CN-122025015-A - Platelet damage assessment method, device, medium and program product for hemodialysis catheter

CN122025015ACN 122025015 ACN122025015 ACN 122025015ACN-122025015-A

Abstract

The invention discloses a platelet damage assessment method, equipment, medium and program product for a hemodialysis catheter, which comprise the steps of obtaining actual structural characteristics and clinical standard dimensions of the hemodialysis catheter, conducting geometric modeling on the hemodialysis catheter, conducting high-precision grid division and hemodynamic simulation on the geometric model of the hemodialysis catheter, setting boundary conditions of each fluid domain, establishing a damage assessment mechanism of coupling shear stress and vortex effect by introducing vortex as coupling characterization of local shear stress and vortex effect, conducting vortex intensity and shear stress calculation on a blood flow velocity field through the damage assessment mechanism, constructing a blood damage model of a coupling time accumulation effect, obtaining particle statistical data through particle tracking in the hemodialysis catheter, and conducting platelet damage calculation through the blood damage model. The invention can improve the accuracy of platelet damage estimation of hemodialysis catheters.

Inventors

Ban Liren
CAO XIAOYING
REN ZHEN
MA QINGBIAN
GE HONGXIA
LI SHU
GAO MING

Assignees

北京建筑大学
北京大学第三医院（北京大学第三临床医学院）

Dates

Publication Date: 20260512
Application Date: 20260130

Claims (10)

1. A method for platelet damage assessment of a hemodialysis catheter, comprising: Obtaining the actual structural characteristics and clinical standard size of the hemodialysis catheter, and performing geometric modeling on the hemodialysis catheter; Performing high-precision grid division and hemodynamic simulation on a geometric model of the hemodialysis catheter; setting boundary conditions of each fluid domain, and establishing a damage assessment mechanism of shear stress and vortex coupling by introducing the vortex as a coupling characterization of local shear stress and vortex effect; calculating the vortex intensity and the shearing stress of blood in the blood flow velocity field through the damage evaluation mechanism, and constructing a blood damage model of a coupling time accumulation effect; particle statistics are obtained through particle tracking in the hemodialysis catheter, and platelet damage calculation is performed through a blood damage model based on the particle statistics and local hemodynamic parameters.
2. The method for platelet damage assessment of a hemodialysis catheter according to claim 1, wherein the performing geometric modeling includes: The hemodialysis catheter is subjected to full-parametric three-dimensional geometric modeling through SolidWorks software, a catheter body comprising an arterial lumen, a venous lumen double-channel structure, a side hole array and a distal conical tip is completely constructed, and an upper vena cava blood vessel model is synchronously integrated.
3. The method for assessing platelet damage of a hemodialysis catheter according to claim 2, wherein said high-precision meshing and hemodynamic simulation of a geometric model of a hemodialysis catheter includes: the method comprises the steps of performing high-efficiency dispersion on a calculation domain by adopting polyhedral grid units, implementing local grid encryption on a key region with obvious flow gradient, and generating boundary layer grids with set layer numbers and thickness at a fluid-solid junction, wherein the key region comprises a side hole jet flow region, a lumen inner wall surface and a catheter tip.
4. The method for assessing platelet damage of a hemodialysis catheter according to claim 3, wherein said high-precision meshing and hemodynamic simulation of a geometric model of a hemodialysis catheter further comprises: And adopting a laminar flow model to carry out numerical solution on an incompressible Navier-Stokes equation set corresponding to the geometric model of the hemodialysis catheter so as to obtain blood flow velocity field distribution in a complete period.
5. The method for platelet damage assessment of a hemodialysis catheter according to claim 4, wherein the setting of boundary conditions of each fluid domain includes: setting the superior vena cava inlet to follow the velocity inlet of the pulsatile waveform for simulating periodically varying blood flow input; setting the corresponding outlet as a pressure outlet with a fixed reference value to characterize the downstream flow environment; the blood material property is set as incompressible Newtonian fluid, and the density and the dynamic viscosity are typical values of blood; And setting a fixed time step which is suitable for the flow rate period, and capturing the dynamic change of the flow field by adopting a transient solver.
6. The method of claim 5, wherein the establishing a shear stress and vorticity coupled lesion assessment mechanism comprises: Constructing a blood viscosity model, solving a functional relation describing the change of the blood viscosity along with the local shear rate, and calculating the local shear force born by the blood after the local shear rate of the whole flow field and the spatial distribution of the corresponding viscosity are obtained so as to evaluate the mechanical load born by blood cells and further quantify the damage degree of the blood cells; an eddy current intensity characterization system is constructed, and the contribution of the coupling rotation effect to the platelet deformation, the collision probability and the aggregation risk is utilized to reflect the real state of the platelet dynamic behavior in the turbulent blood flow environment.
7. The method for assessing platelet damage of a hemodialysis catheter according to claim 6, wherein said calculating platelet damage by a blood damage model comprises: According to the formula: Platelet damage calculation is performed, wherein N is the total number of evaluation intervals, a, b, c are empirical constants, Is that Flow weighting factor, τ, for time of day For local shear stress at time point t j , at j is the corresponding time step, Is a blood injury model.
8. A computer device, characterized in that the device comprises a memory and a processor, the memory being for storing a computer program, the processor executing the computer program to carry out the steps of the method according to any one of claims 1-7.
9. A computer-readable storage medium, on which a computer program is stored, which computer program, when being executed by a processor, carries out the steps of the method according to any one of claims 1-7.
10. A computer program product comprising a computer program, characterized in that the computer program, when being executed by a processor, realizes the steps of the method according to any one of claims 1-7.

