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CN-122017262-A - Sample analyzer and liquid dispensing abnormality recognition method

CN122017262ACN 122017262 ACN122017262 ACN 122017262ACN-122017262-A

Abstract

The embodiment of the application discloses a sample analyzer and a liquid dispensing abnormality identification method. The sample analyzer can acquire pressure data of liquid dispensing and optical signal change data of liquid dispensed in the reaction container, the optical signal change data can represent the optical signal influence condition of the liquid in the reaction container on an incident light beam, so that multiple influence factors such as the pressure data and the optical signal change data can be synthesized to judge whether the liquid dispensing is abnormal or not, false alarm or incapability of identifying the dispensing abnormality caused by judging whether the liquid dispensing is abnormal or not only depending on a single factor is avoided, sensitivity and specificity of abnormal identification of the liquid dispensing can be improved, and accuracy and reliability of abnormal identification of the liquid dispensing are improved.

Inventors

  • LIANG HAOBIN
  • DAI YONG
  • YU QI

Assignees

  • 深圳迈瑞生物医疗电子股份有限公司

Dates

Publication Date
20260512
Application Date
20241111

Claims (18)

  1. 1. The sample analyzer is characterized by comprising a dispensing unit, a pressure detection device, a photoelectric detection device and a processor; the dispensing unit is used for dispensing the target liquid into the reaction container; the pressure detection device is used for acquiring pressure data of the process of the dispensing unit dispensing the target liquid into the reaction container; The photoelectric detection device is used for emitting a light beam to the reaction container, collecting an emergent light signal of the light beam emitted from a mixed liquid containing the target liquid in the reaction container, and acquiring light signal change data based on the emergent light signal, wherein the light signal change data is used for representing the signal influence condition of the mixed liquid in the reaction container on the light beam; The processor is used for judging whether the process of dispensing the target liquid into the reaction container by the dispensing unit is abnormal according to the pressure data and the optical signal change data, and outputting a judging result.
  2. 2. The sample analyzer of claim 1, wherein the pressure data comprises pipetting pressure data for the pipetting unit to aspirate the target liquid and/or pipetting pressure data for the pipetting unit to discharge the target liquid; The processor is specifically configured to determine whether an abnormality exists in a process of dispensing the target liquid into the reaction container by the dispensing unit according to the optical signal variation data and at least one of the liquid suction pressure data and the liquid discharge pressure data.
  3. 3. The sample analyzer of claim 2, wherein the processor is specifically configured to determine that the process of dispensing the target liquid into the reaction vessel by the dispensing unit is normal when the pipetting pressure data, the drain pressure data, and the optical signal variation data are all within respective corresponding preset numerical ranges.
  4. 4. The sample analyzer of claim 2, wherein the processor is specifically configured to determine that the dispensing unit is normal to dispense the target liquid into the reaction vessel when the pipetting pressure data is greater than the first pipetting pressure threshold but less than the second pipetting pressure threshold and the pipetting pressure data and the optical signal variation data are both within respective corresponding predetermined numerical ranges; wherein the second suction pressure threshold is greater than the first suction pressure threshold.
  5. 5. The sample analyzer of claim 2, wherein the processor is configured to determine that the dispensing unit is dispensing the target liquid into the reaction vessel and that the optical signal change data is abnormal when the pipetting pressure data and the drain pressure data are both within respective predetermined ranges of values but the optical signal change data exceeds a predetermined threshold.
  6. 6. The sample analyzer of claim 2, wherein the processor is specifically configured to determine that there is an abnormality in dispensing the target liquid into the reaction vessel by the dispensing unit when the optical signal variation data is greater than a preset threshold and the pipetting pressure data is greater than a first pipetting pressure threshold but less than a second pipetting pressure threshold, or when the optical signal variation data is greater than the preset threshold and the pipetting pressure data is greater than a first pipetting pressure threshold but less than a second pipetting pressure threshold; Wherein the second pipetting pressure threshold is greater than the first pipetting pressure threshold and the second pipetting pressure threshold is greater than the first pipetting pressure threshold.
  7. 7. The sample analyzer of claim 6, wherein the processor is configured to, The preset threshold value comprises a first preset threshold value and a second preset threshold value, and when the optical signal change data is larger than the first preset threshold value but smaller than the second preset threshold value and the imbibition pressure data is larger than the first imbibition pressure threshold value but smaller than the second imbibition pressure threshold value, the abnormality existing in the process of the target liquid being dispensed to the reaction container by the dispensing unit is determined, and the abnormality is particularly one of suction, micro blockage and foreign matter suction; the second preset threshold value is larger than the first preset threshold value, and the micro-plug is used for indicating that the liquid suction amount of the dispensing unit to the target liquid is insufficient; And when the optical signal change data is larger than the second preset threshold value and the imbibition pressure data is larger than the first imbibition pressure threshold value but smaller than the second imbibition pressure threshold value, determining that the process of the target liquid is distributed to the reaction container by the distribution unit, and particularly determining that an imbibition needle of the distribution unit is blocked.
  8. 8. The sample analyzer of claim 6, wherein the processor is specifically configured to determine that an abnormality, in particular one of a suction, a micro-blockage, and a foreign object suction, exists in the process of dispensing the target liquid into the reaction vessel by the dispensing unit when the optical signal variation data is greater than a first preset threshold and the liquid discharge pressure data is greater than the first liquid discharge pressure threshold but less than the second liquid discharge pressure threshold.
