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CN-122017215-A - Dynamic evaluation method and system for column effect of imidazolium resin for on-line separation of At-211

CN122017215ACN 122017215 ACN122017215 ACN 122017215ACN-122017215-A

Abstract

The invention relates to the technical field of column efficiency evaluation, and discloses an imidazolium resin column efficiency dynamic evaluation method and system for on-line separation of an At-211, wherein the method comprises the steps of collecting a bed height value of the imidazolium resin column, a pH value of effluent liquid and radioactivity of the At-211 in eluent in real time in the continuous separation process of the At-211; the method can accurately reflect the abnormal swelling risk and the degradation risk of separation efficiency of the resin, clearly distinguish the reversible fluctuation and the irreversible attenuation of the column effect, reflect the self-recovery capacity and the irreversible degradation accumulation degree in the column, and promote the accuracy and the comprehensiveness of dynamic evaluation of the column effect.

Inventors

  • GU LONG
  • Su Xingkang
  • WANG GUAN
  • HUANG HUA

Assignees

  • 福建睿斯科医疗技术有限公司

Dates

Publication Date
20260512
Application Date
20260410

Claims (10)

  1. 1. The imidazolium resin column efficiency dynamic evaluation method for the on-line separation of the At-211 is characterized by comprising the following steps of: step S1, collecting the bed height value of an imidazolium resin column, the pH value of effluent liquid and the radioactivity of the At-211 in eluent in real time in the continuous separation process of the At-211; Step S2, calculating the height value of the bed after pretreatment and the pH value of effluent liquid to obtain a swelling disturbance index representing abnormal risk of a resin swelling state, and analyzing the radioactivity after pretreatment to obtain a peak broadening coefficient representing degradation risk of separation efficiency; S3, carrying out cooperative analysis on the swelling disturbance index and the peak shape broadening coefficient to respectively obtain a column effect fluctuation factor representing the reversible fluctuation of the column effect and a passivation influence factor representing the irreversible attenuation of the column effect; And S4, analyzing the trend of the column effect fluctuation factor and the passivation influence factor to obtain the health index for evaluating the column effect of the imidazolium resin.
  2. 2. The dynamic evaluation method for on-line separation of At-211 according to claim 1, wherein the calculation of the bed height value after pretreatment and the pH value of the effluent to obtain a swelling disturbance index indicating the risk of abnormal swelling state of the resin comprises: Carrying out distortion analysis on the pretreated bed height value and the pH value of effluent liquid to generate a swelling distortion coefficient which represents the deviation degree of the resin bed and the chemical environment; integrating the pH value of the effluent and correcting the pH value by combining the height value of the bed layer to obtain the ion penetration factor representing the cumulative chemical penetration effect of the eluent on the resin bed layer.
  3. 3. The dynamic evaluation method for an imidazolium resin column effect for At-211 on-line separation according to claim 2, wherein the calculation of the bed height value after pretreatment and the pH value of the effluent liquid gives a swelling disturbance index indicating the risk of abnormal swelling state of the resin, further comprising: and carrying out fusion analysis on the swelling distortion coefficient and the ion penetration factor to obtain a swelling disturbance index which represents the abnormal risk of the swelling state of the resin.
  4. 4. The dynamic evaluation method for on-line separation of an imidazolium resin column according to claim 1, wherein the analysis of the radioactivity after the pretreatment to obtain a peak broadening coefficient representing the risk of separation efficiency degradation comprises: analyzing the time sequence profile of the radioactivity to generate a kurtosis distortion coefficient which represents the symmetry deviation state of an elution peak; and carrying out cumulative analysis on the kurtosis distortion coefficient to obtain a kurtosis broadening coefficient which represents the degradation risk of the separation efficiency.
  5. 5. The dynamic evaluation method for column efficiency of an imidazolium resin for At-211 on-line separation according to claim 4, wherein the collaborative analysis of the swelling disturbance index and the peak shape broadening coefficient is performed to obtain a column efficiency fluctuation factor representing a reversible fluctuation of the column efficiency and a passivation influence factor representing an irreversible attenuation of the column efficiency, respectively, comprising: analyzing the dynamic association of the swelling disturbance index and the peak shape broadening coefficient in the separation process to generate a response coefficient representing the cooperative variation degree of the swelling state and the separation efficiency; Trend-residual decomposition is performed on the response coefficients, and the transient response intensity representing the rapid fluctuation and the baseline migration amount representing the slow drift are calculated.
