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CN-224212641-U - Foam control device in bio-pharmaceuticals fermentation process

CN224212641UCN 224212641 UCN224212641 UCN 224212641UCN-224212641-U

Abstract

The utility model discloses a foam control device in a biopharmaceutical fermentation process, which relates to the technical field of biopharmaceuticals and comprises a liquid medicine chamber, supporting legs, a liquid inlet valve, a liquid outlet valve, a mounting platform, a first motor, a first mounting block, a first bearing, a screw rod, a first umbrella tooth, a second umbrella tooth, a first lifting plate, a second mounting block, a vertical rod, a second lifting plate, a lifting frame, a connecting rod, a foam removing assembly and the like. For example, through the cooperation of the first installation block, the first bearing and the screw rod, the stable lifting movement of the first lifting plate is realized, and the mechanical structure is simple and clear in design and easy to understand and install. For the production enterprises, the equipment can be built quickly without complex installation flow and professional technicians, and the installation time and labor cost are greatly saved.

Inventors

  • YIN HAIXING
  • YOU HAIBO

Assignees

  • 修实生物医药(南通)有限公司

Dates

Publication Date
20260508
Application Date
20250508

Claims (6)

  1. 1. The foam control device in the biopharmaceutical fermentation process is characterized by comprising a liquid medicine chamber (1), supporting legs (2), a liquid inlet valve (3), a liquid outlet valve (4), a mounting platform (5), a first motor (6), a first mounting block (7), a first bearing (8), a screw rod (9), a first umbrella tooth (10), a second umbrella tooth (11), a first lifting plate (12), a second mounting block (13), a vertical rod (14), a second lifting plate (15), a lifting frame (16), a connecting rod (17) and a foam removing assembly; A plurality of supporting legs (2) are fixedly connected to the periphery of the lower surface of the liquid medicine chamber (1); the lower end of the left side surface of the liquid medicine chamber (1) is fixedly communicated with a liquid inlet valve (3), and the lower end of the right side surface of the liquid medicine chamber (1) is fixedly communicated with a liquid outlet valve (4); the upper end of the left side surface of the liquid medicine chamber (1) is fixedly connected with a first mounting block (7), and the lower end of the left side surface of the liquid medicine chamber (1) is fixedly connected with a mounting platform (5); A screw rod (9) is movably connected between the first mounting block (7) and the mounting platform (5) through a first bearing (8), and a second bevel gear (11) is fixedly connected to the lower end of the screw rod (9); The mounting platform (5) is fixedly connected with a first motor (6), the output end of the first motor (6) is fixedly connected with a first bevel gear (10), and the first bevel gear (10) and the second bevel gear (11) are meshed with each other; the screw rod (9) is connected with a first lifting plate (12) through threads; The upper end and the lower end of the right side surface of the liquid medicine chamber (1) are fixedly connected with second installation blocks (13), vertical rods (14) are fixedly connected between the second installation blocks (13), and second lifting plates (15) are connected to the vertical rods (14) in a sliding manner; A lifting frame (16) is fixedly connected between the first lifting plate (12) and the second lifting plate (15); connecting rods (17) are fixedly connected to two sides of the lower end of the lifting frame (16); And a foam removing component is fixedly connected between the tail ends of the connecting rods (17).
  2. 2. The foam control device in the biopharmaceutical fermentation process of claim 1, wherein the foam removing assembly comprises a housing (18), a second bearing (19), a second motor (20), a belt pulley (21), a belt (22), a rotating shaft (23), a positive screw thread (24), a negative screw thread (25), a sliding rail (26), a moving block (27), a baffle (28), a communicating pipe (29) and a pumping pump (30); The housing (18) is fixedly connected to the tail end of the connecting rod (17); The two sides of the inner part of the cavity of the housing (18) are movably connected with a rotating shaft (23) through a second bearing (19); The outer surface of the left end of the rotating shaft (23) is integrally formed with a positive rotation thread (24), and the outer surface of the right end of the rotating shaft (23) is integrally formed with a negative rotation thread (25); A sliding rail (26) is fixedly connected to the top end inside the cavity of the housing (18); the positive rotation threads (24) and the negative rotation threads (25) are connected with a moving block (27) through threads, and the top end of the moving block (27) is connected to a sliding rail (26) in a sliding manner; a baffle (28) is fixedly connected to the tail end of the moving block (27); the casing (18) is fixedly connected with a pumping pump (30), and the pumping pump (30) is communicated with the inside of a cavity of the casing (18) through a communicating pipe (29); The right side of the upper surface of the housing (18) is fixedly connected with a second motor (20), and the output end of the second motor (20) is fixedly connected with a belt pulley (21); the right end of the rotating shaft (23) is fixedly connected with a belt pulley (21), and the belt pulleys (21) are connected together through a belt (22).
  3. 3. The foam control device in the biopharmaceutical fermentation process of claim 1, wherein the bottom of the support leg (2) is provided with a non-slip mat for increasing stability of the device during placement.
  4. 4. The foam control device in a biopharmaceutical fermentation process of claim 2, wherein the pump (30) is a corrosion resistant pump adapted to pump foam and associated liquids in the biopharmaceutical fermentation process.
  5. 5. The foam control device in the biopharmaceutical fermentation process of claim 2, wherein the baffle (28) is made of flexible material, so that the baffle can be better attached to the inner wall of the fermentation container, and the foam removing effect is improved.
  6. 6. The foam control device in the biopharmaceutical fermentation process of claim 1, wherein the first motor (6) is a forward and reverse motor for controlling forward and reverse rotation of the screw (9) to further realize lifting movement of the first lifting plate (12).

