CN-122028951-A - Fluid injection device

Abstract

The present invention provides a fluid injection device (10) capable of more effectively administering a drug. The first conveyance body (11) has a first conveyance channel through which a first fluid (21) flows, and the second conveyance body (12) has a second conveyance channel through which a second fluid (22) flows. The positive-side microneedle (13) provided on the first transport body (11) has a first opening and a first channel to which positive charges are fixed. The negative-side microneedle (14) provided in the second transport body (12) has a second opening and a second flow path to which negative charges are fixed. When a current or voltage is applied between a first electrode (24) disposed in a first transport channel and a second electrode (25) disposed in a second transport channel, an ion current flows in a first fluid (21) and a second fluid (22), and by electroosmosis, the first fluid (21) flows outward from a first opening, and the second fluid (22) flows outward from a second opening.

Inventors

• NISHIZAWA MATSUHIKO

Assignees

• 国立大学法人东北大学

Dates

Publication Date

20260512

Application Date

20240731

Priority Date

20231031

Claims (7)

1. 1. A fluid injection device, comprising: a first conveyance body having a first conveyance flow path through which a first fluid flows; a second conveyance body having a second conveyance flow path through which a second fluid flows; A positive-side microneedle having a first opening provided at a distal end portion and a first channel to which positive charges are fixed and which communicates with the first opening, the positive-side microneedle being provided to the first transport body so that the first channel communicates with the first transport channel; a negative-side microneedle having a second opening provided at a distal end portion and a second flow path fixed with negative charges and communicating with the second opening, the negative-side microneedle being provided on the second conveyance body so that the second flow path communicates with the second conveyance flow path, and A current-voltage applying mechanism having a first electrode disposed in the first transport channel and a second electrode disposed in the second transport channel, the current-voltage applying mechanism being provided so as to be capable of applying a current or a voltage between the first electrode and the second electrode, The fluid injection device is configured such that, when a current or a voltage is applied between the first electrode and the second electrode by the current-voltage application means, an ion current flows through the first fluid in the first flow path and the second fluid in the second flow path, the first fluid flows outward from the first opening and the second fluid flows outward from the second opening by electroosmosis.
2. 2. The fluid injection apparatus of claim 1, wherein the fluid injection apparatus is configured such that the positive side microneedles are adjacent to the negative side microneedles.
3. 3. The fluid injection apparatus of claim 1 wherein the fluid injection apparatus comprises, The first conveying body is elongated, the first conveying flow path extends from one end to the other end of the first conveying body, The second conveying body is elongated, the second conveying flow path extends from one end to the other end of the second conveying body, The positive side microneedle is arranged at the one end of the first conveying body, The negative-side microneedle is disposed at the one end of the second conveyance body.
4. 4. The fluid injection apparatus of claim 3, wherein the fluid injection apparatus comprises, The positive-side microneedle is provided such that a tip end portion thereof protrudes from the one end of the first conveyance body in the extending direction of the first conveyance body, The negative-side microneedle is provided such that a tip end portion thereof protrudes from the one end of the second conveyance body in the extending direction of the second conveyance body.
5. 5. The fluid injection apparatus of claim 1, wherein the first and second conveyance bodies are integrally provided.
6. 6. The fluid injection apparatus according to any one of claim 1 to 4, wherein, The fluid injection device has a rigid tube body that integrally forms the first and second transport bodies, The pipe body is slender and internally provided with 2 hollow parts extending from one end to the other end, one hollow part of each hollow part forms the first conveying flow path, and the other hollow part forms the second conveying flow path.
7. 7. The fluid injection apparatus of any of claims 1-5, wherein the first and second conveyance bodies are each comprised of a flexible tube.

Description

Fluid injection device Technical Field The present invention relates to a fluid injection device. Background Conventionally, iontophoresis (iontophoresis) has been used as a method of administration for promoting permeation of a drug by passing a minute current through a living body. Since iontophoresis can administer a drug directly to a blood vessel or an affected area, it is advantageous in that the drug can be administered more effectively than conventional oral administration and side effects of the drug can be suppressed to a minimum. In particular, iontophoresis has been widely accepted for the effect of promoting penetration of a percutaneous drug (for example, refer to non-patent document 1), and devices such as portable devices and patches to be attached to the body surface have been developed from stationary devices requiring an external power supply. In addition to skin, iontophoresis is considered to be effective for administration to organs or tumors, and it has been reported that it can greatly improve the administration efficiency of an anticancer agent to cancer tumors (for example, refer to non-patent document 2). It is considered that the permeation-promoting effect of iontophoresis can be obtained by electroosmosis flow generated in the skin or tissue in addition to electrophoresis derived from a drug. Since the drug molecules are smaller than the electrolyte ions, migration by electrophoresis is very small, and most migration by electroosmotic flow is thought to be dominant. However, although the skin or tissue in the living body is only slightly negatively charged, the electroosmotic flow is thereby generated only in the migration direction of the cations. Therefore, the action of promoting permeation is limited to the positive electrode, and the negative electrode may flow in a direction of sucking out the body fluid, which may hinder permeation of the drug. The inventors of the present application have developed a porous microneedle to which negative charges are fixed by chemical modification, which generates a large electroosmotic flow on the positive electrode side (for example, refer to non-patent documents 3, 4 or patent document 1). It is reported that by means of the microneedle, the agent is able to penetrate under the skin, independently of the charge of the agent, i.e. independently of the direction of electrophoresis. In contrast, the present inventors have also developed an electroosmotic flow pump using a material for fixing negative charges to the positive electrode side and a material for fixing positive charges to the negative electrode side, which can supply a chemical agent to the surface of skin or tissue from both the positive electrode side and the negative electrode side by electroosmosis without blocking the chemical agent permeation to the negative electrode side (for example, refer to patent document 2). Prior art literature Non-patent literature Non-patent document 1, including Lin times, a method of coating, a volume 37, a period 5, and a method of coating, p.385-387 in 2001 Non-patent literature 2：James D. Byrne et al., "Local iontophoretic administration of cytotoxic therapies to solid tumors", Science Translational Medicine,2015,7,273ra14 Non-patent literature 3：Shinya Kusama et al.,"Transdermal Electroosmotic Flow Generated by a Porous Microneedle Array Patch", Nature Communications,2021,12, 658 Non-patent literature 4：Hiroya Abe et al.,"Porous Microneedle Patch for Electroosmosis-Promoted Transdermal Delivery of Drugs and Vaccines",Advanced NanoBiomedical Research,2022,2,2100066 Patent literature Patent document 1 Japanese patent application laid-open No. 2022-83780 Patent document 2 Japanese patent application laid-open No. 2023-69170 Disclosure of Invention First, the technical problem to be solved The electroosmotic flow pump described in patent document 2 can administer a drug to the surface of skin or tissue from both the positive electrode side and the negative electrode side, and thus can increase the amount of drug administered. Further, two kinds of drugs can be simultaneously administered by supplying different drugs from the positive electrode side and the negative electrode side. Thus, the electroosmotic pump described in patent document 2 can effectively administer a drug as compared with the electroosmotic pump using only the positive electrode side, but development of a device capable of further effectively administering a drug has been desired. The present invention has been made in view of the above-described problems, and an object thereof is to provide a fluid injection device capable of more effectively administering a drug. (II) technical scheme In order to achieve the above object, a fluid injection device according to the present invention includes: a first conveyance body having a first conveyance flow path through which a first fluid flows; a second conveyance body having a second conveyance flow path through which a second flui