  6. 6. The dynamic evaluation method for column efficiency of an imidazolium resin for At-211 on-line separation according to claim 5, wherein the column efficiency fluctuation factor representing the reversible fluctuation of the column efficiency and the passivation influence factor representing the irreversible attenuation of the column efficiency are obtained by performing a collaborative analysis on the swelling disturbance index and the peak shape broadening coefficient, respectively, further comprising: carrying out peak statistics on the instantaneous response intensity, and correcting by combining the change rate of the pH value of the effluent liquid to obtain a dynamic balance coefficient representing the self-recovery capability of the disturbance in the column; The baseline shift amount is corrected based on the bed height value to obtain an aging index indicating the degree of irreversible degradation accumulation in the column.
  7. 7. The dynamic evaluation method for column efficiency of an imidazolium resin for At-211 on-line separation according to claim 6, wherein the column efficiency fluctuation factor representing the reversible fluctuation of the column efficiency and the passivation influence factor representing the irreversible attenuation of the column efficiency are obtained by performing a collaborative analysis on the swelling disturbance index and the peak shape broadening coefficient, respectively, further comprising: Carrying out deviation analysis on the dynamic balance coefficient to generate a column effect fluctuation factor representing reversible fluctuation of the column effect; The aging index is analyzed to generate a passivation influencing factor representing the irreversible attenuation of the column effect.
  8. 8. The dynamic evaluation method for the column efficiency of the imidazolium resin for the on-line separation of At-211 according to claim 7, wherein analyzing the trends of the column efficiency fluctuation factor and the passivation influence factor to obtain the health index for evaluating the column efficiency of the imidazolium resin comprises: performing synthetic analysis on the column efficiency fluctuation factor and the passivation influence factor to generate a health deviation vector representing the deviation degree of the column efficiency comprehensive state; and analyzing the consistency of the variation trend of the column effect fluctuation factor and the passivation influence factor, and generating a degradation trend index which represents the evolution direction of the column effect state.
  9. 9. The dynamic evaluation method for the column efficiency of the imidazolium resin for the on-line separation of At-211 according to claim 8, wherein the analysis of the trends of the column efficiency fluctuation factor and the passivation influence factor to obtain the health index for evaluating the column efficiency of the imidazolium resin, further comprises: And carrying out joint evaluation on the health deviation vector and the degradation trend index to generate a health index for evaluating the column efficiency of the imidazolium resin.
  10. 10. An imidazolium resin column efficiency dynamic evaluation system for At-211 on-line separation, applied to the evaluation method as set forth in any one of claims 1 to 9, comprising: the data acquisition unit is used for acquiring the bed height value of the imidazolium resin column, the pH value of effluent liquid and the radioactivity of the At-211 in eluent in real time in the continuous separation process of the At-211; The column efficiency analysis unit is used for calculating the height value of the pretreated bed layer and the pH value of the effluent liquid to obtain a swelling disturbance index which represents the abnormal risk of the swelling state of the resin, and analyzing the radioactivity after the pretreatment to obtain a peak broadening coefficient which represents the degradation risk of the separation efficiency; The cooperative computing unit is used for carrying out cooperative analysis on the swelling disturbance index and the peak shape broadening coefficient to respectively obtain a column effect fluctuation factor representing the reversible fluctuation of the column effect and a passivation influence factor representing the irreversible attenuation of the column effect; And the column effect evaluation unit is used for analyzing the trend of the column effect fluctuation factor and the passivation influence factor to obtain the health index for evaluating the column effect of the imidazolium resin.

