CN-224207979-U - Fixed trickle bed reactor capable of stably trickling

Abstract

The application discloses a fixed trickle bed reactor capable of stabilizing trickle, which comprises a cylinder, an upper end enclosure arranged at the upper end of the cylinder and a lower end enclosure arranged at the lower end of the cylinder, wherein a trickle distributor and a reaction tube are arranged in the cylinder from top to bottom, the trickle distributor is provided with a trickle tube, the trickle tube is in butt joint with the reaction tube, a liquid-phase feed pipe and a gas-phase feed pipe are arranged on the cylinder or the upper end enclosure, the cylinder and the trickle distributor form a closed cavity, the fixed trickle bed reactor capable of stabilizing trickle also comprises a liquid level sensor, a pressure sensor and a pressure stabilizing tube, wherein the liquid level sensor is used for detecting the liquid level of liquid-phase materials in the closed cavity, one end of the pressure stabilizing tube is communicated with the closed cavity, the other end of the pressure stabilizing tube is used for being connected with a pressure stabilizing air source, and the regulating valve is arranged on the pressure stabilizing tube. When the material is stopped or the material is stopped, the pressure-stabilizing pipe is used for conveying pressure-stabilizing gas to the closed cavity, so that the air pressure in the closed cavity is kept, and the stable dripping of the residual materials in the stopping stage is realized.

Inventors

• LI JIANJUN
• ZHANG DAN
• PAN ZHIHAO
• MA LIEJUN

Assignees

• 浙江德力装备有限公司

Dates

Publication Date

20260508

Application Date

20250528

Claims (10)

1. 1. The utility model provides a stationary type trickle bed reactor of stable trickle, its characterized in that includes the barrel, sets up the upper cover in the barrel upper end and sets up the low head at the barrel lower extreme, is provided with trickle distributor and reaction tube from top to bottom in the barrel, the trickle distributor has the trickle pipe, the trickle pipe with the reaction tube butt joint is provided with liquid phase inlet pipe and gaseous phase inlet pipe on barrel or the upper cover, barrel and trickle distributor form the closed chamber, stationary type trickle bed reactor of stable trickle still includes: The liquid level sensor is used for detecting the liquid level of the liquid-phase material in the closed cavity; A pressure sensor for detecting the air pressure in the closed cavity; one end of the pressure stabilizing tube is communicated with the closed cavity, and the other end of the pressure stabilizing tube is used for connecting a pressure stabilizing air source; And the regulating valve is arranged on the voltage stabilizing tube and used for controlling the opening and closing of the voltage stabilizing tube.
2. 2. The stable trickle fixed trickle bed reactor of claim 1, further comprising a controller, wherein said regulator valve is an electrically operated regulator valve, and wherein said fluid level sensor, pressure sensor and regulator valve are electrically connected.
3. 3. The fixed trickle bed reactor of claim 1, wherein one end of said pressure stabilizing tube is located at the upper end of said head.
4. 4. A stationary trickle bed reactor for stabilizing trickle flow as claimed in claim 3, wherein said closed chamber further comprises a stopper located directly below the outlet of said pressure stabilizing tube.
5. 5. The trickle-stabilized fixed trickle bed reactor of claim 4, wherein said upper end of said stop defines a tapered slot.
6. 6. The stable trickle fixed trickle bed reactor of claim 1, wherein the source of pressurized gas is an inert gas.
7. 7. The fixed trickle bed reactor of claim 6, wherein the source of pressurized gas is nitrogen.
8. 8. The stable trickle fixed trickle bed reactor of claim 1, wherein said pressure sensor is a pressure transducer.
9. 9. The fixed trickle bed reactor of claim 1, further comprising a balancing tube connected to the cylinder at each end, wherein the balancing tube is spaced vertically at each end.
10. 10. The stable trickle fixed trickle bed reactor of claim 1, wherein said cylinder or bottom head is provided with a discharge tube.

Description

Fixed trickle bed reactor capable of stably trickling Technical Field The utility model relates to the field of trickle bed reactors, in particular to a fixed trickle bed reactor capable of stably trickling. Background Fixed bed reactors are shifting from the supplementation of traditional batch processes to the core technology of continuous manufacturing in drug substance production, the application of which is driven by catalytic technology, engineering scale-up and regulatory support together. Although challenges such as catalyst management, process complexity and compliance cost are faced, as technological innovation and industry collaboration deepen, the fixed bed reactor is expected to become a key carrier for efficient and green production of raw medicines. Enterprises combine the process characteristics, balance the technical maturity and the economic benefit, gradually promote continuous upgrading, and are hopeful to become one of the main stream choices of the production of bulk drugs. Trickle distribution tanks are the "hearts" of fixed bed reactors, the design of which directly determines the performance and economics of the reactor. In the prior art, the drip distributor is of an open or semi-closed structure, the flow speed of materials is controlled by gravity or liquid level difference, and when the material feeding is stopped or stopped, the residual liquid materials in the tank cannot drip thoroughly due to unstable flow speed caused by liquid level reduction, so that the production continuity and the material utilization rate are affected, the problems of conversion rate reduction and byproduct increase are easily caused, and the management requirements of drug production related compliance and quality consistency are deviated. Disclosure of utility model The present utility model addresses the above problems by providing a stationary trickle bed reactor that stabilizes the trickle flow. The technical scheme adopted by the utility model is as follows: The utility model provides a stationary type trickle bed reactor of stable trickle, includes the barrel, sets up at the upper end of barrel head and sets up the low head at the barrel lower extreme, is provided with trickle distributor and reaction tube from top to bottom in the barrel, the trickle distributor has a trickle pipe, the trickle pipe with the reaction tube butt joint is provided with liquid phase inlet pipe and gaseous phase inlet pipe on barrel or the upper head, barrel and trickle distributor form the closed chamber, stationary type trickle bed reactor of stable trickle still includes: The liquid level sensor is used for detecting the liquid level of the liquid-phase material in the closed cavity; A pressure sensor for detecting the air pressure in the closed cavity; one end of the pressure stabilizing tube is communicated with the closed cavity, and the other end of the pressure stabilizing tube is used for connecting a pressure stabilizing air source; And the regulating valve is arranged on the voltage stabilizing tube and used for controlling the opening and closing of the voltage stabilizing tube. According to the application, by arranging the pressure stabilizing tube and the pressure sensor, the pressure stabilizing tube can be used for conveying the pressure stabilizing gas to the closed cavity when stopping or stopping feeding, so that the air pressure in the closed cavity is kept, the influence of liquid level drop on the flow rate can be compensated by the pressure of the pressure stabilizing gas, and the stable dripping of the residual materials in the stopping stage is realized. In one embodiment of the present utility model, the present utility model further includes a controller, wherein the control valve is an electric control valve, and the liquid level sensor, the pressure sensor and the control valve are electrically connected. The application can realize interlocking control, reduce manual intervention and improve operation safety and stability. One form of control is: 1. And in the normal feeding stage, the pump of the feeding pipe is controlled through the feedback of the liquid level sensor, the liquid level is kept in a set range basically, and the dripping speed is ensured to be stable. 2. In the stopping stage, after the feeding is stopped, the liquid level is lowered, the liquid level sensor triggers an interlocking signal, the regulating valve automatically increases the air inflow of the regulated pressure gas according to the pressure change, the pressure in the closed cavity is kept constant, and the residual material trickles to be completely emptied at a normal flow rate. In one embodiment of the present utility model, one end of the voltage stabilizing tube is located at the upper end of the upper end socket. In one embodiment of the present utility model, the closed cavity is further provided with a stop block located right below the air outlet of the pressure stabilizing tube. The stop block