CN-122016727-A - Bimodal non-contact elastic detection device based on Brillouin and air-blowing type sweep frequency optical coherence elastic imaging

CN122016727ACN 122016727 ACN122016727 ACN 122016727ACN-122016727-A

Abstract

The application discloses a bimodal non-contact elastic detection device based on Brillouin and air-blowing type sweep frequency optical coherence elastography, and relates to the technical field of imaging devices. The system comprises a Brillouin-sweep frequency optical coherence elastography common-path scanning unit, a Brillouin scattering elastography system, an air-blowing type non-contact excitation unit, a sweep frequency optical coherence tomography unit, a timing controller and a timing controller, wherein the Brillouin-sweep frequency optical coherence elastography common-path scanning unit focuses a Brillouin scattering signal on the surface of a biological tissue sample and focuses sweep frequency light beams in the biological tissue sample, the Brillouin scattering elastography system collects back-oriented Brillouin scattering light and carries out frequency discrimination processing to determine the longitudinal elastic modulus of the biological tissue sample, the air-blowing type non-contact excitation unit applies non-contact air pressure excitation to the surface of the biological tissue sample to generate shear wave propagation, the sweep frequency optical coherence tomography unit collects back scattering light signals and carries out interference to obtain phase change information, caused by the shear wave propagation, in the biological tissue sample. The application can realize in-situ synchronous acquisition of bimodal elastic information and improve measurement consistency and reliability.

Inventors

HE XINGDAO
SHI JIULIN
Ai Sizhu
WANG YIDI
XIA NENGHAO

Assignees

南昌航空大学

Dates

Publication Date: 20260512
Application Date: 20260316

Claims (9)

