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CN-122028845-A - Chemical information in health index

CN122028845ACN 122028845 ACN122028845 ACN 122028845ACN-122028845-A

Abstract

Systems and methods for determining or adjusting a health index of a patient are disclosed, including receiving physiological information of the patient, receiving chemical information of the patient, determining a composite health index of the patient as a weighted function of one or more physiological characteristics of the received physiological information and one or more chemical characteristics of the received chemical information, and generating a composite health index alert as a function of the determined composite health index and an alert threshold.

Inventors

  • Victoria A. Averina
  • LI YINGBO
  • MICHAEL J. KANE
  • Pramodesinger Hirasinger Takur

Assignees

  • 心脏起搏器股份公司

Dates

Publication Date
20260512
Application Date
20241125
Priority Date
20231129

Claims (15)

  1. 1. A medical device system, comprising: A signal receiver circuit configured to receive: physiological information of the patient, and Chemical information of the patient, and An evaluation circuit configured to: Determining the overall health index of the patient as a weighted function of one or more physiological characteristics of the received physiological information and one or more chemical characteristics of the received chemical information, and A composite health index alert is generated as a function of the determined composite health index and the alert threshold.
  2. 2. The medical device system of claim 1, wherein the evaluation circuit is configured to determine the patient's overall health index as a function of at least two characteristics of the received physiological information and one or more characteristics of the received chemical information.
  3. 3. The medical device system of any of claims 1-2, wherein the one or more chemical characteristics include one or more indications of relatively high or relatively low values of the received chemical information relative to one or more chemical characteristic thresholds.
  4. 4. The medical device system of claim 3, wherein the evaluation circuit is configured to: determining the one or more chemical characteristic thresholds as a function of the chemical information received during the first time period, and A comparison of the value of the received chemical information with the determined one or more chemical characteristic thresholds is used to determine an indication of a relatively high value or a relatively low value of the received chemical information.
  5. 5. The medical device system of any one of claims 1-4, wherein the evaluation circuit is configured to determine the weight of the one or more chemical features as a function of the value of the one or more chemical features.
  6. 6. The medical device system of claim 5, wherein the evaluation circuit is configured to determine, independent of the one or more physiological characteristics, a value of the integrated health index that exceeds a value of the alarm threshold for a first range of values of the one or more chemical characteristics.
  7. 7. The medical device system of any one of claims 1-6, wherein the evaluation circuit is configured to determine the alarm threshold as a function of the received chemical information.
  8. 8. The medical device system of claim 7, wherein the evaluation circuit is configured to determine the alarm threshold to increase a sensitivity of the integrated health index alarm to a second range of values of the one or more chemical features.
  9. 9. The medical device system of any one of claims 1-8, wherein the evaluation circuit is configured to determine the one or more physiological characteristics or the one or more chemical characteristics of the weighted function of the integrated health index as a function of one or more values of the one or more chemical characteristics.
  10. 10. The medical device system of claim 9, wherein the evaluation circuit is configured to increase a feature quantity of the one or more physiological features or the one or more chemical features of the weighting function for a third range of values of the one or more chemical features.
  11. 11. The medical device system of any one of claims 1-10, wherein the integrated health index comprises an integrated heart failure index and the integrated health index alarm threshold comprises an integrated heart failure alarm threshold, Wherein at least one of the one or more chemical characteristics or the chemical information comprises at least one of potassium information or creatinine information of the patient, and Wherein the evaluation circuit is configured to provide the output of the generated integrated health index alert to a user interface for display to a user or to a control circuit to control or adjust a process or function of the medical device system.
  12. 12. A method, comprising: Receiving using a signal receiver circuit: physiological information of the patient, and Chemical information of the patient; Determining, using an evaluation circuit, an integrated health index of the patient as a weighted function of one or more physiological characteristics of the received physiological information and one or more chemical characteristics of the received chemical information, and A composite health index alert is generated as a function of the determined composite health index and an alert threshold using the evaluation circuit.
  13. 13. The method of claim 12, wherein the one or more chemical characteristics include one or more indications of relatively high or relatively low values of the received chemical information relative to one or more chemical characteristic thresholds, Wherein the method comprises using the evaluation circuit: Determining one or more chemical characteristic thresholds as a function of the chemical information received during the first time period, and The indication of the relatively high or low value of the received chemical information is determined by comparing the value of the received chemical information to the determined one or more chemical characteristic thresholds.
  14. 14. The method of claim 13, comprising determining weights of the one or more chemical features as a function of values of the one or more chemical features using the evaluation circuit, and Using the evaluation circuit, a value of the integrated health index that exceeds a value of the alarm threshold for a first range of values of the one or more chemical features is determined independent of the one or more physiological features.
  15. 15. The method of claim 12, comprising determining, using the evaluation circuit, the alarm threshold as a function of the received chemical information, comprising determining the alarm threshold to increase sensitivity of the integrated health index alarm to a second range of values of the one or more chemical features.

