CN-122028949-A - Microneedle structure, microneedle patch, and method for manufacturing microneedle structure

Abstract

The present invention aims to provide a microneedle structure capable of analyzing body fluid by means other than a functional member. The solution is that a microneedle structure 10 is provided with a liquid storage layer 20 for absorbing and storing a liquid derived from a living body and needle-shaped portions 11 formed with flow paths 13, wherein the liquid storage layer 20 is in contact with the flow paths 13 of the needle-shaped portions 11.

Inventors

• Gao Li Yang you
• Huo Jiandaizi
• KABUTO AKIO

Assignees

• 琳得科株式会社

Dates

Publication Date

20260512

Application Date

20241114

Priority Date

20231114

Claims (17)

1. 1. A microneedle structure comprising a liquid storage layer for absorbing and storing a liquid derived from a living body and a needle-like portion having a flow path formed therein, The flow path of the needle is connected to the liquid storage layer.
2. 2. The microneedle structure according to claim 1, wherein the liquid storage layer and the needle portion are each made of a porous material.
3. 3. The microneedle structure of claim 1, wherein the liquid storage layer comprises a nonwoven fabric formed of rayon.
4. 4. The microneedle structure according to claim 2, wherein the liquid storage layer and the needle portion are each composed of the porous material having a structure or composition different from each other.
5. 5. The microneedle structure according to claim 2, wherein, The porous material of the liquid storage layer comprises a resin, The resin contains carbon atoms and oxygen atoms in its molecular structure The ratio of the number of oxygen atoms to the number of carbon atoms is 1/2 or more.
6. 6. The microneedle structure according to claim 2, wherein, The porous material of the liquid storage layer comprises a resin, The resin is a water-insoluble resin having a hydroxyl group in a portion other than the molecular terminals.
7. 7. The microneedle structure according to claim 1, wherein the liquid storage layer is a hard porous material, and the thickness of the liquid storage layer is 300 μm or more.
8. 8. The microneedle structure according to claim 1, wherein the regions where the needle-like portions are present are each included in the region of the liquid storage layer when the microneedle structure is viewed from above.
9. 9. The microneedle structure according to claim 1, wherein the needle-like portion is formed on a surface of one side of a sheet-like base, the liquid storage layer is directly laminated on a surface of the other side of the base, and a flow path of the needle-like portion is connected to the liquid storage layer via a flow path formed in the base.
10. 10. The microneedle structure of claim 9, wherein said liquid storage layer is directly secured to said base.
11. 11. A microneedle patch comprising the microneedle structure according to any one of claims 1 to 10.
12. 12. A method for manufacturing a microneedle structure, characterized by comprising, The microneedle structure comprises a needle-like portion formed on one surface of a sheet-like base and having a flow path formed therein, and a liquid storage layer disposed on the other surface of the sheet-like base and absorbing and storing a liquid derived from a living body, wherein the base and the liquid storage layer are made of a porous material, The method for manufacturing the microneedle structure comprises the following steps: Impregnating at least one of the base and the liquid storage layer with a solution of a resin, and And a drying step of evaporating a solvent from the solution of the resin and drying the resin in a state where the base and the liquid storage layer are laminated after the impregnating step.
13. 13. The method of manufacturing a microneedle structure according to claim 12, wherein after the impregnating step, one of the base portion or the liquid storage layer impregnated with the solution of the resin is laminated on the other of the base portion or the liquid storage layer not impregnated with the solution of the resin, and is placed in a laminated state under a reduced pressure atmosphere.
14. 14. The method for producing a microneedle structure according to claim 12, wherein the resin is a hydrophilic resin.
15. 15. A microneedle structure is characterized by comprising a needle-shaped portion formed on one surface of a sheet-like base and having a flow path formed therein, and a liquid storage layer disposed on the other surface of the sheet-like base and absorbing and storing a liquid derived from a living body, wherein the base and the liquid storage layer are composed of a porous material, and a resin is adhered to the inside of the porous material of the base and the liquid storage layer.
16. 16. The microneedle structure of claim 15, wherein said resin attached to the interior of said porous material of said base is a common resin with said resin attached to the interior of said porous material of said liquid storage layer.
17. 17. The microneedle structure of claim 15, wherein said base and said liquid storage layer are bonded by said resin to which they are attached.

