CN-122029179-A - Peptides having skin condition improving activity and uses thereof

Abstract

The present invention relates to peptides having skin condition improving activity. The peptide of the present invention increases the expression level of the extracellular matrix component and the skin barrier-enhancing factor, decreases again the expression of the skin cell damage factor increased by the ultraviolet irradiation, and restores again the expression level of the extracellular matrix component and the skin barrier-enhancing factor decreased by the ultraviolet irradiation.

Inventors

• Zheng Rongchi
• JIN YINMEI
• LI YINGZHI
• Jiang Xianya
• HUANG BOPEI

Assignees

• 凯尔格恩有限公司

Dates

Publication Date

20260512

Application Date

20241011

Priority Date

20231016

Claims (9)

1. 1. A peptide comprising the amino acid sequence of SEQ ID No. 1.
2. 2. A composition for improving skin conditions, comprising the peptide of claim 1 as an active ingredient.
3. 3. The composition of claim 2, wherein the improvement in skin condition is improvement in skin aging, promotion of skin regeneration, improvement in skin elasticity, improvement in skin wrinkles, or improvement in skin barrier.
4. 4. The composition of claim 2, wherein the composition has an activity to improve skin condition by one or more of the following activities: (i) Increasing the expression level of collagen iα1, fibronectin, and elastin genes, which are components of the extracellular matrix; (ii) Increasing the expression of procollagen iα1 and hyaluronic acid; (iii) Increasing the expression level of SIRT1 (sirtuin 1) and AQP3 (aquaporin 3) genes, which are skin barrier enhancers; (iv) Reducing the level of Reactive Oxygen Species (ROS) increased by Ultraviolet (UV) radiation; (v) Increasing the expression level of collagen iα1, fibronectin, and elastin genes, which are extracellular matrix components, reduced by UV irradiation; (vi) Increasing the expression level of SIRT1 and AQP3 genes as skin barrier enhancing factors reduced by UV irradiation, and (Vii) Reducing the level of MMP-1 expression increased by UV irradiation.
5. 5. The composition of claim 2, wherein the composition is a cosmetic composition.
6. 6. The composition of claim 5, wherein the cosmetic composition is in a form selected from the group consisting of solutions, suspensions, emulsions, pastes, gels, creams, lotions, powders, soaps, surfactant-containing cleaners, oils, powder foundations, emulsion foundations, waxy foundations, and sprays.
7. 7. A functional food composition for improving skin conditions, comprising a peptide comprising the amino acid sequence of SEQ ID NO. 1 as an active ingredient.
8. 8. The functional food composition of claim 7, wherein said improving skin condition is improving skin aging, promoting skin regeneration, improving skin elasticity, improving skin wrinkles, or improving skin barrier.
9. 9. A method of improving skin condition in a patient or subject in need thereof, the method comprising administering to the patient or subject a peptide comprising the amino acid sequence of SEQ ID NO:1 or a composition comprising the peptide as an active ingredient.

Description

Peptides having skin condition improving activity and uses thereof Cross Reference to Related Applications The present application claims priority from korean patent application No. 10-2023-0137616 filed on 10 months 16 of 2023, the disclosure of which is incorporated herein by reference in its entirety. Technical Field The present invention relates to novel peptides having skin condition improving activity and uses thereof. Background The skin is an organ covering all organs and organ systems of the human body, protects the body from external damage, and plays an important role in regulating homeostasis by preserving moisture and temperature in the body. Histologically, the skin consists of three layers, epidermis (epidermis), dermis (dermis) and subcutaneous layer (subcutis). Aging of skin can be classified into aging due to intrinsic factors and aging due to extrinsic factors. Aging due to intrinsic factors naturally occurs with age, and it is reported that decrease in skin cell activity due to genetic reasons such as telomere shortening is a cause of skin aging. Aging due to external factors occurs due to environmental factors such as sunlight, cold, wind and dust, and among these factors, ultraviolet rays and infrared rays of sunlight are known to be the most important causes. As skin ages, collagen (which is fibrous tissue that is used to support the skin structure) and elastic fibers harden. Meanwhile, basic substances (group subtotals) such as collagen and elastic fibers filled between cells and between fibrous materials have remarkably high ability to hold moisture, and as such basic substances and the like are reduced, elasticity of skin becomes weak and wrinkles occur. Representative of these base substances are hyaluronic acid (hyaluronic acid) and mucopolysaccharide (mucopolysaccharides), and as skin aging progresses, hyaluronidase (hyaluronidase) increases so that the amount of hyaluronic acid in dermis gradually decreases. In addition, active oxygen (free radical) induced by ultraviolet rays or produced by intracellular respiration reacts with unsaturated fatty acids of cell membranes to form new free radicals-peroxy free radicals (peroxyradical), and the substances cause a chain reaction in the presence of oxygen, thereby again inducing lipid peroxidation. Lipid peroxides can further enhance lipid peroxidation and impair the function of enzymes or receptor systems by reacting with proteins. As described above, active oxygen is a major cause of skin cell and tissue damage. In addition, active oxygen destroys the skin antioxidant defense system composed of antioxidant enzymes and non-enzyme antioxidants, thereby tilting the balance between the oxidizing agent and the antioxidant agent toward an oxidized state, and the sustained oxidative stress damages biological components through processes such as lipid peroxidation, protein oxidation, activation of proteolytic enzymes that destroy interstitial matrix components, chain cleavage and abnormal crosslinking of collagen and elastin which are elastic fibers, cleavage of hyaluronic acid chains, promotion of melanin production and DNA oxidation. Patent documents related to peptide active substances having an activity of improving skin aging or skin wrinkles are korean patent No. 10-2486996, korean patent No. 10-2507392, and PCT international patent application No. PCT-KR 2021-01278. [ Related art literature ] [ Patent literature ] Patent document 1 Korean patent No. 10-2486996 Patent document 2 Korean patent No. 10-2507392 Patent document 3 PCT International patent application No. PCT-KR 2021-01278 Disclosure of Invention Technical problem The present inventors have conducted studies to develop effective active substances useful for inhibiting skin aging and improving skin conditions such as improving skin wrinkles. As a result, the present inventors have experimentally confirmed that novel peptides synthesized by them have excellent activity of improving skin conditions not only for skin aging and prevention of skin wrinkles caused by intrinsic factors but also by extrinsic factors, thereby completing the present invention. It is therefore an object of the present invention to provide novel peptides having skin condition improving activity. It is another object of the present invention to provide a composition for improving skin conditions, which comprises a peptide as an active ingredient. Technical proposal In order to achieve the above-mentioned object of the present invention, In one aspect, the invention provides a peptide comprising the amino acid sequence shown in SEQ ID NO. 1. In another aspect of the invention, a composition for improving skin conditions is provided, the composition comprising a peptide as an active ingredient. Hereinafter, the present invention will be described in detail. Peptides and their activity According to one aspect of the present invention there is provided a peptide comprising the amino acid sequence shown in SE