Description

Chemical information in health index Priority claim The present application claims the benefit of U.S. provisional application No. 63/604,098, filed on 11/29, 2023, which is incorporated herein by reference in its entirety. Technical Field This document relates generally to medical devices and, more particularly, to determining a health index including chemical information. Background Ambulatory medical devices (Ambulatory MEDICAL DEVICE, AMD), including implantable, subcutaneous, wearable, or one or more other medical devices, etc., can monitor, detect, or treat a variety of diseases, including Heart Failure (HF), atrial fibrillation (atrial fibrillation, AF), etc. The ambulatory medical device may include a sensor for sensing physiological information from the patient, and one or more circuits for detecting one or more physiological events using the sensed physiological information, or transmitting the sensed physiological information or the detected physiological events to one or more remote devices. Frequent patient monitoring may provide early detection of worsening patient conditions, including worsening heart failure or atrial fibrillation. Accurate identification of patients or patient groups at high risk of future adverse events may control mode or feature selection or resource management of one or more ambulatory medical devices, control notifications or messages in the connected system to various users associated with a particular patient or patient group, organize or schedule doctor or patient contact or treatment, or prevent or reduce patient hospitalization. The risk of worsening patient condition is accurately identified and safely managed to avoid unnecessary medical intervention, extend the life of ambulatory medical devices, and reduce medical costs. Disclosure of Invention Systems and methods are disclosed for determining or adjusting a health index of a patient, including receiving physiological information of the patient, receiving chemical information of the patient, determining a composite health index of the patient as a weighted function of one or more physiological characteristics of the received physiological information and one or more chemical characteristics of the received chemical information, and generating a composite health index alert as a function of the determined composite health index and an alert threshold. In some examples, the chemical information may include one or more of potassium information or creatinine information. Examples of the subject matter (e.g., a medical device system) may include a signal receiver circuit configured to receive physiological information of a patient and chemical information of the patient, and an evaluation circuit configured to determine a composite health index of the patient as a weighted function of one or more physiological characteristics of the received physiological information and one or more chemical characteristics of the received chemical information, and generate a composite health index alert as a function of the determined composite health index and an alert threshold. In one example, the evaluation circuit is configured to determine the overall health index of the patient as a function of at least two characteristics of the received physiological information and one or more characteristics of the received chemical information. In examples that may be combined with any one or more of the preceding examples, the one or more chemical characteristics include one or more indications of relatively high or relatively low values of the received chemical information relative to one or more chemical characteristic thresholds. In examples that may be combined with any one or more of the preceding examples, the evaluation circuit is configured to determine the one or more chemical characteristic thresholds as a function of the chemical information received within the first time period and to determine an indication of a relatively high value or a relatively low value of the received chemical information using a comparison of the value of the received chemical information with the determined one or more chemical characteristic thresholds. In examples that may be combined with any one or more of the preceding examples, the evaluation circuit is configured to determine the weight of the one or more chemical features as a function of the value of the one or more chemical features. In examples that may be combined with any one or more of the preceding examples, the evaluation circuit is configured to determine, independent of the one or more physiological characteristics, a value of the integrated health index that exceeds a value of the alarm threshold for the first range of values of the one or more chemical characteristics. In examples that may be combined with any one or more of the preceding examples, the evaluation circuit is configured to determine the alarm threshold as a function of the received chemical information. In examp