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CN-224227051-U - Sterile connection device and antigen harvesting device comprising same

CN224227051UCN 224227051 UCN224227051 UCN 224227051UCN-224227051-U

Abstract

The utility model provides a sterile connecting device and an antigen harvesting device comprising the same, and relates to the technical field of antigen preparation, wherein the sterile connecting device comprises a sealing cover, a telescopic sleeve assembly, a catheter and a regulating tube; the sealing cover comprises a cover body and a sterile isolation device arranged at the top of the cover body, one end of a telescopic sleeve assembly is sleeved on the guide pipe and the adjusting pipe, the other end of the telescopic sleeve assembly is connected with the sterile isolation device, the telescopic sleeve assembly comprises a telescopic sleeve, and the length of the telescopic sleeve changes along with the length of the guide pipe positioned in the telescopic sleeve. The telescopic sleeve assembly protects the leading-in hard tube, adjusts the hard tube and connects different parts, realize the independent sterilization. The technical problem that in the prior art, when the sterile antigen is transported at the temperature of-20 ℃ or 2-8 ℃, the sterile connection device is easy to cause the damage of a pipeline to cause antigen pollution is solved.

Inventors

  • HE SUN
  • ZHAO XIAOYING

Assignees

  • 天康生物制药有限公司

Dates

Publication Date
20260512
Application Date
20250411

Claims (10)

  1. 1. An aseptic connecting device is characterized by comprising a sealing cover, a telescopic sleeve assembly, a catheter and an adjusting tube; The sealing cover comprises a cover body (14) and a sterile isolation device (15) arranged at the top of the cover body (14); One end of the telescopic sleeve assembly is sleeved on the guide pipe and the adjusting pipe and used for providing a sealing space for the guide pipe and the adjusting pipe which are positioned in the telescopic sleeve assembly, and the other end of the telescopic sleeve assembly is connected with the sterile isolation device (15); the telescoping tube assembly comprises a telescoping tube (11), the length of the telescoping tube (11) varying with the length of a catheter located within the telescoping tube (11).
  2. 2. Sterile connection device according to claim 1, characterized in that the telescopic tube assembly further comprises a tube bottom (12) and a tube top (13) connected to the telescopic tube (11), the catheter and the adjusting tube extending into the telescopic tube (11) through the tube top (13), respectively; the guide pipe and the adjusting pipe are respectively connected with the sleeve top (13) in a threaded manner.
  3. 3. Sterile connection device according to claim 2, characterized in that the sleeve bottom (12) is provided with preset sealing holes corresponding to the catheter and the regulator tube, respectively; The aseptic isolation device (15) is respectively provided with preset sealing holes corresponding to the guide pipe and the regulating pipe.
  4. 4. Sterile connection device according to claim 1, characterized in that the catheter comprises a rigid catheter (21) connected to a telescopic tube assembly; The adjusting pipe comprises an adjusting hard pipe (31) connected with the telescopic pipe assembly; The length of the hard conduit (21) is equal to or more than the sum of the height of the contracted state of the telescopic tube (11) and the depth of a container connected with the sterile connecting device.
  5. 5. A sterile connection device according to claim 4, wherein the catheter further comprises a flexible catheter (22) and a flexible connection tube (23) communicating with an end of the rigid catheter (21) remote from the sterile isolation device (15); The soft conduit (22) is a silica gel hose or a thermoplastic tube; the flexible connecting pipe (23) is a thermoplastic pipe.
  6. 6. The aseptic connection device according to claim 5, characterized in that the adjustment tube further comprises an adjustment hose (32), said adjustment hose (32) being in communication with an end of the adjustment wand (31) remote from the telescopic tube assembly.
  7. 7. Sterile connection device according to claim 6, characterized in that the open ends of the flexible connection tube (23) and the adjustment hose (32) are provided with gas filtering means (41), respectively.
  8. 8. Sterile connection device according to claim 1, characterized in that the sterile isolation device (15) comprises a sterile connection/disconnection tab, a sterile connector, a sterile valve or a sterile filter.
  9. 9. Sterile connection device according to claim 8, characterized in that the sterile isolation device (15) is a sterile connection/disconnection tab.
  10. 10. An antigen harvesting device characterized by comprising a container (10) and a sterile connection device according to any one of claims 1 to 8; the sterile connection device is connected with the container in a sealing way through one end of the sealing cover, which is provided with a sterile isolation device (15).

