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CN-224212657-U - Nucleic acid extraction detection analyzer

CN224212657UCN 224212657 UCN224212657 UCN 224212657UCN-224212657-U

Abstract

The utility model provides a nucleic acid extraction detection analyzer which comprises a base module, an extraction module, a detection module and a detection module, wherein the base module is used for carrying a reagent kit and driving the reagent kit to reciprocate between a delivery position and a detection position along a Y direction, the extraction module is arranged above the base module and comprises a lifting mechanism, a rotating mechanism, a liquid-transferring pump used for sucking a liquid-transferring gun head and a magnetic-sucking assembly used for magnetically sucking magnetic beads, the magnetic-sucking assembly and the liquid-transferring pump are both connected with the lifting mechanism, the rotating mechanism is used for driving an upper shell of the reagent kit to rotate in a horizontal plane and enabling the magnetic beads to move in different chambers in the reagent kit, and the detection module is arranged at the front end of the base module along the Y direction and is used for detecting a solution in the reagent kit. According to the utility model, the magnetic component is arranged on the extraction module above, so that an upper adsorption mode is formed, the transfer of magnetic beads in the kit can be facilitated, the high infection risk of transfer liquid in the prior art can be avoided, and the detection precision is high.

Inventors

  • LI JUN
  • LUO MANHUA
  • WU KANG
  • DAI LIZHONG

Assignees

  • 圣湘生物科技股份有限公司

Dates

Publication Date
20260508
Application Date
20250408

Claims (10)

  1. 1. A nucleic acid extraction detection analyzer for a kit (200) pre-equipped with a pipette tip and magnetic beads, characterized in that the nucleic acid extraction detection analyzer (100) comprises: The base module (1) is used for carrying the kit (200) and driving the kit (200) to reciprocate between a delivery position and a detection position along the Y direction; The extraction module (2) is arranged above the base module (1), the extraction module (2) comprises a lifting mechanism (21), a rotating mechanism (22), a liquid transfer pump (23) for sucking the liquid transfer gun head and a magnetic suction assembly (24) for magnetically sucking the magnetic beads, the magnetic suction assembly (24) and the liquid transfer pump (23) are connected with the lifting mechanism (21), and the rotating mechanism (22) is used for driving an upper shell of the kit (200) to rotate in a horizontal plane and enabling the magnetic beads to transfer in different chambers in the kit (200); the detection module (3) is arranged at the front end of the base module (1) along the Y direction, and the detection module (3) is used for detecting the solution in the kit (200).
  2. 2. The nucleic acid extraction detection analyzer according to claim 1, wherein the lifting mechanism (21) includes: The magnetic attraction assembly (24) comprises magnetic rods (241) for magnetically attracting the magnetic beads and an insulating sleeve (243) sleeved outside the magnetic rods (241), the first driving pieces (211) are connected with the magnetic rods (241), the number of the first driving pieces (211) is two, one of the first driving pieces is connected with the magnetic rods (241), and the other one of the first driving pieces is connected with the insulating sleeve (243); And a second driving member (213) connected to the pipetting pump (23) and configured to drive the pipetting pump (23) to move up and down.
  3. 3. The nucleic acid extraction detection analyzer according to claim 2, wherein the output ends of the two first driving members (211) are both connected with a magnetic attraction rod (212), the magnetic rod (241) is connected with a first slider (242), the first slider (242) is in threaded engagement with one of the magnetic attraction rods (212), the insulating sleeve (243) is connected with a second slider (244), and the second slider (244) is in threaded engagement with the other magnetic attraction rod (212).
  4. 4. The nucleic acid extraction detection analyzer according to claim 3, wherein two of the magnetic attraction rods (212) are arranged at intervals along a Y direction, the first slider (242) and the second slider (244) are each arranged between the two magnetic attraction rods (212) along the Y direction, and the first slider (242) is located above the second slider (244); and/or the number of the groups of groups, The lifting mechanism (21) further comprises a first guide rod (215), the first guide rod (215) penetrates through the first sliding block (242) and the second sliding block (244), and the first sliding block (242) and the second sliding block (244) are in guide fit with the first guide rod (215).
  5. 5. The nucleic acid extraction detection analyzer according to any one of claims 2 to 4, wherein the pipetting pump (23) is connected with a pipetting slider (231), and an output end of the second driving member (213) is connected with a pipetting screw (214), and the pipetting slider (231) and the pipetting screw (214) are screw-fitted.
  6. 6. The nucleic acid extraction detection analyzer according to claim 5, wherein a pipetting plunger is further preset in the kit (200), the lifting mechanism (21) further comprises a plunger driving assembly and a pushing block (232) connected with the pipetting pump (23), and the pushing block (232) can be driven by the pipetting pump (23) to press down the pipetting plunger through the plunger driving assembly; and/or the number of the groups of groups, The lifting mechanism (21) further comprises a second guide rod (216) in guide fit with the pipetting slider (231).
  7. 7. The nucleic acid extraction detection analyzer of claim 6, wherein the plunger drive assembly comprises: A fixed rod (217), wherein a tooth sleeve (218) is sleeved outside the fixed rod (217), and a pushing protrusion (2181) for being in butt joint with the pushing block (232) is arranged on the tooth sleeve (218); a pressing down piston (219) for pressing down the pipetting plunger; And the tooth sleeve (218) and the pressing piston (219) are meshed with the pipetting gear (210).
  8. 8. The nucleic acid extraction detection analyzer according to claim 7, wherein the pushing block (232) is provided with an escape groove (233) into which the pushing protrusion (2181) extends, and a bottom wall of the escape groove (233) is provided with a pushing plane for surface-contacting with the pushing block (232); and/or the number of the groups of groups, The lifting mechanism (21) further comprises a third guide rod (2101) in guide fit with the pushing block (232).
  9. 9. The nucleic acid extraction detection analyzer according to any one of claims 2 to 4, wherein the nucleic acid extraction detection analyzer (100) further comprises an upper mounting seat (25), a vertical plate (26) and a lower mounting seat (27) connected with the rotation mechanism (22), the vertical plate (26) extends along a Z direction and is supported between the upper mounting seat (25) and the lower mounting seat (27), the first driving member (211) and the second driving member (213) are both mounted on the top of the upper mounting seat (25), the upper mounting seat (25) is provided with an upper avoidance hole (251) for avoiding the liquid transfer pump (23), the lower mounting seat (27) is provided with a lower avoidance hole (271), and the lower hole (271) is used for allowing a pump nozzle of the liquid transfer pump (23) to pass through.
  10. 10. The nucleic acid extraction detection analyzer according to any one of claims 1 to 4, wherein the rotation mechanism (22) includes a rotation driving member (221), a belt (222), and a pulley (223), the rotation driving member (221) drives the pulley (223) to rotate through the belt (222), a bottom of the pulley (223) is provided with a rotation protrusion (224) adapted to the kit (200); and/or the number of the groups of groups, The base module (1) comprises a box base (11), a base driving piece (12), a base gear (13) and a base rack (14) extending along the Y direction, wherein the output end of the base driving piece (12) is connected with the base gear (13), the box base (11) is connected with the base rack (14), and the base gear (13) is meshed with the base rack (14).

