CN-224221374-U - Multichannel microfluidic chip for preparing drug microspheres

CN224221374UCN 224221374 UCN224221374 UCN 224221374UCN-224221374-U

Abstract

The application relates to the technical field of medicine preparation, in particular to a multichannel microfluidic chip for preparing medicine microspheres, which comprises a chip base and a chip end cover, wherein the chip end cover is arranged on the chip base, a liquid medicine bin and a base liquid bin are arranged on the chip end cover, the liquid medicine bin is separated from the base liquid bin through a separation wall, a channel is further arranged on the chip end cover, the channel is communicated with the liquid medicine bin and the base liquid bin, and liquid medicine contained in the liquid medicine bin and base liquid contained in the base liquid bin enter the channel and flow to the output end of the channel. The chip end cover and the chip base of the application have unique shapes, and the liquid medicine bin and the base liquid bin are reasonably distributed, so that the liquid medicine and the base liquid can be orderly distributed in a specific space by the design, and a good foundation is provided for subsequent operation.

Inventors

LIU JING
ZHANG QI
LV DI
Hu Chaoshan
TANG LIJUAN
XIA MEIHONG

Assignees

中日友好医院(中日友好临床医学研究所)

Dates

Publication Date: 20260512
Application Date: 20250529

Claims (10)

1. A multichannel microfluidic chip for preparing medicine microspheres is characterized by comprising a chip base and a chip end cover; the chip end cover is arranged on the chip base; the chip end cover is provided with a liquid medicine bin and a base liquid bin; the liquid medicine bin is separated from the base liquid bin by a separation wall; The chip end cover is also provided with a channel; The channel is communicated with the liquid medicine bin and the base liquid bin; The liquid medicine contained in the liquid medicine bin and the base liquid contained in the base liquid bin enter the channel and flow to the output end of the channel; the liquid medicine and the base liquid are mutually insoluble liquid.
2. The multi-channel microfluidic chip for preparing pharmaceutical microspheres of claim 1, wherein the chip end caps and the chip base are both circular; The liquid medicine bin is round and is arranged at the center of the chip end cover; The base liquid bin is annular and overlapped with the geometric center of the liquid medicine bin.
3. The multi-channel microfluidic chip for preparing pharmaceutical microspheres according to claim 1, wherein the channels are provided with a plurality of channels; All the channels are straight; the virtual axes of all the channels intersect at the geometric center of the chip end cover; The channel is formed by surrounding a concave structure arranged on the lower end face of the chip end cover and the top face of the chip base.
4. The multi-channel microfluidic chip for preparing medicine microspheres according to claim 1, wherein openings are formed at the upper ends of the medicine liquid bin and the base liquid bin for adding medicine liquid and base liquid.
5. The multi-channel microfluidic chip for preparing pharmaceutical microspheres according to claim 1, wherein the lower end of the partition wall is provided with a protrusion; the vertical height of the lower end surface of the protruding part is lower than that of the top end of the channel; the thickness of the protruding portion is the same as the thickness of the partition wall.
6. The multi-channel microfluidic chip for preparing pharmaceutical microspheres according to claim 5, wherein the protrusion is detachably connected to the partition wall.
7. The multi-channel microfluidic chip for preparing a drug microsphere according to claim 6, wherein the protruding portion comprises an upper end face, a lower end face, an inner end face and an outer end face; the upper end face and the outer end face are non-treatment faces, and the lower end face and the inner end face are treatment faces; the treated side has a higher material surface energy than the untreated side.
8. The multi-channel microfluidic chip for preparing pharmaceutical microspheres according to claim 7, wherein the processing surface is provided with annular nano-pits.
9. The multi-channel microfluidic chip for preparing pharmaceutical microspheres of claim 5, further comprising guide sidewalls; The guide side wall is connected with the protruding part and extends along the axial direction of the channel to extend to one side of the channel away from the liquid medicine bin.
10. The multi-channel microfluidic chip for preparing pharmaceutical microspheres according to claim 9, wherein the inner walls of the guiding sidewalls are treated surfaces.

