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CN-122016722-A - Handheld line-field optical coherence tomography system and method of series interference architecture

CN122016722ACN 122016722 ACN122016722 ACN 122016722ACN-122016722-A

Abstract

The invention provides a handheld line-field optical coherence tomography system and method with a serial interference architecture, and belongs to the technical field of tomography. The device comprises a light source module, a compensation interferometer, a handheld sensing interferometer, an intermediate beam splitter and a detection module. The compensating interferometer adopts a Michelson architecture, and the front end light beam with the first optical path difference is obtained after the light source light beam is split and reflected by the fixed reflector and the optical path adjustable reflector. The hand-held sensing interferometer adopts a Mirau architecture and comprises a scanning galvanometer and an immersed Mirau interference objective lens, wherein front-end light beams enter the objective lens after being regulated by the galvanometer, are divided into second reference light and second sample light by a built-in beam splitter, and are reflected by a reference surface of the objective lens and the sample respectively and then return. The return light is directed to the detection module via an intermediate beam splitter. Through the series connection design, the problems of volatilization and leakage of immersion liquid in the traditional Mirau objective lens are avoided through optical path compensation while the light and handiness and portability of the probe are ensured, the imaging quality is improved, the service life is prolonged, and the maintenance cost is reduced.

Inventors

  • WANG JINYU
  • DONG ZHIHAO
  • LI JUN
  • Xiong Lihan
  • CHEN XIAOLONG

Assignees

  • 中国科学院重庆绿色智能技术研究院

Dates

Publication Date
20260512
Application Date
20260210

Claims (10)

  1. 1. The handheld line-field optical coherence tomography system of a serial interference architecture is characterized by comprising: A light source module (1) for emitting a broadband, low coherence line beam; the compensating interferometer (2) adopts a Michelson architecture, and comprises a compensating beam splitter (21), a fixed reflecting mirror (22) and an optical path adjustable reflecting mirror (23), wherein a light beam emitted by the light source module (1) is divided into two beams after passing through the compensating beam splitter (21) and respectively reflected by the fixed reflecting mirror (22) and the optical path adjustable reflecting mirror (23), and then returns to the compensating beam splitter (21) to generate a front-end light beam (6), and the front-end light beam (6) comprises first reference light and first sample light with a first optical path difference, and the first optical path difference is larger than the coherence length of a light source; the hand-held sensing interferometer (3) adopts a Mirau architecture, and comprises a scanning galvanometer (31) and a Mirau interference objective (32), wherein the Mirau interference objective (32) is an immersion objective, the scanning galvanometer (31) is positioned at an entrance pupil of the Mirau interference objective (32), a front-end light beam (6) enters the Mirau interference objective (32) after passing through the adjustment direction of the scanning galvanometer (31), the front-end light beam (6) is divided into a second reference light and a second sample light by a sensing beam splitter (33) in the objective and introduces a second optical path difference, and the second reference light and the second sample light return to obtain return light after passing through an objective reference surface (34) and an object to be measured (35) respectively; And a detection module (5) and an intermediate beam splitter (4) arranged between the compensation interferometer (2) and the hand-held sensing interferometer (3), the return light passing through the intermediate beam splitter (4) to separate a new light beam and being received by the detection module (5).
  2. 2. The serial interference architecture handheld line field optical coherence tomography system of claim 1, wherein: The device also comprises a piezoelectric ceramic displacement table and an electric translation table, wherein the piezoelectric ceramic displacement table is arranged on a moving part of the electric translation table, and the optical path adjustable reflecting mirror (23) is arranged on the moving part of the piezoelectric ceramic displacement table; or, the optical wedge is arranged in pairs, and the optical wedge is arranged between the compensating beam splitter (21) and the optical path adjustable reflecting mirror (23).
  3. 3. The system of claim 1, wherein the scanning galvanometer (31) comprises a mirror and a power source capable of changing the angle of the mirror to change the direction of the reflected light without changing the direction of the incident light.
  4. 4. The serial interference architecture hand-held line-field optical coherence tomography system of claim 1, further comprising a relay lens set disposed between the optical paths of the compensating interferometer (2) and the hand-held sensing interferometer (3).
  5. 5. The system of claim 1, wherein the compensating beam splitter (21) is a non-polarizing beam splitting cube with a splitting ratio of 50:50.
  6. 6. The handheld line-field optical coherence tomography system with a serial interference architecture as recited in claim 1, wherein the detection module (5) is a line scanning camera, and a tube lens (7) is further disposed between the line scanning camera and the intermediate beam splitter (4).
  7. 7. The system of claim 1, wherein the contact window of the Mirau interference objective (32) is made of sapphire.
  8. 8. The handheld line-field optical coherence tomography system of a serial interference architecture of claim 1, wherein the light source module (1) comprises a linear light source (11) and a collimating and shaping lens group (12).
  9. 9. A method for handheld line-field optical coherence tomography of a serial interference architecture, characterized in that a handheld line-field optical coherence tomography system of a serial interference architecture as claimed in claim 2 is used, comprising the steps of: The optical path calibration, the objective lens of handheld sensing interferometer (3) is laminated in strong reflection module, piezoceramics displacement platform and scanning galvanometer (31) keep motionless, electronic translation platform is taken optical path adjustable speculum (23) removal, detection module (5) scanning optical path difference, when optical path difference is zero, electronic translation platform's position locking and completion calibration.
  10. 10. The method of hand-held line-field optical coherence tomography of a serial interference architecture of claim 9, further comprising: Two-dimensional tomography, the piezoelectric ceramic displacement table drives the piezoelectric ceramic displacement table to oscillate reciprocally, the light source module (1) emits light beams, and the detection module (5) synchronously collects interference patterns; And (3) three-dimensional volume imaging, wherein the scanning galvanometer (31) deflects the light beam to move along a straight line on the surface of the sample while performing the two-dimensional tomography.