Description

Foam control device in bio-pharmaceuticals fermentation process Technical Field The utility model relates to the technical field of biopharmaceuticals, in particular to a foam control device in a biopharmaceutical fermentation process. Background In biopharmaceutical fermentation processes, foam generation is a very troublesome and ubiquitous problem, with multiple negative effects on the fermentation process. The fermentation efficiency is affected, and a large amount of foam generated in the fermentation process occupies the effective space of the fermentation container. For example, in large scale fermenters, excessive foam may reduce the actual loading of fermentation broth, limiting the capacity of fermentation substrate and microorganisms, and thus reducing fermentation efficiency. Meanwhile, the existence of foam can interfere with the transfer of substances in the fermentation process, affect the exchange among oxygen, nutrient substances and microbial cells, the microorganisms can not fully acquire the nutrients, the growth metabolism is inhibited, the fermentation process is further slowed down, and the production cost is increased. The risk of bacteria contamination is increased, foam in the fermentation tank is easy to overflow, and fermentation equipment and surrounding environment are polluted. The overflowed foam contains microorganism and fermentation liquor components, and if the foam is not cleaned timely, the substances become a temperature bed for breeding miscellaneous bacteria. Once the mixed bacteria enter the fermentation system, the mixed bacteria compete with target microorganisms for nutrition and living space, the fermentation environment is changed, the fermentation is failed, and the quality and the yield of medicines are seriously affected. The monitoring of the fermentation process is interfered, a large amount of foam can make the liquid level measurement in the fermentation tank difficult, and the accurate monitoring of key parameters such as the liquid level, the dissolved oxygen and the like in the fermentation process is affected. Inaccurate data may mislead the judgment of an operator on the fermentation process, and fermentation conditions cannot be adjusted in time, so that the fermentation effect and the product quality are affected. The production cost is increased, and enterprises generally need to input extra manpower and material resources for solving the foam problem. On the one hand, frequent manual handling of the foam increases the labor costs, and on the other hand, the use of chemical defoamers, while temporarily suppressing the foam, may be toxic to fermenting microorganisms, affecting the quality of the fermentation product, also increases the production costs themselves. Currently, the conventional methods have a number of disadvantages with respect to foam control in biopharmaceutical fermentation processes. Although the chemical defoaming agent can quickly defoam, the chemical defoaming agent can influence the growth and metabolism of fermentation microorganisms, and can remain in fermentation products, so that the difficulty of subsequent separation and purification is increased, and potential risks are generated on the quality of medicines. The mechanical defoaming device is complex in structure, high in installation and maintenance cost, unstable in defoaming effect and difficult to adapt to fermentation processes of different scales and processes. In actual production, a foam control device with simple structure, low cost, convenient installation and complete functions is urgently needed to effectively solve the foam problem in the bio-pharmaceutical fermentation process, ensure the smooth proceeding of the fermentation process and improve the quality and production efficiency of medicines. Disclosure of utility model The utility model aims to solve the problems and provide a foam control device in the biopharmaceutical fermentation process. The technical scheme is that the foam control device in the biological pharmacy fermentation process comprises a liquid medicine chamber, supporting legs, a liquid inlet valve, a liquid outlet valve, a mounting platform, a first motor, a first mounting block, a first bearing, a screw rod, first umbrella teeth, second umbrella teeth, a first lifting plate, a second mounting block, a vertical rod, a second lifting plate, a lifting frame, a connecting rod and a foam removing assembly, wherein the supporting legs are fixedly connected to the periphery of the lower surface of the liquid medicine chamber, the lower end of the left side surface of the liquid medicine chamber is fixedly communicated with the liquid inlet valve, the lower end of the right side surface of the liquid medicine chamber is fixedly communicated with the liquid outlet valve, the upper end of the left side surface of the liquid medicine chamber is fixedly connected with the first mounting block, the lower end of the left side surface of the liq