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CN-122016198-A - Detection method of soft bag integrity cycle detection system

CN122016198ACN 122016198 ACN122016198 ACN 122016198ACN-122016198-A

Abstract

The invention discloses a detection method of a soft bag integrity circulation detection system, which comprises a gas transmission unit, a gas supplementing unit, a gas pressure detection unit, a valve assembly and a control unit, and comprises the following steps of S1, conveying gas in a first soft bag to a second soft bag after the detection of the first soft bag is completed, and carrying out gas supplementing, pressure maintaining and integrity detection on the second soft bag, S3, conveying gas in the second soft bag to a new first soft bag after the detection of the second soft bag is completed, and carrying out gas supplementing, pressure maintaining and integrity detection on the new first soft bag, S4, circularly replacing the soft bag to be detected, and repeating the gas transferring, gas supplementing, pressure maintaining and integrity detection processes. The invention aims to overcome the defects of the prior art and provide a detection method of a soft bag integrity circulation detection system, which can be used for recycling test gas, thereby avoiding waste and saving use cost.

Inventors

  • ZHANG YASHUANG
  • Ou Yunchao
  • KONG XIANGQI
  • YANG SUMEI

Assignees

  • 上海东富龙医用包装材料有限公司

Dates

Publication Date
20260512
Application Date
20260324

Claims (12)

