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CN-122028945-A - Apparatus, systems, and methods for aerosolized drug administration

CN122028945ACN 122028945 ACN122028945 ACN 122028945ACN-122028945-A

Abstract

A system for delivering aerosolized drug to a patient. The system comprises a holding chamber (108) adapted to contain a medicament to be aerosolized, and a connecting element (100) having a first end and a second end opposite the first end and adapted to be connected to the holding chamber (108). The connecting element further includes one or more mating mechanisms (102, 104, 112, 114, 118) located near the first end thereof. The system may also include a mouthpiece (400), a drug assembly (200) including a drug housing (216) and a cartridge (300), and a nebulizer (500).

Inventors

  • PETER FITZPATRICK
  • SEAN O'BRIEN
  • ROSS SPENCER
  • KEVIN JOHNSON
  • Joe Lanaleta
  • Ines Amaro
  • Connor Burke
  • Aaron CAMERON

Assignees

  • GH研究爱尔兰有限公司

Dates

Publication Date
20260512
Application Date
20241018
Priority Date
20231018

Claims (20)

  1. 1. A system for administering an aerosolized drug, the system comprising: a connecting element having a first end, a second end opposite the first end, and one or more mating mechanisms proximate the first end, and A holding chamber connected to the second end of the connecting element, the holding chamber being operable to contain the aerosolized medicament.
  2. 2. The system of claim 1, wherein the holding chamber comprises one or more transparent portions operable to indicate a fill level of the holding chamber.
  3. 3. The system of claim 1, wherein the holding chamber has a volume of about 0.5L to about 4L.
  4. 4. The system of claim 3, wherein the connection element is coupled with the holding chamber via a seal.
  5. 5. The system of claim 4, wherein the seal is a permanent seal.
  6. 6. The system of claim 4, wherein the seal is a ring.
  7. 7. The system of claim 6, wherein the ring is a silicone gasket.
  8. 8. The system of claim 1, wherein the one or more mating mechanisms comprise a plurality of slots formed on an exterior of the connecting element.
  9. 9. The system of claim 8, wherein the one or more mating mechanisms further comprise a plurality of locking clips.
  10. 10. The system of claim 9, wherein the system further comprises a drug assembly comprising: A housing, comprising: A first housing engagement mechanism, and A housing chamber operable to allow air to flow through the housing, and A cartridge coupled with the housing, the cartridge being operable to hold a medicament configured to be aerosolized.
  11. 11. The system of claim 10, wherein the first housing mating mechanism is configured to be removably coupled to the connecting element.
  12. 12. The system of claim 11, wherein the first housing engagement mechanism comprises a first slot and a second slot on opposite sides of the housing.
  13. 13. The system of claim 12, wherein the plurality of locking clips are configured to be removably coupled to the first slot and the second slot of the housing.
  14. 14. The system of claim 13, the connecting element further comprising a valve, wherein the valve is placed in an open state when the drug assembly is coupled with the connecting element.
  15. 15. The system of claim 14, wherein the housing provides a force to the valve to drive the valve to the open state.
  16. 16. The system of claim 15, wherein the open state allows fluid to flow into the holding chamber.
  17. 17. The system of claim 14, wherein the valve has a closed state configured to prevent fluid flow into or out of the holding chamber.
  18. 18. The system of claim 17, wherein the valve is in the closed state when no force is applied.
  19. 19. The system of claim 18, wherein the valve transitions to the closed state when the drug assembly is separated from the connecting element and the holding chamber.
  20. 20. The system of claim 12, wherein the system further comprises a nebulizer, the nebulizer comprising: A drug assembly port operable to removably couple to the port mating mechanism and the connecting element mating mechanism on the housing, and A heating element operable to heat the atomizing volume of air and at least a portion of the cartridge, Wherein the heat provided to the portion of the cartridge atomizes the medicament, Wherein the heated aerosolized volume of air is passed through the cartridge, thereby aerosolizing the medicament, Wherein the aerosolized medicament is subsequently cooled and condensed to form the aerosolized medicament.

