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CN-224227062-U - Sequencing chip pushing mechanism and sequencing chip pushing device

CN224227062UCN 224227062 UCN224227062 UCN 224227062UCN-224227062-U

Abstract

The disclosure relates to the technical field of high-throughput sequencing, in particular to a sequencing chip pushing mechanism and a sequencing chip pushing device, wherein the sequencing chip pushing mechanism comprises a base, a Z-direction adjusting assembly, a pushing component and a pushing component, the Z-direction adjusting assembly is arranged on one side of the base, the Z-direction adjusting assembly comprises a Z-direction moving component which can move along the Z direction, the pushing component is fixedly arranged on one side of the Z-direction moving component away from the base, the pushing component comprises a pushing surface, the pushing surface is positioned on one side of the pushing component away from the Z-direction moving component, the pushing surface is perpendicular to the X direction, a first stirring block extends from one end of the pushing surface in the Z direction and is away from the Z-direction moving component, and a second stirring block extends from the pushing surface on the other end of the Z direction in the X direction and is away from the Z-direction moving component.

Inventors

  • GU XIANGRONG
  • ZHONG XUEFENG
  • Wan Nianlian
  • WANG BO
  • CHEN HAONAN
  • XU JINKE

Assignees

  • 苏州吉因加生物医学工程有限公司

Dates

Publication Date
20260512
Application Date
20250402

Claims (10)

  1. 1. Sequencing chip pushing mechanism, its characterized in that includes: A base (21); A Z-direction adjusting assembly (22), wherein the Z-direction adjusting assembly (22) is arranged on one side of the base (21), the Z-direction adjusting assembly (22) comprises a Z-direction moving component (221) which can move along the Z direction, and The pushing component (23), the pushing component (23) is fixedly arranged at one side of the Z-direction moving component (221) far away from the base (21), and the pushing component (23) comprises: A pushing surface (231), wherein the pushing surface (231) is positioned at one side of the pushing component (23) away from the Z-direction moving component (221), and the pushing surface (231) is perpendicular to the X direction; A first toggle block (232), the first toggle block (232) extending from the pushing surface (231) in the X direction and away from the Z-direction moving member (221) at one end of the Z direction, and And a second toggle block (233), the second toggle block (233) extending from the pushing surface (231) in the X direction on the other end of the Z direction and away from the Z-direction moving member (221).
  2. 2. The sequencing chip pushing mechanism according to claim 1, wherein a first stirring surface (2321) is provided on a side of the first stirring block (232) close to the pushing surface (231), and the first stirring surface (2321) is a horizontal plane or an inclined plane formed by rotating along a Y axis via the horizontal plane.
  3. 3. The sequencing chip pushing mechanism according to claim 1, wherein a second stirring surface (2331) is provided on a side of the second stirring block (233) close to the pushing surface (231), and the second stirring surface (2331) is a horizontal surface or an inclined surface formed by rotating along a Y axis via the horizontal surface.
  4. 4. A sequencing chip pushing mechanism according to any of claims 1 to 3, characterized in that the Z-direction adjustment assembly (22) further comprises: a Z-direction mounting seat (222), wherein the Z-direction mounting seat (222) is arranged on the base (21); A Z-direction guide member (223), the Z-direction guide member (223) being fixedly provided to the Z-direction mount (222), the Z-direction guide member (223) extending in the Z-direction, the Z-direction moving member (221) being movably provided to the Z-direction guide member (223), and And the Z-direction elastic component (224), and the Z-direction elastic component (224) is arranged on both sides of the Z-direction moving component (221) along the Z direction.
  5. 5. The sequencing chip push mechanism of claim 4, wherein the Z-mount (222) comprises: A first mounting block (2221), and A second mounting block (2222), the second mounting block (2222) being located at one side of the first mounting block (2221) in the Z direction, Wherein one end of the Z-direction guiding component (223) is fixedly arranged on the first mounting block (2221), the other end of the Z-direction guiding component (223) is fixedly arranged on the second mounting block (2222), The Z-direction elastic component (224) is arranged between the first mounting block (2221) and the Z-direction moving component (221), and the Z-direction elastic component (224) is arranged between the second mounting block (2222) and the Z-direction moving component (221).
  6. 6. The sequencing chip pushing mechanism of claim 4, the sequencing chip pushing mechanism is characterized by further comprising: And the X-direction buffer assembly (24) is arranged between the base (21) and the Z-direction mounting seat (222).
  7. 7. The sequencing chip pushing mechanism of claim 6, wherein the X-direction buffer assembly (24) comprises: An X-direction moving member (241), wherein the X-direction moving member (241) is arranged between the Z-direction mounting seat (222) and the base (21), and the Z-direction mounting seat (222) is fixedly arranged on the X-direction moving member (241); An X-direction guide member (242), wherein the X-direction guide member (242) extends in the X-direction, one end of the X-direction guide member (242) is fixedly provided to the X-direction moving member (241), and the other end of the X-direction guide member (242) is movably provided to the base (21), and And an X-direction elastic member (243), wherein the X-direction elastic member (243) is provided between the X-direction moving member (241) and the base (21).
  8. 8. The sequencing chip pushing mechanism according to claim 7, wherein an X-direction channel (211) penetrating in the X-direction is provided on the base (21), one end of the X-direction guiding member (242) close to the base (21) is movably provided on the X-direction channel (211), and one end of the X-direction guiding member (242) close to the X-direction moving member (241) is fixedly provided on the X-direction moving member (241).
  9. 9. The sequencing chip pushing mechanism of claim 8, wherein the X-direction guiding member (242) is a shoulder screw, and an end of the shoulder screw near the X-direction moving member (241) is in threaded connection with the X-direction moving member (241).
  10. 10. Sequencing chip thrust unit, its characterized in that includes: the sequencing chip pushing mechanism (20) of any of claims 1 to 9, and -A drive mechanism (10), an actuation end of the drive mechanism (10) being connected to the base (21), the actuation end having at least translational degrees of freedom in the X-direction and the Z-direction.