Description

Multichannel microfluidic chip for preparing drug microspheres Technical Field The application relates to the technical field of medicine preparation, in particular to a multichannel microfluidic chip for preparing medicine microspheres. Background The principle of microfluidic preparation of droplet microspheres is based on microfluidic technology, and by precisely controlling the flow of two or more immiscible fluids in a microchannel, internal phase fluid is sheared into uniform droplet microspheres by external phase fluid using interfacial tension and shear force. Disclosure of utility model The application aims to provide a multichannel microfluidic chip for preparing drug microspheres, which aims to solve at least one technical problem in the prior art. In order to solve the technical problems, the multichannel microfluidic chip for preparing the drug microspheres comprises a chip base and a chip end cover; the chip end cover is arranged on the chip base; the chip end cover is provided with a liquid medicine bin and a base liquid bin; the liquid medicine bin is separated from the base liquid bin by a separation wall; The chip end cover is also provided with a channel; The channel is communicated with the liquid medicine bin and the base liquid bin; The liquid medicine contained in the liquid medicine bin and the base liquid contained in the base liquid bin enter the channel and flow to the output end of the channel. Further, the chip end cover and the chip base are both round; The liquid medicine bin is round and is arranged at the center of the chip end cover; The base liquid bin is annular and overlapped with the geometric center of the liquid medicine bin. Further, the liquid medicine and the base liquid are mutually insoluble liquid. Further, the channel is provided with a plurality of channels; All the channels are straight; the virtual axes of all the channels intersect at the geometric center of the chip end cap. Further, the channel is surrounded by a concave structure arranged on the lower end face of the chip end cover and the top face of the chip base. Further, openings are formed in the upper ends of the liquid medicine bin and the base liquid bin and are used for adding liquid medicine and base liquid. Further, the lower end of the partition wall is provided with a protruding part; the vertical height of the lower end surface of the protruding part is lower than that of the top end of the channel; the thickness of the protruding portion is the same as the thickness of the partition wall. Further, the protrusion is detachably connected with the partition wall. Further, the protruding portion includes an upper end face, a lower end face, an inner end face, and an outer end face; the upper end face and the outer end face are non-treatment faces, and the lower end face and the inner end face are treatment faces; the treated side has a higher material surface energy than the untreated side. Further, the treatment surface is provided with annular nano pits. Further, the guide side wall is also included; The guide side wall is connected with the protruding part and extends along the axial direction of the channel to extend to one side of the channel away from the liquid medicine bin. Further, the inner wall of the guiding side wall is a treatment surface. By adopting the technical scheme, the application has the following beneficial effects: (1) The chip end cover and the chip base are unique in shape, the liquid medicine bin and the base liquid bin are reasonable in layout, and the liquid medicine and the base liquid can be orderly distributed in a specific space by the design, so that a good foundation is provided for subsequent operation. (2) The multiple linear channels and the virtual axes intersect at the geometric center of the chip end cover, and the multiple channels operate simultaneously, so that the efficiency of microsphere preparation is greatly improved compared with that of the traditional single-channel microfluidic chip. (3) The channel is surrounded by the concave structure of the lower end surface of the chip end cover and the top surface of the chip base, the structure is simple and easy to manufacture, the tightness and the stability of the channel are ensured, and the stable flow of the liquid medicine and the base liquid in the channel is facilitated. (4) The openings are formed in the upper ends of the liquid medicine bin and the base liquid bin, so that liquid medicine and base liquid are conveniently added, operators can conveniently supplement liquid in time according to actual demands, and the use convenience is improved. (5) The lower end of the partition wall is provided with the protruding part, the vertical height of the lower end surface of the protruding part is lower than that of the top end of the channel, and the thickness of the protruding part is the same as that of the partition wall. (6) The surface treatment mode can improve the surface liquid tension o