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CN-224220559-U - Targeted drug delivery device with catheter pose monitoring function

CN224220559UCN 224220559 UCN224220559 UCN 224220559UCN-224220559-U

Abstract

The utility model relates to the technical field of minimally invasive medical instruments and discloses a targeted drug delivery device with catheter pose monitoring, which comprises a drug delivery catheter and a monitoring mechanism, wherein the monitoring mechanism is used for monitoring the pose of the drug delivery catheter, a drug delivery channel, a mixing cavity and a passing channel for a guide wire to pass through are formed in the drug delivery catheter, the mixing cavity is positioned at the far end of the drug delivery catheter, the drug delivery channel is spirally distributed and communicated with the mixing cavity, a drug outlet communicated with the mixing cavity is formed in the outer side of the far end of the drug delivery catheter, the monitoring mechanism comprises an excitation assembly and a sensor ring, the sensor ring capable of moving forwards and backwards can acquire three-dimensional position and pose information of the catheter in real time through the monitoring mechanism, high-precision real-time positioning and pose monitoring are realized, limitation of traditional X-ray intermittent imaging is eliminated, repeated perspective adjustment of the position of the catheter is not needed, operation is greatly simplified, and operation difficulty and radiation exposure of doctors and patients are reduced.

Inventors

  • LU SHICHENG
  • Ge Wanning
  • FAN XINJIAN

Assignees

  • 苏州大学

Dates

Publication Date
20260512
Application Date
20260331

Claims (8)

  1. 1. The targeted drug delivery device with the catheter pose monitoring function is characterized by comprising a drug delivery catheter and a monitoring mechanism, wherein the drug delivery catheter penetrates through the monitoring mechanism, the monitoring mechanism is used for monitoring the pose of the drug delivery catheter, a drug delivery channel, a mixing cavity and a passing channel for a guide wire to pass through are formed in the drug delivery catheter, the mixing cavity is located at the far end of the drug delivery catheter and sleeved on the outer side of the passing channel, the drug delivery channel is spirally distributed around the axis of the passing channel and is communicated with the mixing cavity, and a drug outlet hole communicated with the mixing cavity is formed in the outer side of the far end of the drug delivery catheter; The monitoring mechanism comprises an excitation assembly, a sensor ring and a driving assembly for driving the sensor ring to linearly move along the front-back direction, wherein an alternating magnetic field is generated after the excitation assembly is electrified, the drug delivery catheter sequentially passes through the excitation assembly and the sensor ring, and the sensor ring is used for detecting the magnetic induction intensity vector of the guide wire in the magnetic field.
  2. 2. The targeted drug delivery device with catheter pose monitoring as claimed in claim 1, wherein the sensor ring comprises an annular framework capable of moving in the front-back direction, a through hole for the drug delivery catheter to pass through is arranged in the center of the annular framework, and a plurality of three-dimensional magnetic sensors are arranged on the annular framework.
  3. 3. The targeted drug delivery device with catheter pose monitoring as claimed in claim 2, wherein the monitoring mechanism further comprises a support, two driving assemblies are oppositely arranged on the support, the annular framework is located between the two driving assemblies, and the excitation assembly is connected with the support.
  4. 4. The targeted drug delivery device with catheter pose monitoring according to claim 3, wherein the driving assembly comprises a support column and a driving motor which are oppositely arranged along the front-back direction, the output end of the driving motor is provided with a driving wheel, the support column is rotatably provided with a driven wheel, the driving wheel and the driven wheel are sleeved with a synchronous belt, and the inner edge of the synchronous belt is fixedly connected with the annular framework.
  5. 5. The targeted drug delivery device with catheter pose monitoring function according to claim 1, wherein the mixing cavity is of a rotational ellipsoidal structure, and a plurality of protrusions are arranged on the inner wall of the mixing cavity, are of a hemispherical structure and are distributed at intervals along the axial direction of the drug delivery catheter.
  6. 6. The targeted drug delivery device with catheter pose monitoring as claimed in claim 5, wherein three drug delivery channels are arranged, and the three drug delivery channels are distributed in a spiral manner around the axis of the passing channel in parallel.
  7. 7. The targeted drug delivery device with catheter pose monitoring as claimed in claim 2, wherein six three-dimensional magnetic sensors are arranged and distributed in a circumferential array around the axis of the through hole.
  8. 8. The catheter-equipped pose monitoring targeted drug delivery device according to any one of claims 1 to 7, wherein a driving pump is connected to a proximal end of the drug delivery catheter, an output end of the driving pump is connected to the drug delivery channel, and a permanent magnet is connected to a distal end of the guide wire.

