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CN-122016977-A - Dual-reinforced silicone rubber composite ventilated membrane cap and preparation method thereof

CN122016977ACN 122016977 ACN122016977 ACN 122016977ACN-122016977-A

Abstract

The invention belongs to the technical field of biological process analysis and sensors, and discloses a dual-reinforced silicone rubber composite ventilated membrane cap and a preparation method thereof, wherein the dual-reinforced silicone rubber composite ventilated membrane cap comprises a membrane cap shell and a composite ventilated membrane, the composite ventilated membrane is packaged on the membrane cap shell and is made of a dual-reinforced silicone rubber composite material, and the dual-reinforced silicone rubber composite material comprises: the silicone rubber comprises a silicone rubber substrate, a chemical reinforcing agent, a physical regulator, a crosslinking agent, an inhibitor and a catalyst, wherein the silicone rubber substrate is vinyl-terminated polydimethylsiloxane, the chemical reinforcing agent is vinyl MQ silicone resin, and the physical regulator is a nanoscale lamellar material. The invention successfully realizes the unification of the rapid response, high mechanical strength and low flow rate dependence of the ventilated membrane through the innovative 'chemical-physical dual-enhanced network' design, and solves the material selection problem which puzzles the industry for a long time.

Inventors

  • HOU CHENGYU
  • ZHANG YANG

Assignees

  • 喜迪达(上海)智能科技有限公司

Dates

Publication Date
20260512
Application Date
20260226

Claims (10)

  1. 1. The dual-reinforced silicone rubber composite breathable film cap is characterized by comprising a film cap shell and a composite breathable film, wherein the composite breathable film is packaged on the film cap shell; The composite breathable film is made of a dual reinforced silicone rubber composite comprising: The silicone rubber comprises a silicone rubber substrate, a chemical reinforcing agent, a physical regulator, a crosslinking agent, an inhibitor and a catalyst, wherein the silicone rubber substrate is vinyl-terminated polydimethylsiloxane, the chemical reinforcing agent is vinyl MQ silicone resin, and the physical regulator is a nanoscale lamellar material.
  2. 2. The dual-reinforced silicone rubber composite breathable membrane cap of claim 1, wherein said membrane cap shell is made of polysulfone material.
  3. 3. The dual-reinforced silicone rubber composite breathable film cap of claim 1, wherein the nanoscale lamellar material is organized montmorillonite, the crosslinking agent is hydrogen-containing silicone oil, the inhibitor is ethynyl cyclohexanol, and the catalyst is a platinum catalyst.
  4. 4. The dual-reinforced silicone rubber composite breathable film cap of claim 1, wherein the thickness of the composite breathable film is 25-50 μm.
  5. 5. The dual-reinforced silicone rubber composite breathable film cap of claim 1, wherein the composite breathable film has a Shore A hardness of greater than 60, an oxygen permeability coefficient of 3×10 -9 cm < 2 >/(s.cmHg) to 8×10 -9 cm < 2 >/(s.cmHg), and a tensile strength of 8.0 MPa or more.
  6. 6. A method for preparing a dual reinforced silicone rubber composite breathable film, for preparing a composite breathable film according to any one of claims 1 to 5, comprising the steps of: Step S1, premixing and devolatilizing, namely mixing a vinyl-terminated polydimethylsiloxane silicon rubber substrate with vinyl MQ silicon resin, heating and stirring under a vacuum condition, and removing moisture and gas; step S2, nano dispersion, namely adding a nano lamellar material into the mixture obtained in the step S1, and fully stripping and uniformly dispersing the nano lamellar material through mechanical grinding to form uniform paste; step S3, preparing glue, namely cooling the paste obtained in the step S2, sequentially adding a cross-linking agent and an inhibitor, uniformly mixing, adding a platinum catalyst under the condition of isolating air, and uniformly mixing to obtain glue solution; step S4, coating and curing, namely coating the glue solution obtained in the step S3 on a substrate, and heating and curing to form a film; and S5, after the post-treatment, cooling, peeling the film from the base material to obtain the dual-reinforced silicone rubber composite breathable film.
  7. 7. The method of preparing a dual-reinforced silicone rubber composite breathable film according to claim 6, characterized in that the curing in step S4 is a step curing process, the first stage is a primary gelation at 70-90 ℃, and the second stage is a thorough cross-linking curing at 140-160 ℃.
  8. 8. The method of producing a dual-reinforced silicone rubber composite breathable film according to claim 6, characterized in that said mechanical grinding in step S2 is a three-roll mill cycle grinding.
  9. 9. The preparation method of the dual-reinforced silicone rubber composite ventilated membrane cap is characterized by comprising the following steps of: Preparing a composite breathable film using the method of any one of claims 6 to 8; And cutting the composite breathable film, placing the cut composite breathable film in a film cap shell mould, and integrally packaging the cut composite breathable film and polysulfone material through an injection molding process to obtain the composite breathable film cap.
  10. 10. The method for preparing the dual-reinforced silicone rubber composite breathable film cap of claim 9, wherein the injection molding process is two-shot injection molding.

