CN-224207454-U - Auxiliary observation device for chromatographic column loading

Abstract

The utility model discloses an auxiliary observation device for chromatographic column loading, which belongs to the field of experimental instruments and comprises two fixing structures and a strip-shaped light source connected between the two fixing structures, wherein the two fixing structures are detachably and fixedly connected to the outer wall of a chromatographic column when in use. According to the utility model, through the arrangement of the two fixing structures and the strip-shaped light source connected between the two fixing structures, the strip-shaped light source can be axially arranged on the outer wall of the chromatographic column through the two fixing structures, and the chromatographic column is irradiated through a plurality of light source points on the strip-shaped light source, so that the chromatographic column can be strongly and uniformly irradiated everywhere along the length direction of the chromatographic column, the adhesive surface can be conveniently and rapidly observed, and the column loading efficiency and success rate are improved.

Inventors

• ZHOU JIAJIA
• CHENG GUANGYAN
• DU LINA

Assignees

• 上海思伦生物科技有限公司

Dates

Publication Date

20260508

Application Date

20250115

Claims (10)

1. 1. The auxiliary observation device for chromatographic column loading is characterized by comprising two fixing structures and a strip-shaped light source connected between the two fixing structures, wherein the two fixing structures are detachably and fixedly connected to the outer wall of a chromatographic column when in use.
2. 2. The device of claim 1, wherein the securing structure comprises a base and a strap attached to the base.
3. 3. The device of claim 2, wherein a channel for the strip light source to pass through is formed in a base in one of the fixing structures, and a pressing member for pressing the strip light source is screwed on the base.
4. 4. The apparatus of claim 3, wherein the working end of the compression member is provided with a buffer spacer.
5. 5. The device of claim 2, wherein a switch is disposed on the base of the other of the fixed structures, the band light source is fixed on the base, and the band light source is electrically connected to the switch.
6. 6. The apparatus of claim 5, wherein the base is further provided with a power source electrically connected to the switch.
7. 7. The device of claim 6, wherein the power source is a battery and the base is provided with a USB charging interface for charging the battery.
8. 8. The device of claim 2, wherein the strap comprises two opposite side sub-straps secured to the base, one of the sub-straps having a buckle head and the other sub-strap having a plurality of buckle holes spaced apart along the length thereof.
9. 9. The device of claim 2, wherein the strap is made of rubber.
10. 10. The apparatus of claim 1, wherein the strip light source is a COB glue-filled lamp strip.

Description

Auxiliary observation device for chromatographic column loading Technical Field The utility model relates to the field of experimental instruments, in particular to an auxiliary observation device for chromatographic column loading. Background Purification of proteins using chromatography columns is a common and important procedure in downstream purification laboratories. The chromatographic column is arranged as an indispensable operation flow in a purification laboratory, and the effect directly influences the quality and efficiency of the subsequent protein purification. At present, two general methods for observing the gel surface in the column loading process of the chromatographic column are a natural light source observation method and an artificial light source observation method such as a mobile phone, a flashlight and the like. The natural light source observation method has the following two defects that (1) the natural light source observation method is very dependent on the quality of lamplight in a laboratory. If the factors such as insufficient light and over-intensity can have adverse effects on the position of the adhesive surface, the position of the adhesive surface is difficult to clearly observe. (2) inconvenient operation. When packing the chromatographic column with the diameter of more than 2.6 cm, because the volume of the chromatographic column is large, natural light is difficult to fully irradiate all parts in the column, so that the rubber surface position cannot be observed, and the position of the chromatographic column with the larger diameter can be required to be continuously adjusted to find a proper natural light angle, thereby increasing the complexity and difficulty of operation. Although the artificial light source observation methods such as mobile phones and flashlights can make up for the defects of the natural light source observation methods to a certain extent, the following disadvantages still exist (1) the light source is in a dot shape and the observation range is small. The artificial light sources such as a mobile phone and a flashlight show a dot shape on the chromatographic column, which means that the irradiation range is limited, when a rubber surface is found, the position of the light source is required to be continuously moved, the rubber surface is difficult to find rapidly, the column mounting time is prolonged, the experimental progress is influenced, and in the process of finding the rubber surface, other interference factors can be introduced due to frequent movement of the light source, so that the difficulty of column mounting is further increased. The method for observing the gel surface in the column loading process of the chromatographic column has a plurality of problems, which not only affect the column loading efficiency, but also increase the risk of column loading failure. Therefore, a new solution is urgently needed, which can overcome the defects of the existing method and provide a more convenient and accurate glue surface observation mode so as to improve the efficiency and success rate of chromatographic column packing. Disclosure of Invention Aiming at the problem that the gel surface is difficult to be observed rapidly in the column loading process of the chromatographic column in the prior art, the utility model aims to provide an auxiliary observation device for loading the chromatographic column so as to at least partially solve the problem. In order to achieve the above purpose, the technical scheme of the utility model is as follows: An auxiliary observation device for chromatographic column loading comprises two fixing structures and a strip-shaped light source connected between the two fixing structures, wherein the two fixing structures are detachably and fixedly connected to the outer wall of a chromatographic column when in use. In some preferred embodiments, the securing structure includes a base and a strap attached to the base. In some preferred embodiments, a channel for the strip-shaped light source to pass through is formed on a base in one of the fixing structures, and a pressing piece for pressing the strip-shaped light source is further screwed on the base. In some preferred embodiments, the working end of the compression member is provided with a bumper pad. In some preferred embodiments, a switch is disposed on the base in the other fixing structure, the strip-shaped light source is fixed on the base, and the strip-shaped light source is electrically connected with the switch. In some preferred embodiments, the base is further provided with a power source electrically connected to the switch. In some preferred embodiments, the power source is a battery, and the base is provided with a USB charging interface for charging the battery. In some preferred embodiments, the strap comprises sub-straps secured to opposite sides of the base, respectively, wherein one of the sub-straps is provided with a button head and