CN-122025014-A - Clinical assessment method, device, medium and program product for hemodialysis catheter performance

CN122025014ACN 122025014 ACN122025014 ACN 122025014ACN-122025014-A

Abstract

The invention discloses a clinical evaluation method, equipment, medium and program product for hemodialysis catheter performance, which comprises the steps of carrying out geometric modeling on a hemodialysis catheter and an superior vena cava, carrying out high-precision grid division and blood flow simulation on geometric models of the hemodialysis catheter and the superior vena cava, carrying out boundary condition setting on each boundary of a fluid domain in the geometric models, carrying out vortex analysis and flow weight construction, carrying out integral on reflux particle proportion in a volume integral mode in a blood flow area around the whole catheter through particle tracking in the hemodialysis catheter, and carrying out recirculation rate calculation. The invention can improve the estimation accuracy of the recirculation rate of the hemodialysis catheter and meet the theoretical guidance of the performance optimization of the hemodialysis catheter.

Inventors

REN ZHEN
MA QINGBIAN
LI SHU
Ban Liren
CAO XIAOYING
GE HONGXIA
GAO MING
XU DINGHUA
ZHANG LIPING

Assignees

北京大学第三医院（北京大学第三临床医学院）

Dates

Publication Date: 20260512
Application Date: 20260130

Claims (10)

1. A method for clinical assessment of hemodialysis catheter performance, comprising: Geometrically modeling a hemodialysis catheter and an superior vena cava; performing high-precision grid division and blood flow simulation on the geometric models of the hemodialysis catheter and the superior vena cava; setting boundary conditions of each boundary of a fluid domain in the geometric model, and performing vortex analysis and flow weight construction; the recirculation rate is calculated by integrating the proportion of regurgitated particles in a volume-integrated manner throughout the region of blood flow around the hemodialysis catheter by particle tracking within the catheter.
2. The method for clinical assessment of hemodialysis catheter performance according to claim 1, wherein the geometrically modeling of the hemodialysis catheter and superior vena cava comprises: the construction of a geometric model of the hemodialysis catheter and the superior vena cava is completed by utilizing SolidWorks software and utilizing a parameterized modeling function, wherein the geometric model comprises key characteristics of a double-cavity design, a side hole, a distal end and a tip.
3. The method for clinical assessment of hemodialysis catheter performance according to claim 2, wherein the high-precision meshing and blood flow simulation of the geometric model of the hemodialysis catheter and superior vena cava comprises: Performing high-precision discrete division on a catheter model by adopting polyhedral grids, and implementing local grid encryption on a key flow area, wherein the key flow area comprises a side hole surface, a lumen inner wall and a tip area; boundary layer grids are arranged at the junction of the fluid and the solid so as to accurately simulate the flow velocity gradient and the shear stress distribution of the near-wall region and ensure the reliability of blood flow simulation.
4. The method for clinical assessment of hemodialysis catheter performance according to claim 3, wherein the high-precision meshing and blood flow simulation of the geometric model of the hemodialysis catheter and superior vena cava is performed, further comprising: and adopting a laminar flow model to carry out numerical solution on an incompressible Navier-Stokes equation set corresponding to the geometric model of the hemodialysis catheter and the superior vena cava so as to obtain blood flow velocity field distribution in a complete period.
5. The method of claim 4, wherein said boundary condition setting for each boundary of a fluid domain in a geometric model comprises: setting the superior vena cava inlet to follow the velocity inlet of the pulsatile waveform for simulating periodically varying blood flow input; setting the corresponding outlet as a pressure outlet with a fixed reference value to characterize the downstream flow environment; the blood material properties were set to incompressible newtonian fluids, and the density and kinetic viscosity were chosen to be typical values for blood.
6. The method for clinical assessment of hemodialysis catheter performance according to claim 5, the method is characterized in that the vortex analysis and flow weight construction are carried out, and the method comprises the following steps: Introducing a dynamic weighting function of vortex and pulsation characteristics, and performing hydrodynamic enhancement calculation on the recirculation rate of the hemodialysis catheter, wherein the hydrodynamic enhancement calculation comprises vortex intensity calculation, superposition vortex intensity calculation and flow weight calculation; the eddy current intensity calculation includes: the eddy current strength V i is defined as the modulus of the velocity field rotation According to the formula: A rotation component is calculated, wherein, The method is characterized in that the method is a rotation operator, u is a three-dimensional speed vector, u x ,u y ,u z respectively represents components of the speed in the directions of an orthogonal coordinate system x, y and z, and i, j and k are unit vectors in the coordinate directions; The superimposed vortex intensity calculation includes: The total vortex intensity V i,total is equal to the vortex intensity of the side hole area Intensity of eddy current with tip region And (3) summing; the flow weight calculation includes: According to the formula: The flow weight factor w is calculated, where Q max is the maximum flow, Q min is the minimum flow, and k 1 and k 2 weight coefficients.
7. The method for clinical assessment of hemodialysis catheter performance according to claim 6, wherein the performing a recirculation rate calculation comprises: According to the formula: The local reflux probability density is integrated by volume to obtain a recirculation rate RR, wherein N returned is the particle number returned to the arterial lumen, N returned is the released particle number, and V is the volume of the blood flow area.
8. A computer device, characterized in that the device comprises a memory and a processor, the memory being for storing a computer program, the processor executing the computer program to carry out the steps of the method according to any one of claims 1-7.
9. A computer-readable storage medium, on which a computer program is stored, which computer program, when being executed by a processor, carries out the steps of the method according to any one of claims 1-7.
10. A computer program product comprising a computer program, characterized in that the computer program, when being executed by a processor, realizes the steps of the method according to any one of claims 1-7.

