CN-224208003-U - Reaction device for radionuclide labeled microsphere

CN224208003UCN 224208003 UCN224208003 UCN 224208003UCN-224208003-U

Abstract

The utility model provides a reaction device for radionuclide-labeled microspheres, which comprises a control module, a reaction module and a transfer module, wherein the control module comprises a control module main body, a replaceable clamping plate, a peristaltic pump, a bubble sensor, a reagent bottle, an empty bottle and a pipeline, the reaction module comprises a stirrer, a reactor and an outer barrel, and the transfer module comprises a lifter and a transfer device. The reaction device of the radionuclide-labeled microsphere is controlled by an automatic program, can accurately calculate the material quantity, improves the accuracy of the production process, does not need manual operation in the whole process, and is carried out in a closed environment in the whole experimental process, so that the leakage of aerosol is avoided, and the radiation risk of technicians is reduced.

Inventors

ZHU YEMING
WANG FEIYAN
YANG DACAN
TAO LIN
ZHOU WEITAO
LUO ZHIGANG

Assignees

南京江原安迪科正电子研究发展有限公司
烟台东诚核聚医药科技有限公司

Dates

Publication Date: 20260508
Application Date: 20240828

Claims (9)

1. The reaction device for the radionuclide marked microsphere is characterized by comprising a control module, a reaction module and a transfer module, wherein the control module comprises a control module main body, a replaceable clamping plate, a peristaltic pump, a bubble sensor, a reagent bottle, an empty bottle and a pipeline, the reaction module comprises a stirrer, a reactor and an outer barrel, and the transfer module comprises a lifter and a transfer device.
2. The device of claim 1, wherein the reactor comprises a reaction cylinder and a filter membrane, the reaction cylinder is provided with a detachable top cover and a detachable bottom cover, a plurality of pipeline joints are arranged at the upper end of the top cover, a pipette is inserted into one pipeline joint, a pipeline joint is arranged at the bottom of the bottom cover, a thickening platform is arranged in the bottom cover, the filter membrane is positioned on the thickening platform of the bottom cover, a rubber ring is arranged between the filter membrane and the thickening platform, the stirrer comprises a rotary cylinder, a hollow rotary motor and an annular fixed plate from top to bottom, the bottom of the annular fixed plate is fixed on the base through a plurality of fixing seats, and the hollow rotary motor and the rotary cylinder are of hollow cylinder structures.
3. The apparatus of claim 2, wherein the pipe joint of the top cover and the pipe joint of the bottom cover are respectively in communication with the control module through pipes.
4. The device of claim 2, wherein the upper surface of the outer cylinder is in a circular ring sealing shape, a support stand is arranged at the opening, the support stand comprises an upper support and a lower support, the upper support is in a semicircular structure, the inner diameter of the upper support is matched with the outer diameter of the reaction cylinder, the inner diameter of the lower support is slightly larger than the outer diameter of the bottom cover, the top cover of the reaction cylinder is hung on the upper support, and the bottom cover of the reaction cylinder is arranged in the rotary cylinder.
5. The apparatus of claim 4, wherein the bottom cover of the reaction cartridge has a height slightly less than the distance between the upper and lower brackets.
6. The apparatus of claim 4, wherein the bottom of the outer barrel is secured to the base, and the side wall is further provided with a line outlet.
7. The device of claim 2, wherein the elevator comprises an inductor, a first slide rail, a first slide block and a support rod, wherein the upper end of the support rod is fixed on the pipette, and the lower end of the support rod is fixed on the first slide block.
8. The device according to claim 2, wherein the transfer device comprises a second slide block, a second slide rail, a three-way valve and a syringe, wherein the head of the syringe is connected with one valve port of the three-way valve, a tail piston rod is fixed on the second slide block through a bracket, and the other two valve ports of the three-way valve are respectively connected with the pipette and the product bottle.
9. The device according to claim 1, wherein the control module is further provided with a corresponding control valve in the pipeline.

