Search

CN-224198008-U - Production equipment for epinephrine hydrochloride liquid medicine

CN224198008UCN 224198008 UCN224198008 UCN 224198008UCN-224198008-U

Abstract

The utility model discloses production equipment of epinephrine hydrochloride liquid medicine, which relates to the technical field of liquid medicine filling, and comprises a first nitrogen curtain, a second nitrogen curtain and a charging barrel, wherein the first nitrogen curtain is respectively arranged at post-filling, preheating and wire drawing sealing stations, the first nitrogen curtain is communicated with a nitrogen source, the nitrogen source is communicated with the second nitrogen curtain, the second nitrogen curtain is arranged at a weighing station, the charging barrel is arranged at the liquid medicine filling station, the first nitrogen curtain is used for reducing residual oxygen in an ampoule bottle from the time of filling to the time of wire drawing sealing, the second nitrogen curtain is used for reducing residual oxygen in the weighing barrel, and the charging barrel is used for carrying out batching under the protection of nitrogen. The utility model reduces residual oxygen in the weighing barrel through the second nitrogen gas curtain, and the charging barrel is used for batching under the protection of nitrogen gas, so that the residual oxygen of raw materials is effectively reduced, and simultaneously, the time of exposing the ampoule bottle in the air is greatly shortened through the first nitrogen gas curtain, so that the residual oxygen in the ampoule bottle from the operation after filling to the operation before wiredrawing sealing is effectively reduced.

Inventors

  • HUANG FENGHUA
  • WANG HAINING
  • ZHAO YING
  • Yang Jiaxiao
  • WU HANCHEN
  • HUANG YI
  • LUO YANG
  • Zou Hongdi

Assignees

  • 津药和平(天津)制药有限公司

Dates

Publication Date
20260505
Application Date
20250514

Claims (10)

  1. 1. The production equipment of the epinephrine hydrochloride liquid medicine is characterized by comprising a first nitrogen gas curtain which is respectively arranged at post-filling, preheating and wire drawing sealing stations, wherein the first nitrogen gas curtain is communicated with a nitrogen gas source, and the nitrogen gas source is communicated with a second nitrogen gas curtain and a feeding barrel (3), the second nitrogen gas curtain is arranged at a weighing station, and the feeding barrel (3) is arranged at a liquid medicine filling station; The first nitrogen curtain is used for reducing residual oxygen in the ampoule bottle from the operation after filling to the operation before wiredrawing sealing; The second nitrogen curtain is used for reducing residual oxygen in the weighing barrel; The feeding barrel (3) is used for batching under the protection of nitrogen.
  2. 2. The production equipment of the epinephrine hydrochloride liquid medicine of claim 1, wherein the first nitrogen curtain comprises a gas distribution pipe (1), the gas distribution pipe (1) is communicated with a nitrogen source through a gas collection pipe, and a plurality of gas injection parts are arranged at equal intervals at one end of the gas distribution pipe (1) facing the ampoule bottle.
  3. 3. The production equipment of the epinephrine hydrochloride liquid medicine according to claim 2, wherein the air injection part comprises a plurality of air inflation needle tubes (11) communicated with the air distribution pipe (1), and the air inflation needle tubes (11) are arranged on the outer wall of the air distribution pipe (1) at equal intervals.
  4. 4. The production equipment of the epinephrine hydrochloride liquid medicine of claim 1, wherein the second nitrogen curtain comprises a flow equalizing box (2), the center of the top surface of the flow equalizing box (2) is fixedly connected and communicated with a first air inlet pipe (21) communicated with the nitrogen source, and two sides of the bottom of the flow equalizing box (2) are respectively fixedly connected with a supporting plate (24).
  5. 5. The production facility of adrenaline hydrochloride liquid medicine as claimed in claim 4, wherein the interior of the flow equalizing box (2) is divided into an air inlet part and an air outlet part by a flow equalizing film (23), and the air inlet part is arranged above the air outlet part.
  6. 6. The adrenaline hydrochloride liquid medicine production equipment as claimed in claim 5, wherein the air inlet part is communicated with a pressure gauge (22), and the pressure gauge (22) is arranged outside the flow equalizing box (2).
  7. 7. The adrenaline hydrochloride liquid medicine production facility of claim 1, wherein the top surface center of throwing bucket (3) fixedly connected with drain pipe (33), drain pipe (33) are connected with the liquid medicine filling station that is used for carrying out the filling to the ampoule through peristaltic pump intercommunication.
  8. 8. The apparatus for producing a pharmaceutical liquid of epinephrine hydrochloride according to claim 7, wherein a second air inlet pipe (32) and a hopper (34) which are communicated with the feeding barrel (3) are respectively arranged on both sides of the liquid outlet pipe (33).
  9. 9. The apparatus for producing a medicinal solution of epinephrine hydrochloride according to claim 8, wherein the second intake pipe (32) is in communication with the nitrogen source.
  10. 10. The adrenaline hydrochloride liquid medicine production equipment as claimed in claim 1, wherein the bottom center in the feeding barrel (3) is provided with a magnetic stirring rod (31) for stirring the liquid medicine.