1. The bimodal non-contact elastic detection device based on the brillouin and air-blowing type sweep frequency optical coherence elastography is characterized by comprising a brillouin-sweep frequency optical coherence elastography common-path scanning unit, a brillouin scattering elastography system, a sweep frequency optical coherence elastography system and a time sequence controller; the brillouin scattering elastography system and the sweep frequency optical coherence elastography system share the brillouin-sweep frequency optical coherence elastography common-path scanning unit; the time sequence controller is respectively connected with the brillouin scattering elastography system and the sweep frequency optical coherence elastography system; The sweep-frequency optical coherence elastography system comprises a sweep-frequency optical coherence tomography unit and an air-blowing type non-contact excitation unit; The brillouin scattering elastic imaging system is used for exciting a brillouin scattering signal; the Brillouin-sweep frequency optical coherence elastography common-path scanning unit is used for focusing the Brillouin scattering signal to the surface of a biological tissue sample; The Brillouin scattering elastic imaging system is also used for collecting backward Brillouin scattering light at the biological tissue sample and performing frequency discrimination processing to obtain a Brillouin spectrum signal so as to determine the longitudinal elastic modulus of the biological tissue sample; The sweep-frequency optical coherence tomography unit is used for emitting sweep-frequency light beams; the Brillouin-sweep frequency optical coherence elastography common-path scanning unit is used for focusing the sweep frequency light beam into the biological tissue sample; the air-blowing type non-contact excitation unit is used for applying non-contact air pressure excitation to the surface of the biological tissue sample so as to generate shear wave propagation; The sweep frequency optical coherence tomography unit is also used for collecting back scattering light signals generated in the biological tissue sample and interfering the back scattering light signals to obtain interference signals so as to obtain phase change information of the biological tissue sample caused by propagation of shear waves; the time sequence controller is used for synchronously controlling working time sequences of the brillouin scattering elastic imaging system, the sweep frequency optical coherence tomography unit and the air-blowing type non-contact excitation unit.
2. The bimodal non-contact elastic detection device based on brillouin and air-blown sweep frequency optical coherence elastography according to claim 1, wherein the brillouin scattering elastography system comprises a brillouin signal excitation unit and a brillouin signal acquisition unit; The Brillouin signal excitation unit and the Brillouin signal acquisition unit are both connected with the time schedule controller, the Brillouin signal excitation unit is connected with the Brillouin signal acquisition unit through an optical path, and the Brillouin signal excitation unit is also connected with the Brillouin-sweep frequency optical coherence elastography common-path scanning unit through an optical path; The Brillouin signal excitation unit is used for exciting a Brillouin scattering signal; The Brillouin signal acquisition unit is used for acquiring backward Brillouin scattered light at the biological tissue sample and performing frequency discrimination processing to obtain a Brillouin spectrum signal so as to determine the longitudinal elastic modulus of the biological tissue sample.
3. The dual-mode non-contact elastic detection device based on brillouin and air-blowing type sweep-frequency optical coherence elastography according to claim 2, wherein the brillouin signal excitation unit comprises a narrow linewidth continuous laser, a modulator, an optical fiber delay line, a first optical fiber circulator, a first collimator and a beam splitter; The narrow linewidth continuous laser is connected with the time schedule controller, the modulator is connected with the narrow linewidth continuous laser, the optical fiber delay line is connected with the modulator, the first optical fiber circulator is connected with the optical fiber delay line, the first collimator is connected with the first optical fiber circulator through an optical path, the beam splitter is arranged on an emergent optical path of the first collimator, and the beam splitter is connected with the Brillouin-sweep frequency optical coherence elastography common-path scanning unit through an optical path; The narrow linewidth continuous laser is used for emitting light beams; the modulator is used for modulating the light beam to obtain a modulated light beam; The optical fiber delay line is used for carrying out optical path adjustment on the modulated light beam to obtain an adjusted light beam; the first port of the first optical fiber circulator is used for receiving the adjusting light beam, and the second port of the first optical fiber circulator is used for outputting the adjusting light beam to a first collimator; The first collimator is used for carrying out collimation treatment on the adjustment light beam and transmitting the collimated light beam to the beam splitter; The beam splitter is used for splitting the collimated light beam to obtain a split scattered light beam, wherein the split scattered light beam is used as a Brillouin scattering signal, and the Brillouin scattering signal is focused on the surface of a biological tissue sample through the Brillouin-sweep optical coherence elastography common-path scanning unit so as to generate backward Brillouin scattering light through interaction; the Brillouin-sweep frequency optical coherence elastography common-path scanning unit is further used for transmitting the backward Brillouin scattering light to the beam splitter; the beam splitter is further configured to transmit the backward brillouin scattered light to the first collimator; the second port of the first optical fiber circulator is used for receiving the backward Brillouin scattered light and transmitting the backward Brillouin scattered light to the third port of the first optical fiber circulator; And a third port of the first optical fiber circulator is used for transmitting the backward Brillouin scattered light to the Brillouin signal acquisition unit.
4. The dual-mode non-contact elastic detection device based on brillouin and air-blown sweep frequency optical coherence elastography according to claim 3, wherein the brillouin signal acquisition unit comprises a third collimator, a brillouin spectrometer and a first detector; The third collimator is arranged on an emergent light path of a third port of the first optical fiber circulator; the Brillouin spectrometer is connected with the third collimator; the first detector is connected with the Brillouin spectrometer and also connected with the time sequence controller; the third collimator is used for carrying out collimation treatment on the backward Brillouin scattered light and transmitting the collimated backward Brillouin scattered light to the Brillouin spectrometer; The Brillouin spectrometer is used for carrying out frequency discrimination on the collimated backward Brillouin scattered light to obtain a Brillouin spectrum signal; The detector is used for receiving the brillouin spectrum signal.