  9. 9. The sample analyzer of claim 2, wherein the processor is specifically configured to determine that there is an abnormality in dispensing the target liquid into the reaction vessel by the dispensing unit, and that the abnormality is specifically a blockage, when the pipetting pressure data is greater than the first pipetting pressure threshold but less than the second pipetting pressure threshold and the optical signal variation data is within a corresponding preset range of values; Wherein the second pipetting pressure threshold is greater than the first pipetting pressure threshold and the second pipetting pressure threshold is greater than the first pipetting pressure threshold; when the imbibition pressure data is greater than the second imbibition pressure threshold or when the drain pressure data is greater than the second drain pressure threshold, it is determined that there is an abnormality in the process of dispensing the target liquid into the reaction vessel by the dispensing unit, and the abnormality is specifically a blockage.
  10. 10. The sample analyzer of any one of claims 1 to 9, wherein the optical signal variation data comprises photoelectric data and/or absorbance data, the photoelectric data being a signal sequence formed by a relationship between light intensity data of the outgoing optical signal and an acquisition time.
  11. 11. The sample analyzer of claim 10, wherein the optoelectronic data comprises panoramic dynamic photometric data.
  12. 12. The sample analyzer of any one of claims 1 to 9, wherein the processor is configured to, When determining that the process of dispensing the target liquid into the reaction container by the dispensing unit is abnormal, prompting the process of dispensing the target liquid into the reaction container by the dispensing unit to be abnormal; when the optical signal change data is determined to be abnormal based on the optical signal change data, the optical signal change data is prompted to be abnormal, and the optical signal change data is re-measured.
  13. 13. The sample analyzer of any one of claims 1 to 9, wherein the processor is configured to, Acquiring a dispensing liquid abnormality judgment rule set by a user, wherein the dispensing liquid abnormality judgment rule is used for representing the correspondence between the abnormal condition of the pressure data and the abnormal condition of the optical signal change data and the judgment result; Judging whether the process of dispensing the target liquid into the reaction container by the dispensing unit is abnormal or not according to the dispensing liquid abnormality judging rule, the abnormal condition of the pressure data and the abnormal condition of the optical signal change data, and outputting the judging result.
  14. 14. The sample analyzer according to any one of claims 1 to 9, wherein the dispensing unit includes a syringe and a dispensing needle, the syringe being configured with a motor, the syringe being for sucking the target liquid from a liquid container of the target liquid based on driving the dispensing needle by the motor; The processor is specifically used for acquiring motor motion data of the injector and/or liquid level height in the liquid container; judging whether the process of dispensing the target liquid into the reaction container by the dispensing unit is abnormal according to at least one of the motor motion data and the liquid level height, the pressure data and the optical signal change data, and outputting a judging result.
  15. 15. The liquid dispensing abnormality identification method is characterized by being applied to a sample analyzer, wherein the sample analyzer comprises a dispensing unit, a pressure detection device and a photoelectric detection device; the method comprises the following steps: controlling the dispensing unit to dispense the target liquid into the reaction vessel; controlling the pressure detection device to acquire pressure data of the process of dispensing the target liquid into the reaction container by the dispensing unit; Controlling the photoelectric detection device to emit a light beam to the reaction container, collecting an emergent light signal of the light beam emitted from a mixed liquid containing the target liquid in the reaction container, and acquiring light signal change data based on the emergent light signal, wherein the light signal change data is used for representing the signal influence condition of the mixed liquid in the reaction container on the light beam; Judging whether the process of dispensing the target liquid into the reaction container by the dispensing unit is abnormal according to the pressure data and the optical signal change data, and outputting a judging result.
  16. 16. The method of claim 15, wherein the pressure data comprises pipetting pressure data for the pipetting unit to aspirate the target liquid and/or pipetting pressure data for the pipetting unit to discharge the target liquid; The step of judging whether or not there is an abnormality in the process of dispensing the target liquid into the reaction container by the dispensing unit based on the pressure data and the optical signal variation data, includes: Judging whether the process of dispensing the target liquid into the reaction container by the dispensing unit is abnormal or not according to at least one of the liquid suction pressure data and the liquid discharge pressure data and the optical signal change data.
  17. 17. The method according to claim 16, wherein the determining whether there is an abnormality in the process of dispensing the target liquid into the reaction vessel by the dispensing unit based on the light signal variation data and at least one of the suction pressure data and the discharge pressure data, comprises: Determining that there is an abnormality in the process of dispensing the target liquid into the reaction vessel by the dispensing unit when the optical signal variation data is greater than a preset threshold value and the liquid suction pressure data is greater than a first liquid suction pressure threshold value but less than a second liquid suction pressure threshold value, or when the optical signal variation data is greater than the preset threshold value and the liquid discharge pressure data is greater than a first liquid discharge pressure threshold value but less than a second liquid discharge pressure threshold value; Wherein the second pipetting pressure threshold is greater than the first pipetting pressure threshold and the second pipetting pressure threshold is greater than the first pipetting pressure threshold.
  18. 18. The method according to claim 16, wherein the determining whether there is an abnormality in the process of dispensing the target liquid into the reaction vessel by the dispensing unit based on the light signal variation data and at least one of the suction pressure data and the discharge pressure data, comprises: when the imbibition pressure data is larger than the first imbibition pressure threshold value but smaller than the second imbibition pressure threshold value, the drainage pressure data is larger than the first drainage pressure threshold value but smaller than the second drainage pressure threshold value, and the optical signal change data is in a corresponding preset numerical range, determining that an abnormality exists in the process of dispensing the target liquid into the reaction container by the dispensing unit, wherein the abnormality is particularly blockage; Wherein the second pipetting pressure threshold is greater than the first pipetting pressure threshold and the second pipetting pressure threshold is greater than the first pipetting pressure threshold; when the imbibition pressure data is greater than the second imbibition pressure threshold or when the drain pressure data is greater than the second drain pressure threshold, it is determined that there is an abnormality in the process of dispensing the target liquid into the reaction vessel by the dispensing unit, and the abnormality is specifically a blockage.