Description

Nucleic acid extraction detection analyzer Technical Field The utility model belongs to the technical field of detection instruments, and particularly relates to a nucleic acid extraction detection analyzer. Background Molecular diagnosis is the basis of accurate medical treatment and is also the track with the fastest growing speed in the in vitro diagnosis sub-field. The application range is very wide, and the detection and diagnosis of genetic diseases, infectious diseases, tumors and other diseases are included. POCT using molecular diagnosis method is very likely to become the main stream of future in vitro diagnosis industry development by virtue of the advantages of high sensitivity and accuracy, convenient carrying, simple operation, short detection time, no environmental requirement and low cost. Taking Iponatic as an example, the existing molecular POCT integrated machine needs to be separately provided with an external centrifuge, and the whole detection flow is completed by manually transferring a reaction tube. Some full-automatic detection instruments are already proposed in the market at present, the instruments are large-scale instruments, the flow is still consistent with that of the traditional method, the detection results are time-consuming, the detection results cannot be issued at the first time and are difficult to popularize and use widely in the basic level, and some POCT molecular diagnosis instruments in the market aim to realize ideal modes of sample inlet and sample outlet, but in clinic, full-closed detection in the true sense cannot be realized, and the detection results still have high infection risk. Disclosure of utility model The utility model mainly aims to provide a nucleic acid extraction detection analyzer, which aims to solve the technical problem that the detection of the nucleic acid extraction detection analyzer in the prior art has higher infection risk. In order to achieve the above purpose, the utility model provides a nucleic acid extraction detection analyzer, which is used for a kit preset with a pipette tip and magnetic beads, and comprises a base module, an extraction module and a detection module, wherein the base module is used for carrying the kit and driving the kit to reciprocate between a discharging position and a detection position along a Y direction, the extraction module is arranged above the base module and comprises a lifting mechanism, a rotating mechanism, a pipette pump used for sucking the pipette tip and a magnetic attraction component used for magnetically attracting the magnetic beads, the magnetic attraction component and the pipette pump are both connected with the lifting mechanism, the rotating mechanism is used for driving an upper shell of the kit to rotate in a horizontal plane and enabling the magnetic beads to move in different chambers in the kit, and the detection module is arranged at the front end of the base module along the Y direction and is used for detecting a solution in the kit. In the embodiment of the utility model, the lifting mechanism comprises a first driving part, a second driving part and a lifting mechanism, wherein the magnetic attraction assembly comprises a magnetic rod for magnetically attracting the magnetic beads and an insulating sleeve sleeved outside the magnetic rod, the first driving part is connected with the magnetic rod, the number of the first driving part is two, one driving part is connected with the magnetic rod, the other driving part is connected with the insulating sleeve, and the second driving part is connected with the liquid transfer pump and is used for driving the liquid transfer pump to lift. In the embodiment of the utility model, the output ends of the two first driving pieces are connected with the magnetic attraction screw rods, the magnetic rods are connected with the first sliding blocks, the first sliding blocks are in threaded fit with one of the magnetic attraction screw rods, the insulating sleeve is connected with the second sliding blocks, and the second sliding blocks are in threaded fit with the other magnetic attraction screw rod. In the embodiment of the utility model, the two magnetic lead screws are arranged at intervals along the Y direction, the first sliding block and the second sliding block are arranged between the two magnetic lead screws along the Y direction and are positioned above the second sliding block, and/or the lifting mechanism further comprises a first guide rod which penetrates through the first sliding block and the second sliding block and is in guide fit with the first guide rod. In the embodiment of the utility model, the liquid transfer pump is connected with a liquid transfer sliding block, the output end of the second driving piece is connected with a liquid transfer screw rod, and the liquid transfer sliding block is in threaded fit with the liquid transfer screw rod. In the embodiment of the utility model, a pipetting plunger is also pr