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CN-122028918-A - TRIM7 inhibitors and uses thereof

CN122028918ACN 122028918 ACN122028918 ACN 122028918ACN-122028918-A

Abstract

The present disclosure relates to compositions and methods useful for treating diseases, including Trim7 inhibitors, such as therapies for cancers including cancers resistant to checkpoints agents, infectious diseases, and inflammatory diseases.

Inventors

  • T. SCHREIBER
  • G. Fromm
  • T-A.Ruan
  • J. MEDINA
  • A. MENDOZA
  • J. Situ

Assignees

  • 沙塔克实验室有限公司

Dates

Publication Date
20260512
Application Date
20240818
Priority Date
20230818

Claims (20)

  1. 1. A compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I) Wherein in formula (I): A is selected from 、 、 、 、 、 And ; L is a linking group; R 1a 、R 1b 、R 2 、R 3 、R 4a 、R 4b 、R 5a 、R 5b 、R 5c 、R 5d 、R 5e 、R 6a 、R 6b 、R 6c 、R 6d 、R 6e 、R 7a 、R 7b 、R 7c 、R 7d 、R 8 、R 9 、R 10 、R 11a 、R 11b And R 11c are each independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilyl 、-OR a 、-SR a 、-OC(O)-R a 、-SC(O)-R a 、-N(R a ) 2 、-C(O)R a 、-C(O)OR a 、-C(O)SR a 、-OC(O)N(R a ) 2 、-C(O)N(R a ) 2 、-N(R a )C(O)OR a 、-N(R a )C(O)R a 、-N(R a )C(O)N(R a ) 2 、-N(R a )C(NR a )N(R a ) 2 、-N(R a )S(O) t R a 、-S(O) t R a 、-S(O) t OR a 、-S(O) t N(R a ) 2 , and PO 3 (R a ) 2 ; R 12 is H or unsubstituted alkyl; R a is independently at each occurrence selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heteroarylalkyl; n 1 is an integer from 0 to 5; t is 1 or 2; provided that the compound of formula (I) is not a compound of any one of formulas 1001, 1003, 1004 and 1006-1009: 。
  2. 2. The compound of claim 1, wherein R 1a 、R 1b 、R 2 、R 3 、R 4a 、R 4b 、R 5a 、R 5b 、R 5c 、R 5d 、R 5e 、R 6a 、R 6b 、R 6c 、R 6d 、R 6e 、R 7a 、R 7b 、R 7c 、R 7d 、R 8 、R 9 、 R 10 、R 11a 、R 11b and R 11c are each independently selected from hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl optionally substituted with halo, unsubstituted or substituted alkyl and/or unsubstituted or substituted heterocyclyl, unsubstituted or substituted aralkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, halo, -C (O) R a 、-C(O)N(R a ) 2 、-N(R a ) 2 、-N(R a )C(O)R a , and-S (O) t R a .
  3. 3. The compound of claim 1 or 2, wherein L is a bond or comprises one or more linking groups selected from unsubstituted or substituted-C 1 - 10 alkyl-, -O-C 1 - 10 alkyl-, -C 1 - 10 alkenyl-, -O-C 1 - 10 alkenyl-, -C 1 - 10 cycloalkenyl-, -O-C 1 - 10 cycloalkenyl-, -C 1 - 10 alkynyl-, -O-C 1 - 10 alkynyl-, -C 1 - 10 aryl-, -O-C 1 - 10 -, -aryl-, -cycloalkyl-, -heterocyclyl -、-O-、-S-、-S-S-、-S(O) w -、-C(O)-、-C(O)O-、-OC(O)-、-C(O)S-、-SC(O)-、-OC(O)O-、-N(R b )-、-C(O)N(R b )-、-N(R b )C(O)-、-OC(O)N(R b )-、-N(R b )C(O)O-、-SC(O)N(R b )-、-N(R b )C(O)S-、-N(R b )C(O)N(R b )-、-N(R b )C(NR b )N(R b )-、-N(R b )S(O) w -、-S(O) w N(R b )-、-S(O) w O-、-OS(O) w -、-OS(O) w O-、-O(O)P(OR b )O-、(O)P(O-) 3 、-O(S)P(OR b )O-, and (S) P (O-) 3 , wherein w is 1 or 2, and R b is independently hydrogen, optionally substituted alkyl, or optionally substituted aryl, optionally L is a bond and/or-C (O) -and/or-C (H) (CH 2 ) p C(O)NH 2 and/or Wherein p is an integer from 1 to 5, optionally p is 2, optionally L is Wherein the alkyl is substituted or unsubstituted Or (b) 。
