CN-122024932-A - Method and system for enhancing dissolution of active ingredients of traditional Chinese medicine based on nano bubble billow water

CN122024932ACN 122024932 ACN122024932 ACN 122024932ACN-122024932-A

Abstract

The invention provides a method and a system for enhancing dissolution of active ingredients of a traditional Chinese medicine based on nano bubble water. The method comprises the steps of preparing high-concentration nano bubble water, performing physical and chemical property sensing, constructing a standardized nano bubble water sample, dynamically simulating the contact process of the nano bubble water sample and a traditional Chinese medicine, constructing a multidimensional dissolution characteristic parameter, constructing a dissolution enhancement regulator, performing parameter coupling treatment on the multidimensional dissolution characteristic parameter, outputting the multidimensional dissolution characteristic parameter to obtain a dissolution enhancement weight matrix, constructing a multi-mechanism weighted dissolution objective function, respectively calculating to obtain multi-path fusion dissolution results under different preparation processes, predicting the dissolution efficiency of active ingredients, and optimizing and feedback controlling the traditional Chinese medicine extraction process according to the prediction result of the dissolution efficiency of the active ingredients. In this way, the invention can remarkably improve the dissolution efficiency and process controllability of the active ingredients of the traditional Chinese medicine.

Inventors

LI PAN
WANG RU
WANG LING
REN YUEHUA
HE CONG
CHENG KECHENG

Assignees

同济大学

Dates

Publication Date: 20260512
Application Date: 20260203

Claims (10)

