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CN-224227077-U - Immobilized enzyme reactor for bisoprolol synthesis

CN224227077UCN 224227077 UCN224227077 UCN 224227077UCN-224227077-U

Abstract

The utility model relates to the technical field of reactors, and particularly discloses an immobilized enzyme reactor for synthesizing bisoprolol, which comprises a reaction tank, a tank cover arranged at the top of the reaction tank and a bottom support arranged at the bottom of the reaction tank, wherein a feed pipe is arranged at the top of the tank cover, a discharge pipe is arranged at the bottom of the bottom support, the bottom support is fixed at the bottom of the reaction tank through a fastener, a plurality of positioning rods extending into the reaction tank are arranged at the top of the bottom support, a group of filling columns are arranged between the plurality of positioning rods, and a limiting ring which is abutted to the top of the filling columns is arranged on the inner wall of the reaction tank.

Inventors

  • ZHENG XUAN
  • HE CONG
  • WANG JIANWU

Assignees

  • 浙江希尔化工股份有限公司

Dates

Publication Date
20260512
Application Date
20250516

Claims (7)

  1. 1. An immobilized enzyme reactor for synthesizing bisoprolol comprises a reaction tank (1), a tank cover (2) arranged at the top of the reaction tank (1) and a bottom bracket (3) arranged at the bottom of the reaction tank (1); The reaction tank is characterized in that a feeding pipe (6) is arranged at the top of the tank cover (2), a discharging pipe (20) is arranged at the bottom of the bottom support (3), the bottom support (3) is fixed at the bottom of the reaction tank (1) through a fastener, a plurality of positioning rods (19) extending into the reaction tank (1) are arranged at the top of the bottom support (3), a group of filling columns (18) are arranged among the positioning rods (19), and a limiting ring (17) which is abutted to the top of the filling columns (18) is arranged on the inner wall of the reaction tank (1); The reactor is characterized in that a separation disc (9) is arranged at the top of the reaction tank (1), a feeding hole (10) is formed in the separation disc (9), a stirring piece is arranged at the bottom of the separation disc (9) and used for spraying materials output by the feeding hole (10) to a filling column (18), and a driving piece (5) used for driving the stirring piece to work is arranged at the top of the tank cover (2).
  2. 2. The immobilized enzyme reactor for bisoprolol synthesis according to claim 1, wherein the fastener comprises a rotating seat (12) and a rotating rod (13) rotatably connected to the end part of the rotating seat (12), one end, far away from the rotating rod (13), of the rotating seat (12) is fixedly connected to the bottom of the outer ring at the top of the bottom support (3), one end, far away from the rotating seat (12), of the rotating rod (13) is in threaded connection with a threaded sleeve (14), a rotating handle (15) is connected to the threaded sleeve (14), and a groove (16) for placing the rotating rod (13) is formed in the outer ring at the bottom of the reaction tank (1).
  3. 3. The immobilized enzyme reactor for bisoprolol synthesis according to claim 1, wherein an annular groove for installing a separation disc (9) is formed in the top of the reaction tank (1), the outer wall of the separation disc (9) is abutted to the annular groove, the outer diameter of the separation disc (9) is larger than the inner diameter of the reaction tank (1), and the reaction tank (1) is connected with a tank cover (2) through a fastening bolt.
  4. 4. The immobilized enzyme reactor for bisoprolol synthesis according to claim 3, wherein the stirring piece comprises a center rod (7) and a spiral blade (8) connected to the center rod (7), an arc-shaped isolation plate (11) mounted on the center rod (7) is arranged at the top of the spiral blade (8), the top of the arc-shaped isolation plate (11) is in sliding fit with the bottom of the isolation disc (9), and a notch corresponding to the feeding hole (10) is formed in the arc-shaped isolation plate (11).
  5. 5. The immobilized enzyme reactor for synthesizing bisoprolol according to claim 4, wherein the driving part (5) comprises a driving part (5) arranged at the top of the tank cover (2), a power shaft at the power output end of the driving part (5) is connected with the top end of the central rod (7), and a rotating hole in rotating fit with the central rod (7) is formed in the separation disc (9).
  6. 6. The immobilized enzyme reactor for synthesizing bisoprolol according to claim 1, wherein the outer wall of the reaction tank (1) is connected with three groups of support frames (4), and the three groups of support frames (4) are uniformly distributed along the circumference by taking the axis of the reaction tank (1) as the center.
  7. 7. The immobilized enzyme reactor for synthesizing bisoprolol according to claim 1, wherein a heating layer is arranged between the inner wall and the outer wall of the reaction tank (1).