5. The dual-mode non-contact elastic detection device based on brillouin and air-blown sweep optical coherence elastography according to claim 3, wherein the brillouin-sweep optical coherence elastography common-path scanning unit comprises a dichroic mirror, a scanning galvanometer group, an optical shutter and an objective lens; The dichroic mirror is arranged on an emergent light path of the beam splitter, the scanning galvanometer group is arranged on an emergent light path of the dichroic mirror, the optical shutter is arranged on an emergent light path of the scanning galvanometer group, the objective lens is arranged on an emergent light path of the optical shutter, and a biological tissue sample is arranged on an emergent light path of the objective lens.
6. The dual-mode noncontact elastic detection device based on brillouin and air-blowing type sweep optical coherence elastography according to claim 1, wherein the sweep optical coherence tomography unit comprises a sweep light source, a1×2 optical fiber coupler, a2×2 optical fiber coupler, a sample arm light path, a reference arm light path, a photoelectric balance detector and a data acquisition card; The sweep frequency light source is connected with the time sequence controller; the sample arm optical path and the reference arm optical path are connected with the 1X 2 optical fiber coupler, the 2X 2 optical fiber coupler is connected with the photoelectric balance detector, the data acquisition card is connected with the photoelectric balance detector, the 2X 2 optical fiber coupler is also respectively connected with the sample arm optical path and the reference arm optical path, and the sample arm optical path is also connected with the Brillouin-frequency-sweep optical coherence elastography common-path scanning unit through an optical path; the sweep frequency light source is used for emitting sweep frequency light beams; The 1x 2 fiber coupler is used for dividing the sweep beam into sample arm light and reference arm light; The sample arm light path is used for transmitting the sample arm light to the Brillouin-sweep frequency optical coherence elastography common-path scanning unit; The brillouin-sweep optical coherence elastography common-path scanning unit is used for focusing the sample arm light into the biological tissue sample so as to generate a back-scattered light signal, and transmitting the back-scattered light signal to the sample arm light path; The sample arm optical path is used for transmitting the back-scattered optical signal to the 2×2 fiber coupler; The reference arm light path comprises an electric optical delay line, wherein the electric optical delay line is used for adjusting the light path of the reference arm light to obtain reference arm return light; the 2x 2 fiber coupler is used for interfering the back scattered light signal and the return light of the reference arm to obtain an interference signal; The photoelectric balance detector is used for receiving the interference signal; the data acquisition card is used for acquiring the interference signals.
7. The dual-mode non-contact elastic detection device based on brillouin and air-blown sweep optical coherence elastography according to claim 6, wherein the sample arm optical path comprises a second optical fiber circulator and a second collimator; The second optical fiber circulator is connected with the 1 multiplied by 2 optical fiber coupler, the second collimator is connected with the second optical fiber circulator, and the second collimator is also arranged on an incident light path of the Brillouin-sweep optical coherence elastography common-path scanning unit; The first port of the second optical fiber circulator is used for receiving the sample arm light, and the second port of the second optical fiber circulator is used for transmitting the sample arm light to the second collimator; the second collimator is used for carrying out collimation treatment on the sample arm light and transmitting the collimated sample arm light to the Brillouin-sweep optical coherence elastography common-path scanning unit; The second collimator is further configured to receive the back-scattered light signal transmitted back by the brillouin-sweep optical coherence elastography common-path scanning unit, and transmit the back-scattered light signal to a second port of the second optical fiber circulator; And a third port of the second fiber circulator is used for outputting the back scattered light signal to the 2×2 fiber coupler.
8. The bimodal non-contact elastic detection device based on brillouin and air-blowing type sweep frequency optical coherence elastography according to claim 1, wherein the air-blowing type non-contact excitation unit comprises a signal generator, a pressure stabilizing air storage tank, a two-stage precise pressure regulating valve, an air solenoid valve switch, a driving controller and an air tap; The signal generator is connected with the driving controller, the driving controller is connected with the air solenoid valve switch, the pressure stabilizing air storage tank is connected with the two-stage precise pressure regulating valve, and the two-stage precise pressure regulating valve is connected with the air solenoid valve switch; the air solenoid valve switch is connected with the air tap, and the air tap is kept at a non-contact distance from the surface of the biological tissue sample; the signal generator is used for outputting pulse signals; The two-stage precise pressure regulating valve is used for regulating the pressure of the air flow; The driving controller is used for driving and controlling the air solenoid valve switch to perform state change treatment so that the air tap outputs pulse air flow to the surface of the biological tissue sample to generate shear wave propagation to realize non-contact air pressure excitation, and the pulse air flow is determined based on the pulse signal and the air flow.
9. The dual-mode non-contact elastic detection device based on brillouin and air-blowing type sweep frequency optical coherence elastography according to claim 1, further comprising a computer; the computer is respectively connected with the time sequence controller, the Brillouin scattering elastography system and the sweep frequency optical coherence elastography system; the computer is used for acquiring the Brillouin spectrum signal and the interference signal, determining the longitudinal elastic modulus of the biological tissue sample according to the Brillouin spectrum signal, and acquiring phase change information of the biological tissue sample caused by propagation of shear waves according to the interference signal.