Description

Platelet damage assessment method, device, medium and program product for hemodialysis catheter Technical Field The present invention relates to the technical field of hemodialysis platelet damage assessment, and more particularly to a platelet damage assessment method, apparatus, medium and program product for hemodialysis catheters. Background The platelet damage Index BDI (PLATELET DAMAGE Index) is a key Index for assessing the extent of platelet damage during hemodialysis. It reflects the extent to which platelets are damaged during dialysis and is an important parameter in measuring the effectiveness of dialysis. The higher BDI value indicates that the more severe the platelet damage, the more likely the patient's health will be adversely affected. The existing method for evaluating the platelet damage is mainly based on indirect deduction of working parameters and biochemical indexes of hemodialysis equipment, and BDI is calculated by relying on parameters such as blood flow rate, plasma concentration change and the like in the prior art, but has obvious defects that firstly, the existing BDI evaluation model is mostly based on a simplified mathematical model, the spatial distribution characteristic of blood flow and the specific influence of a local flow field on the platelet damage are ignored, so that the calculation accuracy is insufficient, secondly, the existing method is mostly in a static analysis mode, the dynamic change of the blood flow rate and components in the dialysis process cannot be effectively incorporated, so that the dynamic change of the blood flow rate and components in the dialysis process is difficult to adapt to individual differences and treatment condition fluctuation of patients in clinic, and in addition, the traditional evaluation means cannot be fully combined with key design parameters such as tip morphology and side hole flow rate distribution, so that the application of the traditional evaluation means in the aspects of catheter structure optimization and hemodialysis efficiency improvement is obviously limited. Meanwhile, the traditional BDI model is generally difficult to accurately represent the dynamic accumulation effect of the local shear rate under the complex blood flow configuration by adopting a global average or simple integral mode, so that deviation exists in blood damage risk assessment. Therefore, how to accurately evaluate the platelet damage of the hemodialysis catheter so as to meet the requirement of accurate medical treatment has important significance. Disclosure of Invention The invention provides a platelet damage assessment method, equipment, medium and program product for a hemodialysis catheter, which solve the problems that the accuracy is insufficient and the accurate medical requirements are difficult to meet in the platelet damage assessment of the existing hemodialysis catheter, can improve the accuracy of the platelet damage assessment of the hemodialysis catheter and meet the theoretical guidance of the performance optimization of the hemodialysis catheter. In order to achieve the above object, the present invention provides the following technical solutions: A method for platelet damage assessment of a hemodialysis catheter, comprising: Obtaining the actual structural characteristics and clinical standard size of the hemodialysis catheter, and performing geometric modeling on the hemodialysis catheter; Performing high-precision grid division and hemodynamic simulation on a geometric model of the hemodialysis catheter; setting boundary conditions of each fluid domain, and establishing a damage assessment mechanism of shear stress and vortex coupling by introducing the vortex as a coupling characterization of local shear stress and vortex effect; calculating the vortex intensity and the shearing stress of blood in the blood flow velocity field through the damage evaluation mechanism, and constructing a blood damage model of a coupling time accumulation effect; particle statistics are obtained through particle tracking in the hemodialysis catheter, and platelet damage calculation is performed through a blood damage model based on the particle statistics and local hemodynamic parameters. Preferably, the geometric modeling includes: The hemodialysis catheter is subjected to full-parametric three-dimensional geometric modeling through SolidWorks software, a catheter body comprising an arterial lumen, a venous lumen double-channel structure, a side hole array and a distal conical tip is completely constructed, and an upper vena cava blood vessel model is synchronously integrated. Preferably, the high-precision meshing and hemodynamic simulation are performed on the geometric model of the hemodialysis catheter, including: the method comprises the steps of performing high-efficiency dispersion on a calculation domain by adopting polyhedral grid units, implementing local grid encryption on a key region with obvious flow gradient, and generatin