  1. 1. The detection method of the soft bag integrity cycle detection system comprises a gas transmission unit, a gas supplementing unit, a gas pressure detection unit, a valve assembly and a control unit; The gas transmission unit comprises a first pipeline and a reversing device, wherein two ends of the first pipeline are respectively communicated with a first soft bag and a second soft bag, and the reversing device is arranged in the middle of the first pipeline to realize circulating reversing and inflating of gas; the air supplementing unit is communicated with the first pipeline and used for supplementing air during detection; the air pressure detection unit is arranged on the first pipeline and the air supplementing unit and is used for detecting air data in real time; The valve assembly is arranged on the first pipeline and the air supplementing unit, and the control unit is in communication connection with the valve assembly to realize air pressure control and directional air supply of the pipeline; the air pressure detection unit is in communication connection with the control unit; the detection method is characterized by comprising the following steps of: step S1, inflating, maintaining pressure and detecting integrity of a first soft bag; S2, after the detection of the first soft bag is finished, conveying the gas in the first soft bag to a second soft bag, and carrying out gas supplementing, pressure maintaining and integrity detection on the second soft bag; Step S3, after the second soft bag is detected, conveying the gas in the second soft bag to a new first soft bag, and carrying out air supplementing, pressure maintaining and integrity detection on the new first soft bag; and S4, circularly replacing the soft bag to be detected, and repeating the gas transfer, gas supplementing, pressure maintaining and integrity detection processes.
  2. 2. The method for detecting the soft bag integrity cycle detection system of claim 1, the method is characterized in that the step S1 comprises the following steps: Step S11, opening the second pipeline and the related valves on the first branch, and inflating the first soft bag by the air source; step S12, performing pressure maintaining operation after the first soft bag is full, if the pressure maintaining meets the preset requirement, completing detection, if the pressure maintaining operation does not meet the preset requirement, checking leakage points by using a helium probe, and manually retesting after manual treatment.
  3. 3. A method of testing a soft bag integrity cycle test system in accordance with claim 1, the method is characterized in that the step S2 comprises the following steps: Step S21, controlling each valve on the first pipeline to be opened, and sucking the gas in the first soft bag by a second fan (PUMP 02) to be conveyed into the second soft bag; step S22, if the first pressure sensor (PI 01) detects that the air pressure is insufficient, the control unit opens the helium bottle (1) and supplements air in the second soft bag through the second pipeline and the second branch; step S23, the second soft bag is subjected to pressure maintaining operation after reaching the set pressure, if the pressure maintaining meets the preset requirement, detection is completed, if the pressure maintaining meets the preset requirement, a helium probe is used for detecting leakage points, and manual retesting is performed after manual treatment.
  4. 4. A method of testing a soft bag integrity cycle test system in accordance with claim 1, the method is characterized in that the step S3 comprises the following steps: Step S31, a new first soft bag is replaced, the control unit controls each valve on the first pipeline to be opened, and the first fan (PUMP 01) PUMPs gas in the second soft bag and conveys the gas into the new first soft bag; Step S32, if the second pressure sensor (PI 02) detects that the air pressure is insufficient, the control unit opens the helium bottle (1) and supplements air to the new first soft bag through the second pipeline and the first branch; Step S33, performing pressure maintaining operation after the new first soft bag reaches the set pressure, if the pressure maintaining meets the preset requirement, completing detection, if the pressure maintaining meets the preset requirement, checking leakage points by using a helium probe, and manually retesting after manual processing.
  5. 5. The method for detecting the soft bag integrity cycle detection system according to claim 1, wherein the corresponding pressure sensor monitors the air pressure in real time each time when the air is transferred from the detected soft bag to the soft bag to be detected, and the helium bottle (1) is automatically started to supplement the air when the air pressure is insufficient until the pressure in the soft bag to be detected reaches a set value.
  6. 6. The soft bag integrity circulation detection system is characterized by comprising a gas transmission unit, a gas supplementing unit, a gas pressure detection unit, a valve assembly, a control unit and a control device; The gas transmission unit comprises a first pipeline and a reversing device, wherein two ends of the first pipeline are respectively communicated with a first soft bag and a second soft bag, and the reversing device is arranged in the middle of the first pipeline to realize circulating reversing and inflating of gas; the air supplementing unit is communicated with the first pipeline and used for supplementing air during detection; the air pressure detection unit is arranged on the first pipeline and the air supplementing unit and is used for detecting air data in real time; The valve assembly is arranged on the first pipeline and the air supplementing unit, and the control unit is in communication connection with the valve assembly to realize air pressure control and directional air supply of the pipeline; the air pressure detection unit is in communication connection with the control unit; Control means comprising a memory, a processor and a machine executable program stored on the memory and running on the processor, and the processor implementing the detection method according to any one of claims 1 to 5 when executing the machine executable program.
  7. 7. The soft bag integrity cycle detection system according to claim 6, wherein the reversing device comprises a first fan (PUMP 01), a second fan (PUMP 02), a first two-position three-way electromagnetic valve (TSV 01) and a second two-position three-way electromagnetic valve (TSV 02), wherein the first fan (PUMP 01) and the second fan (PUMP 02) are arranged in the middle of the first pipeline, and the air outlets of the first fan (PUMP 01) and the second fan (PUMP 02) are arranged oppositely; the first two-position three-way electromagnetic valve (TSV 01) is electrically connected with the first fan (PUMP 01), and the second two-position three-way electromagnetic valve (TSV 02) is electrically connected with the second fan (PUMP 02); the first two-position three-way electromagnetic valve (TSV 01) and the second two-position three-way electromagnetic valve (TSV 02) are in communication connection with the control unit.
  8. 8. The soft bag integrity cycle detection system according to claim 7, wherein the air supplementing unit comprises a helium bottle (1), an outlet of the helium bottle (1) is communicated with a second pipeline, the other end of the second pipeline is respectively communicated with a first branch and a second branch, the other end of the first branch is communicated between the first soft bag and the reversing device, and the other end of the second branch is communicated between the reversing device and the second soft bag.
  9. 9. The soft bag integrity cycle detection system of claim 8, wherein the air pressure detection unit comprises a first pressure sensor (PI 01), a second pressure sensor (PI 02), and a third pressure sensor (PI 03); The first pressure sensor (PI 01) is arranged on the first pipeline and is close to one end of the first soft bag; the second pressure sensor (PI 02) is arranged on the first pipeline and is close to one end of the second soft bag; the third pressure sensor (PI 03) is arranged on the second line.
  10. 10. The soft bag integrity cycle detection system of claim 9, wherein the valve assembly comprises a first two-position three-way solenoid valve (SV 01), a second two-position three-way solenoid valve (SV 02), a third two-position three-way solenoid valve (SV 03), and a fourth two-position three-way solenoid valve (SV 04); The first two-position three-way electromagnetic valve (SV 01) is arranged on the first pipeline and is positioned between the first soft bag and the reversing device; The second two-position three-way electromagnetic valve (SV 02) is arranged on the first branch; The third two-position three-way electromagnetic valve (SV 03) is arranged on the first pipeline and is positioned between the reversing device and the second soft bag; The fourth two-position three-way electromagnetic valve (SV 04) is arranged on the second branch; the valve assembly further comprises a pressure regulating valve (PR 01), the pressure regulating valve (PR 01) being arranged on the second pipe; The valve assembly further comprises a one-way valve (CV 01), the one-way valve (CV 01) being disposed on the second conduit; the device also comprises a first proportional regulating valve (PV 01) and a second proportional regulating valve (PV 02); the first proportional control valve (PV 01) and the second proportional control valve (PV 02) are both arranged on the first pipeline, the first proportional control valve (PV 01) is positioned between the first soft bag and the reversing device, and the second proportional control valve (PV 02) is positioned between the second soft bag and the reversing device.
  11. 11. The soft bag integrity cycle detection system of claim 10, further comprising a third two-position three-way solenoid valve (TSV 03), the third two-position three-way solenoid valve (TSV 03) being disposed at a junction of the second line with the first and second branches.
  12. 12. The soft bag integrity cycle detection system of claim 11, wherein a first filter (F01) is disposed at an end of the first pipeline adjacent to the first soft bag, a second filter (F02) is disposed at an end of the first pipeline adjacent to the second soft bag, and a third filter (F03) is disposed at an end of the second pipeline adjacent to the helium cylinder (1).

