Search

CN-122025503-A - Ion control device and mass spectrometer

CN122025503ACN 122025503 ACN122025503 ACN 122025503ACN-122025503-A

Abstract

The invention discloses an ion control device and a mass spectrometer, which belong to the technical field of mass spectrometers, wherein the ion control device is provided with a guide mode, a deflection mode and a pulse release mode, in the guide mode, the ion control device continuously transmits ions generated by an ion source to a first mass analyzer through a first electric field configuration, in the deflection mode, the ion control device firstly enriches the ions generated by the ion source through a second electric field configuration, then transmits the enriched ions to the second mass analyzer through a third electric field configuration, in the pulse release mode, the ion control device firstly enriches the ions generated by the ion source through a fourth electric field configuration, and then synchronously transmits the enriched ions to the first mass analyzer through a fifth electric field configuration. The ion control device can be used as a general ion router, and the transmission direction and the transmission mode of ions are changed through electrical control, so that high integration of multiple functions is realized, the instrument structure is remarkably simplified, and the cost is reduced.

Inventors

  • ZHU JIAYU
  • WU YA
  • CHEN GUANJUN

Assignees

  • 合肥引力波智谱科技有限公司

Dates

Publication Date
20260512
Application Date
20260415

Claims (11)

  1. 1. An ion manipulation device, wherein the ion manipulation device is adapted to be connected to an ion source (20), a first mass analyzer (30), a second mass analyzer (40), respectively, the ion manipulation device having a guide mode, a deflection mode, and a pulsed release mode; when the ion manipulation device is switched to the guiding mode, the ion manipulation device continuously transmits ions generated by the ion source (20) to the first mass analyzer (30) through a first electric field configuration; When the ion manipulation device switches to the deflection mode, the ion manipulation device first enriches ions generated by the ion source (20) through a second electric field configuration and then transmits the enriched ions to the second mass analyzer (40) through a third electric field configuration; when the ion manipulation device is switched to a pulse release mode, the ion manipulation device firstly enriches ions generated by the ion source (20) through a fourth electric field configuration, and then synchronously transmits the enriched ions to the first mass analyzer (30) through a fifth electric field configuration.
  2. 2. The ion manipulation device according to claim 1, wherein the first mass analyzer (30) is a fourier transform mass spectrometry cell and the second mass analyzer (40) is a time-of-flight analyzer.
  3. 3. The ion manipulation device of claim 1, wherein the ion manipulation device comprises: The control assembly (1), the control assembly (1) comprises a first lens (11), a first multistage rod (12) and a second lens (13), the first lens (11) is arranged between the ion source (20) and the first multistage rod (12), the second lens (13) is arranged between the first multistage rod (12) and the first mass analyzer (30), and the first multistage rod (12) is provided with a slit facing the second mass analyzer (40); A pulse discharging component (2), wherein the pulse discharging component (2) is arranged between the second lens (13) and the first mass analyzer (30), the pulse discharging component (2) comprises a second multistage rod (21), an accelerating electrode (22) and a third lens (23), the third lens (23) is arranged between the second multistage rod (21) and the first mass analyzer (30), and the accelerating electrode (22) is sleeved outside the second multistage rod (21); The first electric field configuration comprises that the voltages of the first lens (11), the second lens (13) and the third lens (23) are sequentially reduced, the accelerating electrode (22) is not powered, and the first multistage lever (12) and the second multistage lever (21) are in an RF-only guiding mode; The second electric field configuration comprises that the voltages of the first lens (11) and the second lens (13) are equal, the voltage of the third lens (23) is larger than the voltage of the second lens (13), the accelerating electrode (22) is not powered, and the first multi-stage rod (12) and the second multi-stage rod (21) are in an RF-only guiding mode; the third electric field configuration comprises increasing a DC voltage of the first multistage lever (12) away from the slit side stage lever on the basis of the second electric field configuration; The fourth electric field configuration comprises that the voltage of the second lens (13) is smaller than the voltage of the first lens (11) and the voltage of the third lens (23), the accelerating electrode (22) is not powered, the first multi-stage rod (12) and the second multi-stage rod (21) are in an RF-only guiding mode; the fifth electric field configuration comprises increasing the DC voltage of the accelerating electrode (22) on the basis of the fourth electric field configuration.
  4. 4. An ion manipulation device according to claim 3, wherein the accelerating electrode (22) is sleeved on one side of the second multistage lever (21) close to the second lens (13), and the accelerating electrode (22) forms a driving electric field with decreasing electric potential from the enriched ions to the third lens (23) when the fifth electric field is configured.
  5. 5. The ion manipulation device according to claim 4, wherein the inner diameter of the accelerating electrode (22) gradually increases in a direction from the second lens (13) to the third lens (23).
  6. 6. An ion manipulation device according to claim 3, wherein the manipulation assembly (1) further comprises an enrichment electrode (14), the enrichment electrode (14) being mounted to the first multistage lever (12) and corresponding to the position of the slit; the second electric field configuration further comprises that the voltage of the enriching electrode (14) is smaller than the voltage of the first lens (11).
  7. 7. The ion manipulation device according to claim 6, wherein the enrichment electrode (14) corresponds to a central position in the slit length direction.
  8. 8. The ion manipulation device according to any one of claims 3-7, further comprising a prefocusing assembly (3), the prefocusing assembly (3) being arranged between the ion source (20) and the manipulation assembly (1), the prefocusing assembly (3) comprising a fourth lens (31) and a third multistage rod (32), the third multistage rod (32) being arranged between the fourth lens (31) and the first lens (11); the first electric field configuration further comprises that the voltage of the fourth lens (31) is larger than the voltage of the first lens (11); the second and third electric field configurations further comprise that the voltage of the fourth lens (31) is equal to the voltage of the third lens (23); The fourth and fifth electric field configurations further comprise that the voltage of the fourth lens (31) is larger than the voltage of the first lens (11).
  9. 9. The ion manipulation device according to claim 8, further comprising a radial lens assembly (4), the radial lens assembly (4) being disposed between the slit and the second mass analyzer (40), the radial lens assembly (4) comprising at least two fifth lenses (41) with staggered die holes.
  10. 10. The ion manipulation device according to claim 9, further comprising a housing (5), wherein the housing (5) has a mounting cavity (51) and an inflation port (52) in communication, wherein the prefocusing assembly (3), the manipulation assembly (1), the pulse ejection assembly (2) and the radial lens assembly (4) are all disposed within the mounting cavity (51), and wherein the inflation port (52) is configured to inflate the mounting cavity (51) with a buffer gas.
  11. 11. A mass spectrometer comprising an ion source (20), a first mass analyser (30), a second mass analyser (40) and an ion manipulation device according to any one of claims 1 to 10, said ion manipulation device being connected to the ion source (20), the first mass analyser (30), the second mass analyser (40), respectively.

