CN-224207996-U - Filtration reaction kettle for polypeptide synthesis

CN224207996UCN 224207996 UCN224207996 UCN 224207996UCN-224207996-U

Abstract

The utility model discloses a filtering reaction kettle for polypeptide synthesis, which comprises a reaction kettle body, wherein a discharging pipe is fixedly connected to the bottom of the reaction kettle body, the filtering reaction kettle also comprises a first filtering transverse cylinder and a second filtering transverse cylinder which are in cylindrical structures, the centers of the interiors of the first filtering transverse cylinder and the second filtering transverse cylinder are respectively and rotatably connected with a rotating shaft, a cross baffle is fixedly connected on the rotating shaft, and then a cross baffle is driven to rotate and switch through a rotating adjusting shifting block, so that a standby filter element group enters a working position, and the time period of maintaining the optimal filtering efficiency of the system is effectively prolonged.

Inventors

CHEN WEIGUANG
YAN LEI
WANG YUEJIN
XIE LEI
ZHENG FANNA
WU XINGWEI

Assignees

安徽省国平药业有限公司

Dates

Publication Date: 20260508
Application Date: 20250530

Claims (9)

1. The filtering reaction kettle for polypeptide synthesis comprises a reaction kettle body (1), wherein a communicated discharging pipe (2) is fixedly connected to the bottom of the reaction kettle body (1), and is characterized in that: The filter comprises a first filter horizontal cylinder (4) and a second filter horizontal cylinder (5), wherein the first filter horizontal cylinder (4) and the second filter horizontal cylinder (5) are in cylindrical structures, a rotating shaft (6) is rotatably connected to the inner centers of the first filter horizontal cylinder (4) and the second filter horizontal cylinder (5), a cross partition plate (7) is fixedly connected to the rotating shaft (6), and the inner space of the first filter horizontal cylinder (4) or the second filter horizontal cylinder (5) is divided into four equal independent spaces; The rotary shaft (6) is fixedly connected with a staggered partition plate (8) at a position corresponding to the position between the cross partition plates (7), the staggered partition plate (8) divides each quartered independent space into a space of a filtering area (12) and a space of a material passing area (13) again, uniformly distributed through holes (11) are formed in the staggered partition plate (8), and a filter element (9) is arranged in the filtering area (12).
2. The filtration reaction kettle for polypeptide synthesis according to claim 1, wherein the outer edge of the cross-shaped partition plate (7) is abutted against the inner wall of the first filtration horizontal cylinder (4) or the second filtration horizontal cylinder (5), and rubber ribs (23) are embedded in the outer edge of the cross-shaped partition plate (7).
3. The filtration reaction kettle for polypeptide synthesis according to claim 1, wherein the filter element (9) in the first transverse filter cylinder (4) has a smaller filter precision than the filter precision in the second transverse filter cylinder (5).
4. The filtration reaction kettle for polypeptide synthesis according to claim 1, wherein a first communicating pipe (3) is fixedly connected in the middle of the upper part of the first filtration horizontal barrel (4), the first filtration horizontal barrel (4) is connected with the second filtration horizontal barrel (5) through a second communicating pipe (14), one end of the second communicating pipe (14) is communicated with a filtering area (12) of the first filtration horizontal barrel (4), and the other end of the second communicating pipe is communicated with a material passing area (13) of the second filtration horizontal barrel (5).
5. The filtration reaction kettle for polypeptide synthesis according to claim 1, wherein a plurality of discharge pipes (15) are fixedly connected to the second transverse filtering cylinder (5) along the axial direction, and electromagnetic valves (16) are arranged on the discharge pipes (15).
6. The filtering reaction kettle for polypeptide synthesis, which is disclosed in claim 1, is characterized in that one end part of the rotating shaft (6) is provided with an adjusting hole (17), an adjusting rod (19) is inserted into the adjusting hole (17), and the adjusting rod (19) and the adjusting hole (17) are of a regular hexagon structure which are mutually matched.
7. The filtering reaction kettle for polypeptide synthesis according to claim 6, wherein an adjusting shifting block (18) is fixedly connected to the end part of the adjusting rod (19), the adjusting shifting block (18) is composed of a rod body part and a round block part, the round block part is fixedly connected with the adjusting rod (19), and U-shaped clamping blocks (20) are fixedly arranged at positions of the first filtering transverse cylinder (4) and the second filtering transverse cylinder (5) corresponding to the adjusting rod (19).
8. The filtering reaction kettle for polypeptide synthesis, as set forth in claim 1, is characterized in that one end face of the first filtering transverse cylinder (4) and one end face of the second filtering transverse cylinder (5) are both provided with sector-shaped notches (21), and sector-shaped sealing covers (22) are detachably arranged on the sector-shaped notches (21).
9. The filtering reaction kettle for polypeptide synthesis according to claim 1, wherein the cross partition plates (7) and the staggered partition plates (8) are fixedly connected with limiting blocks (10) at positions corresponding to the filtering areas (12), so that a crack is formed between the filter element (9) and the first transverse filtering cylinder (4) or between the filter element (9) and the second transverse filtering cylinder (5).