Description

Reaction device for radionuclide labeled microsphere Technical Field The utility model relates to the technical field of microsphere marking, in particular to a reaction device for radionuclide marked microspheres. Background The microsphere radiation embolism technology is an important cancer treatment method, and the principle is that the radionuclide marked microsphere is injected into tumor to directly kill cancer cells and simultaneously produce embolism action, so that the cancer cells are ischemic necrosis, and the purpose similar to surgical excision is achieved. The technology has been commercialized and widely applied to the treatment of certain cancers, such as 90 Y resin microspheres (SIR-Spheres) approved by the FDA for colorectal cancer liver metastasis in 2002 and approved for sale in 2022 in China, 90 Y glass microspheres (THERASPHERE) approved by the FDA as a class III medical device for treating liver tumors in 2005, and 166 Ho polylactic acid microspheres (QuiremSpheres) obtained by the European Union quality detection approval in 2015 for radiation embolism treatment of unresectable liver cancer. At present, radionuclide labeling of microspheres, such as 188Re、90Y、 166 Ho and the like, is basically finished manually, and a production module capable of realizing automatic labeling of the microspheres has not been developed yet. However, in the process of labeling microspheres with radionuclides, manual labeling has limitations in terms of accuracy, safety, and the like. Disclosure of utility model In order to solve the technical problems, the utility model provides a reaction device for radionuclide-labeled microspheres. In order to achieve the above purpose, the present utility model provides the following technical solutions: The reaction device for the radionuclide marked microsphere is characterized by comprising a control module, a reaction module and a transfer module, wherein the control module comprises a control module main body, a replaceable clamping plate, a peristaltic pump, a bubble sensor, a reagent bottle, an empty bottle and a pipeline, the reaction module comprises a stirrer, a reactor and an outer barrel, and the transfer module comprises a lifter and a transfer device. In particular, the microspheres may be selected from resin microspheres. The reactor comprises a reaction cylinder and a filter membrane, wherein the reaction cylinder is provided with a detachable top cover and a detachable bottom cover, a plurality of pipeline connectors are arranged at the upper end of the top cover, the pipeline connectors are arranged at the bottom of the bottom cover, a thickening platform is arranged in the bottom cover, and the filter membrane is positioned on the thickening platform of the bottom cover. Specifically, the pipeline joints of the top cover are three, one of the pipeline joints is connected with the control module through a pipeline, the other pipeline joint is provided with a pipette, and the other pipeline joint is communicated with the atmosphere. The pipeline joint of the bottom cover is communicated with the control module through a pipeline. Specifically, the number of the pipeline joints of the bottom cover is one or more, and preferably one. The filter membrane is fixed in the reaction cylinder by the way that the filter membrane is spun on the thickening platform under the action of threads of the lower end of the reaction cylinder and the bottom cover, and a rubber ring with a sealing effect is arranged between the filter membrane and the thickening platform. Further, the stirrer comprises a rotary cylinder, a hollow rotary motor and an annular fixing plate from top to bottom, wherein the bottom of the annular fixing plate is fixed on the base through a plurality of fixing seats, and the hollow rotary motor and the rotary cylinder are both of hollow cylinder structures. The rotary cylinder and the reaction cylinder are made of nonmetallic magnetic permeable materials, and a knob for controlling a switch and the rotating speed of the stirrer is arranged on the base. Further, the upper surface of the outer cylinder is in a circular ring sealing shape, a support table is arranged at the opening, the support table comprises an upper support and a lower support, the upper support is of a semicircular structure, the inner diameter of the upper support is matched with the outer diameter of the reaction cylinder, and the inner diameter of the lower support is slightly larger than the outer diameter of the bottom cover. Further, the height of the bottom cover of the reaction cylinder is slightly lower than the distance between the upper bracket and the lower bracket, so that the bottom cover of the reaction cylinder penetrates through the upper bracket and the lower bracket and sinks into the outer cylinder, at the moment, the top cover of the reaction cylinder is suspended on the upper bracket, and the bottom cover of the reaction cylinder is arranged in the rotar