Description

Ion control device and mass spectrometer Technical Field The invention relates to the technical field of mass spectrometers, in particular to an ion control device and a mass spectrometer. Background In mass spectrometry, an ion guide device is used for efficiently transmitting ions from a front stage area to a rear stage mass analyzer, and a common ion guide device such as a linear quadrupole rod can realize radial focusing and axial transmission, has a simple structure, has a single function height and can only complete a linear transmission task. While complex ion traps (such as 3D ion traps or linear ion traps) have ion three-dimensional storage and selective excitation capabilities, their closed ring-shaped or end cap electrode structures essentially limit the path direction of ions in and out, and it is difficult to flexibly change the ion transmission path, and application flexibility and efficiency are obviously limited. Therefore, there is a need for an ion guide device that is compact in structure, versatile in function, and flexible in manipulation to meet the requirements for dynamic regulation of ion paths in complex mass spectrometry. Disclosure of Invention The present invention aims to solve, at least to some extent, one of the above technical problems in the prior art. Therefore, the invention provides the ion control device which can realize high integration of multiple functions, remarkably simplify the structure of the instrument and reduce the cost. The invention also provides a mass spectrometer with the ion control device. According to the ion control device, the ion control device is respectively suitable for being connected with an ion source, a first mass analyzer and a second mass analyzer, the ion control device is provided with a guide mode, a deflection mode and a pulse release mode, ions generated by the ion source are continuously transmitted to the first mass analyzer through a first electric field configuration when the ion control device is switched to the guide mode, the ions generated by the ion source are firstly enriched through a second electric field configuration when the ion control device is switched to the deflection mode, then the enriched ions are transmitted to the second mass analyzer through a third electric field configuration, and the ions generated by the ion source are firstly enriched through a fourth electric field configuration and then the enriched ions are synchronously transmitted to the first mass analyzer through a fifth electric field configuration when the ion control device is switched to the pulse release mode. According to the ion control device provided by the embodiment of the invention, the ion control device can be used as a general ion router, the transmission direction and the transmission mode of ions are changed through electrical control, the guide mode can realize high-efficiency and low-loss straight-through transmission of ions, the deflection mode can realize deflection and extraction of ions, the pulse release mode can improve the utilization rate and sensitivity of high-resolution mass spectrum ions, the ion control device can realize high integration of multiple functions, the instrument structure is remarkably simplified, and the cost is reduced. According to some embodiments of the invention, the first mass analyzer is a fourier transform mass spectrometry cell and the second mass analyzer is a time-of-flight analyzer. According to some embodiments of the invention, the ion manipulation device comprises a manipulation assembly, a first lens, a second lens and a first mass analyzer, wherein the manipulation assembly comprises a first lens, a first multistage rod and a second lens, the first lens is arranged between the ion source and the first multistage rod, the second lens is arranged between the first multistage rod and the first mass analyzer, and the first multistage rod is provided with a slit facing the second mass analyzer; the pulse discharging assembly is arranged between the second lens and the first mass analyzer, the pulse discharging assembly comprises a second multistage rod, an accelerating electrode and a third lens, the third lens is arranged between the second multistage rod and the first mass analyzer, the accelerating electrode is sleeved outside the second multistage rod, the first electric field configuration comprises that the voltages of the first lens, the second lens and the third lens are sequentially reduced, the accelerating electrode is not electrified, the first multistage rod and the second multistage rod are in an RF-only guiding mode, the second electric field configuration comprises that the voltages of the first lens and the second lens are equal, the voltage of the third lens is larger than the voltage of the second lens, the accelerating electrode is not electrified, the first multistage rod and the second multistage rod are in an RF-only guiding mode, the third electric field configura