CN-224221545-U - Magnetic particle separating device

Abstract

The application relates to the technical field of magnetic particle separation, in particular to a magnetic particle separation device which comprises a magnet container, a first magnet group and a second magnet group, wherein the magnet container is provided with a separation cavity, the first magnet group comprises a plurality of first magnets, the first magnets are arranged on the outer peripheral side of the separation cavity along a first circumference, the first magnet group forms a first magnetic field in the whole separation cavity, the second magnet group comprises at least one second magnet, the second magnet is positioned at least one end of the magnet container, the second magnet is arranged on the outer peripheral side of the separation cavity along a second circumference, the diameter of the second circumference is smaller than that of the first circumference, the magnetization direction of the second magnet group is opposite to that of the first magnet group, and the second magnet group is used for correcting the first magnetic field at the end part of the separation cavity. The corrected first magnetic field has an annular magnetic field with a larger radius, and the magnetic particles are distributed on the wall of the reagent bottle more uniformly after being separated in the separation cavity.

Inventors

• KANG YAN
• WU GENGBO

Assignees

• 深圳达远辰光科技有限公司

Dates

Publication Date

20260512

Application Date

20250729

Claims (10)

1. 1. A magnetic particle separation device, comprising: A magnet container having a separation chamber; The first magnet group comprises a plurality of first magnets which are arranged on the outer peripheral side of the separation cavity along a first circumference, wherein an included angle of a magnetization direction is delta alpha, an included angle of a direction opposite to a circle center is delta beta, and delta alpha = 3 delta beta, and a first magnetic field is formed in the whole separation cavity by the first magnet group; And the second magnet group comprises at least one second magnet, the second magnet is positioned at least one end of the magnet container, the second magnets are arranged on the outer circumferential side of the separation cavity along a second circumference, the diameter of the second circumference is smaller than that of the first circumference, the magnetization direction of the second magnet group is opposite to the magnetization direction determined according to the magnetization direction rule of the first magnet group, and the second magnet group forms adjustment of the first magnetic field at the end part of the separation cavity.
2. 2. The magnetic particle separating device according to claim 1, wherein the second magnet is provided at both ends of the magnet container.
3. 3. The magnetic particle separating device according to claim 2, wherein the second magnet is arranged offset from the first magnet in a circumferential direction.
4. 4. A magnetic particle separating device according to claim 3, wherein the second magnet group comprises four second magnets, and the angle between the directions of the adjacent two second magnets with respect to the center of the circle is 90 degrees.
5. 5. The magnetic particle separating device according to claim 4, wherein the first magnet group comprises twelve first magnets, and an included angle between two adjacent first magnets with respect to the center direction is 30 degrees.
6. 6. The magnetic particle separating device according to claim 1, wherein the second magnet has a dimension in the axial direction of the separating chamber of 5-20 mm.
7. 7. The magnetic particle separating device according to any one of claims 1 to 6, wherein the end face of the magnet container is provided with a receiving hole for receiving the first magnet and a receiving groove for receiving the second magnet.
8. 8. The magnetic particle separating device according to claim 7, comprising a fixing assembly comprising a fixing piece covering an end face of the magnet container and a fastener connecting the fixing piece with the magnet container.
9. 9. The magnetic particle separation device according to claim 7 comprising a cover plate connected to the magnet receptacle, the cover plate having a relief aperture disposed therein, the relief aperture being axially aligned with the separation chamber.
10. 10. The magnetic particle separation device according to claim 9 comprising a base connected to the magnet holder and located at an end of the magnet holder remote from the cover plate.

Description

Magnetic particle separating device Technical Field The application relates to the technical field of magnetic particle separation, in particular to a magnetic particle separation device. Background In the fields of biomedicine, chemical detection and the like, magnetic particle separation technology is widely applied to the extraction and purification of target substances such as proteins, nucleic acids and the like. The magnetic separation device generally generates a quadrupole magnetic field in a cylindrical inner area surrounded by a plurality of magnets with a specific relation between a magnetization direction and a space angle, the magnetic field has circular magnetic field distribution in a horizontal plane, magnetic field gradients are distributed along the radial direction of a circular ring, and magnetic particles move along the magnetic field gradient direction to realize magnetic particle separation. However, in the practical use process of the existing magnetic separation device, the magnetic particles can move along the ring shape and finally form aggregation at certain positions on the bottle wall of the reagent bottle, so that the separated magnetic particles are unevenly distributed on the bottle wall of the reagent bottle, and the subsequent treatment of the magnetic particles is not facilitated. Disclosure of utility model The application mainly solves the problem that magnetic particles are unevenly distributed on the bottle wall of the reagent bottle. According to a first aspect, there is provided in one embodiment a magnetic particle separation device comprising: A magnet container having a separation chamber; The first magnet group comprises a plurality of first magnets which are arranged on the outer peripheral side of the separation cavity along a first circumference, wherein an included angle of a magnetization direction is delta alpha, an included angle of a direction opposite to a circle center is delta beta, and delta alpha = 3 delta beta, and a first magnetic field is formed in the whole separation cavity by the first magnet group; And the second magnet group comprises at least one second magnet, the second magnet is positioned at least one end of the magnet container, the second magnets are arranged on the outer circumferential side of the separation cavity along a second circumference, the diameter of the second circumference is smaller than that of the first circumference, the magnetization direction of the second magnet group is opposite to the magnetization direction determined according to the magnetization direction rule of the first magnet group, and the second magnet group forms adjustment of the first magnetic field at the end part of the separation cavity. In some embodiments, the magnet container is provided with the second magnet at both ends. In some embodiments, the second magnets are arranged offset from the first magnets in the circumferential direction. In some embodiments, the second magnet group includes four second magnets, and an included angle between two adjacent second magnets and a direction of a center of the circle is 90 degrees. In some embodiments, the first magnet group includes twelve first magnets, and an included angle between two adjacent first magnets and a center direction is 30 degrees. In some embodiments, the second magnet has a dimension in the axial direction of the separation chamber of 5-20 millimeters. In some embodiments, the end surface of the magnet container is provided with a receiving hole for receiving the first magnet and a receiving groove for receiving the second magnet. In some embodiments, the magnetic particle separation device includes a securing assembly including a securing tab that overlies an end face of the magnet receptacle and a fastener that connects the securing tab with the magnet receptacle. In some embodiments, the magnetic particle separation device comprises a cover plate connected with the magnet container, wherein the cover plate is provided with an avoidance hole, and the avoidance hole is axially aligned with the separation cavity. In some embodiments, the magnetic particle separation device comprises a base coupled to the magnet holder at an end of the magnet holder remote from the cover plate. According to the magnetic particle separating device of the embodiment, the first magnet group forms a first magnetic field in the whole separating cavity, the second magnet group forms adjustment of the first magnetic field at the end part of the separating cavity, the magnetization direction of the second magnet group is opposite to that of the first magnet group, the second magnetic field is used for correcting the first magnetic field at the end part of the separating cavity, the corrected first magnetic field has an annular magnetic field with a larger radius, and the magnetic particles are distributed on the wall of the reagent bottle more uniformly after being separated in the separating cavity. Drawin