Description

Immobilized enzyme reactor for bisoprolol synthesis Technical Field The utility model relates to the technical field of reactors, in particular to an immobilized enzyme reactor for synthesizing bisoprolol. Background Bisoprolol (bisoprolol), having the molecular formula of C18H31NO4, is a yellow oily liquid, and is a beta blocker. It can selectively act by blocking the linkage of epinephrine to the β1 receptor without affecting the β2 receptor, and is a β1-blocker with high affinity and selectivity for the cardiac β1-receptor. S- (-) -bisoprolol is the levorotatory form, involving a multi-step reaction in the synthesis, involving the introduction of chiral centers, possibly with chiral auxiliary or asymmetric catalysis. For example, a packed bed reactor or a microchannel reactor is used, and immobilized lipase (such as CAL-B) or ketoreductase is filled in the reactor to catalyze asymmetric reduction reaction to generate S-configuration alcohol with high ee value. Wherein a reactor is required. In a fixed bed reactor disclosed in the prior patent publication No. CN219377077U, the fixed bed reactor comprises a fixed bed reactor body, a fixed bed layer is arranged in the fixed bed reactor body, positioning rings are arranged at the upper end and the lower end of the fixed bed layer, a supporting plate is arranged at the bottom of the fixed bed layer, a supporting rod is arranged at the bottom of the supporting plate, an electric heating bent pipe is arranged in the fixed bed layer, heating boxes are arranged at two sides of the fixed bed reactor body, a fixing seat is arranged in the heating boxes, an electric heating pipe is arranged in the fixing seat, an end cover is arranged at the top of the fixed bed reactor body, raw materials are added into the fixed bed reactor body through a feed hopper, filtered by a filter screen in the feed hopper and then enter a feed pipe, raw material air flow in the feed pipe is ejected from strip-shaped holes and then enters the fixed bed layer through dispersion of the silk screen, and thus the raw material air uniformly enters the fixed bed layer. The fixed bed layer is arranged in the reactor for reaction, and is fixed inside the reactor through the supporting rods, the supporting plates and the positioning rings, the end cover is required to be disassembled integrally for disassembly, the heating box and the electric heating tube are required to be removed, the operation is complex and time-consuming, the catalyst regeneration or replacement period is long, and the productivity is influenced. For this purpose, an immobilized enzyme reactor for synthesizing bisoprolol has been proposed. Disclosure of utility model The utility model aims to provide an immobilized enzyme reactor for synthesizing bisoprolol, which solves the problems in the prior art. In order to achieve the above purpose, the present utility model provides the following technical solutions: The immobilized enzyme reactor for synthesizing bisoprolol comprises a reaction tank, a tank cover arranged at the top of the reaction tank and a bottom support arranged at the bottom of the reaction tank, wherein a feed pipe is arranged at the top of the tank cover, a discharge pipe is arranged at the bottom of the bottom support, the bottom support is fixed at the bottom of the reaction tank through a fastener, a plurality of positioning rods extending into the reaction tank are arranged at the top of the bottom support, a group of filling columns are arranged between the positioning rods, and a limiting ring which is in butt joint with the top of the filling columns is arranged on the inner wall of the reaction tank; The separation disc is arranged at the top of the reaction tank, a feeding hole is formed in the separation disc, a stirring piece is arranged at the bottom of the separation disc and used for spraying materials output by the feeding hole to the filling column, and a driving piece used for driving the stirring piece to work is arranged at the top of the tank cover. In an alternative scheme, the fastener comprises a rotating seat and a rotating rod rotatably connected to the end part of the rotating seat, one end, far away from the rotating rod, of the rotating seat is fixedly connected to the bottom of the outer ring at the top of the bottom support, one end, far away from the rotating seat, of the rotating rod is in threaded connection with a threaded sleeve, the threaded sleeve is connected with a rotating handle, and a groove for placing the rotating rod is formed in the outer ring at the bottom of the reaction tank. In an alternative scheme, an annular groove for installing a separation disc is formed in the top of the reaction tank, the outer wall of the separation disc is abutted to the annular groove, the outer diameter of the separation disc is larger than the inner diameter of the reaction tank, and the reaction tank is connected with a tank cover through a fastening bolt. In an alternative scheme