Description

Sample analyzer and liquid dispensing abnormality recognition method Technical Field The embodiment of the application relates to the field of medical equipment, in particular to a sample analyzer and a liquid dispensing abnormality identification method. Background The sample analyzer is used for detecting and analyzing biological samples. In sample detection and analysis, a liquid suction needle in a sample analyzer is used for sucking samples and/or reagents and injecting the sucked samples and/or reagents into a reaction cup or a test tube, so that an analysis device of the sample analyzer detects and analyzes reaction liquid in the reaction cup or the test tube. When the liquid suction needle sucks liquid, abnormal liquid suction conditions such as needle blocking, air suction, foreign body suction and the like can possibly occur, the detection and alarm of the abnormal liquid suction conditions are very important, and the inaccurate sample detection result caused by abnormal liquid suction can be avoided. However, the existing detection means of the abnormal liquid absorption only judges whether the abnormal liquid absorption occurs based on a single factor, and cannot consider both the sensitivity and the specificity of the abnormal liquid absorption detection, for example, in order to ensure that false alarm is avoided, the specificity of the abnormal liquid absorption detection is ensured, but the sensitivity cannot be considered, and the abnormal liquid absorption cannot be identified in part of scenes. Disclosure of Invention The embodiment of the application provides a sample analyzer and a liquid dispensing abnormality identification method, which are used for comprehensively diagnosing whether liquid dispensing abnormality is caused by multiple factors in a combined way, and improving the sensitivity and the specificity of identifying the liquid dispensing abnormality. The first aspect of the embodiment of the application provides a sample analyzer, which comprises a dispensing unit, a pressure detection device, a photoelectric detection device and a processor; the dispensing unit is used for dispensing the target liquid into the reaction container; the pressure detection device is used for acquiring pressure data of the process of the dispensing unit dispensing the target liquid into the reaction container; The photoelectric detection device is used for emitting a light beam to the reaction container, collecting an emergent light signal of the light beam emitted from a mixed liquid containing the target liquid in the reaction container, and acquiring light signal change data based on the emergent light signal, wherein the light signal change data is used for representing the signal influence condition of the mixed liquid in the reaction container on the light beam; The processor is used for judging whether the process of dispensing the target liquid into the reaction container by the dispensing unit is abnormal according to the pressure data and the optical signal change data, and outputting a judging result. The second aspect of the embodiment of the application provides a liquid dispensing abnormality identification method, which is applied to a sample analyzer, wherein the sample analyzer comprises a dispensing unit, a pressure detection device and a photoelectric detection device; the method comprises the following steps: controlling the dispensing unit to dispense the target liquid into the reaction vessel; controlling the pressure detection device to acquire pressure data of the process of dispensing the target liquid into the reaction container by the dispensing unit; Controlling the photoelectric detection device to emit a light beam to the reaction container, collecting an emergent light signal of the light beam emitted from a mixed liquid containing the target liquid in the reaction container, and acquiring light signal change data based on the emergent light signal, wherein the light signal change data is used for representing the signal influence condition of the mixed liquid in the reaction container on the light beam; Judging whether the process of dispensing the target liquid into the reaction container by the dispensing unit is abnormal according to the pressure data and the optical signal change data, and outputting a judging result. From the above technical solutions, the embodiment of the present application has the following advantages: The sample analyzer can acquire pressure data of liquid dispensing and optical signal change data of liquid dispensed in the reaction container, the optical signal change data can represent the optical signal influence condition of the liquid in the reaction container on an incident light beam, so that multiple influence factors such as the pressure data and the optical signal change data can be synthesized to judge whether the liquid dispensing is abnormal or not, false alarm or incapability of identifying the dispensing abnormality caused