1. A method for enhancing dissolution of active ingredients of a traditional Chinese medicine based on nano bubble water is characterized by comprising the following steps: Preparing high-concentration nano bubble water and performing physical and chemical property sensing to construct a standardized nano bubble water sample; Dynamically simulating the contact process of the nano bubble water sample and the traditional Chinese medicinal materials by adopting a multi-scale interface mass transfer modeling method, and constructing to obtain multi-dimensional dissolution characteristic parameters; Constructing a dissolution enhancement regulator, carrying out parameter coupling processing on the multidimensional dissolution characteristic parameters by adopting a multi-objective collaborative optimization network in the regulator, and outputting to obtain a dissolution enhancement weight matrix; constructing a multi-mechanism-based weighted dissolution objective function based on the dissolution enhancement weight matrix, respectively calculating to obtain multi-path fusion dissolution results under different preparation processes, and predicting the dissolution efficiency of the active ingredient according to the dissolution results; and optimizing and feedback controlling the traditional Chinese medicine extraction process according to the active ingredient dissolution efficiency prediction result.
2. The method for enhancing the dissolution of the active ingredients of the traditional Chinese medicine based on nano bubble water according to claim 1, wherein the process for preparing the high-concentration nano bubble water and performing physical and chemical property sensing and constructing the standardized nano bubble water sample is as follows: preparing nano bubble water by adopting any one of a pneumatic pressurizing, dissolving, decompressing and releasing method, a drop method or a rotary evaporation method; Synchronously collecting data of the particle size distribution, the bubble concentration, the Zeta potential and the dissolved oxygen content of the nano bubble water, and constructing a standardized nano bubble water sample according to the data, wherein the standardized nano bubble water sample comprises physical parameters and chemical activity indexes of bubbles.
3. The method for enhancing dissolution of active ingredients of a traditional Chinese medicine based on nanobubble water according to claim 1, wherein the process of dynamically simulating the contact process of the nanobubble water sample and the traditional Chinese medicine by adopting a multi-scale interface mass transfer modeling method is as follows: Modeling a micro-area flow field and a concentration gradient of the interface between the nano bubble water sample and the medicinal material, extracting key features, and performing dimensionless treatment to obtain a normalized interface mass transfer feature vector, wherein the key features comprise a surface tension change rate, a local free radical generation rate and a cell wall stress strain response feature; and constructing a multi-scale mass transfer coupling model based on a random differential equation, adopting the model to dynamically evolve and analyze the normalized interface mass transfer characteristic vector, and outputting a multi-dimensional dissolution characteristic parameter.
4. The method for enhancing dissolution of active ingredients of a traditional Chinese medicine based on nanobubble water according to claim 3, wherein the process of constructing a multi-scale mass transfer coupling model based on a random differential equation, dynamically evolving and analyzing the normalized interface mass transfer characteristic vector by adopting the model, and outputting multidimensional dissolution characteristic parameters is as follows: Acquiring a normalized interface mass transfer characteristic, and inputting the normalized interface mass transfer characteristic into a multi-scale mass transfer coupling model to obtain a model hidden state variable output matrix; Defining a target functional of a multi-scale mass transfer coupling model, taking the hidden state variable output matrix as the input of the target functional, and solving to obtain the optimal mass transfer path weight; and combining the hidden state variable output matrix and the optimal mass transfer path weight to construct and obtain the multidimensional dissolution characteristic parameters.
5. The method for enhancing the dissolution of the active ingredients of the traditional Chinese medicine based on nano bubble water according to claim 1, wherein the process of constructing a dissolution enhancement regulator, carrying out parameter coupling treatment on the multidimensional dissolution characteristic parameters by adopting a multi-objective collaborative optimization network in the regulator, and outputting to obtain a dissolution enhancement weight matrix is as follows: initializing a dissolution enhancement weight matrix based on the multi-dimensional dissolution characteristic parameters; Constructing a dissolution enhancement regulator by adopting a multi-target collaborative optimization network, and iteratively updating the initialized dissolution enhancement weight matrix by utilizing the regulator and a self-adaptive particle swarm algorithm to output a maximized multi-target comprehensive benefit function; and taking the dissolution enhancement weight matrix corresponding to the maximized multi-objective comprehensive benefit function as an output result.
6. The method for enhancing dissolution of active ingredients in nano bubble-based water according to claim 5, wherein the maximizing multi-objective comprehensive benefit function is specifically: ; Wherein Φ represents a multi-objective comprehensive benefit function, R i is the relative dissolution rate of the ith active ingredient, E i is the corresponding energy consumption or time cost, alpha i and beta i are the dissolution gain weight and the cost penalty coefficient respectively, and omega i is the ingredient importance weight.
7. The method for enhancing the dissolution of the active ingredients of the traditional Chinese medicine based on nano bubble water according to claim 1, wherein the process for constructing the dissolution enhancement weight matrix to obtain the dissolution objective function based on multi-mechanism weighting, respectively calculating to obtain the multi-path fusion dissolution results under different preparation processes, and predicting the dissolution efficiency of the active ingredients according to the dissolution results is as follows: constructing a weighted dissolution response matrix according to the dissolution enhancement weight matrix and the hidden state variable output matrix; constructing a dissolution objective function based on multi-mechanism weighting according to the weighted dissolution response matrix and the multi-objective comprehensive benefit function, and calculating according to the function to obtain a fusion dissolution response vector; Calculating to obtain the dissolution efficiency scores under each process path based on the weighted dissolution response matrix and the fusion dissolution response vector; and carrying out fusion analysis on the dissolution efficiency scores by adopting an entropy weight-fuzzy comprehensive evaluation method to obtain an optimal dissolution process recommendation result.
8. The method for enhancing dissolution of active ingredients of a nano bubble-based water according to claim 7, wherein the dissolution objective function based on multi-mechanism weighting is specifically: ; wherein K is the total number of process paths, lambda k is the mechanism contribution coefficient of the kth process, gamma is regularization parameter, B is fusion dissolution response vector, For the multi-mechanism weighted dissolution objective function value, W k is the dissolution enhancement weight matrix corresponding to the kth process, H k is the corresponding hidden state variable output matrix, Y k is the measured dissolution response vector, and then indicates the element-by-element product, Indicating the Frobenius norm.
9. The method for enhancing dissolution of active ingredients in nano bubble-based water according to claim 7, wherein the fusion analysis of the dissolution efficiency scores by adopting the entropy weight-fuzzy comprehensive evaluation method comprises the following steps of: Calculating the dissolution efficiency membership degree of berberine, geniposide and hesperidin under each process path respectively, and constructing a fuzzy evaluation matrix; calculating objective weights of the component indexes based on an information entropy theory, and forming a comprehensive weight vector by combining expert weights; performing synthesis operation on the fuzzy evaluation matrix and the comprehensive weight vector to obtain a comprehensive evaluation value of each process path; and selecting a process path with the highest comprehensive evaluation value as an optimal digestion process recommendation result.
10. The traditional Chinese medicine active ingredient dissolution enhancement system based on nano bubble water is used for realizing the method according to any one of claims 1-9, and is characterized by comprising a nano bubble water preparation and perception module (1), a multi-scale mass transfer modeling module (2), a dissolution enhancement regulation and control module (3), a multi-path fusion dissolution analysis module (4) and a process optimization feedback control module (5); The nanometer bubble water preparation and perception module (1) is used for preparing high-concentration nanometer bubble water and perceiving physical and chemical properties, and a standardized nanometer bubble water sample is obtained by construction; The multi-scale mass transfer modeling module (2) is used for dynamically simulating the contact process of the nano bubble water sample and the traditional Chinese medicinal materials by adopting a multi-scale interface mass transfer modeling method, so as to construct and obtain multi-dimensional dissolution characteristic parameters; the dissolution enhancement regulation and control module (3) is used for constructing a dissolution enhancement regulator, carrying out parameter coupling treatment on the multidimensional dissolution characteristic parameters by adopting a multi-objective collaborative optimization network in the regulator, and outputting to obtain a dissolution enhancement weight matrix; The multi-path fusion dissolution analysis module (4) is used for constructing a multi-mechanism weighted dissolution objective function based on a dissolution enhancement weight matrix, calculating multi-path fusion dissolution results under different preparation processes and predicting the dissolution efficiency of active ingredients; The process optimization feedback control module (5) is used for dynamically adjusting and performing closed-loop optimization on the traditional Chinese medicine extraction process parameters according to the prediction result of the multi-path fusion dissolution analysis module (4).