Description

Dynamic evaluation method and system for column effect of imidazolium resin for on-line separation of At-211 Technical Field The invention relates to the technical field of column efficiency evaluation, in particular to an imidazolium resin column efficiency dynamic evaluation method and system for on-line separation of At-211. Background At present, in the column efficiency evaluation of the imidazolium resin for online separation of the At-211, the adsorption capacity and the elution recovery rate of the imidazolium resin for the At-211 are mainly monitored, a column efficiency change curve is constructed by combining column pressure change data, meanwhile, the radioactivity activity of the At-211 in eluent is monitored by adopting an online radioactivity detector, and the column efficiency attenuation condition is judged through the change of activity peak values and peak value occurrence time, so that the dynamic evaluation effect of the column efficiency is achieved. However, the above evaluation method still has the technical defects that in the analysis of At-211 continuous for a long time, the imidazolium resin is slightly swelled and surface active sites are passivated due to repeated adsorption-elution, the pH value of the eluent is slightly fluctuated along with the increase of separation batches, and in the existing evaluation method, the column effect is judged only by the adsorption capacity and the elution recovery rate, the swelling degree of the resin and the passivation rate of the active sites are not considered, so that the column effect fluctuation caused by reversible swelling and the column effect attenuation caused by irreversible active site loss cannot be analyzed, and the dynamic evaluation effect on the column effect is further influenced. Disclosure of Invention Aiming At the defects of the prior art, the invention provides an imidazolium resin column efficiency dynamic evaluation method and system for on-line separation of At-211, which solve the problems. The technical aim of the invention is realized by the following technical scheme: An imidazolium resin column efficiency dynamic evaluation method for At-211 on-line separation, comprising: step S1, collecting the bed height value of an imidazolium resin column, the pH value of effluent liquid and the radioactivity of the At-211 in eluent in real time in the continuous separation process of the At-211; Step S2, calculating the height value of the bed after pretreatment and the pH value of effluent liquid to obtain a swelling disturbance index representing abnormal risk of a resin swelling state, and analyzing the radioactivity after pretreatment to obtain a peak broadening coefficient representing degradation risk of separation efficiency; S3, carrying out cooperative analysis on the swelling disturbance index and the peak shape broadening coefficient to respectively obtain a column effect fluctuation factor representing the reversible fluctuation of the column effect and a passivation influence factor representing the irreversible attenuation of the column effect; And S4, analyzing the trend of the column effect fluctuation factor and the passivation influence factor to obtain the health index for evaluating the column effect of the imidazolium resin. Further, the pretreated bed height value and the pH value of the effluent are calculated to obtain a swelling disturbance index representing the abnormal risk of the swelling state of the resin, and the method comprises the following steps: Carrying out distortion analysis on the pretreated bed height value and the pH value of effluent liquid to generate a swelling distortion coefficient which represents the deviation degree of the resin bed and the chemical environment; integrating the pH value of the effluent and correcting the pH value by combining the height value of the bed layer to obtain the ion penetration factor representing the cumulative chemical penetration effect of the eluent on the resin bed layer. Further, the step of calculating the height value of the bed after pretreatment and the pH value of the effluent liquid to obtain a swelling disturbance index representing the abnormal risk of the swelling state of the resin, and the step of: and carrying out fusion analysis on the swelling distortion coefficient and the ion penetration factor to obtain a swelling disturbance index which represents the abnormal risk of the swelling state of the resin. Further, the radioactivity after pretreatment is analyzed to obtain peak broadening coefficients representing the risk of separation efficiency degradation, comprising: analyzing the time sequence profile of the radioactivity to generate a kurtosis distortion coefficient which represents the symmetry deviation state of an elution peak; and carrying out cumulative analysis on the kurtosis distortion coefficient to obtain a kurtosis broadening coefficient which represents the degradation risk of the separation efficiency. F