Description

Sterile connection device and antigen harvesting device comprising same Technical Field The utility model relates to the technical field of antigen preparation, in particular to a sterile connecting device and an antigen harvesting device comprising the same. Background Antigen harvesting is an important step in the biopharmaceutical and biotechnology fields, and generally involves the isolation and purification of antigens from large scale cultured cells or culture media. At present, when the prepared large-volume antigen is harvested, the antigen needs to be connected into a prepared sterile container 50L barrel through a thermoplastic pipe in a sterile mode, the antigen is stored at 2-8 ℃ or-20 ℃ according to the test result of the pre-preservation condition of the antigen, and then the antigen is transported for a long distance through a transport company. In the transportation process, if the temperature is 2-8 ℃, a protection device is required to be installed for cold chain transportation, the price is high, and if the temperature is 2-8 ℃ or-20 ℃, the pipeline on the barrel cover is easy to damage in the transportation process, so that antigen pollution is caused. In view of this, the present utility model has been made. Disclosure of utility model The utility model aims to provide a sterile connecting device, which solves the technical problem that in the prior art, when the sterile connecting device is transported at the temperature of 2-8 ℃ or-20 ℃, the sterile connecting device is easy to cause antigen pollution due to pipeline breakage. The second object of the present utility model is to provide an antigen harvesting device. In order to achieve the above object of the present utility model, the following technical solutions are specifically adopted: in a first aspect, the present utility model provides an aseptic connection device comprising a seal cap, a telescoping tube assembly, a catheter and a regulator tube; the sealing cover comprises a cover body and a sterile isolation device arranged at the top of the cover body; One end of the telescopic sleeve assembly is sleeved on the guide pipe and the adjusting pipe and used for providing a sealing space for the guide pipe and the adjusting pipe which are positioned in the telescopic sleeve assembly, and the other end of the telescopic sleeve assembly is connected with the sterile isolation device; The telescoping tube assembly includes a telescoping tube having a length that varies with the length of a catheter positioned within the telescoping tube. Further, the telescopic sleeve assembly further comprises a sleeve bottom and a sleeve top which are connected with the telescopic sleeve, and the guide pipe and the adjusting pipe respectively penetrate through the sleeve top and extend into the telescopic sleeve; preferably, the guide tube and the adjusting tube are respectively in threaded connection with the sleeve top. Further, preset sealing holes corresponding to the guide pipe and the regulating pipe are respectively arranged on the sleeve bottom; Preferably, the aseptic isolation device is provided with preset sealing holes corresponding to the guide pipe and the regulating pipe respectively. Further, the catheter comprises a rigid catheter connected to the telescoping tube assembly; The adjusting pipe comprises an adjusting hard pipe connected with the telescopic sleeve component; Preferably, the length of the rigid conduit is greater than or equal to the sum of the height of the collapsed state of the telescoping tube and the depth of the container connected to the sterile connection device. Further, the catheter also comprises a soft catheter and a flexible connecting tube which are communicated with one end of the hard catheter far away from the sterile isolation device; preferably, the soft catheter is a silicone hose or a thermoplastic tube; preferably, the flexible connection pipe is a thermoplastic pipe. Further, the adjusting tube further comprises an adjusting hose which is communicated with one end, far away from the telescopic tube assembly, of the adjusting hard tube. Further, the open ends of the flexible connecting pipe and the adjusting hose are respectively provided with a gas filtering device. Further, the sterile isolation device comprises a sterile connection/disconnection tab, a sterile connector, a sterile valve or a sterile filter, preferably a sterile connection/disconnection tab. In a second aspect, the present utility model provides an antigen harvesting device comprising a container and a sterile connection device as described above; The sterile connection device is connected with the container in a sealing way through one end of the sealing cover, which is provided with the sterile isolation device. The sterile connecting device is characterized in that a sterile isolation device is arranged on a sealing cover, so that the sterile state is maintained when the sterile connecting device is operated in a non-steri