Search

CN-122013204-A - Ion channel protein near-atomic-scale finite-domain dissolution electrolytic processing method based on bionic finite-domain interface

CN122013204ACN 122013204 ACN122013204 ACN 122013204ACN-122013204-A

Abstract

An ion channel protein near-atomic-scale finite-field dissolution electrolytic processing method based on a bionic finite-field interface. The core is that a bionic phospholipid bilayer mask is spread on a workpiece anode to shield a non-processing area, an ion channel protein is embedded into the workpiece anode to serve as an electrolyte channel, and when the workpiece anode is electrified, anodic dissolution reaction is strictly limited inside the ion channel protein channel. And millivolt-level picosecond pulse voltage or millivolt-nanosecond pulse current is adopted on a time scale to remove anode metal atoms one by one, and electrolytic products are discharged by adopting modes of regulating electrolyte, microcosmic acting force, micro vibration and the like so as to ensure sustainable occurrence of electrochemical reaction, so that near-atomic-scale electrolytic machining is realized. The invention constructs an electrochemical dissolution reaction space with a near atomic scale by interdisciplinary fusion of an electrolytic processing technology and a biological field, approximates the capability of electrolytic processing for removing materials in an ionic form, and realizes the electrolytic processing with the near atomic scale.

Inventors

  • XU ZHENGYANG
  • XIAO YOUPING
  • WANG YUDI

Assignees

  • 南京航空航天大学

Dates

Publication Date
20260512
Application Date
20260113

Claims (9)

  1. 1. A bionic finite field interface for near-atomic-scale electrolytic machining is characterized by comprising a phospholipid bilayer insulating mask supported on the surface of a workpiece anode and ion channel proteins embedded in the phospholipid bilayer insulating mask, wherein the ion channel proteins form a unique electrolyte channel with nano-scale or near-atomic-scale in the phospholipid bilayer insulating mask.
  2. 2. A preparation method of a bionic finite field interface according to claim 1 is characterized by comprising the following steps of (a) preprocessing an atomically flat workpiece anode surface to form a hydrophilic surface modification layer, (b) forming a compact phospholipid bilayer insulating mask on the preprocessed workpiece anode surface through self-assembly of phospholipid monomers in electrolyte, and (c) embedding ion channel proteins or functional analogues thereof into the phospholipid bilayer insulating mask through hydrophobic interaction, so that transmembrane pore channels of the ion channel proteins penetrate through the mask to form unique electrolyte channels.
  3. 3. The method according to claim 2, wherein in the step (a), the pretreatment includes degreasing, washing with water, drying, and plasma treatment, and the surface modification layer is a hydrophilic layer formed by the plasma treatment.
  4. 4. The method according to claim 2, wherein in step (b), the self-assembling is performed using a raw material selected from at least one of dioleoyl phosphatidylcholine, natural phospholipids, synthetic phospholipids or block copolymers.
  5. 5. The method of claim 2, wherein in step (c), the ion channel protein structure allows selective passage of electrolyte ions and smooth discharge of electrolysis products, and the transmembrane hydrophobic region structure matches the thickness of the hydrophobic region of the phospholipid bilayer insulating mask.
  6. 6. The method of claim 2, further comprising the step of subjecting the phospholipid bilayer insulation mask to a stability enhancing treatment after step (c), wherein the stability enhancing treatment is polymerization, cross-linking, or a combination thereof.
  7. 7. The method of claim 2, wherein the ion channel protein has a channel inner wall with controllable charge characteristics such that it exhibits a predetermined stable charge profile at the pH of the processing electrolyte to optimize the transport selectivity of a particular reactive ion.
  8. 8. An ion channel protein near-atomic scale finite field dissolution electrolytic processing method based on a bionic finite field interface according to claim 1 is characterized by comprising the following steps of (i) placing a workpiece with the bionic finite field interface as an anode in electrolyte, (ii) applying a pulse electric field between the anode and a tool cathode, wherein the pulse width of the pulse electric field is picosecond to nanosecond, and the amplitude of the pulse electric field is millivolt, and (iii) driving reactive ions in the electrolyte to directionally transmit to a tiny micro-area on the anode surface of the workpiece through a unique electrolyte channel of the ion channel protein by the pulse electric field, so as to induce electrochemical dissolution removal of metal atoms in the micro-area.
  9. 9. The method of claim 8, wherein in step (iii), controlled processing of nanostructure shape and depth is achieved by controlling the number and parameters of the application of the pulsed electric field.