Description

Filtration reaction kettle for polypeptide synthesis Technical Field The utility model belongs to the technical field of polypeptide synthesis equipment, and particularly relates to a filtering reaction kettle for polypeptide synthesis. Background The basic principle of the two chemical synthesis methods is that amino acids are connected into polypeptide chains one by one through chemical reaction, and the polypeptide synthesis method is widely applied to the fields of medicine research and development, antibiosis and anticancer, food health, biological materials and the like, and is an important biochemical technology. In the process of polypeptide synthesis (especially solid phase synthesis), by separating solid phase carrier (such as resin) from liquid phase reactant, by-product or solvent, the reaction can be ensured to be carried out efficiently, and the purity of the product can be improved. Since each step of solid phase synthesis (deprotection→washing→coupling→washing) requires cyclic operation, filtration is the basis for realizing multi-step automation, ensuring that the reaction conditions of each step are independently controllable. Patent CN222567720U discloses a polypeptide synthesis device, which comprises a reaction kettle, a first filtering device and a second filtering device, wherein polypeptide synthesis reaction and filtration are integrated on the same polypeptide synthesis device, so that continuous operation of the polypeptide synthesis reaction and filtration is realized, the treatment efficiency and the production efficiency are improved, and a product solution with better quality is obtained through two-stage different-precision filtration. In the technical scheme of the patent, continuous operation of polypeptide synthesis reaction and filtration is realized through first filter equipment and second filter equipment, but can undoubtedly lead to taking place to block up after the filter core of first filter equipment and second filter equipment carries out filtering function for a long time, and the filter effect becomes poor gradually or can't filter any more, need stop the change filter core, has prolonged the continuous operation ability of polypeptide synthesis reation kettle, has certain shortcoming. Disclosure of utility model In order to solve the technical problems that in the prior art, when a filter element is blocked during polypeptide synthesis, more time is required to be consumed for replacing the filter element, and the continuous operation capacity of a polypeptide synthesis reaction kettle is prolonged, the utility model provides a filter reaction kettle for polypeptide synthesis. The aim of the utility model can be achieved by the following technical scheme: A filtering reaction kettle for polypeptide synthesis comprises a reaction kettle body, a discharge pipe communicated with the bottom of the reaction kettle body is fixedly connected with the bottom of the reaction kettle body, a first filtering transverse cylinder and a second filtering transverse cylinder which are in cylindrical structures, a rotating shaft is rotatably connected to the inner centers of the first filtering transverse cylinder and the second filtering transverse cylinder, a cross partition plate is fixedly connected to the rotating shaft, the inner space of the first filtering transverse cylinder or the second filtering transverse cylinder is divided into four equal-divided independent spaces, a staggered partition plate is fixedly connected to the position, corresponding to the position between the cross partition plates, of the rotating shaft, each four equal-divided independent space is divided into a filtering area space and a material passing area space again by the staggered partition plate, and a filter element is arranged in the filtering area. Further, the outer edge of the cross-shaped partition plate is abutted against the inner wall of the first filter horizontal cylinder or the second filter horizontal cylinder, and rubber convex ribs are embedded in the outer edge of the cross-shaped partition plate. Further, the filter precision of the filter element in the first filter transverse cylinder is smaller than that in the second filter transverse cylinder. Further, a first communicating pipe is fixedly connected in the middle of the upper part of the first filtering transverse cylinder, the first filtering transverse cylinder is connected with the second filtering transverse cylinder through a second communicating pipe, one end of the second communicating pipe is communicated with the filtering area of the first filtering transverse cylinder, and the other end of the second communicating pipe is communicated with the material communicating area of the second filtering transverse cylinder. Further, a plurality of discharging pipes are fixedly connected to the second filtering transverse cylinder along the axial direction, and electromagnetic valves are arranged on the discharging p