CN-122029269-A - Powder supply device

Abstract

A powder supply device for continuously supplying powder to a mixing vessel in order to continuously prepare a biotechnology solution of a set concentration in the mixing vessel, the powder supply device comprising a1 st vessel for storing the powder and being connected to the mixing vessel via a feeder so as to supply the powder to the feeder, and a2 nd vessel for storing the powder and being connected to the 1 st vessel so as to supply the powder to the 1 st vessel.

Inventors

• Haragikawa Masataka
• Inoh Tatsuya
• YAMAMOTO TAKASHI

Assignees

• 富士胶片株式会社

Dates

Publication Date

20260512

Application Date

20240920

Priority Date

20230928

Claims (20)

1. 1. A powder supply device for continuously supplying powder to a mixing vessel in order to continuously prepare a bioprocess solution of a set concentration in the mixing vessel, The powder supply device is provided with: A1 st container which stores the powder and is connected to the mixing container via a feeder so as to supply the powder to the feeder, and And a2 nd container storing the powder and connected to the 1 st container so as to supply the powder to the 1 st container.
2. 2. The powder supplying device according to claim 1, wherein, The 2 nd container is replaceably connected to the 1 st container.
3. 3. The powder supplying device according to claim 1, wherein, The 1 st container expands and contracts.
4. 4. The powder supplying device according to claim 3, wherein, The 1 st container is closed.
5. 5. The powder supplying device according to claim 3, wherein, A portion of the 1 st container expands and contracts.
6. 6. The powder supplying device according to claim 1, wherein, The 2 nd container expands and contracts.
7. 7. The powder supplying device according to claim 6, wherein, The 2 nd container is closed.
8. 8. The powder supplying device according to claim 6, wherein, A portion of the 2 nd container expands and contracts.
9. 9. The powder supplying device according to claim 1, wherein, The 1 st container has a1 st vent.
10. 10. The powder supplying device according to claim 9, wherein, And supplying humidity-controlled air by a humidity control mechanism from the 1 st vent to the 1 st container.
11. 11. The powder supplying device according to claim 9, wherein, The 1 st container does not expand and contract.
12. 12. The powder supplying device according to claim 1, wherein, The 2 nd container has a 2 nd vent.
13. 13. The powder supplying device according to claim 12, wherein, The 2 nd container does not expand and contract.
14. 14. The powder supplying device according to claim 1, wherein, The 1 st container and the 2 nd container expand and contract.
15. 15. The powder supplying device according to claim 1, wherein, The 1 st container is expanded and contracted, The 2 nd container has a 2 nd vent.
16. 16. The powder supplying device according to claim 1, wherein, The 1 st container has a1 st vent, The 2 nd container is expanded and contracted, And supplying humidity-controlled air by a humidity control mechanism from the 1 st vent to the 1 st container.
17. 17. The powder supplying device according to claim 1, wherein, The 1 st container has a1 st vent, The 2 nd container has a 2 nd vent, And supplying humidity-controlled air by a humidity control mechanism from the 1 st vent to the 1 st container.
18. 18. The powder supplying device according to claim 1, wherein, The solvent mixed with the powder in the mixing container is purified water, the powder is a powder culture medium, The biotechnology solution is a culture medium.
19. 19. The powder supplying device according to claim 18, wherein, The culture medium is continuously supplied from the mixing vessel to a culture tank.
20. 20. The powder supplying device according to claim 1, wherein, The 1 st container and the 2 nd container are disposable after being used once.

Description

Powder supply device Technical Field The present invention relates to a powder supply device. Background Various biotechnological solutions are required for culturing chinese hamster ovary cells into which antibody genes have been embedded to obtain antibody drugs and the like. International publication No. 2021/123248 describes a method of continuously supplying a solvent and a powder to a mixing vessel and mixing the solvent and the powder in the mixing vessel, thereby continuously preparing a bioprocess solution of a set concentration. The mixing vessel is connected to a bioprocess vessel, from which the bioprocess solution is continuously supplied. The solvent is, for example, purified water such as pure water, the powder is, for example, a powder medium, and the bioprocess solution is, for example, a medium (culture solution). The bioprocess container is a culture tank, for example. Disclosure of Invention Problems to be solved by the invention For example, in continuous preparation of a long-term biotechnological solution for 1 month or the like, stable supply of the powder to the mixing vessel is not required. However, in International publication No. 2021/123248, no measures are taken for stable supply of the powder to the mixing vessel. An embodiment of the present invention provides a powder supply device that can contribute to stable supply of powder to a mixing container. Means for solving the problems The powder supply device is provided with a1 st container for storing powder and being connected with the mixing container via a feeder so as to supply the powder to the feeder, and a2 nd container for storing the powder and being connected with the 1 st container so as to supply the powder to the 1 st container, wherein the bioprocess solution with a set concentration is continuously prepared in the mixing container, and the powder is continuously supplied into the mixing container. Preferably, the 2 nd container is interchangeably connected with the 1 st container. Preferably, the 1 st container expands and contracts. Preferably, the 1 st container is closed. Preferably, a portion of the 1 st container expands and contracts. Preferably, the 2 nd vessel expands and contracts. Preferably, the 2 nd vessel is closed. Preferably, a portion of the 2 nd vessel expands and contracts. Preferably, the 1 st container has a1 st vent. Preferably, the 1 st container is supplied with the humidity control air by the humidity control mechanism from the 1 st vent. Preferably, the 1 st container does not expand or contract. Preferably, the 2 nd container has a2 nd vent. Preferably, the 2 nd vessel does not expand or contract. Preferably, the 1 st container and the 2 nd container expand and contract. Preferably, the 1 st container is inflated and deflated, and the 2 nd container has a2 nd vent. Preferably, the 1 st container has a1 st vent, and the 2 nd container expands and contracts, and the 1 st vent supplies the inside of the 1 st container with the humidity control air by the humidity control mechanism. Preferably, the 1 st container has a1 st vent, the 2 nd container has a2 nd vent, and the humidity control air by the humidity control mechanism is supplied from the 1 st vent into the 1 st container. Preferably, the solvent mixed with the powder in the mixing container is purified water, the powder is a powder culture medium, and the biotechnology solution is a culture medium. Preferably, the culture medium is continuously supplied from the mixing vessel to the culture tank. Preferably, the 1 st container and the 2 nd container are disposed after disposable use. Effects of the invention According to the technology of the present invention, it is possible to provide a powder supply device that can contribute to stable supply of powder to a mixing container. Drawings FIG. 1 is a diagram showing a culture medium preparing apparatus and a culture tank. FIG. 2 is a view showing a powder medium supply device. FIG. 3 is a view showing a process sequence of the powder medium supply apparatus. Fig. 4 is a view showing the 1 st container and the 2 nd container, a part of which is expanded and contracted. Fig. 5 is a view showing another example of the 1 st container partially expanded and contracted. FIG. 6 is a view showing a powder medium supply device according to embodiment 2. FIG. 7 is a view showing a powder medium supply device according to embodiment 3. Fig. 8 is a view showing another example of the humidity control mechanism. Fig. 9 is a view showing still another example of the humidity control mechanism. FIG. 10 is a view showing a powder medium supply device according to embodiment 4. Fig. 11 is a table summarizing the conceivable combinations of embodiment 1 and the evaluation thereof in which both the 1 st container and the 2 nd container expand and contract. Fig. 12 is a table summarizing the conceivable combinations of embodiment 2 and the evaluation thereof in which the 1 st container is expanded and c