CN-224227064-U - Device for monitoring and evaluating microbial effect of combined medication on dairy products

CN224227064UCN 224227064 UCN224227064 UCN 224227064UCN-224227064-U

Abstract

The utility model provides a device for monitoring and evaluating microbial effect of combined medication on dairy products, and relates to the technical field of microbial analysis. The main body of the device for monitoring and evaluating the microbial effect of the combined drug on the dairy products is a microbial effect migration disc. The microorganism effect migration tray comprises a circular tray body formed by a bottom plate and a side plate. The separating ring table is convexly arranged on the bottom plate so as to divide the inner space of the disc body into an inner ring space and an outer ring space. The inner annular space is mainly used for inoculating primary microorganisms, the outer annular space is provided with a plurality of partition plates, and the partition plates are arranged in the outer annular space at intervals along the circumferential direction of the outer annular space so as to divide the outer annular space into a plurality of independent isolation spaces. The method aims at synchronously and in-situ testing the microbial effect in the dairy product by combining medicines in different combinations, different proportions and different dosages in the same microbial effect migration disc, realizes high-flux and visual in-situ control, and effectively avoids errors caused by inconsistent sources of microbial flora.

Inventors

LI YUN
QIU JING
Liang Yannei
BAI MEIJUAN
YAN YURU
CHEN LU
CHEN LEI

Assignees

中国农业科学院农业质量标准与检测技术研究所
内蒙古国家乳业技术创新中心有限责任公司

Dates

Publication Date: 20260512
Application Date: 20250427

Claims (10)

1. A device for monitoring and evaluating the effect of a combination on microorganisms in milk, comprising a microorganism effect migration disc (110); the microorganism effect migration disc (110) comprises: A circular tray body (113) formed by a bottom plate (111) and a side plate (112); a spacer ring stage (114), wherein the spacer ring stage (114) is convexly arranged on the bottom plate (111) so as to divide the internal space of the tray body (113) into an inner ring space (116) and an outer ring space (117); The plurality of division plates (115) are arranged on the outer annular space (117) at intervals along the circumferential direction of the outer annular space (117) so as to divide the outer annular space (117) into a plurality of independent isolation spaces (118).
2. The apparatus for monitoring and evaluating the effects of combination medications on microorganisms in milk according to claim 1, wherein the spacer ring stage (114) comprises a first spacer ring stage (119) and a second spacer ring stage (120); The first separation ring table (119) and the second separation ring table (120) are concentrically arranged on the bottom plate (111) in a protruding mode, and the diameter of the second separation ring table (120) is larger than that of the first separation ring table (119); -said first spacer ring stage (119) enclosing said inner ring space (116); -said first spacer ring stage (119) and said second spacer ring stage (120) enclosing therebetween said outer annular space (117); the microorganism effect migration disc (110) further comprises a water tank (121), wherein the water tank (121) is annular and is arranged between the second separation ring table (120) and the side plate (112).
3. The apparatus for monitoring and evaluating the effects of combination medications on microorganisms in milk according to claim 2, wherein the spacer ring stage (114) further comprises a third spacer ring stage (122); The third spacer ring stage (122) is arranged between the first spacer ring stage (119) and the second spacer ring stage (120) to divide the outer annular space (117) into a first outer annular space (123) between the first spacer ring stage (119) and the third spacer ring stage (122) and a second outer annular space (124) between the third spacer ring stage (122) and the second spacer ring stage (120); the first outer annular space (123) and the second outer annular space (124) are internally provided with the separation plates (115) at intervals along the circumferential direction.
4. A device for monitoring and evaluating the effect of combined medications on microorganisms in milk according to claim 3, characterized in that the first spacer ring stage (119) and the third spacer ring stage (122) are of the same height; The second spacer ring stage (120) has a height greater than the heights of the first spacer ring stage (119) and the third spacer ring stage (122); The divider plate (115) has a height that is greater than the heights of the first divider ring stage (119) and the third divider ring stage (122) and less than the height of the second divider ring stage (120).
5. A device for monitoring and evaluating the effect of combination medications on microorganisms in milk according to claim 3, characterized in that the divider plate (115) comprises a first divider plate (125) and a second divider plate (126); the first separation plate (125) comprises at least two separation plates, the first separation plate (125) is convexly arranged on the bottom plate (111), one end of the first separation plate is connected with the first separation ring table (119), and the other end of the first separation plate is connected with the second separation ring table (120) so as to circumferentially separate the first outer ring space (123) and the second outer ring space (124); The second partition plates (126) are multiple, the second partition plates (126) are convexly arranged on the bottom plate (111), one end of each second partition plate is connected with the second partition ring table (120), and the other end of each second partition plate is connected with the third partition ring table (122) so as to circumferentially partition the second outer ring space (124).
6. The device for monitoring and evaluating the effect of combination medications on microorganisms in milk according to claim 5, characterized in that said first divider plates (125) have two, and the central angle between two of said first divider plates (125) is 180 °.
7. The device for monitoring and evaluating the effect of combination medications on microorganisms in milk according to claim 6, wherein said second divider (126) has six, six said second dividers (126) and two said first dividers (125) capable of equally dividing said second outer annular space (124) into eight said isolated spaces (118).
8. The device for monitoring and evaluating the effect of combination drugs on microorganisms in milk according to any one of claims 1 to 7, characterized in that the dividing plate (115) is arranged along the radial direction of the tray (113).
9. The device for monitoring and evaluating the effect of combination drugs on microorganisms in milk according to any one of claims 1 to 7, characterized in that said base plate (111) is made of a black opaque material; The microorganism effect migration tray (110) further comprises a cover plate (127); The side plates (112), the separation ring table (114) and the cover plate (127) are made of transparent materials, and the side plates (112) are provided with scales.
10. The apparatus for monitoring and evaluating the effects of co-administered drugs on microorganisms in milk according to any one of claims 1 to 7, further comprising a reaction tank (130), an imaging device (140), a tank water tank (150), a heating assembly (160), a lifting and rotating tray (170), an environmental monitoring device (180) and a carbon dioxide gas cylinder (190); the reaction box (130) is provided with a reaction cavity (131); The imaging device (140) is arranged at the top of the reaction cavity (131) and can be connected with a computer to transmit pictures; The lifting rotary tray (170) is arranged at the bottom of the reaction cavity (131) and corresponds to the imaging device (140); The environment monitoring device (180) is arranged in the reaction cavity (131); the carbon dioxide gas cylinder (190) is connected to the reaction tank (130) to supply carbon dioxide to the reaction chamber (131); the box water tank (150) is arranged at the top of the lifting rotary tray (170), and the heating assembly (160) is arranged at the box water tank (150); The microorganism effect migration disc (110) is arranged in the box water tank (150).