Description

Clinical assessment method, device, medium and program product for hemodialysis catheter performance Technical Field The present invention relates to the technical field of clinical assessment of hemodialysis catheters, and more particularly to a clinical assessment method, apparatus, medium and program product for hemodialysis catheter performance. Background In the prior art, clinical evaluation of hemodialysis catheter recirculation rate mainly depends on detection of specific solute concentration in blood at the venous end of the catheter, and representative methods include urea nitrogen method, glucose injection test method, ultrasonic dilution method and the like. However, such concentration detection-based methods, whose measurement accuracy is susceptible to interference from the "solute bounce" phenomenon, result in widespread poor repeatability and accuracy of measurement results, and risk of systematically overestimating the recirculation rate. To overcome the limitations, some researches are turned to adopting numerical simulation technology based on computational fluid dynamics or combining in-vitro particle image velocimetry and other methods. Such techniques indirectly evaluate recirculation rates by constructing and analyzing flow field models within and around the catheter, which, while avoiding solute rebound problems to some extent, rely mostly on macroscopic flow balance or static particle release counts, such as by calculating the ratio of the number of particles captured by the arterial lumen to the total number of venous lumen releases, or by measuring dye concentration in the steady state flow field. Although the methods are visual, key local transient vortex structures and dynamics characteristics thereof in a flow field are generally ignored, and internal relations among tip jet flow, side hole outflow and local vortex strength cannot be established, so that the mechanism of a recirculation phenomenon induced by complex flow is insufficient, prediction accuracy is limited, and the catheter performance optimization lacks accurate theoretical guidance, so that the requirement of accurate medical treatment is difficult to meet. Therefore, how to accurately evaluate the performance of the hemodialysis catheter in clinic so as to meet the requirement of accurate medical treatment has important significance. Disclosure of Invention The invention provides a clinical evaluation method, equipment, medium and program product for hemodialysis catheter performance, which solve the problems that the existing clinical evaluation of hemodialysis catheter performance is insufficient in accuracy and difficult to meet the accurate medical requirements, can improve the estimation accuracy of the hemodialysis catheter recirculation rate and meet the theoretical guidance of hemodialysis catheter performance optimization. In order to achieve the above object, the present invention provides the following technical solutions: a method for clinical assessment of hemodialysis catheter performance, comprising: Geometrically modeling a hemodialysis catheter and an superior vena cava; performing high-precision grid division and blood flow simulation on the geometric models of the hemodialysis catheter and the superior vena cava; setting boundary conditions of each boundary of a fluid domain in the geometric model, and performing vortex analysis and flow weight construction; the recirculation rate is calculated by integrating the proportion of regurgitated particles in a volume-integrated manner throughout the region of blood flow around the hemodialysis catheter by particle tracking within the catheter. Preferably, the geometric modeling of the hemodialysis catheter and the superior vena cava includes: the construction of a geometric model of the hemodialysis catheter and the superior vena cava is completed by utilizing SolidWorks software and utilizing a parameterized modeling function, wherein the geometric model comprises key characteristics of a double-cavity design, a side hole, a distal end and a tip. Preferably, the high-precision mesh division and blood flow simulation are performed on the geometric model of the hemodialysis catheter and the superior vena cava, and the method comprises the following steps: Performing high-precision discrete division on a catheter model by adopting polyhedral grids, and implementing local grid encryption on a key flow area, wherein the key flow area comprises a side hole surface, a lumen inner wall and a tip area; boundary layer grids are arranged at the junction of the fluid and the solid so as to accurately simulate the flow velocity gradient and the shear stress distribution of the near-wall region and ensure the reliability of blood flow simulation. Preferably, the high-precision mesh division and blood flow simulation are performed on the geometric model of the hemodialysis catheter and the superior vena cava, and the method further comprises: and adopting a lamina