CN-122029616-A - Alarm state determination based on chemical information

Abstract

Systems and methods for determining an alarm state of a health index using the health index and one or more pieces of chemical information are disclosed. The chemical information may include potassium level, creatinine level, and the like. The determined alarm state may be provided to a user or process.

Inventors

• Pramodesinger Hirasinger Takur
• LI YINGBO
• MICHAEL J. KANE
• Victoria A. Averina

Assignees

• 心脏起搏器股份公司

Dates

Publication Date

20260512

Application Date

20241125

Priority Date

20231129

Claims (15)

1. 1. A medical device system, comprising: A signal receiver circuit configured to receive physiological information of a patient, and An evaluation circuit configured to determine a health index for the patient as a function of the received physiological information, Wherein the signal receiver circuit is configured to receive chemical information of the patient, and Wherein the evaluation circuit is configured to determine an alarm state of the patient using the determined health index and the received chemical information.
2. 2. The medical device system of claim 1, wherein the health index comprises a composite health index, wherein the evaluation circuit is configured to determine the composite health index for the patient as a function of at least two characteristics of the received physiological information.
3. 3. The medical device system of any one of claims 1-2, wherein to determine the alarm state of the patient, the evaluation circuit is configured to: Determining a first alarm state of the patient using the determined value of the health index and the health index alarm threshold, and A second alarm state is determined based on the determined first alarm state and the received chemical information of the patient.
4. 4. The medical device system of claim 3, wherein the second alarm state is one of a plurality of criteria-directed medical treatment (GDMT) alarm states associated with treatment adjustments, Wherein the evaluation circuit is configured to provide an output of the determined alarm state to a user interface for display to a user or to a control circuit to control or adjust a process or function of the medical device system.
5. 5. The medical device system of claim 4, wherein the evaluation circuit is configured to determine the first chemical parameter and the second chemical parameter using the received chemical information, Wherein the received chemical information includes at least one of potassium information or creatinine information of the patient, Wherein the first and second chemical parameters include an indication of a relatively high or low value of the received chemical information relative to one or more thresholds, Wherein, to determine the first alarm state, the evaluation circuit is configured to determine that the value of the determined health index is above the health index alarm threshold, and Wherein the evaluation circuit is configured to determine the second alarm state based on the determined first alarm state and at least one of the determined first chemical parameter and second chemical parameter.
6. 6. The medical device system of claim 5, wherein determining the second alarm state includes determining that potassium information of the patient is below a potassium threshold and that creatinine information of the patient is below a creatinine threshold, and Wherein the evaluation circuit is configured to provide a control signal to provide or increase a potassium-preserving diuretic in response to determining the second alarm state.
7. 7. The medical device system of claim 5, wherein determining the second alarm state includes determining that potassium information of the patient is above a potassium threshold and that creatinine information of the patient is below a creatinine threshold, and Wherein the evaluation circuit is configured to provide a control signal to provide or increase a thiazide diuretic in response to determining the second alarm state.
8. 8. The medical device system of claim 5, wherein determining the second alarm state includes determining that creatinine information of the patient is above a creatinine threshold, and Wherein the evaluation circuit is configured to provide a control signal to provide or increase a vasodilator in response to determining the second alarm state.
9. 9. The medical device system of any one of claims 3-8, wherein the health index comprises a heart failure index and the health index alarm threshold comprises a heart failure alarm threshold.
10. 10. A method, comprising: a signal receiver circuit is used to receive physiological information of a patient, An evaluation circuit is used to determine a health index for the patient as a function of the received physiological information, Receiving chemical information of a patient using the signal receiver circuit, and Using the evaluation circuit, an alarm state of the patient is determined using the determined health index and the received chemical information.
11. 11. The method of claim 10, wherein determining the alarm state of the patient comprises: Determining a first alarm state of the patient using the determined value of the health index and the health index alarm threshold, and A second alarm state is determined based on the determined first alarm state and the received chemical information of the patient.
12. 12. The method of claim 11, comprising: the output of the determined alarm state is provided to a user interface for display to a user, using the evaluation circuit, or to a control circuit to control or adjust a process or function of the medical device system, Wherein the second alarm state is one of a plurality of criteria-directed medical treatment (GDMT) alarm states associated with treatment adjustment.
13. 13. The method of claim 12, comprising using the evaluation circuit to determine a first chemical parameter and a second chemical parameter using the received chemical information, Wherein the received chemical information includes at least one of potassium information or creatinine information of the patient, Wherein the first and second chemical parameters include an indication of a relatively high or low value of the received chemical information relative to one or more thresholds, Wherein determining the first alarm state comprises determining that the value of the determined health index is above the health index alarm threshold, and Wherein determining the second alarm state comprises determining the second alarm state based on the determined first alarm state and at least one of the determined first and second chemical parameters.
14. 14. The method of claim 13, wherein determining the second alarm state comprises determining that the patient's potassium information is below a potassium threshold and the patient's creatinine information is below a creatinine threshold, and In response to determining the second alarm state, a control signal is provided to provide or increase a potassium-preserving diuretic.
15. 15. The method of claim 13, wherein determining the second alarm state comprises determining that the patient's potassium information is above a potassium threshold and the patient's creatinine information is below a creatinine threshold, and In response to determining the second alarm state, a control signal is provided to provide or increase a thiazide diuretic.

