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CN-224221380-U - Annotate liquid ware and density gradient system preparation facilities

CN224221380UCN 224221380 UCN224221380 UCN 224221380UCN-224221380-U

Abstract

The utility model discloses a liquid injector and a density gradient system preparation device, wherein the liquid injector comprises a liquid injection pipe, the liquid injection pipe is provided with an inlet and an outlet, the liquid injection pipe comprises an outflow section, the outflow section is provided with an outlet, when the liquid injector is in a liquid injection posture, the inner wall surface of the outflow section comprises a bearing surface positioned at the bottommost part of the inner wall surface, the bearing surface is continuously arranged and extends to the furthest end of the outflow section, and the outlet is configured at least for liquid to flow out in the process of flowing along the outflow section. The embodiment can prevent the liquid from directly flowing downwards from the bottom of the outflow section before flowing out of the outflow section, so that the liquid is prevented from directly impacting the injected liquid layer downwards. On the other hand, the outlet is configured at least for the outflow of liquid during flow along the outflow section, in which case the liquid is able to diffuse relatively uniformly, avoiding accumulation of liquid at the distal end surface into the injected liquid layer, compared to conventional tubing which is open only at the distal end surface.

Inventors

  • BIAN YINGJIE
  • LIN ZHENYU

Assignees

  • 广州国家实验室

Dates

Publication Date
20260512
Application Date
20250529

Claims (15)

  1. 1. A liquid injector for injecting liquid into the sample container in a set liquid injection posture, characterized in that the liquid injector comprises a liquid injection pipe, the liquid injection pipe is provided with an inlet for liquid to flow in and an outlet for liquid to flow out; The liquid injection pipe comprises an outflow section, the outflow section is provided with the outlet, when the liquid injector is in the liquid injection posture, the inner wall surface of the outflow section comprises a bearing surface positioned at the bottommost part of the inner wall surface, the bearing surface is continuously arranged and extends to the farthest end of the outflow section, and the outlet is configured at least for liquid to flow out in the process of flowing along the outflow section.
  2. 2. The injector of claim 1, wherein the outlet extends along a length of the outflow section, the outlet having a first end along the length, the first end extending to a distal-most end of the outflow section.
  3. 3. The injector of claim 2, wherein the first end extends to the bearing surface.
  4. 4. The injector of claim 2, wherein the outlet further has a second end along the length, wherein the distance between the bearing surface and the outlet tapers in a direction from the second end to the first end.
  5. 5. The infuser of claim 1 wherein a distal face of the outflow section is closed.
  6. 6. The injector of claim 5, wherein the outlet extends along the length of the outflow section or the outlet is provided in plurality and the outlets are spaced apart along the length of the outflow section.
  7. 7. The liquid injector of claim 1, wherein the liquid injector further comprises an inflow segment, one end of the inflow segment is communicated with the outflow segment, the other end of the inflow segment is provided with the inlet, and an axis of the inflow segment intersects with an axis of the outflow segment.
  8. 8. The injector of claim 7, wherein the axis of the inflow segment is perpendicular to the axis of the outflow segment.
  9. 9. The syringe of claim 7, further comprising an inlet tube connected to the syringe tube, the inlet tube having a fluid inlet and a fluid outlet at each end, the fluid outlet communicating with the inlet of the inflow section, the fluid inlet having a cross-sectional area greater than the cross-sectional area of the inlet.
  10. 10. The injector of claim 1, wherein the inner wall surface of the outflow section is configured as an arcuate wall surface.
  11. 11. A density gradient system preparation apparatus, characterized by comprising: The injector of any one of claims 1 to 10; the bearing seat is used for bearing the sample container; The mounting bracket is connected to the bearing seat and used for mounting the liquid injector in the liquid injection posture.
  12. 12. The apparatus of claim 11, further comprising a drive device, the carriage being coupled to at least one of the drive devices in the mounting frame, the drive device being configured to drive relative movement between the carriage and the mounting frame, the relative movement having at least a component of movement in a vertical direction.
  13. 13. The apparatus of claim 11, wherein the mounting bracket comprises a mounting plate having a first placement hole, the injector further comprising a mounting flange connected to the injection tube, the injection tube passing through the first placement hole, the mounting flange abutting the mounting plate to suspend the injector from the mounting plate.
  14. 14. The density gradient system manufacturing apparatus of claim 11, wherein the carrier has a second placement hole for placement of the sample container; Or the density gradient system preparation device further comprises a bearing part, wherein the bearing part is provided with a second placing hole for placing the sample container, is placed on the bearing seat, and can move relative to the bearing seat to be separated from the bearing seat.
  15. 15. The apparatus according to claim 14, wherein an axis of the second placement hole is arranged in a vertical direction, and an axis of the outflow section is parallel to a horizontal direction when the injector is in the set posture.