Description

Detection method of soft bag integrity cycle detection system Technical Field The invention relates to a detection method of a soft bag integrity cycle detection system. Background For example, in the biopharmaceutical industry, disposable sterile flexible bags have been used to replace stainless steel biological fermenters for biological fermentation in order to speed up the production cycle of biological products, increase production efficiency, and reduce production costs. In this context, the safety and stability of disposable soft bags is extremely challenging, and a series of measures are typically taken to test and verify that the soft bags are acceptable for their leak tightness integrity. The conventional common disposable soft bag integrity test scheme generally adopts a pressure drop method, namely an integrity detection device adopts pressure drop for filling air in a bag to detect. The method can only judge the leakage of the bag and cannot confirm the position of the leakage point. The product with higher pressure drop needs to screen leakage points, so that air needs to be pumped out, helium is used for detecting again to find whether leakage points exist, a certain amount of helium is filled into the detected bag, positive pressure difference is kept in the bag relative to the external environment, all gas transmission channels are closed after the inflation is completed, a gas probe of an external helium leakage detection device scans the outer surface of the bag, and the bag body has the characteristics of small volume of helium atoms and extremely small content ratio in the atmosphere, so that helium atoms leak from the bag on the surface of the bag body, and the probe detects the leakage points to trigger an alarm, thereby determining the integrity of the bag body. Helium is completely discharged after the existing test scheme is finished, the cost of the helium is high, and large cost waste is caused. The helium can not be recycled in the detection mode, and the detection method is low in efficiency and high in cost. A detection method of a soft bag integrity cycle detection system is therefore proposed for the above problems. Disclosure of Invention The invention aims to overcome the defects of the prior art and provide a detection method of a soft bag integrity circulation detection system, which can be used for recycling test gas, thereby avoiding waste and saving use cost. In order to achieve the aim, the invention provides the technical scheme that the detection method of the soft bag integrity cycle detection system comprises a gas transmission unit, a gas supplementing unit, a gas pressure detection unit, a valve assembly and a control unit; The gas transmission unit comprises a first pipeline and a reversing device, wherein two ends of the first pipeline are respectively communicated with a first soft bag and a second soft bag, and the reversing device is arranged in the middle of the first pipeline to realize circulating reversing and inflating of gas; the air supplementing unit is communicated with the first pipeline and used for supplementing air during detection; the air pressure detection unit is arranged on the first pipeline and the air supplementing unit and is used for detecting air data in real time; The valve assembly is arranged on the first pipeline and the air supplementing unit, and the control unit is in communication connection with the valve assembly to realize air pressure control and directional air supply of the pipeline; the air pressure detection unit is in communication connection with the control unit; the detection method comprises the following steps: step S1, inflating, maintaining pressure and detecting integrity of a first soft bag; S2, after the detection of the first soft bag is finished, conveying the gas in the first soft bag to a second soft bag, and carrying out gas supplementing, pressure maintaining and integrity detection on the second soft bag; Step S3, after the second soft bag is detected, conveying the gas in the second soft bag to a new first soft bag, and carrying out air supplementing, pressure maintaining and integrity detection on the new first soft bag; and S4, circularly replacing the soft bag to be detected, and repeating the gas transfer, gas supplementing, pressure maintaining and integrity detection processes. The step S1 includes: Step S11, opening the second pipeline and the related valves on the first branch, and inflating the first soft bag by the air source; step S12, performing pressure maintaining operation after the first soft bag is full, if the pressure maintaining meets the preset requirement, completing detection, if the pressure maintaining operation does not meet the preset requirement, checking leakage points by using a helium probe, and manually retesting after manual treatment. The step S2 includes: Step S21, controlling each valve on the first pipeline to be opened, and sucking the gas in the first soft bag