CN-224221377-U - Multistage micro-fluidic chip and chip production die

Abstract

The utility model relates to the technical field of microfluidics and discloses a multistage microfluidic chip, which at least comprises a first-stage collision fluid passage and a second-stage collision fluid passage, wherein a mixing passage of the upper-stage fluid passage is arranged as a premixing fluid passage of the lower-stage fluid passage, the first-stage collision fluid passage comprises a first premixing fluid passage and a second premixing fluid passage, a first-stage fluid collision passage is arranged between the first premixing fluid passage and the second premixing fluid passage, the first-stage fluid collision passage collides and enters the second-stage premixing fluid passage, a second-stage fluid collision passage is arranged between the third premixing fluid passage and the fourth premixing fluid passage, and the second-stage fluid collision passage collides and enters the mixing passage. The multistage microfluidic chip has the advantages of high-efficiency mixing, low shearing damage, easiness in integrated packaging, batch manufacturing and the like, and the microfluidic mixing performance and the system practicability are remarkably improved.

Inventors

• ZHAO YAOLIN
• CHEN YANHONG

Assignees

• 广州纳微流控科技有限公司

Dates

Publication Date

20260512

Application Date

20250721

Claims (10)

1. 1. The multistage microfluidic chip is characterized by at least comprising a primary collision fluid passage and a secondary collision fluid passage, wherein a mixing channel of the primary fluid passage is set as a premixing fluid channel of the next fluid passage; The first-stage collision fluid passage comprises a first premixing fluid passage and a second premixing fluid passage, a first-stage fluid collision passage is arranged between the first premixing fluid passage and the second premixing fluid passage, and the first-stage fluid collision passage enters the second-stage premixing fluid passage after collision; The second-stage collision fluid passage comprises a third premixed fluid passage and a fourth premixed fluid passage, wherein the third premixed fluid passage is communicated with the first-stage fluid collision passage, a second-stage fluid collision passage is arranged between the third premixed fluid passage and the fourth premixed fluid passage, and the second-stage fluid collision passage enters the mixing passage after collision.
2. 2. The multi-stage microfluidic chip of claim 1, wherein the injection ports of the peer premix fluid channels are at the same level and the pipe diameters of the premix fluid channels are uniform, i.e., the injection ports of the first premix fluid channel and the second premix fluid channel are at the same level and the injection ports of the third premix fluid channel and the fourth premix fluid channel are at the same level.
3. 3. The multistage microfluidic chip according to claim 2, wherein the primary fluid collision channel is arranged at the middle position of the first premixed fluid channel and the second premixed fluid channel, the primary fluid collision channel comprises a fluid acceleration part and a fluid collision part, the two ends of the collision channel are connected with the premixed fluid channel to form the fluid acceleration part, the middle part is the fluid collision part, the pipe diameter of the fluid acceleration part is gradually reduced from the premixed fluid channel to the fluid collision part, and the two sides of the collision channel are symmetrically arranged.
4. 4. The multistage microfluidic chip according to claim 3, wherein the starting ends of the third premixed fluid channel and the fourth premixed fluid channel are arranged on the same horizontal plane, the starting ends of the mixed fluid channels are provided with arc slow flow bends, the slow flow bends are extended to form a horizontal flow channel, the secondary fluid collision channel comprises a fluid accelerating portion and a fluid collision portion, the connecting ends of the two ends of the collision channel and the premixed fluid channels are the fluid accelerating portion, the middle of the collision channel is the fluid collision portion, the pipe diameters of the fluid accelerating portion are gradually reduced from the premixed fluid channel to the fluid collision portion, and the two sides of the collision channel are symmetrically arranged.
5. 5. The multi-stage microfluidic chip of claim 3 or 4, wherein said primary and secondary impinging fluid pathways comprise, but are not limited to, a peer having only two premix fluid channels.
6. 6. The multi-stage microfluidic chip according to claim 4, wherein a mixing channel extends after the secondary fluid impinges on the channel, and a discharge port is provided at a distal end of the mixing channel.
7. 7. The multi-stage microfluidic chip according to claim 6, wherein the chip comprises an upper cover and a lower cover, fluid channels are formed in corresponding positions of the upper cover and the lower cover, the upper cover and the lower cover are mutually embedded to form the multi-stage microfluidic chip, and an injection port and an exhaust port are formed on surfaces of the upper cover and the lower cover.
8. 8. The production die for injection molding the multistage microfluidic chip according to any one of claims 1 to 6 is characterized by comprising a front die and a rear die, wherein the front die is provided with a glue injection port, the front die is communicated into a model groove, the surface of the rear die is provided with a die groove with an upper cover and a lower cover, groove bodies are symmetrically arranged, and S-shaped glue injection channels are arranged between the groove bodies.
9. 9. The production tool of claim 8, wherein the front and rear molds are laterally provided with cold and hot runners extending through the mold body.
10. 10. The production die of claim 9, wherein a plurality of fool-proof cylinders are arranged in the die groove of the rear die, and the rear die is provided with garbage nail holes along the outer edge of the die groove.