Description

Ion channel protein near-atomic-scale finite-domain dissolution electrolytic processing method based on bionic finite-domain interface Technical Field The invention belongs to the technical field of intersection of micro-nano manufacturing and electrochemical processing, in particular to an ion channel protein near-atomic-scale limited-domain dissolution electrolytic processing method based on a bionic limited-domain interface, and particularly relates to a processing technology for constructing a nano-scale electrolyte channel by utilizing an ion channel protein and phospholipid bilayer mask and realizing near-atomic-scale localized dissolution of a metal material through a precise pulse electric field, preparation of a corresponding bionic interface and application thereof. Background As micro-nano device feature sizes continue to approach physical limits, fabrication techniques face significant challenges spanning from the micro-scale to the nano-or even atomic scale. Electrochemical processing technology is considered as an important path to break through the limitations of the prior art due to its stress-free processing characteristics, high material adaptability, and batch processing potential. The technique is based on the principle of anodic ion dissolution and theoretically has the potential for atomic scale precision in removing material in the form of a single ion. However, the traditional electrochemical machining technology is based on the macroscopic electrochemical principle, and the machining precision is fundamentally limited by basic physical laws. In order to improve the processing localization, the research community develops a plurality of micro electrolytic processing technologies. The ultra-short pulse electrolytic machining （Schuster R, Kirchner V, Allongue P, et al. Electrochemical Micromachining. Science, 2000, 289(5476): 98-101.） remarkably improves the processing localization by shortening the pulse width to nanosecond level and restricting the reaction time by utilizing the charge-discharge characteristics of the double electric layers. The jet electrolytic machining adopts a micro electrolyte jet as a tool, and the spatial resolution is improved by controlling the jet form. Mask electrolytic machining defines a machining region by patterning the mask. However, these methods still have inherent limitations in that further reduction of pulse width is physically limited by the double electric layer charging time, jet stability limits further improvement of processing accuracy, and mask preparation process is complex and difficult to implement three-dimensional nanostructure processing. In-depth analysis shows that although these techniques improve processability to some extent, they fail to break through the basic framework of "three-dimensional macroscopic electrolytes". Under this framework, there are two intrinsic limitations, firstly the inherent limitation of the electric field distribution, the electric field necessarily diverges in the three-dimensional medium according to the principle of electrodynamics, and secondly the statistical randomness of the mass transfer process, the diffusion motion of ions in the electrolyte causing the blurring of the processing boundary. These physical properties determine that the accuracy limits of conventional electrochemical machining are typically on the order of microns. The prior art, such as chinese inventions CN104551282A, CN111515480A, CN106064261a and CN113458513a, attempts to further constrain the reaction space by introducing a series of measures of particle assist, magnetic field enhancement, etc., but the feature sizes that can be achieved are still between a few microns to hundreds of nanometers. At the root of the method, the electrochemical reaction does not have self-limiting characteristic, metal atoms tend to separate from the surface in a group form, and true atomic-level accurate localization is difficult to realize. In recent years, discipline crossing provides a new idea for technological breakthroughs. Patent document CN112719491a introduced the biological concept for the first time into electrolytic processing, using microbial films as masks, which suggests an innovative direction of bio-fabrication crossover. However, the biofilm employed in this technique relies on microbial aggregates, utilizing gaps between microbial monomers as electrolyte channels, the dimensions of which are still on the order of microns. Meanwhile, related researches related to self-assembled masks are few, for example, academic papers such as hard particle mask electrolytic processing micro-texture technical research propose to prepare anode masks by adopting hard nano particles in a self-assembly way, but the stability and scale effect of the masks still need to be solved. In summary, the conventional and existing improved electrochemical machining techniques are limited by their physical principles and implementation, and are difficult t