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CN-122013450-A - Hymexazol-loaded sodium alginate/carboxymethyl chitosan slow-release fiber membrane and preparation method thereof

CN122013450ACN 122013450 ACN122013450 ACN 122013450ACN-122013450-A

Abstract

The invention discloses a sodium alginate/carboxymethyl chitosan slow-release fiber membrane loaded with hymexazol and a preparation method thereof, relates to the fields of agricultural chemical materials and nano, and aims to solve the problems that the hymexazol is easy to decompose, has short duration and is used excessively to threaten the stability of an ecological system in application. The method comprises the technical key points of (1) dissolving polyvinyl alcohol and sodium alginate in deionized water to obtain a first solution, dissolving carboxymethyl chitosan in deionized water to obtain a second solution, finally uniformly mixing the first solution and the second solution to obtain the sodium alginate/carboxymethyl chitosan spinning solution, (2) adding hymexazol into the sodium alginate/carboxymethyl chitosan spinning solution, uniformly mixing to obtain the hymexazol/sodium alginate/carboxymethyl chitosan spinning solution, and (3) adding the hymexazol/sodium alginate/carboxymethyl chitosan spinning solution into electrostatic spinning equipment to perform electrostatic spinning to obtain the hymexazol/sodium alginate/carboxymethyl chitosan fiber membrane.

Inventors

  • ZHAO DONGMEI
  • HU JIAYUAN
  • Dou tianwei
  • YU YANG
  • SONG YANG
  • HE MENG
  • Zhang Tiankang
  • WANG JINGSHUO

Assignees

  • 黑龙江东方学院

Dates

Publication Date
20260512
Application Date
20260403

Claims (10)

  1. 1. The preparation method of the hymexazol-loaded sodium alginate/carboxymethyl chitosan slow-release fiber membrane is characterized by comprising the following steps of; (1) Dissolving polyvinyl alcohol and sodium alginate in deionized water to obtain a first solution, dissolving carboxymethyl chitosan in deionized water to obtain a second solution, and finally uniformly mixing the first solution and the second solution to obtain the sodium alginate/carboxymethyl chitosan spinning solution; (2) Adding hymexazol into the sodium alginate/carboxymethyl chitosan spinning solution, and uniformly mixing to obtain the hymexazol/sodium alginate/carboxymethyl chitosan spinning solution; (3) The preparation method of the hymexazol/sodium alginate/carboxymethyl chitosan fiber membrane comprises the steps of adding the hymexazol/sodium alginate/carboxymethyl chitosan spinning solution into electrostatic spinning equipment for electrostatic spinning to obtain the hymexazol/sodium alginate/carboxymethyl chitosan fiber membrane.
  2. 2. The method according to claim 1, wherein the mass ratio of sodium alginate, carboxymethyl chitosan and polyvinyl alcohol in the step (1) is 1:1:10.
  3. 3. The method according to claim 1, wherein the first solution in step (1) is prepared by adding polyvinyl alcohol and sodium alginate to deionized water to a pH of 6-8 and continuously stirring at a rotation speed of 500 rpm at 60 ℃ for 6h to obtain the first solution.
  4. 4. The method according to claim 1, wherein the condition of stirring and mixing the first solution and the second solution in the step (1) is that the pH of the mixed solution is 6-8, and stirring is continuously performed at a rotation speed of 500rpm at 60 ℃ for 6 h.
  5. 5. The method according to claim 1, wherein the condition for stirring and mixing the hymexazol and the spinning solution in the step (2) is that stirring and mixing are performed at a mild stirring speed of 300 rpm at room temperature.
  6. 6. The method of claim 1, wherein the mass ratio of the hymexazol in the hymexazol/sodium alginate/carboxymethyl chitosan spinning solution in the step (2) is 5% -25%.
  7. 7. The method according to claim 1, wherein the electrostatic spinning condition in the step (3) is that the spinning voltage is 15kV, the spinning distance is 15cm, and the pushing rate is 0.5mL/h.
  8. 8. The method according to claim 1, wherein the ambient temperature of the electrospinning in step (3) is 25±2 ℃.
  9. 9. The method according to claim 1, wherein the ambient humidity of the electrospinning in step (3) is 35±5%.
  10. 10. A hymexazol-loaded sodium alginate/carboxymethyl chitosan slow release fiber membrane, characterized in that the fiber membrane is prepared by the method of any one of claims 1 to 9.