Description

Production equipment for epinephrine hydrochloride liquid medicine Technical Field The utility model relates to the technical field of medicine liquid filling, in particular to production equipment of epinephrine hydrochloride medicine liquid. Background The method is characterized in that the raw material medicine of the epinephrine hydrochloride injection is extremely easy to oxidize, the character of the liquid medicine changes after oxidation, the color of the liquid medicine is deepened along with the deepening of the oxidation degree, the effect of residual oxygen in the liquid medicine is almost colorless to dark brown, the residual oxygen in the liquid medicine is very important to the character of a product, even the physicochemical data such as impurities are influenced, the lower the residual oxygen is, the better and more stable the product quality is from the aspect of product quality, however, the ampoule bottle mouth of the traditional equipment is in a normally open state from the liquid medicine filling to the wire drawing sealing position, namely, the post filling, preheating and wire drawing sealing position, and the air replacement is generated in the ampoule bottle from the filling to the wire drawing sealing position for about 6 seconds, so that the residual oxygen in the ampoule bottle is improved, and therefore, the method is needed to greatly shorten the time of exposing the opened ampoule bottle in the air by adding a nitrogen curtain to the post filling, preheating and wire drawing sealing position, and effectively reducing the residual oxygen in the ampoule bottle. Disclosure of utility model The utility model aims to provide an epinephrine hydrochloride liquid medicine production device which solves the problems existing in the prior art. The utility model provides equipment for producing epinephrine hydrochloride liquid medicine, which comprises a first nitrogen curtain, a second nitrogen curtain and a feeding barrel, wherein the first nitrogen curtain is respectively arranged at post-filling, preheating and wire drawing sealing stations, the first nitrogen curtain is communicated with a nitrogen source, the nitrogen source is communicated with the second nitrogen curtain and the feeding barrel, the second nitrogen curtain is arranged at a weighing station, the feeding barrel is arranged at a liquid medicine filling station, the first nitrogen curtain is used for reducing residual oxygen in an ampoule bottle from the time of filling to the time of wire drawing sealing, the second nitrogen curtain is used for reducing residual oxygen in a weighing barrel, and the feeding barrel is used for batching under the protection of nitrogen. Preferably, the first nitrogen gas curtain comprises a gas distribution pipe, the gas distribution pipe is communicated with a nitrogen source through a gas collection pipe, and a plurality of gas injection parts are arranged at equal intervals towards one end of the ampoule bottle. Preferably, the air injection part comprises a plurality of air inflation needle tubes communicated with the air distribution pipe, and the air inflation needle tubes are arranged on the outer wall of the air distribution pipe at equal intervals. Preferably, the second nitrogen curtain comprises a flow equalizing box, a first air inlet pipe communicated with the nitrogen source is fixedly connected and communicated with the center of the top surface of the flow equalizing box, and support plates are fixedly connected to two sides of the bottom of the flow equalizing box respectively. Preferably, the interior of the flow equalizing box is divided into an air inlet part and an air outlet part by a flow equalizing film, and the air inlet part is arranged above the air outlet part. Preferably, the air inlet part is communicated with a pressure gauge, and the pressure gauge is arranged outside the flow equalizing box. Preferably, the top surface center fixedly connected with drain pipe of throwing the storage bucket, the drain pipe is through peristaltic pump intercommunication has the liquid medicine filling station that is used for carrying out the filling to the ampoule. Preferably, the two sides of the liquid outlet pipe are respectively provided with a second air inlet pipe and a charging hopper which are communicated with the charging barrel. Preferably, the second air inlet pipe is communicated with the nitrogen source. Preferably, a magnetic stirring rod for stirring the liquid medicine is arranged at the center of the bottom in the feeding barrel. The utility model discloses the following technical effects: the utility model reduces residual oxygen in the weighing barrel through the second nitrogen curtain, and the charging barrel is used for batching under the protection of nitrogen, so that the residual oxygen of raw materials is effectively reduced, and simultaneously, the time of exposing the ampoule bottle in the air is greatly shortened through the first nitrogen