Description

Alarm state determination based on chemical information Priority claim The application claims the benefit of U.S. provisional application No. 63/604,054, filed on 11/29 of 2023, which is incorporated herein by reference in its entirety. Technical Field This document relates generally to medical devices and, more particularly, to determining or adjusting alarm conditions using health indices and chemical information. Background Ambulatory medical devices (Ambulatory MEDICAL DEVICE, AMD), including implantable, subcutaneous, wearable, or one or more other medical devices, etc., can monitor, detect, or treat a variety of diseases, including Heart Failure (HF), atrial fibrillation (atrial fibrillation, AF), etc. The ambulatory medical device can include a sensor that senses physiological information from the patient, and one or more circuits that detect one or more physiological events using the sensed physiological information or transmit the sensed physiological information or the detected physiological events to one or more remote devices. Frequent patient monitoring may provide early detection of worsening patient conditions, including worsening heart failure or atrial fibrillation. The accurate identification of patients or patient groups at high risk of future adverse events may control the mode or feature selection or resource management of one or more ambulatory medical devices, control notifications or messages in the connected system to various users associated with a particular patient or patient group, organize or schedule doctor or patient contact or treatment, or prevent or reduce patient hospitalization. The risk of worsening patient condition is properly identified and safely managed, avoiding unnecessary medical intervention, extending the life of ambulatory medical devices, and reducing medical care costs. Disclosure of Invention Systems and methods are disclosed to determine an alarm state for a health index using the health index and one or more pieces of chemical information. The chemical information may include potassium level, creatinine level, and the like. The determined alarm state may be provided to a user or process. Examples of the subject matter (e.g., a medical device system) may include a signal receiver circuit configured to receive physiological information of a patient, and an evaluation circuit configured to determine a health index of the patient as a function of the received physiological information, wherein the signal receiver circuit is configured to receive chemical information of the patient, and wherein the evaluation circuit is configured to determine an alarm state of the patient using the determined health index and the received chemical information. In an example, the health index includes a composite health index, and the evaluation circuit is configured to determine the composite health index of the patient as a function of at least two features of the received physiological information. In an example, which may be combined with any one or more of the preceding examples, to determine an alarm state of the patient, the evaluation circuit is configured to determine a first alarm state of the patient using the determined value of the health index and the health index alarm threshold, and to determine a second alarm state based on the determined first alarm state and the received chemical information of the patient. In an example, the example may be combined with any one or more of the preceding examples, the second alarm state is one of a plurality of criteria-directed medical treatment (GDMT) alarm states associated with treatment adjustment, wherein the evaluation circuit is configured to provide an output of the determined alarm state to a user interface for display to a user, or to a control circuit to control or adjust a process or function of the medical device system. In an example, the example may be combined with any one or more of the preceding examples, the evaluation circuit is configured to determine the first chemical parameter and the second chemical parameter using the received chemical information, wherein the received chemical information comprises at least one of potassium information or creatinine information of the patient, wherein the first chemical parameter and the second chemical parameter comprise an indication of a relatively high or low value of the received chemical information relative to one or more thresholds, wherein to determine the first alarm state, the evaluation circuit is configured to determine that the value of the determined health index is above the health index alarm threshold, and wherein the evaluation circuit is configured to determine the second alarm state based on the determined first alarm state and the determined at least one of the first chemical parameter and the second chemical parameter. In an example, the example may be combined with any one or more of the preceding examples, determining the second alarm stat