CN-224203018-U - Tumor marker detection device based on sers spectral technology

CN224203018UCN 224203018 UCN224203018 UCN 224203018UCN-224203018-U

Abstract

The utility model belongs to the technical field of marker detection, and particularly relates to a tumor marker detection device based on sers spectrum technology, which comprises a treatment bin, wherein a partition plate is arranged on the inner side of the treatment bin, the inside of the treatment bin is divided into an adsorption bin and a cleaning bin by the partition plate, an adsorption structure is arranged in the adsorption bin, a second drain pipe is arranged at the bottom of the adsorption bin, a central column is fixed at the central position of the partition plate in the treatment bin, a driving structure for driving the adsorption structure to move from the adsorption bin to the cleaning bin is arranged at the top of the central column, a detection bin is arranged at the bottom of the cleaning bin, a first drain pipe is arranged at the bottom of the detection bin, a detection component for detecting tumor markers is arranged in the detection bin, the adsorption structure comprises an adsorption plate, and first electromagnets are uniformly arranged in the adsorption plate. The utility model can accurately separate the target object and discharge the useless body fluid, obviously reduce impurity interference through cleaning, and greatly improve detection accuracy.

Inventors

WANG JIACHENG
Zhong Yemin
CHEN YUJIE
PAN JIAYI
ZHANG XINDI
XU JINYANG
Lin Ruile
GUO XIAOXUE
ZHU JIAYING
WANG SIQI

Assignees

福建铭仕途教育科技有限责任公司

Dates

Publication Date: 20260505
Application Date: 20250523

Claims (7)

1. The tumor marker detection device based on sers spectrum technology comprises a treatment bin (1) and is characterized in that a partition board (2) is arranged on the inner side of the treatment bin (1), and the inside of the treatment bin (1) is divided into an adsorption bin (3) and a cleaning bin (4) by the partition board (2); An adsorption structure is arranged in the adsorption bin (3), a second drain pipe (21) is arranged at the bottom of the adsorption bin (3), a center column (9) is fixed at the center position of the partition board (2) in the treatment bin (1), a driving structure is arranged at the top of the center column (9), the driving structure is used for driving the adsorption structure to move from the adsorption bin (3) to the cleaning bin (4), a detection bin (16) is arranged at the bottom of the cleaning bin (4), and a first drain pipe (18) is arranged at the bottom of the detection bin (16); And a detection component for detecting tumor markers is arranged in the detection bin (16).
2. The device for detecting tumor markers based on sers spectrum technology according to claim 1, wherein the adsorption structure comprises an adsorption plate (5), and first electromagnets (7) are uniformly arranged in the adsorption plate (5).
3. The device for detecting tumor markers based on sers spectrum technology according to claim 2 is characterized in that a tangential plane (8) is arranged on the upper surface of the adsorption plate (5).
4. The device for detecting tumor markers based on sers spectrum technology according to claim 2 is characterized in that liquid leakage holes (6) are uniformly formed in the adsorption plate (5).
5. The tumor marker detection device based on sers spectrum technology according to claim 2, wherein the driving structure comprises a rotating piece (10) rotatably connected to the top of the central column (9), a half gear (11) is fixed on the outer side of the rotating piece (10), a rotating gear (12) is connected on the outer side of the half gear (11) in a meshed manner, a motor (13) is installed on the outer side of the treatment bin (1), and the output end of the motor (13) is vertically upwards connected with the rotating gear (12) through a connecting rod; The electric push rod (14) is arranged in the rotary plate (10) and far away from the center of the rotary plate (10), an adsorption iron plate (15) is vertically fixed downwards on a travel rod of the electric push rod (14), and the adsorption iron plate (15) is attached to the center of the top of the adsorption plate (5) and adsorbed by the first electromagnet (7).
6. The tumor marker detection device based on sers spectrum technology according to claim 1, wherein the detection assembly comprises a second electromagnet (17) installed inside the detection bin (16), a protective cover (19) is installed in the detection bin (16) and located on the outer side of the second electromagnet (17), and a laser emitter (20) is installed in the detection bin (16) and located on the obliquely upper side of the protective cover (19).
7. The device for detecting tumor markers based on sers spectral technology according to claim 6, wherein the top of the protective cover (19) is provided with an inclined plane.