Description

Dual-reinforced silicone rubber composite ventilated membrane cap and preparation method thereof Technical Field The invention relates to the technical field of biological process analysis and sensors, in particular to a dual-reinforced silicone rubber composite breathable film cap and a preparation method thereof. Background In the processes of microbial fermentation, bioreactor, cell culture and the like, the concentration of dissolved oxygen is a key core physicochemical parameter, and accurate, real-time and in-situ monitoring is important for process control and optimization. Polarographic dissolved oxygen sensors (also known as Clark sensors) are widely used in the above fields because of their stable performance and accurate measurement. The core component of the sensor is a breathable film cap at the top, and the breathable film on the film cap allows oxygen molecules to enter the sensor to participate in electrochemical reaction through permeation, and simultaneously blocks electrolyte solution and a measured medium, so that the selective detection of dissolved oxygen is realized. The breathable film materials in the prior art face fundamental contradiction in material science, and are difficult to simultaneously meet multiple requirements of high-performance sensors: On the one hand, traditional silicone rubber membranes (e.g. polydimethylsiloxane, PDMS) have extremely high oxygen transmission rates, giving sensors extremely fast response speeds (t 90 can be <10 seconds). However, the material is low in mechanical strength and soft (Shore A hardness is generally lower than 40), and is easy to deform and break when being installed, sterilized by high-pressure steam or subjected to water pressure. More seriously, the excessively high oxygen flux causes that the sensor output signal is seriously dependent on the flow rate of the medium to be measured, the reading is low in static or low agitation culture, and the accurate value can be obtained by relying on strong agitation, which increases the risk of shearing force for cell culture and is not suitable for the cell culture process sensitive to the shearing force. On the other hand, the traditional fluorine polymer membrane (such as FEP and PTFE) has high mechanical strength and stable chemical property, but has extremely low oxygen transmittance, so that the response speed of the sensor is low (t 90 is usually more than 60 seconds), the sensitivity is low, and the application requirements of cell culture and the like, which need to rapidly monitor the dynamic oxygen change process, are difficult to meet. Therefore, developing a novel breathable film material that combines rapid response, high mechanical strength, and low flow rate dependence is a technical challenge to be addressed in the art. Disclosure of Invention The invention aims to solve the defects in the prior art, and provides a dual-reinforced silicone rubber composite ventilated membrane cap and a preparation method thereof. In order to solve the problems, the invention adopts the following technical scheme: the dual-reinforced silicone rubber composite breathable film cap comprises a film cap shell and a composite breathable film, wherein the composite breathable film is packaged on the film cap shell; The composite breathable film is made of a dual-reinforced silicone rubber composite material, wherein the dual-reinforced silicone rubber composite material comprises a silicone rubber base material, a chemical reinforcing agent, a physical regulator, a crosslinking agent, an inhibitor and a catalyst, the silicone rubber base material is vinyl-terminated polydimethylsiloxane, the chemical reinforcing agent is vinyl MQ silicone resin, and the physical regulator is a nanoscale lamellar material. The vinyl MQ silicon resin and the silicon rubber substrate are crosslinked through hydrosilylation reaction to form a chemical reinforced network, and the nanoscale lamellar material is uniformly dispersed in the silicon rubber substrate to form a physical regulation network. Preferably, the membrane cap shell is made of polysulfone material. Preferably, the nanoscale lamellar material is organized montmorillonite, the cross-linking agent is hydrogen-containing silicone oil, the inhibitor is ethynyl cyclohexanol, and the catalyst is a platinum catalyst. Preferably, the thickness of the composite breathable film is 25-50 μm. Preferably, the Shore A hardness of the composite breathable film is more than 60, the oxygen permeability coefficient is between 3×10 -9 cm < 2 >/(s.cmHg) and 8×10 -9 cm < 2 >/(s.cmHg), and the tensile strength is more than or equal to 8.0 MPa. The preparation method of the dual-reinforced silicone rubber composite breathable film is used for preparing the composite breathable film and comprises the following steps of: Step S1, premixing and devolatilizing, namely mixing a vinyl-terminated polydimethylsiloxane silicon rubber substrate with vinyl MQ silicon resin, heating and s