Description

Handheld line-field optical coherence tomography system and method of series interference architecture Technical Field The invention relates to the technical field of tomography, in particular to a handheld line-field optical coherence tomography system and method of a serial interference architecture. Background In the field of Optical Coherence Tomography (OCT), interferometer architecture is the core to achieve high resolution tomography. Currently, the mainstream interference architecture includes classical Michelson architecture, and the Mirau architecture and Linnik architecture developed on the basis of the classical Michelson architecture and dedicated to microscopic imaging scenes. Referring to fig. 2, the michelson architecture has clear structure and flexible adjustment, is the basis of a plurality of systems, and the Mirau architecture realizes a very compact structure by integrating a reference surface in an objective lens, is beneficial to integration, and the Linnik architecture adopts a pair of matched objective lenses to respectively guide a reference arm and a sample arm, so that excellent imaging quality can be obtained, but the structure determines the inherent volume and weight. The above architecture has significant limitations in the context of handheld, high stability clinical diagnostic applications. The traditional Linnik interferometer needs to use two independent microscope objectives, so that the system is large and heavy, the mechanical inertia is large, the scanning speed is limited, and the traditional Linnik interferometer is difficult to design into a portable probe which is convenient for a doctor to hold. While the compact Mirau architecture solves the volume problem, the immersion interference objective at the core relies on an internal liquid layer to achieve optical function, which is prone to volatilization or leakage during long-term use. This not only directly results in reduced imaging quality and signal attenuation, but also brings the problem of frequent maintenance, calibration and even replacement of the objective lens, and significantly increases the use cost and instability of the system. Disclosure of Invention Aiming at the defects of the prior art, the invention provides a handheld line field optical coherence tomography system and a method of a series interference architecture, which are used for solving the technical problems that the Linnik interferometer architecture is huge and heavy in size, large in inertia, low in scanning speed and unfavorable for doctors to hold, the Mirau interference architecture is compact in structure, but an immersed objective is easy to volatilize in the using process and leak, imaging quality is affected and maintenance cost is extremely high. The technical scheme adopted by the invention is that a handheld line-field optical coherence tomography system and a method of a serial interference architecture are adopted. Wherein, handheld line field optical coherence tomography system of series connection interference framework includes: The light source module is used for emitting broadband low-coherence linear light beams; The compensating interferometer adopts a Michelson architecture and comprises a compensating beam splitter, a fixed reflecting mirror and an optical path adjustable reflecting mirror, wherein a light beam emitted by a light source module is divided into two beams after passing through the compensating beam splitter and respectively reflected by the fixed reflecting mirror and the optical path adjustable reflecting mirror, and then returns to the compensating beam splitter to generate a front-end light beam, and the front-end light beam comprises first reference light and first sample light with first optical path difference, and the first optical path difference is larger than the coherence length of a light source; The hand-held sensing interferometer adopts a Mirau architecture and comprises a scanning galvanometer and a Mirau interference objective lens, wherein the Mirau interference objective lens is an immersion objective lens, the scanning galvanometer is positioned at an entrance pupil of the Mirau interference objective lens, a front-end light beam enters the Mirau interference objective lens after passing through the adjustment direction of the scanning galvanometer, the front-end light beam is divided into a second reference light and a second sample light by a sensing beam splitter in the objective lens and introduces a second optical path difference, and the second reference light and the second sample light return to obtain return light after passing through an objective lens reference surface and an object to be measured respectively; and a detection module and an intermediate beam splitter disposed between the compensation interferometer and the hand-held sensing interferometer, the return light passing through the intermediate beam splitter to separate a new light beam and being received by