Description

Hymexazol-loaded sodium alginate/carboxymethyl chitosan slow-release fiber membrane and preparation method thereof Technical Field The invention relates to the field of agricultural chemical materials and nanotechnology, in particular to a sodium alginate/carboxymethyl chitosan slow-release fiber membrane loaded with hymexazol and a preparation method thereof. Background Hymexazol (Hymexazol) is a high-efficiency, low-toxicity systemic fungicide and is also widely used as a soil disinfectant and a plant growth regulator. However, hymexazol has good water solubility, is very easy to leach and run off along with rainwater or irrigation water in field application, leads to short efficacy period, low utilization rate and causes potential pressure on the environment. Therefore, the development of a novel pesticide formulation capable of controlling the release of hymexazol, prolonging the duration and reducing the loss has important practical significance. Sodium Alginate (SA) and carboxymethyl chitosan (Carboxymethyl Chitosan, CMCS) are natural polysaccharide materials which are rich in sources, good in biocompatibility and biodegradable. In the prior art, researchers have used both materials to prepare hydrogels or fibers. For example, patent document publication number CN113197200B discloses a method of triggering sodium alginate and carboxymethyl chitosan solution to form a supramolecular hydrogel using hymexazol itself as a "gelling agent". The research skillfully utilizes the hydrogen bonding effect between the hymexazol and the polysaccharide to construct a drug-carrying system. However, this solution produces a hydrogel form with high water content, which has limitations in storage, transportation and application of solid dosage forms for certain specific agricultural scenarios (e.g. seed coating, soil blending). The electrostatic spinning technology is an effective means for preparing the nanofiber membrane, and the obtained nanofiber membrane has extremely high specific surface area and porosity and is very suitable for being used as a drug carrier. However, since sodium alginate and carboxymethyl chitosan are both polyelectrolytes, strong electrostatic repulsion and hydrogen bonding effect exist between molecular chains, and independent spinning is extremely difficult, and a synthetic high polymer is usually needed to be used as an auxiliary polymer. Polyvinyl alcohol (PVA) is a good water-soluble, high spinnability co-polymer. At present, no report on the preparation of a solid nanofiber slow-release drug-carrying system by combining an electrostatic spinning technology with a hymexazol triggering gelation mechanism exists. Disclosure of Invention The invention aims to solve the technical problems that: aims at solving the technical problems that hymexazol is easy to decompose, has short lasting period and is used excessively to threaten the stability of an ecological system in practical application. The invention aims to reduce the dosage of hymexazol, reduce the off-target loss and improve the utilization rate, and provides a solid composite nanofiber which is convenient to store and transport and can realize slow release of the hymexazol and a preparation method thereof. The invention adopts the technical scheme for solving the technical problems: The invention provides a preparation method of a hymexazol-loaded sodium alginate/carboxymethyl chitosan slow-release fiber membrane, which comprises the following steps of; (1) Dissolving polyvinyl alcohol and sodium alginate in deionized water to obtain a first solution, dissolving carboxymethyl chitosan in deionized water to obtain a second solution, and finally uniformly mixing the first solution and the second solution to obtain the sodium alginate/carboxymethyl chitosan spinning solution; (2) Adding hymexazol into the sodium alginate/carboxymethyl chitosan spinning solution, and uniformly mixing to obtain the hymexazol/sodium alginate/carboxymethyl chitosan spinning solution; (3) The preparation method of the hymexazol/sodium alginate/carboxymethyl chitosan fiber membrane comprises the steps of adding the hymexazol/sodium alginate/carboxymethyl chitosan spinning solution into electrostatic spinning equipment for electrostatic spinning to obtain the hymexazol/sodium alginate/carboxymethyl chitosan fiber membrane. Further, in the step (1), the mass ratio of the sodium alginate to the carboxymethyl chitosan to the polyvinyl alcohol is 1:1:10. Further, the preparation method of the first solution in the step (1) comprises the steps of adding polyvinyl alcohol and sodium alginate into deionized water to enable the pH value of the solution to be 6-8, and continuously stirring the solution at 60 ℃ and the rotating speed of 500 rpm for 6h to obtain the first solution. Further, the condition of stirring and mixing the first solution and the second solution in the step (1) is that the pH of the mixed solution is 6-8, and stirring is continuously carried out