CN-224207771-U - Liquid separating device for tangential flow filtration system

CN224207771UCN 224207771 UCN224207771 UCN 224207771UCN-224207771-U

Abstract

The utility model relates to a liquid separating device for a tangential flow filtration system, which comprises a cover plate, a back plate and a mounting plate, wherein the cover plate is hinged with the back plate, the mounting plate is arranged at one end of the back plate, which is far away from the cover plate, corresponding main path hose mounting grooves and a plurality of branch path hose mounting grooves are formed in the side wall of one end of the cover plate, which is opposite to the back plate, and are communicated with the main path hose mounting grooves, the main path hose mounting grooves and the branch path hose mounting grooves are respectively used for mounting main path hoses and branch path hoses, a plurality of blocking mechanisms which are arranged in one-to-one correspondence with the branch path hose mounting grooves are arranged on the mounting plate, the blocking mechanisms are arranged to block the branch path hoses, and a locking mechanism is arranged on the back plate and is arranged to lock the cover plate and the back plate. The utility model can realize the automatic switching of different liquids in the tangential flow filtration system, reduces the labor cost and improves the working efficiency of the tangential flow filtration.

Inventors

WANG TAO
GU FENG
Xiao Kaihang
LI XUE
SUN ZHENTAO

Assignees

鲸智时代科技(北京)有限公司

Dates

Publication Date: 20260508
Application Date: 20250530

Claims (10)

1. A liquid separation device for a tangential flow filtration system, comprising a cover plate (1), a back plate (2) and a mounting plate (3), wherein: the cover plate (1) is hinged with the back plate (2), and the mounting plate (3) is arranged at one end of the back plate (2) far away from the cover plate (1); the side wall of one end of the cover plate (1) opposite to the backboard (2) is provided with a main path hose installation groove (14) and a plurality of branch path hose installation grooves (15) which are corresponding to each other, and the branch path hose installation grooves (15) are communicated with the main path hose installation groove (14), wherein the main path hose installation groove (14) and the branch path hose installation grooves (15) are respectively used for installing a main path hose (17) and a branch path hose (18); A plurality of blocking mechanisms which are arranged in one-to-one correspondence with the branch hose installation grooves (15) are arranged on the installation plate (3), and the blocking mechanisms are arranged to be capable of blocking the branch hoses (18); The backboard (2) is provided with a locking mechanism, and the locking mechanism is arranged to lock the cover plate (1) and the backboard (2).
2. The liquid separating device for a tangential flow filtration system according to claim 1, wherein the blocking mechanism comprises a branch telescopic motor (8) mounted on the mounting plate (3), a plurality of branch telescopic motors (8) are arranged in one-to-one correspondence with a plurality of branch hose mounting grooves (15), and a branch blocking block (10) is mounted on the telescopic end of the branch telescopic motor (8); The backboard (2) is provided with a plurality of branch pipe through blocking holes (12) which are arranged in a one-to-one correspondence with the branch pipe hose installation grooves (15) and are respectively communicated with the branch pipe hose installation grooves (15), the branch pipe through blocking blocks (10) are respectively positioned in the branch pipe through blocking holes (12), and one end, away from the branch pipe telescopic motor (8), of the branch pipe through blocking blocks (10) is used for conducting through blocking on the branch pipe hose (18).
3. A liquid separator for tangential flow filtration system according to claim 2, wherein the end of the branch passage block (10) remote from the branch telescopic motor (8) is of hemispherical structure; The cover plate (1) is close to one end of the backboard (2) and is provided with a plurality of branch hemispherical grooves which are arranged in one-to-one correspondence with the branch through blocking blocks (10), and the hemispherical structure of the branch through blocking blocks (10) is matched with the branch hemispherical grooves and is arranged to be capable of moving into the branch hemispherical grooves.
4. A liquid separator for tangential flow filtration system according to claim 1, wherein the locking mechanism comprises a locking lever (5) rotatably mounted on the back plate (2), wherein the cover plate (1) and the back plate (2) are provided with locking grooves (7) in communication, and wherein the locking lever (5) is arranged to be displaceable into the locking grooves (7); One end of the locking rod (5) far away from the backboard (2) is in threaded connection with a locking knob (6), and one end of the locking knob (6) close to the locking rod (5) is arranged to be capable of being abutted to one end of the cover plate (1) far away from the backboard (2) so as to lock the cover plate (1) with the backboard (2).
5. The liquid separation device for a tangential flow filtration system according to claim 4, wherein a locking mounting block (4) is detachably mounted on the back plate (2), the locking lever (5) is rotatably mounted on the locking mounting block (4), and the locking lever (5) is rotatably connected with the back plate (2) through the locking mounting block (4).
6. The liquid separating device for the tangential flow filtration system according to claim 4, wherein a locking knob placing groove (16) communicated with a locking groove (7) is formed at one end of the cover plate (1) far away from the back plate (2), and the locking knob placing groove (16) is matched with one end of the locking knob (6) close to the locking rod (5); When the cover plate (1) and the back plate (2) are locked, one end, close to the locking rod (5), of the locking knob (6) is positioned in the locking knob placing groove (16) and is abutted to the inner wall of one end, far away from the back plate (2), of the locking knob placing groove (16).
7. The liquid separating device for a tangential flow filtration system according to claim 2, wherein a main path telescopic motor (9) which is arranged corresponding to the main path hose installation groove (14) is installed on the installation plate (3), the main path telescopic motor (9) is positioned on the same side of a plurality of the branch path telescopic motors (8), and a main path blocking block (11) is installed on the telescopic end of the main path telescopic motor (9); The back plate (2) is provided with a main passage blocking hole (13) communicated with the main passage hose installation groove (14), the main passage blocking block (11) is positioned in the main passage blocking hole (13), and one end, far away from the main passage telescopic motor (9), of the main passage blocking block (11) is used for blocking the main passage hose (17).
8. The liquid separator for tangential flow filtration system of claim 7, wherein the end of the main passage block (11) remote from the main passage telescopic motor (9) is of hemispherical structure; The cover plate (1) is close to one end of the backboard (2) and is provided with a main road hemispherical groove which is arranged corresponding to the main road blocking block (11), and the hemispherical structure of the main road blocking block (11) is matched with the main road hemispherical groove and is arranged to be capable of moving into the main road hemispherical groove.
9. The liquid separation device for tangential flow filtration system according to claim 5, characterized in that the top ends of the cover plate (1) and the back plate (2) are provided with hinges by which the cover plate (1) and the back plate (2) are hinged to each other; The locking installation block installation groove that is linked together with locking groove (7) has been seted up to the bottom of backplate (2), just locking installation block installation groove with locking installation block (4) looks adaptation, locking installation block (4) demountable installation is in the locking installation block installation groove, in order with backplate (2) demountable connection.
10. A liquid separator for tangential flow filtration system according to claim 1, wherein the cover plate (1) and the back plate (2) are each of a double layer structure.