Description

Method and system for enhancing dissolution of active ingredients of traditional Chinese medicine based on nano bubble billow water Technical Field The invention relates to the technical field of traditional Chinese medicine extraction and preparation, in particular to a method and a system for enhancing the dissolution of traditional Chinese medicine active ingredients based on nano bubble water. Background Along with the continuous promotion of the modernization process of traditional Chinese medicines, the improvement of the dissolution efficiency of active ingredients in the traditional Chinese medicines has become a key technical bottleneck for improving the efficacy, guaranteeing the quality of the preparation and realizing green pharmacy. In the traditional Chinese medicine decoction process, "water in the form of water after physical treatment such as repeated pouring, lifting and the like is often adopted, so that the medicine extraction effect is enhanced. At present, partial researches are tried to introduce micro-nano bubble technology into the field of traditional Chinese medicine or natural product extraction, but the problem still exists in the field of traditional Chinese medicine extraction, namely, firstly, a high-stability nano bubble water standardization preparation method which is based on the traditional water-in-wave concept and can be controlled quantitatively is lacking, secondly, the system optimization and comparison research on the physical and chemical properties of bubbles under different generation technologies (such as a water fall method, a pressurized release method and a rotary evaporation method) is insufficient, and thirdly, the relationship between the physical and chemical properties of nano bubbles and the action mechanism between the physical and chemical properties of nano bubbles and the dissolution kinetics of active ingredients of the traditional Chinese medicine is not established. Therefore, a scientific, controllable and green method for enhancing the dissolution of active ingredients of traditional Chinese medicine is needed, which not only inherits the water wisdom of traditional Chinese medicine, but also can be combined with the modern nanotechnology, thereby realizing the technical progress from experience to standard and qualitative to quantitative. Disclosure of Invention The invention provides a method and a system for enhancing the dissolution of active ingredients of a traditional Chinese medicine based on nano bubble water, which solve the technical problems of low dissolution efficiency of active ingredients, uncontrollable process and lack of system integration of nano bubble physical and chemical action mechanisms in the traditional Chinese medicine extraction technology by constructing high-stability and high-concentration nano bubble water as a green extraction medium and combining a multi-mechanism synergistic dissolution regulation strategy. According to a first aspect of the present invention, there is provided a method for enhancing dissolution of active ingredients of a traditional Chinese medicine based on nanobubble water, comprising the steps of: Preparing high-concentration nano bubble water and performing physical and chemical property sensing to construct a standardized nano bubble water sample; Dynamically simulating the contact process of the nano bubble water sample and the traditional Chinese medicinal materials by adopting a multi-scale interface mass transfer modeling method, and constructing to obtain multi-dimensional dissolution characteristic parameters; Constructing a dissolution enhancement regulator, carrying out parameter coupling processing on the multidimensional dissolution characteristic parameters by adopting a multi-objective collaborative optimization network in the regulator, and outputting to obtain a dissolution enhancement weight matrix; constructing a multi-mechanism-based weighted dissolution objective function based on the dissolution enhancement weight matrix, respectively calculating to obtain multi-path fusion dissolution results under different preparation processes, and predicting the dissolution efficiency of the active ingredient according to the dissolution results; and optimizing and feedback controlling the traditional Chinese medicine extraction process according to the active ingredient dissolution efficiency prediction result. Preferably, the preparing high-concentration nano bubble water and performing physical and chemical property sensing, and constructing and obtaining a standardized nano bubble water sample comprises the following steps: preparing nano bubble water by adopting any one of a pneumatic pressurizing, dissolving, decompressing and releasing method, a drop method or a rotary evaporation method; Synchronously collecting data of the particle size distribution, the bubble concentration, the Zeta potential and the dissolved oxygen content of the nano bubble water, and constructing