CN-122029435-A - Automatic analysis device, diagnosis system, and diagnosis method

CN122029435ACN 122029435 ACN122029435 ACN 122029435ACN-122029435-A

Abstract

An automatic analyzer includes an ultrasonic vibrator including a piezoelectric body and an electrode attached to the piezoelectric body, and a control device for performing a failure diagnosis of the ultrasonic vibrator, wherein the control device defines and stores a normal range of an electrical impedance inherent to the ultrasonic vibrator based on a measured value of the electrical impedance obtained by applying a voltage to the electrode, and compares the measured value of the electrical impedance obtained by applying the voltage to the electrode at the time of the diagnosis with the normal range to perform the failure diagnosis of the ultrasonic vibrator.

Inventors

SUGINO FUMIYA
Takaei Tomoki
ZHOU GUANGBIN
Haruki Yoichiro

Assignees

株式会社日立高新技术

Dates

Publication Date: 20260512
Application Date: 20241031
Priority Date: 20240115

Claims (13)

1. An automatic analysis device, comprising: An ultrasonic vibrator including a piezoelectric body and an electrode attached to the piezoelectric body; a control device for performing a fault diagnosis of the ultrasonic transducer, It is characterized in that the method comprises the steps of, The control device defines and stores a normal range of electrical impedance inherent to the ultrasonic vibrator based on a measured value of electrical impedance obtained by applying a voltage to the electrode, and compares the measured value of electrical impedance obtained by applying a voltage to the electrode at the time of diagnosis with the normal range to perform fault diagnosis of the ultrasonic vibrator.
2. The automatic analyzer according to claim 1, wherein, The ultrasonic transducer used in the definition of the normal range is the same as the ultrasonic transducer for performing the failure diagnosis.
3. The automatic analyzer according to claim 1, wherein, The normal range is defined according to feature quantities extracted from the electrical impedance spectrum.
4. The automatic analyzer according to claim 3, wherein, The normal range includes a first normal range in which a minimum value of the electrical impedance and a frequency corresponding to the minimum value are defined as the feature quantity.
5. The automatic analyzer according to claim 4, wherein, The normal range includes a second normal range in which a maximum value of the electrical impedance and a frequency corresponding to the maximum value are defined as the characteristic amount.
6. The automatic analyzer according to claim 3, wherein, The control means defines the normal range based on a deviation of the feature quantity extracted for each electrical impedance spectrum obtained by a plurality of determinations using the electrodes.
7. The automatic analyzer according to claim 3, wherein, The ultrasonic vibrator has a plurality of electrodes with the same shape, The control means defines the normal range based on a deviation of a feature quantity extracted from the electrical impedance spectrum of each of the electrodes.
8. The automatic analyzer according to claim 1, wherein, The normal range of the electrical impedance inherent to the ultrasonic vibrator is defined based on a measured value of the electrical impedance obtained at the timing of estimating the normal state of the ultrasonic vibrator.
9. The automatic analyzer according to claim 1, wherein, The normal range is divided into a first region and a second region including the first region, The control device diagnoses that the ultrasonic vibrator is in a normal state when a measured value of an electrical impedance obtained by applying a voltage to the electrode is a value within a range of the first region at the time of diagnosis, diagnoses that the ultrasonic vibrator is in a failure state when a measured value of an electrical impedance obtained by applying a voltage to the electrode is a value outside a range of the second region at the time of diagnosis, and diagnoses that the ultrasonic vibrator is in a deteriorated state when a measured value of an electrical impedance obtained by applying a voltage to the electrode is a value outside a range of the first region and within a range of the second region at the time of diagnosis.
10. The automatic analyzer according to claim 1, wherein, The control device outputs an alarm to an output device when the ultrasonic vibrator is diagnosed as malfunctioning.
11. A diagnostic system having a control device for performing a fault diagnosis of an ultrasonic vibrator including a piezoelectric body and electrodes attached to the piezoelectric body, the ultrasonic vibrator being provided in an automatic analysis device, It is characterized in that the method comprises the steps of, The control device defines and stores a normal range of electrical impedance inherent to the ultrasonic vibrator based on a measured value of electrical impedance obtained by applying a voltage to the electrode, and compares the measured value of electrical impedance obtained by applying a voltage to the electrode at the time of diagnosis with the normal range to perform fault diagnosis of the ultrasonic vibrator.
12. The diagnostic system of claim 11, wherein the diagnostic device comprises a sensor, The control device is provided to the automatic analysis device.
13. A diagnostic method for diagnosing a fault of an ultrasonic vibrator comprising a piezoelectric body and electrodes attached to the piezoelectric body, the ultrasonic vibrator being provided in an automatic analyzer, It is characterized in that the method comprises the steps of, Defining a normal range of electrical impedance inherent to the ultrasonic vibrator based on a measured value of electrical impedance obtained by applying a voltage to the electrode, And comparing a measured value of the electrical impedance obtained by applying a voltage to the electrode during diagnosis with the normal range, and performing fault diagnosis of the ultrasonic vibrator.

