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CN-122012234-A - Organoid chip platform for simulating multi-organ interaction

CN122012234ACN 122012234 ACN122012234 ACN 122012234ACN-122012234-A

Abstract

The utility model provides a simulation multi-organ interaction's organoid chip platform, includes the culture dish, the outside of culture dish is covered with the braced frame, the upper end fixedly connected with guide frame of braced frame, slidable mounting has first movable guide strip, second movable guide strip on the guide frame, first movable guide strip, second movable guide strip movable contact each other, first movable guide strip, second movable guide strip intersection movable sleeve have movable supporting seat, movable supporting seat interpolation has the ear washing ball. The ear washing ball is inserted back into the movable supporting seat after the target culture solution is sucked after being taken down, the palm is placed on the movable supporting seat, the ear washing ball is pressed by fingers, the ear washing ball drops the target culture solution into the target position of the culture dish, the ear washing ball is positioned by the movable supporting seat, the shaking of hands is avoided, and the accuracy is improved.

Inventors

  • SUN TAO

Assignees

  • 零壹人工智能科技研究院(南京)有限公司

Dates

Publication Date
20260512
Application Date
20251219

Claims (8)

  1. 1. The multi-organ interaction simulation organoid chip platform comprises a culture dish (1) and is characterized in that a supporting frame (2) is covered on the outer side of the culture dish (1), a guide frame (3) is fixedly connected to the upper end of the supporting frame (2), a first movable guide strip (4) and a second movable guide strip (5) are slidably mounted on the guide frame (3), the first movable guide strip (4) and the second movable guide strip (5) are in movable contact with each other, a movable supporting seat (6) is movably sleeved at the intersection of the first movable guide strip (4) and the second movable guide strip (5), and an ear washing ball (7) is inserted in the movable supporting seat (6).
  2. 2. The multi-organ-simulated interaction organoid chip platform of claim 5, wherein said support frame (2) is fixedly attached to a suction cup (8) at its lower end.
  3. 3. The multi-organ-interaction-simulating organoid chip platform of claim 2, wherein the supporting frame (2) comprises a frame body (21), a connecting column (22) is fixedly connected to the corner of the frame body (21), a fixing hole (23) is formed in the lower end of the connecting column (22), and the upper end of the sucker (8) is fixedly arranged in the fixing hole (23).
  4. 4. The multi-organ-in-a-simulation organoid chip platform according to claim 3, wherein the guide frame (3) comprises a first guide rod (31) and a second guide rod (32), the first guide rod (31) and the second guide rod (32) are provided with a pair, the side ends of the first guide rod (31) are fixedly connected with the side ends of the second guide rod (32), and the lower ends of the first guide rod (31) and the second guide rod (32) are fixedly connected with the upper ends of the frame body (21) and the connecting column (22).
  5. 5. The multi-organ-in-a-analog chip platform according to claim 4, wherein the first movable guiding strip (4) comprises a first strip body (41), a first sliding sleeve (42) is fixedly connected to the side end of the first strip body (41), and the first sliding sleeve (42) is sleeved on the first guiding rod (31) in a sliding manner.
  6. 6. The multi-organ-in-a-analog chip platform according to claim 4, wherein the second movable guiding strip (5) comprises a second strip body (51), a second sliding sleeve (52) is fixedly connected to the side end of the second strip body (51), and the second sliding sleeve (52) is slidably mounted on the second guiding rod (32).
  7. 7. The multi-organ-interaction-simulating organoid chip platform of claim 6, wherein the movable supporting seat (6) comprises a seat body (61), the seat body (61) is slidably mounted outside the first strip body (41) and the second strip body (51), a lantern ring (64) is fixedly connected to the side end of the seat body (61), a connecting sheet (62) is fixedly connected to the side end of the seat body (61), and a cushion block (63) is fixedly connected to the connecting sheet (62).
  8. 8. The multi-organ-in-a-analog chip platform according to claim 7, wherein the ear washing ball (7) comprises a glass tube (71), the glass tube (71) is inserted into the collar (64), a baffle ring (72) is fixedly connected to the middle part of the glass tube (71), the baffle ring (72) is blocked on the collar (64), and an elastic air bag (73) is fixedly connected to the upper end of the glass tube (71).