Description

Device for monitoring and evaluating microbial effect of combined medication on dairy products Technical Field The utility model relates to the technical field of microbial analysis, in particular to a device for monitoring and evaluating microbial effect of combined medication on dairy products. Background The safety and the quality stability of the dairy product serving as special food with easy microorganism breeding are directly related to public health and industrial development. The inhibitory or pro-proliferative effects of drugs on microorganisms are a central concern for risk control, where combination drugs can delay or reduce the risk of microorganisms through complex interaction mechanisms (e.g., synergistic, antagonistic or additive effects). However, the effects of combination are affected by a number of factors, including the drug formulation dose, the mode of combination, the population heterogeneity of ancestral and different generations of microbial strains, etc., the dynamic and uncertainty of these factors makes the exploration of the characteristics of microbial population effects and the screening of control means very complex. In the prior art, the study of the combined drug effect aiming at dairy microorganisms generally adopts a single variable test mode, namely, independent tests are respectively carried out on different proportioning doses or drug combinations, and then analysis results are integrated. However, this method has significant limitations in that, on the one hand, a large number of independent tests result in a significant increase in workload, and on the other hand, it is difficult for the test environments (such as temperature and humidity, medium batch, initial concentration of microorganisms, etc.) to remain completely consistent, systematic errors may be introduced, affecting the comparability of the data and the reliability of the conclusions. Therefore, how to realize high-throughput synchronous test and real-time observation comparison of multiple variables (such as different drug ratios and combination modes) becomes a technical bottleneck in the art that needs to be broken through. Disclosure of utility model The utility model aims to provide a device for monitoring and evaluating the microbial effect of combined medicines on milk products, which can synchronously test the microbial effect of the combined medicines with different proportioning dosages and different combination modes on the milk products in one microbial effect migration disc, so that the test amount can be reduced, the mutual comparison is convenient, and the problem of systematic errors can be avoided. Embodiments of the utility model may be implemented as follows: the utility model provides a device for monitoring and evaluating the microbial effect of combined medication on dairy products, which comprises a microbial effect migration disc; The microorganism effect migration disc comprises: a circular tray body formed by a bottom plate and side plates; the separating ring table is convexly arranged on the bottom plate so as to separate the inner space of the disc body into an inner ring space and an outer ring space; The plurality of separation plates are arranged in the outer annular space at intervals along the circumferential direction of the outer annular space so as to separate the outer annular space into a plurality of independent isolation spaces. In an alternative embodiment, the spacer ring stage comprises a first spacer ring stage and a second spacer ring stage; The first separation ring table and the second separation ring table are concentrically arranged on the bottom plate in a protruding mode, and the diameter of the second separation ring table is larger than that of the first separation ring table; The first separation ring table is enclosed to form an inner ring space; an outer ring space is formed by enclosing the first separation ring platform and the second separation ring platform; The microorganism effect migration disc further comprises a water tank which is annular and is arranged between the second partition ring table and the side plate. In an alternative embodiment, the spacer ring stage further comprises a third spacer ring stage; The third separating ring stage is arranged between the first separating ring stage and the second separating ring stage so as to separate the outer ring space into a first outer ring space between the first separating ring stage and the third separating ring stage and a second outer ring space between the third separating ring stage and the second separating ring stage; And the first outer annular space and the second outer annular space are internally provided with partition plates at intervals along the circumferential direction. In an alternative embodiment, the first spacer ring stage and the third spacer ring stage are the same height; the height of the second separating ring platform is greater than that of the first separating