  4. 4. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (10): (10) Wherein in formula (10): R 9a 、R 9b 、R 9c 、R 9d and R 9e are each independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilyl 、-OR a 、-SR a 、-OC(O)-R a 、-SC(O)-R a 、-N(R a ) 2 、-C(O)R a 、-C(O)OR a 、-C(O)SR a 、-OC(O)N(R a ) 2 、-C(O)N(R a ) 2 、-N(R a )C(O)OR a 、-N(R a )C(O)R a 、-N(R a )C(O)N(R a ) 2 、-N(R a )C(NR a )N(R a ) 2 、-N(R a )S(O) t R a 、-S(O) t R a 、-S(O) t OR a 、-S(O) t N(R a ) 2 , and PO 3 (R a ) 2 ; R a is independently at each occurrence selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heteroarylalkyl; n 2 is an integer from 0 to 5, and T is 1 or 2.
  5. 5. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (20) or (21): Wherein in formulae (20) and (21): n 3 is an integer from 0 to 5.
  6. 6. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (30) or (31): Wherein in formulas (30) and (31): p is an integer from 0 to 5.
  7. 7. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (32): (32) Wherein in formula (32): q is an integer from 1 to 3.
  8. 8. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (40): (40) Wherein in formula (40): n 4 is an integer from 0 to 5.
  9. 9. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (50): (50) Wherein in formula (50): R 10a 、R 10b 、R 10c 、R 10d and R 10e are each independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilyl 、-OR a 、-SR a 、-OC(O)-R a 、-SC(O)-R a 、-N(R a ) 2 、-C(O)R a 、-C(O)OR a 、-C(O)SR a 、-OC(O)N(R a ) 2 、-C(O)N(R a ) 2 、-N(R a )C(O)OR a 、-N(R a )C(O)R a 、-N(R a )C(O)N(R a ) 2 、-N(R a )C(NR a )N(R a ) 2 、-N(R a )S(O) t R a 、-S(O) t R a 、-S(O) t OR a 、-S(O) t N(R a ) 2 , and PO 3 (R a ) 2 ; R a is independently at each occurrence selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heteroarylalkyl; n 5 is an integer from 0 to 5, and T is 1 or 2.
  10. 10. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (60): (60) Wherein in formula (60): n 6 is an integer from 0 to 5.
  11. 11. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (70): (70) Wherein in formula (70): R 11a and R 11b are each independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilyl 、-OR a 、-SR a 、-OC(O)-R a 、-SC(O)-R a 、-N(R a ) 2 、-C(O)R a 、-C(O)OR a 、-C(O)SR a 、-OC(O)N(R a ) 2 、-C(O)N(R a ) 2 、-N(R a )C(O)OR a 、-N(R a )C(O)R a 、-N(R a )C(O)N(R a ) 2 、-N(R a )C(NR a )N(R a ) 2 、-N(R a )S(O) t R a 、-S(O) t R a 、-S(O) t OR a 、-S(O) t N(R a ) 2 , and PO 3 (R a ) 2 , and R a is independently at each occurrence selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heteroarylalkyl.
  12. 12. The compound of claim 11, wherein the compound of formula (70) is a compound of formula (700) or (701): Formula (700) formula (701).
  13. 13. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (80) or formula (81): (80) Wherein in formula (80): R 11a and R 11b are each independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilyl 、-OR a 、-SR a 、-OC(O)-R a 、-SC(O)-R a 、-N(R a ) 2 、-C(O)R a 、-C(O)OR a 、-C(O)SR a 、-OC(O)N(R a ) 2 、-C(O)N(R a ) 2 、-N(R a )C(O)OR a 、-N(R a )C(O)R a 、-N(R a )C(O)N(R a ) 2 、-N(R a )C(NR a )N(R a ) 2 、-N(R a )S(O) t R a 、-S(O) t R a 、-S(O) t OR a 、-S(O) t N(R a ) 2 , and PO 3 (R a ) 2 ; R a is independently at each occurrence selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heteroarylalkyl, and N 8 is an integer from 1 to 5; (81) Wherein in formula (81): alk is a substituted or unsubstituted alkyl group; R 11a and R 11b are each independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilyl 、-OR a 、-SR a 、-OC(O)-R a 、-SC(O)-R a 、-N(R a ) 2 、-C(O)R a 、-C(O)OR a 、-C(O)SR a 、-OC(O)N(R a ) 2 、-C(O)N(R a ) 2 、-N(R a )C(O)OR a 、-N(R a )C(O)R a 、-N(R a )C(O)N(R a ) 2 、-N(R a )C(NR a )N(R a ) 2 、-N(R a )S(O) t R a 、-S(O) t R a 、-S(O) t OR a 、-S(O) t N(R a ) 2 , and PO 3 (R a ) 2 , and R a is independently at each occurrence selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heteroarylalkyl.