Description

Liquid separating device for tangential flow filtration system Technical Field The utility model relates to the technical field of tangential flow filtration, in particular to a liquid separating device for a tangential flow filtration system. Background Tangential flow filtration is a fundamental unit of operation in biopharmaceutical processes that allows for the separation of cells and derivatives in cells in a feed solution, and thus the selective separation of target products, using hollow fiber modules (according to different molecular weight cut-off pore sizes) in the tangential flow filter. For example, in vaccine or antibody production, when feed liquid (e.g., cell culture liquid) flows into the tangential flow filter, intact cells are directly trapped by the tangential flow filter, and derivatives (e.g., proteins, viral vectors or DNA fragments) released after cell disruption are selectively separated according to the molecular weight difference, i.e., small molecule metabolic waste and other impurities are discharged with the filtrate, and macromolecular target products (e.g., antibodies, vaccine components) are trapped, thereby achieving separation of the target products. In the tangential flow filtration, different liquids, such as lye, water, buffer, feed liquid (e.g., cell culture liquid) and the like, need to be introduced into the tangential flow filtration system according to the actual working conditions. Specifically, for example, before the tangential flow filtration is required, alkali liquor and water need to be sequentially introduced into the tangential flow filtration system in advance to disinfect, rinse and rinse the pipelines and the tangential flow filters in the tangential flow filtration system, then buffer solution needs to be introduced into the tangential flow filtration system to infiltrate the tangential flow filters, and finally, the feed liquor can be introduced into the tangential flow filtration system to perform the tangential flow filtration. However, at present, when the operation is performed, the different liquids are required to be sequentially switched and introduced into the tangential flow filtration system by relying on manpower, which is time-consuming and labor-consuming, greatly increases the labor cost and reduces the working efficiency of tangential flow filtration. Therefore, how to realize the automatic switching of different liquids in the tangential flow filtration system, namely, how to rely on the manual work to sequentially introduce different liquids into the tangential flow filtration system, so that the labor cost can be reduced, the working efficiency of the tangential flow filtration can be improved, and the problem to be solved is urgent. Disclosure of utility model It is an object of the present utility model to provide a liquid separation device for tangential flow filtration systems that solves the above mentioned problems of the prior art. In order to achieve the above object, the present utility model provides the following solutions: The utility model provides a liquid separating device for a tangential flow filtration system, which comprises a cover plate, a back plate and a mounting plate, wherein: The cover plate is hinged with the back plate, and the mounting plate is arranged at one end of the back plate far away from the cover plate; The side wall of one end of the cover plate, which is opposite to the backboard, is provided with a main path hose installation groove and a plurality of branch hose installation grooves, and the branch hose installation grooves are communicated with the main path hose installation groove; The mounting plate is provided with a plurality of blocking mechanisms which are arranged in one-to-one correspondence with the branch hose mounting grooves, and the blocking mechanisms are arranged to block the branch hoses; The locking mechanism is arranged on the backboard and can lock the cover plate and the backboard. According to one embodiment of the utility model, the blocking mechanism comprises a branch telescopic motor arranged on the mounting plate, a plurality of branch telescopic motors are arranged in one-to-one correspondence with a plurality of branch hose mounting grooves, and branch blocking blocks are arranged on telescopic ends of the branch telescopic motors; The backboard is provided with a plurality of branch pipe blocking holes which are arranged in one-to-one correspondence with the branch pipe hose installation grooves and are respectively communicated with the branch pipe hose installation grooves, the branch pipe blocking blocks are respectively positioned in the branch pipe blocking holes, and one end, away from the branch pipe telescopic motor, of the branch pipe blocking block is used for blocking the branch pipe hose. According to one embodiment of the utility model, one end of the branch passage blocking block, which is far away from the branch telescopic motor, is of a hemispher