Description

Targeted drug delivery device with catheter pose monitoring function Technical Field The utility model relates to the technical field of minimally invasive medical instruments, in particular to a targeted drug delivery device with catheter pose monitoring function. Background The current clinical intravascular local administration technology is mainly divided into two major categories, namely traditional direct injection administration and catheter-based drug delivery systems. The traditional direct injection drug delivery injects the drug into the target vascular region through the catheter by manual injection, the drug is naturally diluted and passively diffused depending on blood flow to reach the focus, and the defects of short local residence time, low utilization rate, uneven distribution of focus regions, poor accuracy of manual injection dosage and rate control are caused, so that insufficient local curative effect and high systemic toxicity risk are easily caused. The existing catheter-based drug delivery systems, including end hole infusion catheters, side hole infusion catheters, balloon drug delivery catheters, etc., although optimizing drug coverage to some extent, still suffer from a number of shortcomings: (1) The flow channel lacks of fluid dynamics optimization design, liquid medicine is easy to flow back and permeate out, and potential safety hazards exist; (2) The drug release is still in a passive outflow mode, turbulence cannot be actively formed to destroy the boundary of the blood flow laminar flow, and the mixed permeation efficiency of the drug, focal tissues and thrombus is low; (3) The catheter is single in function, the posture and the position monitoring function are not integrated, the administration operation completely depends on X-ray image positioning, the radiation exposure and the operation complexity are increased, the accurate fixed-point administration can not be realized, and the administration and the positioning system are mutually separated and are difficult to cooperate. In addition, the related technology of current targeting delivery is mostly through increasing external mechanical structure and is realized dosing position optimization, a device is dosed to ischemic cerebrovascular disease traditional chinese medicine targeting thrombolysis is proposed to chinese patent application number 2025118420405, including the pipe body, the inner tube, the orifice of dosing, medicine circulation passageway and be located the displacement mechanism of pipe body distal end, the passageway of passing that supplies the seal wire to pass is seted up to the inner tube inner wall, displacement mechanism includes two sets of sacculus groups of respectively distributing in the orifice both ends department of dosing, every sacculus group includes four anchor sacculus that are annular array distribution along the pipe body outer wall at least, four anchor sacculus in the single sacculus group are each independent distribution, this dosing device, through initiative control, ensure to dosing orifice is just to the most concentrated region of thrombus all the time, avoid the unnecessary washing of medicine waste and vessel wall, greatly improved the utilization efficiency and the thrombolysis speed of traditional chinese medicine thrombolysis medicine. However, the method has the defects of large outer diameter of the catheter, poor vascular trafficability, complicated operation and easy damage to the vascular wall, and the problems of fluid control of dilution, backflow and uneven mixing after the liquid medicine flows out are not fundamentally solved. In summary, the existing intravascular targeting drug delivery technology has the common bottlenecks of passive inefficiency of fluid control, disconnection of drug delivery and positioning sensing and lack of systematic optimization of structural design, so that the drug utilization rate in clinical application is low, the side effect risk is high, the operation depends on experience, the drug delivery accuracy is limited, and the use requirement of clinical accurate interventional therapy is difficult to meet. Disclosure of utility model The utility model aims to overcome the defects in the prior art, and provides a targeted drug delivery device with catheter pose monitoring, which enhances the local residence and mixing efficiency of drugs by optimizing the fluid structure in a drug delivery catheter, and integrates pose sensing to realize accurate navigation and evaluation, thereby improving the treatment efficiency and the operation intelligentization level of intravascular local targeted drug delivery. In order to achieve the above purpose, the utility model adopts the following technical scheme: The utility model provides a take target dosing device of pipe position monitoring, includes dosing pipe and monitoring mechanism, dosing pipe runs through monitoring mechanism, monitoring mechanism is used for monitoring dosing pipe's