  14. 14. The compound of claim 13, wherein the compound of formula (80) is a compound of formula (800) or formula (801), or the compound of formula (81) is a compound of formula (802) or formula (803): Formula (800) formula (801) Formula (802) formula (803).
  15. 15. The compound of any one of claims 11-14, wherein R 5b and/or R 5c are each independently selected from unsubstituted or substituted alkynyl, optionally substituted alkynyl, substituted aryl, substituted heteroaryl, halo, optionally Br, -N (R a ) 2 , optionally-NH 2 and-N (R a )C(O)R a , optionally 、 、 Or (b) Optionally wherein R 5b is selected from 、 、 、 、 、 、 、 、 、 、 、 、 、 、 And Optionally wherein R 5c is selected from 、 、 、 、 、 、 、 、 、 And 。
  16. 16. The compound of any one of claims 11-15, wherein R 11a and R 11b are each unsubstituted alkyl, or R 11a and R 11b are each independently Or R 11a is selected from H and unsubstituted alkyl and R 11b is Or R 11a is H and R 11b is unsubstituted alkyl, wherein Y is selected from unsubstituted or substituted alkyl, optionally unsubstituted or substituted C 1 -C 5 alkyl, unsubstituted or substituted aryl, optionally unsubstituted or substituted phenyl, unsubstituted or substituted cycloalkyl, optionally unsubstituted or substituted C 3 -C 7 cycloalkyl, and unsubstituted or substituted alkoxy, optionally unsubstituted or substituted C 1 -C 5 alkoxy, and n 7 is an integer from 1 to 3, optionally n 7 is 1 or 2, optionally wherein R 11a and R 11b are each independently selected from 、 、 、 、 、 、 、 、 、 、 And Optionally wherein R 11a and R 11b are each independently selected from 、 、 、 、 、 、 、 、 And 。
  17. 17. The compound of claim 16, wherein R 11a is selected from H and-CH 3 and R 11b is selected from 、 、 、 、 、 、 、 、 、 、 、 And Optionally wherein R 11a is selected from H and-CH 3 and R 11b is selected from 、 、 And Optionally wherein R 11a is selected from H and-CH 3 and R 11b is selected from 、 、 、 And Optionally wherein R 11a is H and R 11b is-CH 3 or wherein R 11a and R 11b are each-CH 3 .
  18. 18. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (82): (82) Wherein in formula (82): R 11a 、R 11b 、 R 11c and R 11d are each independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilyl 、-OR a 、-SR a 、-OC(O)-R a 、-SC(O)-R a 、-N(R a ) 2 、-C(O)R a 、-C(O)OR a 、-C(O)SR a 、-OC(O)N(R a ) 2 、-C(O)N(R a ) 2 、-N(R a )C(O)OR a 、-N(R a )C(O)R a 、-N(R a )C(O)N(R a ) 2 、-N(R a )C(NR a )N(R a ) 2 、-N(R a )S(O) t R a 、-S(O) t R a 、-S(O) t OR a 、-S(O) t N(R a ) 2 , and PO 3 (R a ) 2 , and R a is independently at each occurrence selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heteroarylalkyl.
  19. 19. The compound of claim 18, wherein the compound of formula (82) is a compound of formula (804) or (805): Formula (804) formula (805).
  20. 20. A compound according to any one of claims 1 to 3, wherein the compound of formula (I) is a compound of formula (90): (90) Wherein in formula (90): n is an integer from 1 to 5.