Description

Bimodal non-contact elastic detection device based on Brillouin and air-blowing type sweep frequency optical coherence elastic imaging Technical Field The application relates to the technical field of imaging devices, in particular to a bimodal non-contact elastic detection device based on Brillouin and air-blowing type sweep frequency optical coherence elastography. Background In elastography, brillouin elastography (Brillouin SCATTERING ELASTIC IMAGING, BSE) measures the longitudinal elastic modulus by Brillouin frequency shift, reflecting the axial stiffness of cells and extracellular matrix. The sweep-frequency optical coherence elastography (Swept-Source Optical Coherence Elastography, SS-OCE) adopts a high-speed sweep-frequency light source with a central wavelength of 1310nm and a sweep-frequency rate of 100kHz-400kHz to replace a traditional broadband light source, measures the shear modulus and Young modulus, improves the penetration depth of 1310nm wave band in brain tissue by 2mm-3mm compared with 850nm, combines an electric optical delay line to realize the active synchronous adjustment of the optical path length of a reference arm, and is suitable for deep elastography. However, the traditional contact excitation has the problems of couplant pollution, interface reflection interference, mechanical damage and the like, and is not suitable for fragile samples such as brain tissues and the like. Therefore, how to realize synchronous measurement of fragile samples such as brain tissues, ocular surfaces and the like so as to acquire biomechanical characteristics of the fragile samples is important to improve measurement consistency and reliability. Disclosure of Invention The application aims to provide a bimodal non-contact elastic detection device based on Brillouin and air-blowing type sweep frequency optical coherence elastography, which can realize in-situ synchronous acquisition of bimodal elastic information and improve measurement consistency and reliability. In order to achieve the above object, the present application provides the following solutions: The application provides a bimodal non-contact elastic detection device based on Brillouin and air-blowing type sweep-frequency optical coherence elastography, which comprises a Brillouin-sweep-frequency optical coherence elastography common-path scanning unit, a Brillouin scattering elastography system, a sweep-frequency optical coherence elastography system and a time sequence controller, wherein the Brillouin-sweep-frequency optical coherence elastography common-path scanning unit is used for scanning the optical coherence elastography common-path of the optical coherence elastography system; the brillouin scattering elastography system and the sweep frequency optical coherence elastography system share the brillouin-sweep frequency optical coherence elastography common-path scanning unit; the time sequence controller is respectively connected with the brillouin scattering elastography system and the sweep frequency optical coherence elastography system; The sweep-frequency optical coherence elastography system comprises a sweep-frequency optical coherence tomography unit and an air-blowing type non-contact excitation unit; The brillouin scattering elastic imaging system is used for exciting a brillouin scattering signal; the Brillouin-sweep frequency optical coherence elastography common-path scanning unit is used for focusing the Brillouin scattering signal to the surface of a biological tissue sample; The Brillouin scattering elastic imaging system is also used for collecting backward Brillouin scattering light at the biological tissue sample and performing frequency discrimination processing to obtain a Brillouin spectrum signal so as to determine the longitudinal elastic modulus of the biological tissue sample; The sweep-frequency optical coherence tomography unit is used for emitting sweep-frequency light beams; the Brillouin-sweep frequency optical coherence elastography common-path scanning unit is used for focusing the sweep frequency light beam into the biological tissue sample; the air-blowing type non-contact excitation unit is used for applying non-contact air pressure excitation to the surface of the biological tissue sample so as to generate shear wave propagation; The sweep frequency optical coherence tomography unit is also used for collecting back scattering light signals generated in the biological tissue sample and interfering the back scattering light signals to obtain interference signals so as to obtain phase change information of the biological tissue sample caused by propagation of shear waves; the time sequence controller is used for synchronously controlling working time sequences of the brillouin scattering elastic imaging system, the sweep frequency optical coherence tomography unit and the air-blowing type non-contact excitation unit. In one embodiment, the brillouin scattering elastography system comprises a