Description

Annotate liquid ware and density gradient system preparation facilities Technical Field The utility model relates to the technical field of biology, in particular to a liquid injector and a density gradient system preparation device. Background The density gradient centrifugation technology is to form a continuous or discontinuous density gradient system in a centrifuge tube through a certain liquid, place a cell suspension or tissue homogenate on top of the liquid, and complete the separation of cells, organelles or particles under the action of gravity or centrifugal force. In the whole density gradient centrifugation technical architecture, the emphasis is that liquids with different densities are stably loaded into a centrifuge tube and form clear boundaries, and particularly when liquid adding operation is carried out, the liquids can be sequentially added according to the order from large to small or from small to large. In the related art, the liquid injector is used for adding liquid, the liquid can be led to the pipe wall of the centrifuge pipe by the liquid injector, and the liquid is buffered through the pipe wall, so that the liquid can flow downwards along the pipe wall, however, the injected liquid still can impact the injected liquid layer in the mode, and thus the problems such as solution mixing, density gradient disturbance and the like are generated. Disclosure of utility model The present utility model aims to solve at least one of the technical problems existing in the prior art. Therefore, the utility model provides the liquid injector, which can reduce the impact of post-injection liquid on the injected liquid and improve the problems of solution mixing, density gradient disturbance and the like. The utility model also provides a device for preparing the density gradient system. According to the liquid injector in the first embodiment of the present utility model, the liquid injector is used for injecting liquid into a sample container in a set liquid injection posture, and comprises a liquid injection pipe, wherein the liquid injection pipe is provided with an inlet for liquid to flow in and an outlet for liquid to flow out; The liquid injection pipe comprises an outflow section, the outflow section is provided with the outlet, when the liquid injector is in the liquid injection posture, the inner wall surface of the outflow section comprises a bearing surface positioned at the bottommost part of the inner wall surface, the bearing surface is continuously arranged and extends to the farthest end of the outflow section, and the outlet is configured at least for liquid to flow out in the process of flowing along the outflow section. The liquid injector provided by the embodiment of the utility model has at least the following beneficial effects: The embodiment can prevent the liquid from directly flowing downwards from the bottom of the outflow section before flowing out of the outflow section, so that the liquid is prevented from directly impacting the injected liquid layer downwards. On the other hand, the outlet is configured at least for the outflow of liquid during flow along the outflow section, in which case the liquid is able to diffuse relatively uniformly, avoiding accumulation of liquid at the distal end surface into the injected liquid layer, compared to conventional tubing which is open only at the distal end surface. In other embodiments of the utility model, the outlet extends along the length of the outflow section, the outlet having a first end along the length, the first end extending to the most distal end of the outflow section. In other embodiments of the utility model, the first end extends to the bearing surface. In other embodiments of the utility model, the outlet further has a second end along the length, wherein the distance between the bearing surface and the outlet tapers in a direction from the second end to the first end. In other embodiments of the utility model, the distal face of the outflow section is closed. In other embodiments of the present utility model, the outlet may extend along the length direction of the outflow section, or the outlet may be provided in plurality, and the outlets may be provided in plurality at intervals along the length direction of the outflow section. In other embodiments of the present utility model, the liquid injection pipe further includes an inflow section, one end of the inflow section is communicated with the outflow section, the other end of the inflow section is provided with the inlet, and an axis of the inflow section intersects with an axis of the outflow section. In other embodiments of the utility model, the axis of the inflow section is perpendicular to the axis of the outflow section. In other embodiments of the present utility model, the liquid injector further includes an inlet pipe connected to the liquid injection pipe, two ends of the inlet pipe are respectively provided with a liquid injection port a