Description

TRIM7 inhibitors and uses thereof Cross Reference to Related Applications The present application claims priority and rights from U.S. provisional patent application No. 63/520,551 filed on 8 months of 2023, U.S. provisional patent application No. 63/561,076 filed on 4 months of 2024, and U.S. provisional patent application No. 63/631,138 filed on 8 months of 2024, the contents of all of which are hereby incorporated by reference in their entireties. Technical Field The present disclosure relates, inter alia, to compositions and methods useful for treating diseases, including compounds comprising Trim7 inhibitors, such as therapies for cancers including cancers resistant to checkpoints agents, infectious diseases, and inflammatory diseases. Sequence listing The present application contains a sequence table that has been submitted via EFS-Web in XML format. The content of the XML copy named "SHK-085PC_116981-5085-WO_sequence_Listing" was created at 8.15 of 2024 and is 4,096 bytes in size, the content of which is incorporated herein by reference in its entirety. Background Drug resistance remains one of the greatest challenges in cancer therapy. Resistance can be seen in all types of cancer and in all modes of treatment, including molecular targeted therapies, immunotherapy and chemotherapy. In some patients, the onset of effective therapy is delayed due to unpredictable responses. Furthermore, patients with advanced cancers receive drugs that help shrink their tumors, but it is also common for the cancer to develop resistance to the drug later. Unfortunately, for some patients with cancers that are resistant to anti-checkpoint therapies, there is little effective treatment option. Thus, there is a need for methods for developing new therapies for patients suffering from drug resistant cancers to improve the efficacy of cancer patients. Disclosure of Invention Accordingly, the present disclosure provides, in part, compositions and methods for treating cancers, including, but not limited to, cancers that are resistant to anti-checkpoint agents. Methods for treating infectious diseases and inflammatory diseases are also provided. Also provided are methods for selecting cancer treatments for patients, as well as methods for cancer treatments based on, for example, expression profiles of Trim7 genes, which Trim7 is deregulated in anti-checkpoint resistant cancers. In one embodiment, the present disclosure provides a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I) Wherein in formula (I): A is selected from 、、、、、And; L is a linking group; R1a、R1b、R2、R3、R4a、R4b、R5a、R5b、R5c、R5d、R5e、R6a、R6b、R6c、R6d、R6e、R7a、R7b、R7c、R7d、R8、R9、R10、R11a、R11b And R 11c are each independently selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted heteroalkyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, hydroxy, halo, cyano, trifluoromethyl, trifluoromethoxy, nitro, trimethylsilyl 、-ORa、-SRa、-OC(O)-Ra、-SC(O)-Ra、-N(Ra)2、-C(O)Ra、-C(O)ORa、-C(O)SRa、-OC(O)N(Ra)2、-C(O)N(Ra)2、-N(Ra)C(O)ORa、-N(Ra)C(O)Ra、-N(Ra)C(O)N(Ra)2、-N(Ra)C(NRa)N(Ra)2、-N(Ra)S(O)tRa、-S(O)tRa、-S(O)tORa、-S(O)tN(Ra)2, and PO 3(Ra)2; R 12 is H or unsubstituted alkyl; R a is independently at each occurrence selected from the group consisting of hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkenyl, unsubstituted or substituted haloalkyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted heterocycloalkyl, unsubstituted or substituted heteroaryl, and unsubstituted or substituted heteroarylalkyl; n 1 is an integer from 0 to 5; t is 1 or 2; provided that the compound of formula (I) is not a compound of any one of formulas 1001, 1003, 1004 and 1006-1009: In some embodiments, the compound is a compound of formula (I) wherein R1a、R1b、R2、R3、R4a、R4b、R5a、R5b、R5c、R5d、R5e、R6a、R6b、R6c、R6d、R6e、R7a、R7b、R7c、R7d、R8、R9、R10、R11a、R11b and R 11c are each independently selected from hydrogen, unsubstituted or substituted alkyl, unsubstituted or substituted alkynyl, unsubstituted or substituted cycloalkyl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted aryl optionally substituted with halo, unsubstituted or substituted alkyl, and/or unsubstituted or substituted heterocyclyl, Unsubstituted or substituted aralkyl, unsubstituted or substituted cycloalkylalkyl, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, halo, -C (O) R a、-C(O)N(R