CN-224207131-U - Self-driven deformed neural pad pasting

Abstract

The utility model belongs to the technical field of medical biological materials, and particularly relates to a self-driven deformable neural pad pasting. The self-driven deformed nerve pad pasting comprises a self-driven layer (1) and an adhesive layer (2), wherein the self-driven layer (1) comprises at least two nanofiber layers, the porosity of the nanofiber layers is distributed in a gradient manner from small to large from the upper surface to the lower surface of the self-driven layer (1), the adhesive layer (2) is arranged above the upper surface of the self-driven layer (1), and the adhesive layer (2) is used for adhering the whole self-driven deformed nerve pad pasting to a nerve adventitia. The self-driven deformation neural pad provided by the utility model can realize self-driven deformation in the presence of tissue fluid, realize dynamic adaptation and wrapping, and reduce the complexity of surgical operation.

Inventors

• WEN YONGQIANG
• AN HENG

Assignees

• 北京科技大学

Dates

Publication Date

20260508

Application Date

20250121

Claims (5)

1. 1. A self-driven deformed neural patch, characterized in that the self-driven deformed neural patch comprises a self-driven layer (1) and an adhesive layer (2); The self-driven layer (1) comprises at least two nanofiber layers, and the porosity of the nanofiber layers is distributed in a gradient manner from small to large in the direction from the upper surface to the lower surface of the self-driven layer (1); The adhesive layer (2) is arranged above the upper surface of the self-driven layer (1), and the adhesive layer (2) is used for adhering the whole self-driven deformable neural adhesive film on the adventitia.
2. 2. The self-driven deformable neural pad according to claim 1, wherein the thickness of the self-driven layer (1) is 1mm to 5mm, the thickness of the adhesive layer is 0.2mm to 1mm, and the thickness ratio of the self-driven layer (1) to the adhesive layer (2) is in the range of 1 (0.1 to 1).
3. 3. A self-driving deformation neural patch according to claim 1, characterized in that the self-driving layer (1) comprises 2-4 nanofiber layers.
4. 4. The self-driven deformable neural pad pasting according to claim 3, wherein the diameter range of the nanofibers in the nanofiber layer is 100nm-500nm, the porosity of the nanofiber layer is 30% -70%, and the porosity of two adjacent nanofiber layers is 5% -30%.
5. 5. The self-driving deformation neural patch of claim 1, wherein the self-driving deformation neural patch has a circular, oval, rectangular shape.

Description

Self-driven deformed neural pad pasting Technical Field The utility model belongs to the technical field of medical biological materials, and particularly relates to a self-driven deformable neural pad pasting. Background Peripheral nerve injury is a major challenge in clinical medicine, especially for the treatment of dissociative nerve injury. Such injuries typically require the connection of the injured proximal nerve to the distal nerve so that the axons of the proximal nerve can regenerate and extend along the distal nerve, ultimately restoring the function of the nerve. However, there are several situations in the clinic that make it difficult to achieve direct access to the distal nerve, thereby affecting the repair effect. Particularly in some patients, there is a longer gap between the proximal and distal nerves (e.g., a neurological deficit) or a proximal nerve loss (e.g., an brachial plexus root avulsion). In this case, it becomes very difficult to suture the proximal and distal nerves directly, and the repair effect tends to be undesirable and the recovery of nerve function is limited. For these patients, traditional nerve suturing methods have been difficult to meet repair needs and are prone to a range of complications. Currently, conventional nerve repair methods are typically performed by appropriately pulling the adventitia of the proximal nerve and suturing it to the adventitia of the distal nerve. However, when the diameter of the proximal nerve differs significantly, or there is no properly matched nerve conduit, the adventitia of the suture point may be stripped off, increasing the risk of neuroma formation, and even resulting in nerve suture failure. Therefore, aiming at the nerve diameter difference of different patients, a large gap exists between the nerve conduit and the nerve of the standard model, so that the artificial nerve conduit bracket which is adaptive, seamless and fast closed is developed as a substitute, and the artificial nerve conduit bracket has important clinical significance and application prospect. There are a number of nerve conduit products on the market today that aim to improve and promote nerve repair, especially for repair of peripheral nerve damage. Patent CN202210377724.2 discloses a double-layer tubular product, which is provided with a tubular outer layer and a tubular inner layer which is tightly attached to the inner wall, wherein the weight ratio of the outer layer to the inner layer is 100:20-100, and the thickness of the tube wall is 50-500 mu m. The design is mainly used for promoting the regeneration of defective nerves. Patent CN202110504965.4 the nerve conduit employs a technique of active oxygen response hydrogen sulfide release, utilizing excess active oxygen in the peripheral nerve injury to activate the hydrogen sulfide donor within the conduit. The release of hydrogen sulfide helps to anti-inflammatory, antioxidant and modulate macrophage polarization, thereby improving the neural repair microenvironment and providing targeted drug delivery. Patent CN201820330275.5 discloses a nerve sleeve for nerve transposition repair, which is designed to comprise a small-diameter section, a large-diameter section and a middle-diameter section, is connected with a gap through a row of pore canals, is suitable for realizing tension-free suture during nerve transposition repair, simplifies the operation process and promotes nerve regeneration. The patent CN2015110825106. X is a double-layer fiber nerve repair sleeve, wherein the inner layer is an oriented polymer fiber layer, the outer layer is a non-woven polymer fiber layer, the fiber direction of the inner layer is favorable for the growth of neurons along the fibers, and the outer layer provides structural support, so that the strength and the stability of the sleeve are enhanced. While the prior art provides a variety of methods of nerve repair, there are still difficulties such as inadaptation to individual differences, inability to achieve completely tensionless repair, difficulty in treating large interstitial nerve injuries, and lack of adaptive and responsive repair materials. Therefore, there is an urgent need for a new nerve repair material that can solve the shortcomings of the prior art, and particularly provide a more effective and flexible solution when dealing with the problems of nerve defects, nerve diameter mismatch, long gap repair, and the like. Disclosure of utility model Aiming at the technical problems, the utility model provides a self-driven deformed neural pad pasting. The film can be self-driven to deform under the stimulation of a humidity environment, so that dynamic adaptation and wrapping are realized, and the complexity of a surgical operation is reduced. The utility model is realized by the following technical scheme: A self-driven deformed neural patch comprising a self-driven layer (1) and an adhesive layer (2); The self-driven layer (1) comprises at least two nanofibe