Description

Microneedle structure, microneedle patch, and method for manufacturing microneedle structure Technical Field The present invention relates to a microneedle structure, a microneedle patch, and a method for manufacturing a microneedle patch. Background In recent years, a microneedle patch has been proposed which uses a microneedle structure for supplying a drug into the body and collecting body fluid from the body through a through-hole formed in a needle-like portion having a minute size. As a microneedle patch, for example, a microneedle patch is known which comprises a liquid impermeable base material having a through hole, a liquid absorbable material filled in the through hole, a needle-like portion provided on one surface side of the base material and having a flow path formed therein, and a functional member provided on the other surface side of the base material, wherein the needle-like portion and the absorbable material are connected to each other, and the absorbable material and the functional member are connected to each other (patent document 1). Prior art literature Patent literature Patent document 1 International publication No. 2023/042525 Disclosure of Invention First, the technical problem to be solved In recent years, since analytical methods for collecting and analyzing body fluids are also pursued to reduce pain and burden on the human body, microneedle patches have been studied as analytical means. Regarding the examination, the microneedle patch is preferable in terms of less pain and less burden on the human body. However, since the microneedle patch described in patent document 1 is configured to transfer a tissue fluid (INTERSTITIAL FLUID) from a needle portion to a functional member through a through hole of a base material, the microneedle patch can be simply inspected as an inspection patch for a functional member, but is not suitable for performing a precise analysis by a dedicated device or absorbing an amount required for analysis by a means other than the functional member, for example. The present invention has been made in view of such a practical situation, and an object thereof is to provide a microneedle structure capable of analyzing body fluid by means other than a functional member. (II) technical scheme In order to achieve the above object, in a first aspect, the present invention provides a microneedle structure comprising a liquid storage layer for absorbing and storing a liquid derived from a living body, and needle-like portions having flow paths formed therein, wherein the flow paths of the needle-like portions are in contact with the liquid storage layer (invention 1). In the above invention (invention 1), the microneedle structure has a structure having a liquid storage layer for absorbing and storing a liquid derived from a living body, and thus can store a liquid and is suitable for various analyses. In the above invention (invention 1), it is preferable that the liquid storage layer and the needle-like portion are each made of a porous material (invention 2). In the above invention (invention 1), the liquid storage layer preferably comprises a nonwoven fabric formed of rayon (invention 3). In the above invention (invention 2), it is preferable that the liquid storage layer and the needle-like portion are each composed of the porous material having a structure or composition different from each other (invention 4). In the above invention (invention 2), the porous material of the liquid storage layer comprises a resin containing carbon atoms and oxygen atoms in its molecular structure, and the ratio of the number of the oxygen atoms to the number of the carbon atoms may be 1/2 or more (invention 5). In the above invention (invention 2), the porous material of the liquid storage layer may contain a resin which has a hydroxyl group at a portion other than a molecular terminal and is insoluble in water (invention 6). In the above invention (invention 1), it is preferable that the region where the needle-like portion is present is included in the region of the liquid storage layer (invention 7) when the microneedle structure is viewed in plan. In the above invention (invention 1), the liquid storage layer is preferably a hard porous material, and the thickness of the liquid storage layer is preferably 300 μm or more (invention 8). By setting the thickness of the liquid storage layer to 300 μm or more, even when an analysis of a required amount of liquid is performed, the liquid can be sufficiently stored, and the strength of the microneedle structure can be improved. In the invention (invention 1), it is preferable that the needle-shaped portion is formed on one surface of the sheet-like base portion, the liquid storage layer is directly laminated on the other surface of the base portion, and the flow path of the needle-shaped portion is connected to the liquid storage layer via the flow path formed in the base portion (invention 9). By forming the needle-like po