CN-122028806-A - Growth promoter for butyric acid bacteria, and production enhancer for butyric acid or lactic acid

Abstract

The present invention relates to a growth promoter for butyric acid bacteria, which contains concentrated soy sauce or soy sauce-like seasoning liquid, or ethanol precipitate thereof. In addition, the present invention relates to an enhancer for the production of butyric acid or lactic acid, which contains a concentrated soy sauce or soy sauce-like seasoning liquid, or an ethanol precipitate thereof.

Inventors

• Lin Huanaizi
• SAITO YASUYUKI

Assignees

• 龟甲万株式会社
• 国立大学法人千叶大学

Dates

Publication Date

20260512

Application Date

20241015

Priority Date

20231013

Claims (10)

1. 1. A growth promoter for butyric acid bacteria, which contains concentrated soy sauce or soy sauce-like seasoning liquid, or ethanol precipitate thereof.
2. 2. The growth promoter of butyric acid bacteria according to claim 1, which comprises polysaccharides derived from concentrated soy sauce or soy sauce-like seasoning liquid.
3. 3. A food composition comprising the growth promoter of butyric acid bacteria according to claim 1 or 2.
4. 4. A food composition for promoting the growth of butyric acid bacteria, comprising a concentrated soy sauce or soy sauce-like flavor liquid, or an ethanol precipitate thereof.
5. 5. A method for promoting the growth of butyric acid bacteria, which uses concentrated soy sauce or soy sauce-like seasoning liquid, or ethanol precipitate thereof.
6. 6. An enhancer for the production amount of butyric acid or lactic acid, which contains a concentrated soy sauce or soy sauce-like seasoning liquid, or an ethanol precipitate thereof.
7. 7. The production-amount-of-butyric acid or lactic acid enhancer according to claim 6, which contains polysaccharides derived from a concentrated soy sauce or soy sauce-like seasoning liquid.
8. 8. A food composition comprising the butyric or lactic acid production enhancer according to claim 6 or 7.
9. 9. A food composition for enhancing the production of butyric acid or lactic acid, comprising a concentrated soy sauce or soy sauce-like seasoning liquid, or an ethanol precipitate thereof.
10. 10. A method for enhancing the production of butyric acid or lactic acid, which uses concentrated soy sauce or soy sauce-like seasoning liquid, or ethanol precipitate thereof.

Description

Growth promoter for butyric acid bacteria, and production enhancer for butyric acid or lactic acid Technical Field The present invention relates to a growth promoter for butyric acid bacteria. The present invention also relates to an enhancer for the production of butyric acid or lactic acid. Background Short chain fatty acids such as butyric acid, acetic acid, propionic acid are known to bring about various effects to the intestines. For example, non-patent document 1 discloses the effects of maintaining the barrier function of the intestine, inhibiting the proliferation of pathogenic bacteria by lowering the pH value in the intestine, having an anti-inflammatory effect, having an immunoregulatory function, and having an effect of inhibiting obesity by improving insulin sensitivity or improving the maintenance of satiety, and the like. Among the effects of short chain fatty acids on the intestines, it is important to maintain the barrier function of the intestines. The intestines have a function of absorbing moisture and nutrients, which are substances necessary for the living body, and a function of appropriately removing unwanted substances such as harmful substances and pathogenic cells, and play an important role as a barrier for restricting invasion of foreign substances. If the barrier function of the intestine is disrupted and the intestine is damaged, foreign substances invade the mucous membrane to cause excessive immune reaction, and inflammation is caused, and further, foreign substances enter the blood stream to cause systemic inflammatory conditions. Non-patent document 2 discloses that an intestine in which an opening is formed in the intestine and leaks into blood is called an intestinal leak (leak gun), and intestinal leak is regarded as a problem that causes chronic inflammation. Thus, intestinal barrier function is an essential function for animals to maintain health. Here, non-patent document 1 and non-patent document 2 disclose that, among short chain fatty acids, in particular, butyric acid can enhance tight junctions (tight junction), and mucin and antimicrobial peptides are produced, thereby improving intestinal barrier function. Therefore, butyric acid is expected to limit passage of microorganisms and foreign substances through the mucosa lamina propria, and prevent intestinal leakage. Further, non-patent document 3 discloses that butyric acid is necessary for differentiation of regulatory T cells (Treg) having an effect of suppressing allergic and Inflammatory Bowel Disease (IBD), and non-patent document 4 discloses that when butyric acid is metabolized by intestinal epithelial cells, oxygen consumption in the intestine increases. Thus, in addition to suppressing IBD and improving the barrier function of the intestine, butyric acid is expected to have an effect of maintaining the immune response in the intestine, increasing beneficial bacteria typified by bifidobacteria by maintaining the intestine in an anaerobic state, and improving the intestinal flora. In summary, butyric acid plays various important roles in the intestines, typified by strengthening the barrier function of the intestines. Here, butyric acid can be produced by assimilation of dietary fiber by intestinal bacteria, or assimilation of fructose, fructooligosaccharide, or inulin by butyric acid bacteria such as eubacterium rectum (Eubacterium rectale) (now referred to as Agathobacter rectalis) (see non-patent document 5). Also, since Agathobacter rectalis among the butyric acid bacteria is colonized in a mucus layer covering the intestinal epithelium, butyric acid can be produced in the vicinity of the intestinal epithelial cells, and physiological actions such as strengthening of the intestinal barrier function by butyric acid can be efficiently exerted (see non-patent document 6). In addition, a decrease in microbiota including Agathobacter rectalis was confirmed in IBD patients, suggesting that Agathobacter rectalis is involved in IBD inhibition (see non-patent document 7). Patent document 1 discloses a butyric acid bacteria growth promoter for effectively increasing butyric acid bacteria and butyric acid bacteria in the intestines, and an intestinal butyric acid increasing agent comprising 1-kestose, which is one of oligosaccharides, as an active ingredient. Prior art literature Patent literature Patent document 1 International publication No. 2017/159543 Non-patent literature Non-patent document 1 Riviere et al ,Bifidobacteria and Butyrate-Producing Colon Bacteria： Importance and Strategies for Their Stimulation in the Human Gut. Frontiers in Microbiology. 2016, 7, Article 979. Non-patent document 2, small Lin Xingfu, shallow see, effect of yogurt on intestinal barrier function, jpn.j. Food microbiol 2019, 36 (1), 32-35. Non-patent document 3 Furusawa et al ,Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013, 504, 446-450. Non-patent document 4 Belleville