Description

Multistage micro-fluidic chip and chip production die Technical Field The utility model relates to the technical field of microfluidic chips, in particular to a multistage microfluidic chip and a chip production die. Background As an emerging technical means for treating micro-volume fluid, the microfluidic technology has the remarkable advantages of less reagent consumption, high reaction speed, high heat and mass transfer efficiency, easiness in integration and automatic control and the like. In the fields of biological medicine analysis, chemical synthesis, environmental monitoring, life science research and the like, the microfluidics technology shows great application value and economic benefit by virtue of high flux control capability and accurate reaction condition management. In microfluidic systems, mixers are critical components to achieve thorough mixing of multiphase or multicomponent fluids. According to different design requirements, common micro-fluid mixer structural forms comprise a T-shaped structure, a Y-shaped structure, a cross-shaped structure, an interlaced herringbone (STAGGERED HERRINGBONE) structure, a network structure formed by a plurality of circular rings or spiral channels and the like. These structures, through different geometry and flow characteristics designs, allow two or more phases of fluid to mix in a microscale channel, thus being useful for preparing nanoparticles, synthesizing compounds, or performing chemical/biological reactions. Taking the most commonly used T-shaped structure as an example, it is usually composed of a section of simple three-way pipeline, two-phase fluid enters from inlets on both sides respectively, is preliminarily mixed in straight pipe sections of the same size, and then is discharged from a third pipeline and enters a subsequent process or detection unit. At present, the structure has the following main defects in practical application: 1. The mixing efficiency is low and the reagent waste is serious, and because the two-phase fluid flows in parallel in a straight pipe at a higher linear speed, and lack of sufficient shearing and vortex effects, the mixing effect is not ideal, and the flow speed or multi-stage mixing is often required to be increased, so that the consumption and waste of the reagent are further aggravated. 2. The pipeline connection is tedious, the integration level is low, and the traditional T-shaped mixer relies on an external pipeline and a joint to connect an input interface and an output interface, so that the assembly and debugging difficulty of the system are increased, and the follow-up modularization integration and on-site rapid deployment are not facilitated. Therefore, a microfluidic mixer structure having both efficient mixing performance and easy integration characteristics is needed to further improve the overall performance and practicality of the microfluidic system. Disclosure of utility model The utility model provides a multistage microfluidic chip, which combines the advantages of high-efficiency mixing, low shearing damage, easy integrated packaging, batch manufacturing and the like through the innovative structural design of the combination of the stage premixing and the stage clash, and remarkably improves the microfluidic mixing performance and the system practicability. The utility model solves the technical problems by the following technical proposal: The multistage microfluidic chip at least comprises a primary collision fluid passage and a secondary collision fluid passage, wherein a mixing channel of the primary fluid passage is set as a premixing fluid channel of the next fluid passage; The first-stage collision fluid passage comprises a first premixing fluid passage and a second premixing fluid passage, a first-stage fluid collision passage is arranged between the first premixing fluid passage and the second premixing fluid passage, and the first-stage fluid collision passage enters the second-stage premixing fluid passage after collision; The second-stage collision fluid passage comprises a third premixed fluid passage and a fourth premixed fluid passage, wherein the third premixed fluid passage is communicated with the first-stage fluid collision passage, a second-stage fluid collision passage is arranged between the third premixed fluid passage and the fourth premixed fluid passage, and the second-stage fluid collision passage enters the mixing passage after collision. In a specific embodiment, the injection ports of the same-stage premix fluid channels are in the same horizontal plane, and the pipe diameters of the premix fluid channels are identical, that is, the injection ports of the first premix fluid channel and the second premix fluid channel are in the same horizontal plane, and the injection ports of the third premix fluid channel and the fourth premix fluid channel are in the same horizontal plane. In a specific embodiment, the primary fluid collision channel is arranged at the