Description

Automatic analysis device, diagnosis system, and diagnosis method Technical Field The present invention relates to an automatic analyzer having an ultrasonic vibrator, a diagnostic system and a diagnostic method for diagnosing whether the ultrasonic vibrator of the automatic analyzer is normal or abnormal. Background In an automatic analyzer, a sample and a reagent are dispensed into a reaction unit, stirred and reacted, and a specific component contained in the sample is quantitatively analyzed based on absorbance of a liquid after the reaction. In addition to a method of directly stirring the liquid in the reaction unit with a stirring rod, there is a non-contact method based on ultrasonic waves. Non-contact agitation by ultrasonic waves is useful for avoiding contamination between a sample and a reagent, and is used in some automatic analyzers. On the other hand, failure of the ultrasonic transducer that generates ultrasonic waves is directly related to degradation of accuracy and reproducibility of component analysis. In contrast, patent document 1 discloses a method of diagnosing an ultrasonic transducer based on the electrical impedance spectrum of the ultrasonic transducer. Prior art literature Patent literature Patent document 1 Japanese patent application laid-open No. 2022-177414 Disclosure of Invention Problems to be solved by the invention In patent document 1, regarding the electrical impedance, a normal parent group is generated in advance from a plurality of normal ultrasonic transducers, and a normal range defined by the normal parent group is compared with a measured value at the time of diagnosis, thereby performing a fault diagnosis of the ultrasonic transducers. However, the measured value of the electrical impedance of the ultrasonic transducer in the automatic analyzer also fluctuates due to factors other than the failure. For example, even if the corresponding ultrasonic transducers of the same type of automatic analyzer are different from each other, the measured value of the electrical impedance varies depending on the length of the wiring connected to the electrode, the route of retrieving the wiring, and the individual difference between the ultrasonic transducers. In the past, including the technique of patent document 1, a normal range was defined for each electrode of the ultrasonic transducer based on a plurality of data obtained by a plurality of automatic analyzers, and this normal range was commonly used for fault diagnosis of the ultrasonic transducer of the plurality of automatic analyzers under control. However, as described above, the normal range is a value obtained by statistics without considering the influence of various factors such as the wire length, which influence the measured value of the electrical impedance. Accordingly, the present inventors have found that there is room for improvement in the accuracy of diagnosis, depending on the automatic analyzer, in some cases, the ultrasonic transducer is diagnosed as normal. If it is determined that the ultrasonic vibrator is normal, the ultrasonic vibrator is replaced, which is not necessary in nature, and the operation rate of the automatic analyzer is reduced, and the number of man-hours and the cost of parts required for replacement may be increased to be more than necessary. The invention aims to provide an automatic analysis device, a diagnosis system and a diagnosis method capable of improving the reliability of fault diagnosis of an ultrasonic vibrator. Means for solving the problems In order to achieve the above object, the present invention provides an automatic analyzer comprising an ultrasonic vibrator including a piezoelectric body and an electrode attached to the piezoelectric body, and a control device for performing a failure diagnosis of the ultrasonic vibrator, wherein the control device defines and stores a normal range of an electrical impedance inherent to the ultrasonic vibrator based on a measured value of the electrical impedance obtained by applying a voltage to the electrode, and compares the measured value of the electrical impedance obtained by applying the voltage to the electrode at the time of the diagnosis with the normal range to perform the failure diagnosis of the ultrasonic vibrator. Effects of the invention According to the present invention, the reliability of the failure diagnosis of the ultrasonic vibrator of the automatic analyzer can be improved. Drawings FIG. 1 is a schematic diagram of a diagnostic system according to an embodiment of the present invention. Fig. 2 is a schematic diagram showing a cross section of an ultrasonic agitation mechanism and a driving system thereof included in an automatic analyzer according to an embodiment of the present invention. Fig. 3 is a diagram illustrating a difference in electrical impedance spectra between a normal ultrasonic transducer and a failed ultrasonic transducer. Fig. 4 is an explanatory view of a normal range of fault diagno