Description

Organoid chip platform for simulating multi-organ interaction Technical Field The invention belongs to the technical field of medical equipment, and particularly relates to an organoid chip platform for simulating multi-organ interaction. Background The core of the integrated micro-fluidic bionic system is that two or more functional organ chip units (such as liver, kidney, heart, intestine, brain and the like) are precisely connected through a micro-channel network, and the substance exchange process of blood/body fluid circulation in a human body is simulated, so that cross-organ crosstalk can be realized among different organ units through transmitting signals of metabolites, cytokines, drug molecules and the like, thereby reducing the physiological scene of the cooperative work of multiple organs of the human body. When the culture solution is dripped into the organoid chip, a skilled old doctor is required to ensure that hands are not trembled, and when a novice who only grasps theoretical knowledge operates, the culture solution is easy to skew, so that the problem that the accuracy of dripping the culture solution into the organoid chip by the novice is lower is caused. For this reason, we propose an organoid chip platform that mimics multi-organ interactions to solve the above-mentioned problems. Disclosure of Invention The invention aims to solve the problem that the accuracy of the culture solution dripped into the organoid chip by a novice is low, and provides an organoid chip platform for simulating multi-organ interaction. In order to achieve the above purpose, the present invention adopts the following technical scheme: The utility model provides a simulation multi-organ interaction's organoid chip platform, includes the culture dish, the outside of culture dish is covered with the braced frame, the upper end fixedly connected with guide frame of braced frame, slidable mounting has first movable guide strip, second movable guide strip on the guide frame, first movable guide strip, second movable guide strip movable contact each other, first movable guide strip, second movable guide strip intersection movable sleeve have movable supporting seat, movable supporting seat interpolation has the ear washing ball. The ear washing ball is taken down to absorb target culture solution, inserted back into the movable supporting seat, the palm is placed on the movable supporting seat, the ear washing ball is pressed by fingers, the target culture solution is dripped into the target position of the culture dish by the ear washing ball, and the ear washing ball is positioned by the movable supporting seat, so that the shaking of the hand is avoided, the dripping is facilitated, and the accuracy is improved. Preferably, the lower end of the supporting frame is fixedly connected with a sucker. The stability of placing the supporting frame on the smooth table top is improved by utilizing the sucker and the smooth table top of the target. Preferably, the supporting frame comprises a frame body, a connecting column is fixedly connected to the corner of the frame body, a fixing hole is formed in the lower end of the connecting column, and the upper end of the sucker is fixedly arranged in the fixing hole. The firmness of the edge of the frame body is increased by using the connecting column. Preferably, the guide frame comprises a first guide rod and a second guide rod, the first guide rod and the second guide rod are both provided with a pair, the side ends of the first guide rod are fixedly connected with the side ends of the second guide rod, and the lower ends of the first guide rod and the second guide rod are fixedly connected with the upper ends of the frame body and the connecting column. The first movable guide bar is guided to slide by the first guide bar, and the second movable guide bar is guided to slide by the second guide bar. Preferably, the first movable guiding strip comprises a first strip body, the side end of the first strip body is fixedly connected with a first sliding sleeve, and the first sliding sleeve is sleeved on the first guiding rod in a sliding manner. The first sliding sleeve is guided to slide by the first guide rod. Preferably, the second movable guiding strip comprises a second strip body, the side end of the second strip body is fixedly connected with a second sliding sleeve, and the second sliding sleeve is slidably mounted on the second guiding rod. The second sliding sleeve is guided to slide by the second guide rod. Preferably, the movable supporting seat comprises a seat body, the seat body is slidably arranged outside the first strip body and the second strip body, the side end of the seat body is fixedly connected with a lantern ring, the side end of the seat body is fixedly connected with a connecting sheet, and the connecting sheet is fixedly connected with a cushion block. The ear washing ball is restrained by the lantern ring, the hand is padded on the cushion block