Description

Apparatus, systems, and methods for aerosolized drug administration Cross Reference to Related Applications The present application claims the benefit of U.S. application Ser. No. 63/591,432, filed on 10/18 of 2023, the entire contents of which are incorporated herein by reference. Technical Field The present disclosure relates generally to devices, systems, and methods for administering aerosolized medicaments. The present disclosure also relates generally to medicaments for treating diseases or conditions, wherein the medicaments are administered by the devices, systems and methods of the present disclosure. Background Inhalation of aerosolized medicaments is one technique for delivering the medicament to the user. The aerosolized drug is inhaled into the patient's lungs, which causes the drug to be absorbed into the blood stream and distributed throughout the body. Drawings Further features of the present disclosure will become apparent to those skilled in the art to which the present disclosure relates upon reading the following specification with reference to the accompanying drawings, in which: FIG. 1A is an isometric view of a connection element and a holding chamber according to at least one example of the present disclosure; FIG. 1B is a front view of the connecting element and holding chamber; FIG. 2 is a bottom view of the connecting element and holding chamber; FIG. 3 is an isometric view of a drug assembly; FIG. 4 is a front view of the drug assembly; FIG. 5 is a left side view of the drug assembly; FIG. 6 is a right side view of the drug assembly; FIG. 7 is a bottom isometric view of the drug assembly; FIG. 8 is an isometric view of a suction nozzle; FIG. 9 is a front view of the suction nozzle; FIG. 10 is a rear view of the suction nozzle; FIG. 11 is an isometric view of the atomizer; FIG. 12 is a front view of the atomizer; FIG. 13 is a rear view of the atomizer, and FIG. 14 is a flow chart of a method in one embodiment. Detailed Description It will be appreciated that for simplicity and clarity of illustration, reference numerals have been repeated among the different figures to indicate corresponding or analogous elements, where appropriate. Furthermore, numerous specific details are set forth in order to provide a thorough understanding of the embodiments described herein. However, it will be understood by those of ordinary skill in the art that the embodiments described herein may be practiced without these specific details. In other instances, methods, procedures, and components have not been described in detail so as not to obscure the relevant features described. The figures are not necessarily to scale and the proportion of some parts may be exaggerated to better illustrate details and features. The description should not be taken as limiting the scope of the embodiments described herein. Several definitions will now be presented as applicable throughout this disclosure. The term "coupled" is defined as connected, whether directly or indirectly through intermediate components, and is not necessarily limited to physical connection. The connection may be such that the objects are permanently connected, or releasably connected. The term "substantially" is defined as a term that essentially conforms to a particular size, shape or other substantial modification so that the component does not need to be precise. For example, substantially cylindrical means that the object resembles a cylinder, but may have one or more deviations from a true cylinder. The term "comprising" means "including but not necessarily limited to," and it specifically means including or belonging to the group, series, etc. so described. As used herein, when referring to any numerical value, the term "about" means a value that is within + -10% of the stated value. Ranges may be expressed herein as from "about" one particular value, and/or to "about" another particular value. When such a range is expressed, yet another aspect includes from the one particular value and/or to the other particular value. Similarly, when values are expressed as approximations, by use of the antecedent "about," it will be understood that the particular value forms yet another aspect. It will be further understood that the endpoints of each of the ranges are significant both in relation to the other endpoint, and independently of the other endpoint. It is also to be understood that a number of values are disclosed herein, and that each value is also disclosed herein as "about" the particular value, except for the value itself. For example, if the value "10" is disclosed, then "about 10" is also disclosed. The term "about" is optional when used in reference to a particular value. Furthermore, it should also be understood that each unit between two particular units is also disclosed. For example, if 10 and 15 are disclosed, then 11, 12, 13 and 14 are also disclosed. The terms "aerosol," "aerosolization," or any other variation of such terms ar