CN-122028974-A - Ribonucleic acid-based microcapsules

Abstract

The present invention relates to a novel method for preparing ribonucleic acid-based microcapsules. Ribonucleic acid based microcapsules are also an object of the present invention. Perfuming compositions and consumer products comprising said microcapsules, in particular perfumed consumer products in the form of household care or personal care products, are also part of the invention.

Inventors

• L. Wally
• V. Valmark
• N. Walter's
• C. Rommel

Assignees

• 弗门尼舍有限公司

Dates

Publication Date

20260512

Application Date

20241015

Priority Date

20231017

Claims (15)

1. 1. A delivery system comprising a hydrophobic material and a carrier, wherein the carrier comprises ribonucleic acid (RNA).
2. 2. The delivery system of claim 1, wherein it is a core-shell microcapsule, wherein the carrier is a shell, and wherein the core comprises the hydrophobic material.
3. 3. Delivery system according to any one of the preceding claims, wherein the carrier comprises a polymeric material, preferably selected from the group consisting of polyureas, polyurethanes, polyamides, polyesters, polyhydroxyalkanoates, polyaminoesters, polyepoxides, polyacrylates, polysiloxanes, polycarbonates, polysulfonamides, poly (β -amino esters), polylactic acid, poly (thiol-acrylate), polymers of urea and formaldehyde, polymers of melamine and urea, or polymers of melamine and glyoxal, gelatin/acacia shell walls and mixtures thereof.
4. 4. The delivery system according to any of the preceding claims, wherein the carrier comprises an amino compound.
5. 5. The delivery system according to claim 4, wherein the amino compound is selected from the group consisting of polylysine, chitosan, peptides, amino acids, guar gum, proteins, and mixtures thereof.
6. 6. Delivery system according to claim 5, wherein the amino compound is a vegetable protein, preferably selected from the group consisting of soy protein, rice protein, whey protein, potato protein, chickpea protein, pea protein, algae protein, broad bean protein, barley protein, oat protein, wheat gluten protein, lupin protein, and mixtures thereof.
7. 7. The delivery system according to any of the preceding claims, wherein the carrier is crosslinked.
8. 8. The delivery system according to any of the preceding claims, wherein the carrier is cross-linked by uv light, glutaraldehyde, glyoxal, formaldehyde, polyanhydrides, genipin, transglutaminase and mixtures thereof.
9. 9. A delivery system according to any one of the preceding claims, wherein the hydrophobic material comprises a perfume.
10. 10. A method of preparing a delivery system comprising the steps of: -dispersing an oil phase comprising a hydrophobic material into the dispersed phase to obtain a two-phase dispersion. A curing step is carried out to obtain a delivery system, Wherein ribonucleic acid (RNA) is added to the oil phase and/or to the dispersed phase and/or to the two-phase dispersion.
11. 11. The method according to claim 10, wherein an amino compound is added to the dispersed phase and/or the oil phase.
12. 12. The method according to claim 10 or 11, wherein a stabilizer is added to the dispersed phase and/or the oil phase, preferably selected from the group consisting of inorganic particles, polysaccharides, proteins, glycoproteins and mixtures thereof.
13. 13. The method according to any one of claims 10 to 12, wherein a reactant selected from the group consisting of alcohols, amines, phenols, thiols is added in the dispersed phase and/or the aqueous phase.
14. 14. The method according to any one of claims 10 to 13, wherein the ribonucleic acid (RNA) is added to the oil phase.
15. 15. A consumer product comprising the delivery system disclosed in any one of claims 1 to 9.

Description

Ribonucleic acid-based microcapsules Technical Field The present invention relates to a novel method for preparing ribonucleic acid-based microcapsules. Ribonucleic acid based microcapsules are also an object of the present invention. Perfuming compositions and consumer products comprising said microcapsules, in particular perfumed consumer products in the form of household care or personal care products, are also part of the invention. Background One of the problems faced by the perfumery (perfumery, daily chemical flavour) industry is that the olfactory benefit provided by odoriferous compounds is lost relatively quickly due to their volatility, in particular the volatility of "top notes". In order to adjust the release rate of the volatiles, a delivery system (e.g., microcapsules containing perfume) is required to protect and release the core payload upon triggering. A key requirement in the industry for these systems is to be able to maintain suspension in the challenging base without physical decomposition or degradation. This is referred to as stability of the delivery system. For example, fragrance personal and household cleaners containing high levels of aggressive surfactant detergents are very challenging for microcapsule stability. Polyurea and polyurethane-based microcapsule slurries are widely used in, for example, the perfumery industry because they provide a durable and pleasant olfactive effect after application to different substrates. These microcapsules are widely disclosed in the prior art. In addition to performance in terms of stability and olfactory performance, consumer demand for eco-friendly delivery systems is becoming more and more important and development of new delivery systems is being driven. Thus, there remains a need to provide new microcapsules using more eco-friendly materials, while not compromising the performance of the microcapsules, in particular in terms of stability in challenging media such as consumer product bases, and in terms of providing olfactory performance in the case of active ingredient delivery, e.g. in the case of perfuming ingredients. The present invention provides a solution to the above-mentioned problems by providing ribonucleic acid based microcapsules and a method for preparing said microcapsules. Disclosure of Invention The present invention relates to a delivery system comprising a hydrophobic material and a carrier, wherein the carrier comprises ribonucleic acid (RNA). The present invention relates to a method of preparing a delivery system comprising the steps of: -dispersing an oil phase comprising a hydrophobic material into the dispersed phase to obtain a two-phase dispersion. A curing step is carried out to obtain a delivery system, Wherein ribonucleic acids are added to the oil phase and/or to the disperse phase and/or to the two-phase dispersion. The invention also relates to a perfumed consumer product and a flavoured (flavoured ) edible product comprising microcapsules as defined above. Detailed Description Unless otherwise indicated, percentages (%) refer to weight percentages of the composition. By "active ingredient" is meant a single compound or a combination of ingredients. By "perfume oil or flavour (flavouring) oil" is meant a single perfuming or flavouring compound, or a mixture of several perfuming or flavouring compounds. By "consumer product" or "end product" is meant a manufactured product that is ready for distribution, sale, and use by a consumer. For the sake of clarity, the expression "dispersion" in the present invention refers to a system in which the particles are dispersed in continuous phases of different composition, and it specifically includes suspensions or emulsions. In the present invention, "microcapsules" or similar expressions mean that the core-shell microcapsules have a particle size distribution in the micrometer range (e.g., an average diameter (d (v, 0.5)) of about 1 to 3000 micrometers, preferably 1 to 500 micrometers, more preferably 10 to 500 micrometers). Nanocapsules (typically less than 1 micron in particle size) are not within the scope of the present invention. The microcapsule comprises an outer solid polymer shell and an inner continuous oil phase surrounded by the outer shell. According to a particular embodiment, the polymeric shell is a polyamide-based shell. According to another particular embodiment, the polymeric shell is a coacervate comprising at least ribonucleic acid (RNA). According to one embodiment, the slurry is an aqueous slurry, i.e. the microcapsules are dispersed in an aqueous phase. By "amino compound" is understood a compound containing at least one reactive amine group. By "polyamide-based microcapsules" it is meant that the shell of the microcapsules comprises a polyamide material. The expression "polyamide-based microcapsules" also covers shells made of a complex comprising a polyamide material and another material, such as ribonucleic acid (RNA) or a protein as def