Description

Sequencing chip pushing mechanism and sequencing chip pushing device Technical Field The present disclosure relates to the field of high throughput sequencing technologies, and in particular, to a sequencing chip pushing mechanism and a sequencing chip pushing device. Background High throughput sequencing technology, also known as "next generation" sequencing technology, is marked by the ability to sequence hundreds of thousands to millions of DNA molecules in parallel at a time, and generally short read lengths. The experimental process of high throughput sequencing comprises the following steps in sequence, sample preparation, library construction, sequencing reaction and data analysis. In the sequencing reaction step, a sequencing chip loaded with a sample is required to be inserted into a slot of a gene sequencer. Specifically, one end of the sequencing chip in the length direction can be inserted into the slot in advance, and then an acting force is applied to the other end of the sequencing chip in the length direction, so that the sequencing chip is inserted into a preset position of the slot. After the sequencing chip is pre-inserted into the slot, the slot can limit the movement of the sequencing chip in the width direction and the thickness direction, namely, the sequencing chip can only move along the length direction, so that the accurate insertion of the sequencing chip into the preset position of the slot is ensured, and the gene sequencer can work normally. In a scenario known to the inventors, during the process of inserting the sequencing chip into the slot, the interior of the gene sequencer applies pressure to the surface of the sequencing chip in the thickness direction, so that the sequencing chip can reach a predetermined position after moving in the thickness direction. However, the inventors found that the sequencing chip may be stuck at a position within the slot and cannot be moved in the thickness direction, and thus a sequencing chip pushing device is required so as to be able to move the sequencing chip in the thickness direction. Disclosure of utility model The disclosure aims to provide a sequencing chip pushing mechanism and a sequencing chip pushing device, which can drive a sequencing chip to move along the thickness direction of the sequencing chip so as to ensure that the sequencing chip can be accurately inserted into a preset position of a slot of a gene sequencer. To achieve the above object, the present disclosure provides a sequencing chip pushing mechanism comprising: A base; The Z-direction adjusting assembly is arranged on one side of the base and comprises a Z-direction moving part capable of moving along the Z direction, and The pushing component is fixedly arranged on one side, far away from the base, of the Z-direction moving component, and the pushing component comprises: The pushing surface is positioned at one side of the pushing component far away from the Z-direction moving component and is vertical to the X direction; a first toggle block extending from the pushing surface in the X direction at one end of the Z direction and away from the Z-direction moving member, and The second poking block extends from the pushing surface along the X direction on the other end of the Z direction and is far away from the Z-direction moving component. To achieve the above object, the present disclosure further provides a sequencing chip pushing device, including: The sequencing chip pushing mechanism and And the actuating end of the actuating mechanism is connected to the base, and at least has translational degrees of freedom along the X direction and the Z direction. Compared with the prior art, the method at least comprises the following beneficial effects: The base and the pushing component are connected through the Z-direction adjusting component, so that the pushing component can move in the Z direction (namely the thickness direction of the sequencing chip). When the sequencing chip needs to be adjusted, the base can be moved along the Z direction, so that the first stirring block or the second stirring block on the pushing component stirs the sequencing chip, and the sequencing chip is stirred in place. Drawings Fig. 1 shows a schematic diagram of a gene sequencer, sequencing chip, and sequencing chip pushing device according to an embodiment of the present disclosure. Fig. 2 shows a schematic diagram of a chip pushing mechanism according to an embodiment of the disclosure. Fig. 3 shows an exploded view of a chip pushing mechanism according to an embodiment of the present disclosure. FIG. 4 illustrates a cross-sectional view of a base and an X-direction buffer assembly according to an embodiment of the present disclosure. Reference numerals: 10. A driving mechanism; 20. Sequencing chip pushing mechanism, 21, base, 211, X-direction channel, 22, Z-direction adjusting component, 221, Z-direction moving component, 222, Z-direction installation seat, 2221, first inst