CN-224220478-U - Stromal lens cornea donor based on hydrogel bonding

Abstract

The present disclosure relates to a stromal lens corneal donor based on hydrogel bonding, the corneal donor comprising a plurality of layers of corneal stromal lenses stacked in a thickness direction thereof, and an adhesive layer bonded between two adjacent pieces of corneal stromal lenses, the adhesive layer comprising a composite hydrogel having a mesh porous structure formed after curing. The stacked multilayer cornea matrix lenses are bonded to the preset thickness by the combined adhesive, so that the cornea donor has stronger structural strength, the problem of sliding or distortion in the surgical suture process is effectively avoided, a grid porous structure is formed after the composite material hydrogel is solidified, the air permeability and the structural strength of the cornea donor based on the hydrogel bonding matrix lenses are ensured, and the reliability of cornea repair is improved.

Inventors

• DONG HE
• DONG XUFENG
• YU XIAOXIA
• LI PENGFEI

Assignees

• 大连市第三人民医院

Dates

Publication Date

20260512

Application Date

20241218

Claims (9)

1. 1. A hydrogel-based adhesive stromal lens corneal donor, the corneal donor comprising: A multi-layered corneal stroma lens stacked in a thickness direction thereof, and And the adhesive layer is adhered between two adjacent pieces of cornea matrix lenses and comprises a composite hydrogel with a grid porous structure formed after curing.
2. 2. The hydrogel-based on-bonded stromal lens corneal donor of claim 1, wherein the composite hydrogel is a sodium polyacrylamide acrylate hydrogel.
3. 3. The hydrogel-based adhesive stromal lens corneal donor of claim 1 or 2, wherein the adhesive layer has a transmittance of 94% or more.
4. 4. The hydrogel-based adhesive stromal lens corneal donor of claim 1 or 2, wherein the adhesive layer has a tensile modulus of 2-2.1 kpa and a compressive modulus of 7.5-8.5 kpa.
5. 5. The hydrogel-based adhesive stromal lens corneal donor of claim 1 or 2, wherein the adhesive layer has an adhesion of 2 to 2.2kpa.
6. 6. The hydrogel-based on-bonded stromal lens corneal donor of claim 1, wherein the composite hydrogel is a double-crosslinked hydrogel.
7. 7. The hydrogel-based adhesive stromal lens corneal donor of claim 1, wherein the thickness of the plurality of layers of the corneal stromal lens is the same.
8. 8. The hydrogel-based adhesive stromal lens corneal donor of claim 1, wherein two adjacent layers of the corneal stromal lenses are fully adhered to one another.
9. 9. The hydrogel-based adhesive stromal lens corneal donor of claim 1 or 8, wherein the outer contoured edges of each layer of the corneal stromal lens are aligned.

Description

Stromal lens cornea donor based on hydrogel bonding Technical Field The present disclosure relates to the technical field of cornea transplantation, and in particular, to a stromal lens cornea donor based on hydrogel bonding. Background The amount of cornea grafting surgery is very limited due to the extreme scarcity of the cornea donor. Most of keratopathy is early but not affected by full layer, and infection can be partially controlled by auxiliary drug therapy of cornea focus lamellar excision, but a very satisfactory postoperative effect cannot be achieved, and the problems of irregular astigmatism caused by postoperative cornea tissue, influence on vision due to formation of cornea scar, difficulty in complete excision of deep focus, infection control and the like exist. In the related art, the problem of corneal stroma defect or perforation is treated by SMILE stroma lens implantation, however, in the process of performing related surgical suturing, the problem of sliding and distortion is very easy to occur due to the lack of stability of the single-layer stroma lens. Meanwhile, the stress at the edge of the belt is uneven, so that the attaching precision is greatly reduced, and the situation of inconsistent edge angulation occurs. These problems can cause not only post-operative astigmatism in the patient, but also may lead to clouding of the implant, affecting vision. In addition, the biomechanical strength is also difficult to meet the clinical practical requirements. Disclosure of utility model It is an object of the present disclosure to provide a stromal lens corneal donor based on hydrogel bonding to at least partially solve the technical problems existing in the related art. To achieve the above object, the present disclosure provides a hydrogel-based adhesive matrix lens cornea donor, the cornea donor comprising: A multi-layered corneal stroma lens stacked in a thickness direction thereof, and And the adhesive layer is adhered between two adjacent pieces of cornea matrix lenses and comprises a composite hydrogel with a grid porous structure formed after curing. Optionally, the composite hydrogel is a sodium polyacrylamide acrylate hydrogel. Optionally, the transmittance of the adhesive layer is 94% or more. Optionally, the tensile modulus of the adhesive layer is 2-2.1 kpa, and the compressive modulus is 7.5-8.5 kpa. Optionally, the adhesion force of the adhesive layer is 2-2.2 KPa. Optionally, the composite hydrogel is a double-crosslinked hydrogel. Optionally, the thickness of the plurality of layers of the corneal stromal lenses is the same. Optionally, two adjacent layers of the corneal stroma lenses are completely adhered to each other. Optionally, the outer contour edges of the stromal corneal lenses of each layer are aligned. Through the technical scheme, the stacked multilayer cornea stroma lenses are bonded to the preset thickness by the combined adhesive, so that the cornea donor has stronger structural strength, the problem of sliding or distortion deformation in the surgical suture process is effectively avoided, a grid porous structure is formed after the composite material hydrogel is solidified, the air permeability and the structural strength of the stroma lens cornea donor based on hydrogel bonding are ensured, and the reliability of cornea repair is improved. Additional features and advantages of the present disclosure will be set forth in the detailed description which follows. Drawings The accompanying drawings are included to provide a further understanding of the disclosure, and are incorporated in and constitute a part of this specification, illustrate the disclosure and together with the description serve to explain, but do not limit the disclosure. In the drawings: FIG. 1 is a combined view of a cornea donor and a cornea to be repaired provided in an exemplary embodiment of the present disclosure; FIG. 2 is a schematic illustration of the structure of a cornea donor provided in an exemplary embodiment of the present disclosure; Fig. 3 is a schematic view of a multilayer corneal stroma lens stack provided in an exemplary embodiment of the present disclosure. Description of the reference numerals 1-Cornea donor, 11-cornea stroma lens, 2-cornea to be repaired, 21-groove. Detailed Description Specific embodiments of the present disclosure are described in detail below with reference to the accompanying drawings. It should be understood that the detailed description and specific examples, while indicating and illustrating the disclosure, are not intended to limit the disclosure. In the present disclosure, unless otherwise indicated, the use of orientation words such as "inner" and "outer" are intended to refer to the outline of the respective component parts, and the use of orientation words such as "upper" and "lower" are intended to be defined based on the usage habits of hydrogel-adhesive-based stromal lens corneal donors provided in the present disclosure, and in par