.37 MPa and a Young's modulus ranging from 12.32 MPa to 47.32 MPa. The preparation method of the all-bio-based physical crosslinked hydrogel comprises the following steps: s1, mixing gelatin and starch, heating and standing at a low temperature to obtain full bio-based raw gel; S2, carrying out primary salting-out on the whole bio-based raw gel; s3, directionally stretching the hydrogel subjected to the first salting-out treatment; s4, salting out the stretched hydrogel again. Preferably, the step S1 specifically comprises the steps of placing gelatin and starch in ultrapure water, heating and stirring to obtain a uniform mixed solution, carrying out ultrasonic treatment on the mixed solution to effectively remove bubbles and obtain ultrasonic treatment feed liquid, and then pouring the ultrasonic treatment feed liquid into a glass mold and standing at a low temperature to obtain the full bio-based raw gel. Preferably, in step S1, the mass of gelatin is 5% -7% of the sum of the mass of gelatin, starch and ultrapure water, the mass of starch is 3% -5% of the sum of the mass of gelatin, starch and ultrapure water, and the mass of ultrapure water is 88% -92% of the sum of the mass of gelatin, starch and ultrapure water. Preferably, in the step S1, the heating and stirring conditions are that the stirring temperature is 75-90 ℃ and the stirring time is 1.5-3.5 h. Preferably, in the step S1, during ultrasonic treatment, the ultrasonic power is 90-120W, and the ultrasonic time is 8-15 min. Preferably, in the step S1, the low-temperature standing condition is that the low-temperature range is 2-6 ℃ and the standing time is 1-3 h. Preferably, the step S2 specifically comprises the steps of cutting the whole bio-based raw gel into rectangular hydrogel, soaking the rectangular hydrogel in organic salt solution to obtain a hydrogel primary product, and sucking the organic salt solution on the surface of the hydrogel primary product by using water absorption paper to obtain the first salting-out treated hydrogel. Preferably, in the step S2, the molar concentration of the organic salt solution is 1-2.5 mol/L, and the soaking time is 1-1.5 h. Preferably, in step S2, the organic salt solution is an organic salt solution whose anion is citrate. Preferably, in step S2, one of an aqueous sodium citrate solution, an aqueous ammonium citrate solution and an aqueous potassium citrate solution is used. Preferably, the step S3 specifically comprises the steps of stretching the first salting-out hydrogel to enable the first salting-out hydrogel to be stretched to 150% -250% of the original length along the length direction, and then fixing the stretched state of the first salting-out hydrogel to obtain the stretched hydrogel. Preferably, the step S4 specifically comprises the steps of soaking the stretching-treated hydrogel in an organic salt solution to obtain a re-salted-out hydrogel, and sucking the organic salt solution on the surface of the re-salted-out hydrogel by using water absorption paper to obtain the full bio-based physical crosslinked hydrogel. Preferably, in the step S4, the molar concentration of the organic salt solution is 1-2.5 mol/L, and the soaking time is 12-20 h. Preferably, in step S4, the organic salt solution is one of an aqueous sodium citrate solution, an aqueous ammonium citrate solution and an aqueous potassium citrate solution. Compared with the prior art, the application has the beneficial technical effects that: Because gelatin can be solidified after being heated and placed at low temperature, in the step S1, gelatin and starch are mixed, the mixed gelatin and starch are placed at low temperature after being heated, the gelati