Description

Tumor marker detection device based on sers spectral technology Technical Field The utility model belongs to the technical field of marker detection, and particularly relates to a tumor marker detection device based on sers spectrum technology. Background The tumor marker detection plays a very critical role in early diagnosis of tumor, has great significance in improving the survival rate and the treatment effect of cancer patients, and at present, the Surface Enhanced Raman Spectroscopy (SERS) technology has great attention in the field of tumor marker detection by virtue of the outstanding advantages of high detection sensitivity, capability of providing component fingerprint information and the like; In the related technology of the existing tumor marker detection device based on the SERS spectrum technology, detection of a tumor marker can be realized, for example, some devices can realize detection of a low-concentration tumor marker by constructing a specific SERS substrate and utilizing the enhancement effect of the metal structure surface to ensure that a Raman signal is greatly amplified when molecules are adsorbed on metal colloid nano particles or a rough metal surface; However, in the actual detection process, the clinical sample often has complex components, and the sample contains not only tumor markers, but also a large amount of other impurities, such as various proteins, cell fragments, metabolites and the like, which interfere with the detection of the tumor markers and reduce the detection accuracy; In addition, in the detection process, how to effectively separate and enrich the tumor markers is also a great difficulty, and the traditional detection method is difficult to accurately separate the tumor markers from complex body fluid, so that the unnecessary body fluid components can interfere with detection signals during detection, and the reliability of detection results is greatly reduced; based on this, the present utility model aims to improve the existing tumor marker detection device based on SERS spectroscopy technology. Disclosure of utility model The utility model aims to provide a tumor marker detection device based on sers spectrum technology, which can accurately separate a target object and discharge useless body fluid, remarkably reduces impurity interference through cleaning, and greatly improves detection accuracy. The technical scheme adopted by the utility model is as follows: The tumor marker detection device based on sers spectrum technology comprises a treatment bin, wherein a baffle is arranged on the inner side of the treatment bin, and the interior of the treatment bin is divided into an adsorption bin and a cleaning bin by the baffle; An adsorption structure is arranged in the adsorption bin, a second drain pipe is arranged at the bottom of the adsorption bin, a central column is fixed at the central position of the partition plate in the treatment bin, a driving structure for driving the adsorption structure to move from the adsorption bin to the cleaning bin is arranged at the top of the central column, a detection bin is arranged at the bottom of the cleaning bin, and a first drain pipe is arranged at the bottom of the detection bin; And a detection component for detecting tumor markers is arranged in the detection bin. The adsorption structure comprises an adsorption plate, and first electromagnets are uniformly arranged in the adsorption plate. The upper surface of the adsorption plate is provided with a tangent plane. The inside of adsorption plate evenly is provided with weeping hole. The driving structure comprises a rotating piece rotatably connected to the top of the center column, a half gear is fixed on the outer side of the rotating piece, a rotating gear is connected to the outer side of the half gear in a meshed mode, a motor is installed on the outer side of the treatment bin, and the output end of the motor is vertically upwards connected with the rotating gear through a connecting rod; The electric push rod is arranged in the rotating piece and far away from the center of the rotating piece, an adsorption iron piece is vertically fixed downwards on a travel rod of the electric push rod, and the adsorption iron piece is attached to the center of the top of the adsorption plate and is adsorbed by the first electromagnet. The detection assembly comprises a second electromagnet arranged in the detection bin, a protective cover is arranged in the detection bin and positioned on the outer side of the second electromagnet, and a laser transmitter is arranged in the detection bin and positioned above the protective cover in an inclined manner. The top of the protective cover is provided with an inclined plane. The utility model has the technical effects that: According to the utility model, the tumor markers can be separated from a complex body fluid environment by utilizing the magnetic bead probes to specifically adsorb the tumor markers, then the a